DE69839768D1 - Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung - Google Patents

Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Info

Publication number
DE69839768D1
DE69839768D1 DE69839768T DE69839768T DE69839768D1 DE 69839768 D1 DE69839768 D1 DE 69839768D1 DE 69839768 T DE69839768 T DE 69839768T DE 69839768 T DE69839768 T DE 69839768T DE 69839768 D1 DE69839768 D1 DE 69839768D1
Authority
DE
Germany
Prior art keywords
lactoferrin
derived proteins
plants
production
plant cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69839768T
Other languages
English (en)
Inventor
Dominique Legrand
Valerie Salmon
Genevieve Spik
Veronique Gruber
Philippe Bournat
Bertrand Merot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meristem Therapeutics SA
Original Assignee
Meristem Therapeutics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meristem Therapeutics SA filed Critical Meristem Therapeutics SA
Application granted granted Critical
Publication of DE69839768D1 publication Critical patent/DE69839768D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fertilizers (AREA)
DE69839768T 1997-05-02 1998-05-04 Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung Expired - Fee Related DE69839768D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9705699A FR2762850B1 (fr) 1997-05-02 1997-05-02 Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
PCT/FR1998/000895 WO1998050543A1 (fr) 1997-05-02 1998-05-04 Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

Publications (1)

Publication Number Publication Date
DE69839768D1 true DE69839768D1 (de) 2008-09-04

Family

ID=9506722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839768T Expired - Fee Related DE69839768D1 (de) 1997-05-02 1998-05-04 Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung

Country Status (9)

Country Link
US (3) US6569831B1 (de)
EP (1) EP0981617B1 (de)
JP (1) JP2001527406A (de)
AT (1) ATE402260T1 (de)
AU (1) AU7659298A (de)
CA (1) CA2288435A1 (de)
DE (1) DE69839768D1 (de)
FR (1) FR2762850B1 (de)
WO (1) WO1998050543A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762850B1 (fr) * 1997-05-02 2000-02-11 Biocem Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
IT1299565B1 (it) * 1998-07-17 2000-03-16 Plantechno S R L Polinucleotide sintetico codificante per la lattoferrina umana, vettori, cellule e piante transgeniche che lo contengono.
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US6835868B1 (en) 1999-03-17 2004-12-28 University Of Victoria Innovation And Development Corporation Transgenic plants expressing dermaseptin peptides providing broad spectrum resistance to pathogens
EP1163352A1 (de) * 1999-03-17 2001-12-19 University Of Victoria Innovation And Development Corporation Transgene pflanzen die gegen ein breites spektrum von pathogenen resistent sind
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
US6991824B2 (en) * 2000-05-02 2006-01-31 Ventria Bioscience Expression of human milk proteins in transgenic plants
US7304208B2 (en) 2000-05-02 2007-12-04 Ventria Bioscience Expression of human serum albumin (HSA) in monocot seeds
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
AU2001255797A1 (en) 2000-05-02 2001-11-12 Applied Phytologics, Inc. Enhanced gene expression in plants using transcription factors
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
CA2437868A1 (en) * 2001-02-14 2002-08-22 Ventria Bioscience Expression of human milk proteins in transgenic plants
AU2002250126A1 (en) * 2001-02-14 2002-08-28 Ventria Bioscience Feed additive compositions and methods
AU2012202697B2 (en) * 2001-02-14 2015-05-07 Ventria Bioscience Expression of human milk proteins in transgenic plants
ES2467155T3 (es) * 2001-02-14 2014-06-12 Ventria Bioscience Expresión de proteínas de leche humana en plantas transgénicas
SE0200598D0 (sv) * 2002-02-27 2002-02-27 A & Science Invest Ab Pharmaceutical composition and method for treatment or prevention of vascular disease or states of tissue hypoperfusion with hypoxic and/or ischemic consequences
AU2002360677A1 (en) * 2002-12-20 2004-07-29 Ventria Bioscience Lactoferrin protein with iron for treating iron deficiency and anemia
CA2548749A1 (en) * 2003-12-09 2005-06-23 Ventria Bioscience High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers
US20080010697A1 (en) * 2003-12-23 2008-01-10 Daichang Yang Methods of Expressing Heterologous Protein in Plant Seeds Using Monocot Non Seed-Storage Protein Promoters
EP2431458A1 (de) * 2005-06-28 2012-03-21 Ventria Bioscience Komponenten von aus Pflanzenzellen hergestellten Zellkulturmedien
EP1904638A2 (de) 2005-07-18 2008-04-02 Metabogal Ltd. Mukosale oder enterale verabreichung biologisch aktiver makromoleküle
WO2007038623A2 (en) * 2005-09-28 2007-04-05 Ventria Bioscience Oral formulation for enteric disorders and/or rehydration
EP1808491A1 (de) * 2006-01-13 2007-07-18 Meristem Therapeutics S.A. Genetisch modifizierte Pflanze mit verändertem Gehalt an Reserveproteinen
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
CA2752729A1 (en) 2009-02-20 2010-08-26 Ventria Bioscience Cell culture media containing combinations of proteins
US10894812B1 (en) 2020-09-30 2021-01-19 Alpine Roads, Inc. Recombinant milk proteins
AU2021353004A1 (en) 2020-09-30 2023-04-13 Nobell Foods, Inc. Recombinant milk proteins and food compositions comprising the same
US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2436095A (en) * 1994-05-05 1995-11-29 Ferrodynamics, Inc. Cloning, expression, and uses of human lactoferrin
KR0154495B1 (ko) * 1995-05-22 1998-10-15 김은영 인체 락토페린 유전자로 형질전환된 항바이러스성 식물체의 제조방법
FR2736930B1 (fr) 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
KR20000029948A (ko) 1996-08-14 2000-05-25 한스 루돌프 하우스;헨리테 브룬너;베아트리체 귄터 식물병원성진균에대해억제활성을갖는펩타이드
FR2762850B1 (fr) * 1997-05-02 2000-02-11 Biocem Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations

