ATE308614T1 - Durch pflanzen hergestelltes rekombinantes kollagen, verfahren zu ihrer herstellung und verwendung - Google Patents
Durch pflanzen hergestelltes rekombinantes kollagen, verfahren zu ihrer herstellung und verwendungInfo
- Publication number
- ATE308614T1 ATE308614T1 AT97952089T AT97952089T ATE308614T1 AT E308614 T1 ATE308614 T1 AT E308614T1 AT 97952089 T AT97952089 T AT 97952089T AT 97952089 T AT97952089 T AT 97952089T AT E308614 T1 ATE308614 T1 AT E308614T1
- Authority
- AT
- Austria
- Prior art keywords
- plants
- derived proteins
- production
- recombinant collagen
- collagen produced
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title abstract 4
- 108010035532 Collagen Proteins 0.000 title abstract 4
- 229920001436 collagen Polymers 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000002299 complementary DNA Substances 0.000 abstract 2
- 230000035897 transcription Effects 0.000 abstract 2
- 238000013518 transcription Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9616224A FR2757874B1 (fr) | 1996-12-17 | 1996-12-17 | Collagenes recombinants et proteines derivees produits par les plantes, leurs procedes d'obtention et leurs utilisations |
PCT/FR1997/002331 WO1998027202A1 (fr) | 1996-12-17 | 1997-12-17 | Collagenes recombinants et proteines derivees produits par les plantes, leurs procedes d'obtention et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE308614T1 true ATE308614T1 (de) | 2005-11-15 |
Family
ID=9499306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97952089T ATE308614T1 (de) | 1996-12-17 | 1997-12-17 | Durch pflanzen hergestelltes rekombinantes kollagen, verfahren zu ihrer herstellung und verwendung |
Country Status (9)
Country | Link |
---|---|
US (2) | US6617431B1 (de) |
EP (1) | EP0951537B1 (de) |
JP (1) | JP2001507573A (de) |
AT (1) | ATE308614T1 (de) |
AU (1) | AU5563798A (de) |
CA (1) | CA2274807A1 (de) |
DE (1) | DE69734528T2 (de) |
FR (1) | FR2757874B1 (de) |
WO (1) | WO1998027202A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19834909A1 (de) * | 1998-08-03 | 2000-02-17 | Mpb Cologne Gmbh Molecular Pla | Faserproteine und ihre Herstellung |
WO2000066732A2 (en) * | 1999-04-30 | 2000-11-09 | Biostratum, Inc. | Laminin 8 and methods for its use |
DE60036636T2 (de) * | 1999-11-12 | 2008-07-17 | Fibrogen, Inc., South San Francisco | Bovines kollagen und verfahren zur herstellung rekombinanter gelatine |
WO2001034646A2 (en) * | 1999-11-12 | 2001-05-17 | Fibrogen, Inc. | Recombinant gelatins |
US6992172B1 (en) | 1999-11-12 | 2006-01-31 | Fibrogen, Inc. | Recombinant gelatins |
AU2005246967B2 (en) * | 1999-11-12 | 2008-09-04 | Fibrogen, Inc. | Recombinant gelatins |
FR2807436B1 (fr) * | 2000-04-10 | 2002-05-24 | Meristem Therapeutics | Methode d'obtention de fibres d'un polypeptide collagenique recombinant non-hydroxyle, et fibres de polypeptide collagenique recombinant non-hydroxyle ainsi obtenues |
FR2854328B1 (fr) * | 2003-04-29 | 2006-08-04 | Rocher Yves Biolog Vegetale | Composition cosmetique ou dermatologique ou pharmaceutique contenant un facteur de croissance du type vegetal de nature peptidique |
US7268116B2 (en) * | 2003-10-02 | 2007-09-11 | Genhunter Corp. | Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins |
MX2007003767A (es) | 2004-09-29 | 2007-07-17 | Collplant Ltd | Colageno recombinante producido en planta. |
US8455717B2 (en) | 2004-09-29 | 2013-06-04 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
US20110070201A1 (en) | 2005-07-18 | 2011-03-24 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
WO2007041627A1 (en) | 2005-10-03 | 2007-04-12 | Pinsky Mark A | Compositions and methods for improved skin care |
US20080081353A1 (en) * | 2006-09-29 | 2008-04-03 | Universite Laval | Production of recombinant human collagen |
EP2220246B1 (de) * | 2007-10-26 | 2015-05-20 | Collplant Ltd. | Verfahren zur prozessierung von rekombinantem procollagen |
ES2710498T3 (es) * | 2007-12-26 | 2019-04-25 | Mark A Pinsky | Formulaciones de colágeno para la mejora del cuidado de la piel |
WO2009128076A2 (en) | 2008-04-18 | 2009-10-22 | Collplant Ltd. | Methods of generating and using procollagen |
WO2011060583A1 (zh) | 2009-11-19 | 2011-05-26 | 浙江大学 | 非天然的胶原样蛋白及其应用 |
EP2504472A1 (de) | 2009-11-24 | 2012-10-03 | Collplant Ltd. | Verfahren zur erzeugung von kollagenfasern |
US9732321B2 (en) | 2010-02-16 | 2017-08-15 | The General Hospital Corporation | Engineered craniofacial constructs with composite scaffold |
WO2012066543A2 (en) | 2010-11-16 | 2012-05-24 | Collplant Ltd. | Collagen structures and method of fabricating the same |
WO2013093921A1 (en) | 2011-12-20 | 2013-06-27 | Collplant Ltd. | Collagen coated synthetic polymer fibers |
DK2976097T3 (da) | 2013-03-21 | 2021-08-16 | Collplant Ltd | Sammensætninger, som omfatter kollagen og prp, til vævsregenerering og fremgangsmåde til fremstilling deraf |
CN114225013A (zh) * | 2015-12-23 | 2022-03-25 | 菲尼克斯组织修复公司 | 胶原蛋白7的组合物及其使用方法 |
US11377490B2 (en) | 2017-05-31 | 2022-07-05 | Sichuan Clover Biopharmaceuticals, Inc | Method for treating cancer using disulfide-linked trimeric 4-1BBL |
KR20190020644A (ko) * | 2017-07-18 | 2019-03-04 | 모던 메도우 아이엔씨. | 생제작된 가죽 물품 및 이의 방법 |
US11180541B2 (en) | 2017-09-28 | 2021-11-23 | Geltor, Inc. | Recombinant collagen and elastin molecules and uses thereof |
WO2019211854A1 (en) | 2018-05-03 | 2019-11-07 | Collplant Holdings Ltd. | Dermal fillers and applications thereof |
GB2579036A (en) * | 2018-11-15 | 2020-06-10 | Rejuvenated Ltd | Compositions comprising amino acids |
WO2020210440A1 (en) | 2019-04-12 | 2020-10-15 | Geltor, Inc. | Recombinant elastin and production thereof |
FR3105792B1 (fr) | 2019-12-26 | 2022-08-12 | Michel Assor | Matériau biocomposite collagène/matrice polymérique poreuse et son utilisation comme implant de réparation de lésions méniscales du genou et/ou de prévention ou de traitement de l’arthrose du genou |
MX2022009036A (es) | 2020-01-24 | 2022-11-14 | Geltor Inc | Colageno dietetico no de animales. |
WO2021229577A1 (en) | 2020-05-12 | 2021-11-18 | Collplant Ltd. | Collagen as a delivery tool for metal-based anti-viral agents |
WO2021249116A1 (en) | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Coronavirus vaccine compositions, methods, and uses thereof |
WO2023194333A1 (en) | 2022-04-04 | 2023-10-12 | Swiftpharma Bv | Recombinant spider silk-reinforced collagen proteins produced in plants and the use thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
US5650554A (en) * | 1991-02-22 | 1997-07-22 | Sembiosys Genetics Inc. | Oil-body proteins as carriers of high-value peptides in plants |
WO1993007889A1 (en) * | 1991-10-23 | 1993-04-29 | Thomas Jefferson University | Synthesis of human procollagens and collagens in recombinant dna systems |
FR2685347A1 (fr) * | 1991-12-23 | 1993-06-25 | Univ Pasteur | Procede biotechnologique d'obtention et de production microbienne d'oligomeres peptidiques comme substituts de la gelatine. |
DK0636179T3 (da) * | 1992-04-15 | 2004-12-20 | Sembiosys Genetics Inc | Olielegemeproteiner som bærestoffer af höjværdi-peptider i planter |
US5693506A (en) * | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
US6713662B1 (en) * | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
WO1997004123A1 (en) * | 1995-07-19 | 1997-02-06 | Gel Tech Group Inc. | Collagen compound production in plants |
WO1998006861A2 (en) * | 1996-08-15 | 1998-02-19 | Agrivax Incorporated | Delivery of tolerogenic antigens via edible plants or plant-derived products |
-
1996
- 1996-12-17 FR FR9616224A patent/FR2757874B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-17 CA CA002274807A patent/CA2274807A1/fr not_active Abandoned
- 1997-12-17 JP JP52740898A patent/JP2001507573A/ja active Pending
- 1997-12-17 US US09/331,347 patent/US6617431B1/en not_active Expired - Fee Related
- 1997-12-17 AU AU55637/98A patent/AU5563798A/en not_active Abandoned
- 1997-12-17 EP EP97952089A patent/EP0951537B1/de not_active Revoked
- 1997-12-17 DE DE69734528T patent/DE69734528T2/de not_active Expired - Fee Related
- 1997-12-17 AT AT97952089T patent/ATE308614T1/de not_active IP Right Cessation
- 1997-12-17 WO PCT/FR1997/002331 patent/WO1998027202A1/fr active IP Right Grant
-
2002
- 2002-08-09 US US10/216,705 patent/US20030096973A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030096973A1 (en) | 2003-05-22 |
AU5563798A (en) | 1998-07-15 |
FR2757874A1 (fr) | 1998-07-03 |
FR2757874B1 (fr) | 2003-04-25 |
WO1998027202A1 (fr) | 1998-06-25 |
DE69734528T2 (de) | 2006-07-27 |
DE69734528D1 (de) | 2005-12-08 |
EP0951537B1 (de) | 2005-11-02 |
EP0951537A1 (de) | 1999-10-27 |
US6617431B1 (en) | 2003-09-09 |
CA2274807A1 (fr) | 1998-06-25 |
JP2001507573A (ja) | 2001-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |