DE69837760D1 - Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht - Google Patents

Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht

Info

Publication number
DE69837760D1
DE69837760D1 DE69837760T DE69837760T DE69837760D1 DE 69837760 D1 DE69837760 D1 DE 69837760D1 DE 69837760 T DE69837760 T DE 69837760T DE 69837760 T DE69837760 T DE 69837760T DE 69837760 D1 DE69837760 D1 DE 69837760D1
Authority
DE
Germany
Prior art keywords
cleansing
chromatography
protein
subsequent filtration
loaded layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837760T
Other languages
English (en)
Other versions
DE69837760T2 (de
DE69837760T3 (de
Inventor
Gregory S Blank
Daljit S Narindray
Gerardo A Zapata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21968517&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69837760(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE69837760D1 publication Critical patent/DE69837760D1/de
Publication of DE69837760T2 publication Critical patent/DE69837760T2/de
Application granted granted Critical
Publication of DE69837760T3 publication Critical patent/DE69837760T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
DE69837760T 1997-06-13 1998-06-12 Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht Expired - Lifetime DE69837760T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5095197P 1997-06-13 1997-06-13
US50951P 1997-06-13
PCT/US1998/012334 WO1998056808A1 (en) 1997-06-13 1998-06-12 Protein recovery by chromatography followed by filtration upon a charged layer
EP98926586A EP0998486B2 (de) 1997-06-13 1998-06-12 Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht

Publications (3)

Publication Number Publication Date
DE69837760D1 true DE69837760D1 (de) 2007-06-21
DE69837760T2 DE69837760T2 (de) 2008-02-28
DE69837760T3 DE69837760T3 (de) 2012-06-21

Family

ID=21968517

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837760T Expired - Lifetime DE69837760T3 (de) 1997-06-13 1998-06-12 Proteinreinigung mittels chromatographie und darauffolgende filtration auf beladener schicht

Country Status (12)

Country Link
US (4) US6121428A (de)
EP (1) EP0998486B2 (de)
JP (1) JP2001510483A (de)
AT (1) ATE361930T1 (de)
AU (1) AU735883C (de)
CA (1) CA2289665C (de)
DE (1) DE69837760T3 (de)
DK (1) DK0998486T4 (de)
ES (1) ES2287976T3 (de)
IL (1) IL132838A (de)
PT (1) PT998486E (de)
WO (1) WO1998056808A1 (de)

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EA006605B1 (ru) * 2000-02-22 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
JP5113314B2 (ja) * 2000-09-01 2013-01-09 ザ センター フォー ブラッド リサーチ インク 所望のコンホメーションで安定させた改変ポリペプチド及び該ポリペプチドの作製方法
WO2002060377A2 (en) * 2000-12-15 2002-08-08 The Johns Hopkins University The separation, identification and quantitation of protein mixtures
US20040067599A1 (en) * 2001-12-14 2004-04-08 Katz Joseph L. Separation identification and quantitation of protein mixtures
WO2003059935A2 (en) * 2001-12-21 2003-07-24 Immunex Corporation Methods for purifying protein
US20050271639A1 (en) * 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
HUE027196T2 (hu) * 2002-09-06 2016-10-28 Genentech Inc Eljárás fehérjeextrakcióra
EP1581644B1 (de) 2003-01-09 2007-06-06 Genentech, Inc. Reinigung von polypeptiden
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CN100526453C (zh) * 2005-05-20 2009-08-12 麦克奥迪实业集团有限公司 激光显微切割后细胞收集方法
AU2006292433B2 (en) * 2005-09-20 2011-05-19 Amgen Inc. Method for generating F(ab')2 antibody fragments
WO2007075283A2 (en) * 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
WO2008079280A1 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
EP2142206B1 (de) * 2007-03-30 2014-07-30 The Cleveland Clinic Foundation SDf-1 zur Verwendung bei der Behandlung der ischämischen peripheren Gefäßerkrankungen
RU2009148891A (ru) 2007-06-01 2011-07-20 Ф.Хоффманн-Ля Рош Аг (Ch) Очистка иммуноглобулина
CA2709398C (en) 2007-12-14 2017-11-07 The Cleveland Clinic Foundation Use of stromal cell-derived factor 1 for promoting wound healing
CN105037535A (zh) 2008-12-16 2015-11-11 Emd密理博公司 搅拌槽反应器及方法
BRPI0923541A2 (pt) 2008-12-22 2016-01-26 Hoffmann La Roche purificação de imunoglobulina
JP5856059B2 (ja) 2009-08-28 2016-02-09 ザ クリーブランド クリニック ファウンデーション 虚血組織を治療するためのｓｄｆ−１送達
KR20120065383A (ko) * 2009-09-10 2012-06-20 론자 바이올로직스 피엘씨 폴리펩티드 정제를 위한 방법 및 시스템
EP2571903B1 (de) 2010-05-17 2019-09-04 EMD Millipore Corporation Stimulusreaktive polymere zur aufreinigung von biomolekülen
US9220775B2 (en) 2011-11-23 2015-12-29 Medimmune Llc Binding molecules specific for HER3 and uses thereof
WO2015048008A2 (en) 2013-09-24 2015-04-02 Medimmune, Llc Binding molecules specific for her3 and uses thereof
WO2015157634A1 (en) 2014-04-11 2015-10-15 Kolltan Pharmaceuticals, Inc. Anti-erbb antibodies and methods of use thereof

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CA1148872A (en) * 1979-04-06 1983-06-28 Eugene A. Ostreicher Filter with inorganic cationic colloidal silica
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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CA2008213A1 (en) 1989-02-21 1990-08-21 David A. Hilborn Method of fragmenting certain monoclonal antibodies
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GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
EP0586505A1 (de) * 1991-05-14 1994-03-16 Repligen Corporation Heterokonjugat-antikörper zur behandlung von hiv-infektionen
WO1993008829A1 (en) * 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
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AU735883C (en) * 1997-06-13 2002-02-07 Genentech Inc. Protein recovery by chromatography followed by filtration upon a charged layer

Also Published As

Publication number Publication date
IL132838A (en) 2004-08-31
US6121428A (en) 2000-09-19
EP0998486B2 (de) 2012-02-01
WO1998056808A1 (en) 1998-12-17
PT998486E (pt) 2007-08-21
DE69837760T2 (de) 2008-02-28
US6716598B2 (en) 2004-04-06
ES2287976T3 (es) 2007-12-16
US20020058324A1 (en) 2002-05-16
JP2001510483A (ja) 2001-07-31
US6322997B1 (en) 2001-11-27
DE69837760T3 (de) 2012-06-21
AU735883B2 (en) 2001-07-19
DK0998486T4 (da) 2012-05-14
CA2289665C (en) 2005-08-09
US20040138426A1 (en) 2004-07-15
IL132838A0 (en) 2001-03-19
CA2289665A1 (en) 1998-12-17
DK0998486T3 (da) 2007-09-10
AU7838898A (en) 1998-12-30
EP0998486A1 (de) 2000-05-10
AU735883C (en) 2002-02-07
EP0998486B1 (de) 2007-05-09
ATE361930T1 (de) 2007-06-15

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