Also Published As

Publication number Publication date
CA2288435A1 (fr) 1998-11-12
AU7659298A (en) 1998-11-27
US8334254B2 (en) 2012-12-18
ATE402260T1 (de) 2008-08-15
WO1998050543A1 (fr) 1998-11-12
FR2762850B1 (fr) 2000-02-11
EP0981617B1 (de) 2008-07-23
US20110092411A1 (en) 2011-04-21
EP0981617A1 (de) 2000-03-01
FR2762850A1 (fr) 1998-11-06
JP2001527406A (ja) 2001-12-25
US7354902B2 (en) 2008-04-08
US6569831B1 (en) 2003-05-27
US20030229925A1 (en) 2003-12-11

Similar Documents

Publication Publication Date Title
DE69839768D1 (de) Rekombinante lactoferrin, verfahren zu ihrer herstellung mittels pflanzen und ihre verwendung
ATE308614T1 (de) Durch pflanzen hergestelltes rekombinantes kollagen, verfahren zu ihrer herstellung und verwendung
DE60123079D1 (de) Stress-gekoppelter transkriptionsfaktor und dessen verwendung in pflanzen
ATE252157T1 (de) Nucleinsäuremoleküle aus pflanzen codierend enzyme, die an der stärkesynthese beteiligt sind
DE69333731D1 (de) Glialmitogene faktoren, ihre herstellung und verwendung
DE69737507D1 (de) Neue nukleinsäuremoleküle aus mais und deren verwendung zur herstellung modifizierter stärke
ATE447855T1 (de) Verfahren zur herstellung einer modifizierten stärke
DE69030539D1 (de) Wachstumsfaktor aus parenchymalen Lebenszellen, dafür kodierendes Gen, Verfahren zur Herstellung dieses Faktors und Transformanten
DE59003144D1 (de) Destillationsanlage zur Herstellung von Wasserstoff-Peroxid.
DE68907608D1 (de) Verfahren zur herstellung von lignin-peroxidase durch verwendung von nichtproliferierenden phanerochaete chryosporium-zellen.
DE59404358D1 (de) Verfahren zur herstellung von 1,4-butandiol
MX9707973A (es) Lipasas preduodenales recombinantes y polipeptidos derivados producidos por las plantas, sus procedimientos de obtencion y sus utilizaciones.
DE69634753D1 (de) "targeting" polypeptide der inneren plastidenhüllmembran; ihre herstellung und verwendung
DE50010015D1 (de) Tetrahydropyrimidin-dioxygenase-gen, dadurch kodierte polypeptide und verfahren zur deren herstellung
DE68920358D1 (de) Verfahren zur Herstellung von Schwefelwasserstoff.
DE3768985D1 (de) Verwendung eines feststoffkatalysators zur herstellung von chlorfluorkohlenwasserstoffen.
ATA186592A (de) Nukleotidsequenz, die für den transforming growth faktor-beta2 kodiert, transforming growth faktor-beta2 sowie verfahren und zellen zur herstellung desselben
ATE38032T1 (de) Mehrstufenverfahren unter verwendung von adiabatischen reaktoren zur herstellung von isocyanaten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee