DE69624942D1 - Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese - Google Patents

Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese

Info

Publication number
DE69624942D1
DE69624942D1 DE69624942T DE69624942T DE69624942D1 DE 69624942 D1 DE69624942 D1 DE 69624942D1 DE 69624942 T DE69624942 T DE 69624942T DE 69624942 T DE69624942 T DE 69624942T DE 69624942 D1 DE69624942 D1 DE 69624942D1
Authority
DE
Germany
Prior art keywords
screening
capillary electrophoresis
therapeutic compounds
new therapeutic
natural samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69624942T
Other languages
English (en)
Other versions
DE69624942T2 (de
Inventor
Dallas E Hughes
L Karger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northeastern University Boston
Original Assignee
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northeastern University Boston filed Critical Northeastern University Boston
Publication of DE69624942D1 publication Critical patent/DE69624942D1/de
Application granted granted Critical
Publication of DE69624942T2 publication Critical patent/DE69624942T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69624942T 1995-12-11 1996-12-10 Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese Expired - Fee Related DE69624942T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US850395P 1995-12-11 1995-12-11
US08/662,085 US5783397A (en) 1995-12-11 1996-06-12 Screening natural samples for new therapeutic compounds using capillary electrophoresis
PCT/US1996/019779 WO1997022000A1 (en) 1995-12-11 1996-12-10 Screening natural samples for new therapeutic compounds using capillary electrophoresis

Publications (2)

Publication Number Publication Date
DE69624942D1 true DE69624942D1 (de) 2003-01-02
DE69624942T2 DE69624942T2 (de) 2003-09-18

Family

ID=26678258

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69624942T Expired - Fee Related DE69624942T2 (de) 1995-12-11 1996-12-10 Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese

Country Status (8)

Country Link
US (1) US5783397A (de)
EP (1) EP0876609B1 (de)
JP (1) JP3603267B2 (de)
CA (1) CA2239418C (de)
DE (1) DE69624942T2 (de)
DK (1) DK0876609T3 (de)
ES (1) ES2187685T3 (de)
WO (1) WO1997022000A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
JP3788519B2 (ja) * 1996-06-28 2006-06-21 カリパー・ライフ・サイエンシズ・インコーポレーテッド 微小スケール流体装置の高処理能力スクリーニングアッセイシステム
US6528098B2 (en) * 1996-10-22 2003-03-04 Advanced Viral Research Corp. Preparation of a therapeutic composition
US6455323B1 (en) * 1997-07-03 2002-09-24 Pharmacia & Upjohn Company Anti-bacterial methods and materials
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6299747B1 (en) * 1997-12-17 2001-10-09 Cetek Corporation Capillary electrophoretic methods to detect new biologically active compounds in complex biological material
WO1999034203A1 (en) * 1997-12-24 1999-07-08 Cetek Corporation Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
EP1095267A1 (de) * 1998-07-10 2001-05-02 Cetek Corporation Verfahren zur feststellung und analyse von stark bindenden liganden in komplexen biologischen proben
US6432651B1 (en) 1998-07-10 2002-08-13 Cetek Corporation Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US20010041964A1 (en) 1998-09-14 2001-11-15 George M. Grass Pharmacokinetic-based drug design tool and method
AU3349900A (en) * 1999-01-26 2000-08-07 Du Pont Pharmaceuticals Company Electrophoretic assays to assess conformational changes of integrins induced by ligand binding
US6329145B1 (en) * 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
CA2362052A1 (en) 1999-02-12 2000-08-17 Cetek Corporation High throughput size-exclusive method of screening complex biological materials for affinity ligands
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
US7217573B1 (en) * 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
WO2001077365A2 (en) 2000-04-06 2001-10-18 Pharmacia & Upjohn Company Antimicrobial methods and materials
US7252932B1 (en) 2000-08-23 2007-08-07 Ambergen, Inc. Methods for the detection, analysis and isolation of nascent proteins
EP1720011A1 (de) 2000-12-01 2006-11-08 Cetek Corporation Kapillares Elektrophoresesystem mit hoher Durchlaufleistung
US20030132117A1 (en) * 2002-01-14 2003-07-17 Andras Guttman Thin film electrophoresis apparatus and method
US20040266021A9 (en) * 2001-01-26 2004-12-30 Andras Guttman Multicapillary fraction collection system and method
US20030087321A1 (en) * 2001-09-28 2003-05-08 Tomich Che-Shen C. Antimicrobial methods and materials
US20050272089A1 (en) * 2001-10-19 2005-12-08 Mott John E Critical genes and polypeptides of haemophilus influenzae and methods of use
AU2003209054A1 (en) * 2002-02-07 2003-09-02 Discovery Genomics, Inc. Factors for angiogenesis, vasculogenesis, cartilage formation, bone formation and methods of use thereof
JP4795688B2 (ja) * 2002-10-09 2011-10-19 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中の化合物を同定する方法および装置
US7672786B2 (en) 2003-07-02 2010-03-02 Sergey Krylov Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development
JP4512745B2 (ja) * 2004-10-29 2010-07-28 独立行政法人産業技術総合研究所 細胞の分離、同定装置及び方法
ES2391278T3 (es) * 2005-06-03 2012-11-23 Ohr Pharmaceutical, Inc. Métodos para proporcionar cuidado paliativo con Producto R
US7959861B2 (en) * 2007-09-19 2011-06-14 Stc.Unm Integrated affinity microcolumns and affinity capillary electrophoresis
JP5498399B2 (ja) 2008-02-12 2014-05-21 ヒューレット−パッカード デベロップメント カンパニー エル．ピー． 色検出器
KR20100126379A (ko) 2008-02-13 2010-12-01 휴렛-팩커드 디벨롭먼트 컴퍼니, 엘.피. 면적이 스케일링된 광 검출기들을 구비하는 컬러 검출기
BRPI0901112A2 (pt) * 2009-03-12 2010-11-16 Luiz Augusto Pinto processo de produção de oligonucleotìdeos de alta afinidade e alta especificidade para moléculas orgánicas e inorgánicas
US20110065101A1 (en) 2009-06-04 2011-03-17 Lockheed Martin Corporation Multiple-sample microfluidic chip for DNA analysis
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006850A1 (en) * 1989-11-06 1991-05-16 Massachusetts Institute Of Technology Affinity co-electrophoresis
US5532124A (en) * 1991-02-11 1996-07-02 Thomas Jefferson University Genetically engineered bacteria to identify and produce medically important agents
AU647929B2 (en) * 1991-03-28 1994-03-31 Perseptive Biosystems, Inc. On-line product identification in a chromatography effluent by subtraction
US5413686A (en) * 1992-07-17 1995-05-09 Beckman Instruments, Inc. Multi-channel automated capillary electrophoresis analyzer
US5348633A (en) * 1993-01-22 1994-09-20 Northeastern University Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis
US5534410A (en) * 1993-01-28 1996-07-09 The Regents Of The University Of California TATA-binding protein associated factors drug screens
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US5567282A (en) * 1994-01-25 1996-10-22 Wang; Hann-Ping On-capillary electrophoretic immunosubtraction for classification and typing of M-proteins
US5536382A (en) * 1994-05-23 1996-07-16 Advanced Molecular Systems, Inc. Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample
US5431793A (en) * 1994-07-29 1995-07-11 Beckman Instruments, Inc. Quantitative analysis of glycosylated hemoglobin by immunocappillary electrophoresis

Also Published As

Publication number Publication date
US5783397A (en) 1998-07-21
EP0876609A1 (de) 1998-11-11
ES2187685T3 (es) 2003-06-16
JP2000502443A (ja) 2000-02-29
DK0876609T3 (da) 2003-03-17
EP0876609B1 (de) 2002-11-20
JP3603267B2 (ja) 2004-12-22
CA2239418A1 (en) 1997-06-19
DE69624942T2 (de) 2003-09-18
WO1997022000A1 (en) 1997-06-19
CA2239418C (en) 2005-09-20

Similar Documents

Publication Publication Date Title
DE69624942D1 (de) Screening von natürlichen proben für neue therapeutische verbindungen mittels kapillarelectrophorese
DK0746398T3 (da) Antistofrensning
DE69609922T2 (de) Verfahren zur Trocknung von Gasen mittels Glycol mit anschliessender Raffinierung von gasförmigen Abflüssen
DE69918549D1 (de) Gerät zur feststellung von zahnbelag mittels fluoreszenzmessung
DE68926428D1 (de) Personalisierung von Benutzerschnittstellen für Anwendungsprogramme
DE19681286T1 (de) Neue Kristallform von Olanzapin
ATE332368T1 (de) Selektion von proteinen mittels rns-protein fusionen
DE69632447D1 (de) Analysator zur Analyse von Urinbestandteilen
AU3876993A (en) Analysis of samples by capillary electrophoretic immunosubtraction
DE69531197D1 (de) Verdrängungschromatographie von proteinen mittels verdrängungsreagentien von geringem molekulargewicht
DE69822934D1 (de) Chirale Trennung von pharmazeutischen Verbindungen mit geladenen Cyclodextrinen durch Kapillarelektrophorese
BR9609148A (pt) Método para aumentar o fluxo por eletrotransporte de polipeptídeos
DE69420750T2 (de) Verfahren zur Probenanalyse mittels Kapillarelektroforese
DE69622978T2 (de) Analysator zur Analyse von Urinbestandteilen
DE69817749D1 (de) Verwendung von mittels leitenten Mischmembranen hergestelltem Synthesegas
DE69718506T2 (de) Neue verwendung von kreatin
DE69505840T2 (de) Hydrogenierung von halogenierten verbindungen
IT1243515B (it) Metodo per la determinazione della espressione differenziale degli rna messangers per la proteina precursore dell'amiloide (amyloid precursor protein, app)
DE69505105D1 (de) Neue Klasse von stabilisierenden Verbindungen für Phosphorschirme
ATA80784A (de) Verfahren zur verlaengerung von resthaar mittels ergaenzungshaaren
DK0401657T3 (da) Fremgangsmåde til C-terminal modificering af proteiner
DE69506384D1 (de) Neue Klasse von stabilisierenden Verbindungen für Phosphorschirme
DE29512292U1 (de) Halterung zur reproduzierbaren Lagerung von Patienten
NO952921L (no) Innvendig stöttekonstruksjon for strengeinstrument
DE29707343U1 (de) Stangenförmiger Abstandhalter für Bewehrung von Betonbauteilen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee