DE69834024D1 - Tetracycline verbindungen zur behandlung von spezifischen krebsarten - Google Patents
Tetracycline verbindungen zur behandlung von spezifischen krebsartenInfo
- Publication number
- DE69834024D1 DE69834024D1 DE69834024T DE69834024T DE69834024D1 DE 69834024 D1 DE69834024 D1 DE 69834024D1 DE 69834024 T DE69834024 T DE 69834024T DE 69834024 T DE69834024 T DE 69834024T DE 69834024 D1 DE69834024 D1 DE 69834024D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- cancer
- growth
- tetracycline compounds
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US783655 | 1997-01-15 | ||
US08/783,655 US5837696A (en) | 1997-01-15 | 1997-01-15 | Method of inhibiting cancer growth |
PCT/US1998/000332 WO1998031224A1 (en) | 1997-01-15 | 1998-01-15 | Method of inhibiting cancer growth |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69834024D1 true DE69834024D1 (de) | 2006-05-18 |
DE69834024T2 DE69834024T2 (de) | 2006-12-07 |
Family
ID=25130005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69834024T Expired - Lifetime DE69834024T2 (de) | 1997-01-15 | 1998-01-15 | Tetracycline verbindungen zur behandlung von spezifischen krebsarten |
Country Status (11)
Country | Link |
---|---|
US (2) | US5837696A (de) |
EP (1) | EP0971585B1 (de) |
JP (1) | JP4428727B2 (de) |
KR (1) | KR20000070212A (de) |
AT (1) | ATE321452T1 (de) |
AU (1) | AU729886B2 (de) |
CA (1) | CA2277865C (de) |
DE (1) | DE69834024T2 (de) |
ES (1) | ES2262221T3 (de) |
PT (1) | PT971585E (de) |
WO (1) | WO1998031224A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
US6429204B1 (en) | 1997-01-15 | 2002-08-06 | University Of Miami | Method of inhibiting cancer growth |
AU2001599A (en) * | 1997-12-19 | 1999-07-05 | New York University | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
US6015804A (en) * | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
JP2002533387A (ja) * | 1998-12-23 | 2002-10-08 | ジー.ディー.サール & カンパニー | 腫瘍治療の複合療法としてインテグリン拮抗物質と一つ以上の抗腫瘍剤を使用する方法 |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6984619B1 (en) * | 1999-03-19 | 2006-01-10 | Arch Development Corporation | Method for protection against tumor metastasis formation |
DE10032256C2 (de) * | 2000-07-03 | 2003-06-05 | Infineon Technologies Ag | Chip-ID-Register-Anordnung |
EP1383483A4 (de) * | 2001-04-05 | 2006-08-09 | Collagenex Pharm Inc | Kontrollierte freisetzung von tetracyclin-verbindungen und tetracyclin-derivativen |
EP2332548A1 (de) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclinverbindungen zur Behandlung von Schlaganfall |
US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
RU2300380C2 (ru) * | 2001-10-05 | 2007-06-10 | Тетрадженекс Фармасьютикалс, Инк. | Производные тетрациклина и способы их применения |
PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
AU2003235759A1 (en) | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
EP1482926A4 (de) | 2002-03-08 | 2006-04-12 | Paratek Pharm Innc | Amino-methyl-substituierte tetracyclin-verbindungen |
KR101025400B1 (ko) | 2002-03-21 | 2011-03-28 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
US20050153943A1 (en) * | 2002-05-06 | 2005-07-14 | Ashley Robert A. | Methods of simultaneously treating mucositis and fungal infection |
EP1505961A4 (de) * | 2002-05-20 | 2009-09-02 | Collagenex Pharm Inc | Verfahren zur behandlung allergischer reaktionen |
AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
WO2004038000A2 (en) * | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
CA2803922C (en) | 2003-04-07 | 2015-09-15 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
US20050137174A1 (en) | 2003-07-09 | 2005-06-23 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2319829A1 (de) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | 9-subsituierte Tetracycline-Verbindungen |
CA2553510C (en) | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
EP2284151A3 (de) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituierte Tetracyclin-Verbindungen |
CA2585418A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
AU2006272698B2 (en) * | 2005-07-21 | 2012-11-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
US8513223B2 (en) * | 2006-12-21 | 2013-08-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
BRPI0720569B8 (pt) | 2006-12-21 | 2021-05-25 | Paratek Pharm Innc | compostos de tetraciclina substituída e uso dos ditos compostos para o tratamento de uma infecção bacteriana, viral ou parasitária |
JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
ES2386926T3 (es) * | 2007-07-06 | 2012-09-06 | Paratek Pharmaceuticals, Inc. | Métodos para sintetizar minociclina9-sustituida |
TW202216656A (zh) * | 2008-05-23 | 2022-05-01 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
SG10201806714PA (en) | 2008-08-08 | 2018-09-27 | Tetraphase Pharmaceuticals Inc | C7-fluoro substituted tetracycline compounds |
CA2761241C (en) | 2009-05-08 | 2018-02-27 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
CA2772386C (en) | 2009-08-28 | 2017-09-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
CN102821769A (zh) * | 2010-03-10 | 2012-12-12 | 大学健康网络 | 替加环素用于治疗癌症的用途 |
TWI592390B (zh) | 2010-03-31 | 2017-07-21 | 四相製藥公司 | 聚環狀四環素化合物 |
BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
CN105142631A (zh) | 2013-01-14 | 2015-12-09 | 健康诊所有限公司 | 抗癌药物和用途 |
SG11201903327PA (en) | 2016-10-19 | 2019-05-30 | Tetraphase Pharmaceuticals Inc | Crystalline forms of eravacycline |
US11197872B2 (en) | 2017-04-21 | 2021-12-14 | Lunella Biotech, Inc. | Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs) |
CA3060509A1 (en) | 2017-04-21 | 2018-10-25 | Federica Sotgia | Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy |
CA3063450A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
MX2019013735A (es) | 2017-05-19 | 2020-01-15 | Lunella Biotech Inc | Antimitoscinas: inhibidores especificos de la biogenesis mitocondrial para erradicar celulas madre cancerosas. |
US20210395198A1 (en) | 2018-11-09 | 2021-12-23 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
CN115006411A (zh) * | 2022-07-26 | 2022-09-06 | 中南大学湘雅医院 | 依拉环素类化合物的应用、药物及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
US5668122A (en) * | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
US5563130A (en) * | 1994-12-13 | 1996-10-08 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5574026A (en) * | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
US5567693A (en) * | 1994-12-13 | 1996-10-22 | American Cyanamid Company | Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
-
1997
- 1997-01-15 US US08/783,655 patent/US5837696A/en not_active Expired - Lifetime
-
1998
- 1998-01-15 DE DE69834024T patent/DE69834024T2/de not_active Expired - Lifetime
- 1998-01-15 CA CA002277865A patent/CA2277865C/en not_active Expired - Fee Related
- 1998-01-15 WO PCT/US1998/000332 patent/WO1998031224A1/en active IP Right Grant
- 1998-01-15 JP JP53443498A patent/JP4428727B2/ja not_active Expired - Fee Related
- 1998-01-15 US US09/007,645 patent/US6100248A/en not_active Expired - Lifetime
- 1998-01-15 KR KR1019997006438A patent/KR20000070212A/ko not_active Application Discontinuation
- 1998-01-15 EP EP98902437A patent/EP0971585B1/de not_active Expired - Lifetime
- 1998-01-15 AU AU59104/98A patent/AU729886B2/en not_active Ceased
- 1998-01-15 AT AT98902437T patent/ATE321452T1/de active
- 1998-01-15 ES ES98902437T patent/ES2262221T3/es not_active Expired - Lifetime
- 1998-01-15 PT PT98902437T patent/PT971585E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
EP0971585A4 (de) | 2001-01-24 |
ATE321452T1 (de) | 2006-04-15 |
DE69834024T2 (de) | 2006-12-07 |
AU5910498A (en) | 1998-08-07 |
EP0971585A1 (de) | 2000-01-19 |
CA2277865C (en) | 2009-06-02 |
PT971585E (pt) | 2006-08-31 |
US6100248A (en) | 2000-08-08 |
WO1998031224A1 (en) | 1998-07-23 |
EP0971585B1 (de) | 2006-03-29 |
CA2277865A1 (en) | 1998-07-23 |
KR20000070212A (ko) | 2000-11-25 |
AU729886B2 (en) | 2001-02-15 |
JP4428727B2 (ja) | 2010-03-10 |
US5837696A (en) | 1998-11-17 |
ES2262221T3 (es) | 2006-11-16 |
JP2001508794A (ja) | 2001-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |