DE69830600D1 - Anilidverbindungen und medikamente, die diese enthalten - Google Patents
Anilidverbindungen und medikamente, die diese enthaltenInfo
- Publication number
- DE69830600D1 DE69830600D1 DE69830600T DE69830600T DE69830600D1 DE 69830600 D1 DE69830600 D1 DE 69830600D1 DE 69830600 T DE69830600 T DE 69830600T DE 69830600 T DE69830600 T DE 69830600T DE 69830600 D1 DE69830600 D1 DE 69830600D1
- Authority
- DE
- Germany
- Prior art keywords
- substituent
- lower alkyl
- alkyl group
- aryl group
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- -1 anilide compound Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005516 coenzyme A Substances 0.000 abstract 1
- 229940093530 coenzyme a Drugs 0.000 abstract 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9014697 | 1997-03-25 | ||
| JP9014697 | 1997-03-25 | ||
| PCT/JP1998/001337 WO1998042680A1 (fr) | 1997-03-25 | 1998-03-25 | Nouveaux composes anilide et medicaments les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69830600D1 true DE69830600D1 (de) | 2005-07-21 |
| DE69830600T2 DE69830600T2 (de) | 2006-05-04 |
Family
ID=13990371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69830600T Expired - Lifetime DE69830600T2 (de) | 1997-03-25 | 1998-03-25 | Anilidverbindungen und medikamente, die diese enthalten |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6362208B1 (de) |
| EP (1) | EP1020451B1 (de) |
| JP (1) | JP4647726B2 (de) |
| AT (1) | ATE297900T1 (de) |
| AU (1) | AU6517698A (de) |
| DE (1) | DE69830600T2 (de) |
| ES (1) | ES2245026T3 (de) |
| WO (1) | WO1998042680A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0987254B1 (de) * | 1997-05-26 | 2004-12-22 | Kowa Co., Ltd. | Neue zyklische diaminverbindungen und heilmittel das diese enthält |
| US6969711B2 (en) | 1997-05-26 | 2005-11-29 | Kowa Company, Ltd. | Cyclic diamine compounds and medicine containing the same |
| JP2003012647A (ja) * | 2000-10-04 | 2003-01-15 | Shionogi & Co Ltd | ２，３−ジアミノピリジンの製造方法 |
| US7163944B2 (en) * | 2004-01-26 | 2007-01-16 | Kowa Co., Ltd. | Cyclic diamine compound and pharmaceutical containing the same |
| EP3658138B1 (de) * | 2017-07-27 | 2023-04-19 | Stingray Therapeutics, Inc. | Substituierte-3h-imidazo(4,5-c)pyridin- und -1h-pyrrolo(2,3-c)pyridin-reihen von neuartigen ectonukleotid-pyrophsphatase/phosphodiestrase-1 (enpp1) und stimulator für modulator von interferon-genen (sting) als krebsimmuntherapeutika |
| EP3829561A4 (de) | 2018-08-01 | 2021-12-29 | Stingray Therapeutics, Inc. | Substituierte-3h-imidazo[4,5-c]pyridin- und 1h-pyrrolo[2,3-c]pyridin-serie von neuartigen ektonukleotid-pyrophsphatase/phosphodiesterase-1 (enpp1) und stimulator für modulator von interferon-genen (sting) als immuntherapeutika bei krebs |
| EP4262790A1 (de) * | 2020-12-15 | 2023-10-25 | Royal College of Surgeons in Ireland | Selektiver hdac6-hemmer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE744970A (fr) * | 1969-01-28 | 1970-07-27 | Lilly Co Eli | Agents antiviraux et immuno-depresseurs |
| US3720686A (en) * | 1971-04-01 | 1973-03-13 | Squibb & Sons Inc | Mercaptobenzimidazole derivatives |
| FR2148362A1 (en) * | 1971-08-11 | 1973-03-23 | Ferlux | 2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity |
| FR2190426A1 (en) * | 1972-06-27 | 1974-02-01 | Ferlux | Derivs of pyrido oxazolyl thiocarboxylic acids - analgesics hypotensives and choleretics, prepd from 2-mercapto oxazolo pyridine and halo acid deriv |
| DE2422700A1 (de) * | 1974-05-10 | 1975-11-20 | Walentin Nikolajewitsc Ufimzew | Disperse monoazofarbstoffe und verfahren zu ihrer herstellung |
| US4088768A (en) | 1975-05-06 | 1978-05-09 | Eli Lilly And Company | N-heterocyclic ureas as immune regulants |
| EP0005501B1 (de) * | 1978-05-20 | 1981-11-25 | Bayer Ag | Heteroaryl-oxyessigsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide |
| US4265900A (en) * | 1979-10-29 | 1981-05-05 | Mcneilab, Inc. | N-Aryl-N'-imidazol-2-ylureas |
| JPS57183764A (en) * | 1981-04-06 | 1982-11-12 | Nippon Tokushu Noyaku Seizo Kk | Substituted acetanilide compound, its preparation, and herbicide |
| JPS58116489A (ja) * | 1981-12-28 | 1983-07-11 | Otsuka Pharmaceut Factory Inc | カルボン酸アミド誘導体 |
| FR2636064B1 (fr) * | 1988-09-08 | 1990-12-07 | Fabre Sa Pierre | Thioformamidines, leur preparation et leur application en tant que medicaments |
| CA2003283A1 (en) * | 1988-12-05 | 1990-06-05 | C. Anne Higley | Imidazoles for the treatment of atherosclerosis |
| US5166214A (en) * | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
| IT1227527B (it) | 1988-12-05 | 1991-04-12 | Ciatti Maurizio | Spazzolino da denti a setole rotanti |
| JPH04139172A (ja) * | 1990-10-01 | 1992-05-13 | Sankyo Co Ltd | α―スルフィニル置換アセトアミド誘導体 |
| US5162360A (en) * | 1991-06-24 | 1992-11-10 | Warner-Lambert Company | 2-heteroatom containing urea and thiourea ACAT inhibitors |
| US5290801A (en) * | 1992-05-29 | 1994-03-01 | The Du Pont Merck Pharmaceutical Company | Benzimidazoles for the treatment of atherosclerosis |
| US5700819A (en) * | 1994-11-29 | 1997-12-23 | Grelan Pharmaceutical Co., Ltd. | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| JP4191269B2 (ja) * | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
| JP2000510870A (ja) * | 1997-02-14 | 2000-08-22 | バイエル・コーポレーシヨン | Ｎｐｙ５受容体アンタゴニストとしてのアミド類 |
| JP2000510164A (ja) * | 1997-02-14 | 2000-08-08 | バイエル・コーポレーシヨン | 選択的神経ペプチドｙ受容体アンタゴニストとしてのアミド誘導体 |
| US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
-
1998
- 1998-03-25 AT AT98911008T patent/ATE297900T1/de not_active IP Right Cessation
- 1998-03-25 DE DE69830600T patent/DE69830600T2/de not_active Expired - Lifetime
- 1998-03-25 JP JP54544398A patent/JP4647726B2/ja not_active Expired - Fee Related
- 1998-03-25 US US09/381,850 patent/US6362208B1/en not_active Expired - Fee Related
- 1998-03-25 WO PCT/JP1998/001337 patent/WO1998042680A1/ja active IP Right Grant
- 1998-03-25 ES ES98911008T patent/ES2245026T3/es not_active Expired - Lifetime
- 1998-03-25 EP EP98911008A patent/EP1020451B1/de not_active Expired - Lifetime
- 1998-03-25 AU AU65176/98A patent/AU6517698A/en not_active Abandoned
-
2001
- 2001-12-19 US US10/034,669 patent/US6797717B2/en not_active Expired - Fee Related
-
2002
- 2002-02-20 US US10/079,641 patent/US20030087928A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6797717B2 (en) | 2004-09-28 |
| US20030087928A1 (en) | 2003-05-08 |
| EP1020451A1 (de) | 2000-07-19 |
| EP1020451B1 (de) | 2005-06-15 |
| ATE297900T1 (de) | 2005-07-15 |
| AU6517698A (en) | 1998-10-20 |
| ES2245026T3 (es) | 2005-12-16 |
| WO1998042680A1 (fr) | 1998-10-01 |
| EP1020451A4 (de) | 2001-06-13 |
| DE69830600T2 (de) | 2006-05-04 |
| US20020099074A1 (en) | 2002-07-25 |
| US6362208B1 (en) | 2002-03-26 |
| JP4647726B2 (ja) | 2011-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69828276D1 (de) | Neue zyklische diaminverbindungen und heilmittel das diese enthält | |
| DE60232739D1 (de) | Aktivator des peroxisomproliferator-aktivierten rezeptors delta | |
| IL160304A (en) | Compounds and composition for activating peroxisome proliferators-responsive receptor ?? | |
| MY106596A (en) | Antifungal agents based on amides containing a phenyl group | |
| FI943561A (fi) | Uudet ainekoostumukset | |
| ATE321759T1 (de) | Neue amidverbindungen und medikamente die diese enthalten | |
| DE69529619T2 (de) | Pyrimidinylpyrazolderivate | |
| DE69830600D1 (de) | Anilidverbindungen und medikamente, die diese enthalten | |
| ATE314352T1 (de) | Anilide als acat-hemmer | |
| ATE372320T1 (de) | Cyclische amidderivate | |
| EP1375489A4 (de) | Medizinische zusammensetzung, die ein 1,3-thiazinderivat enthält | |
| WO2003075928A3 (en) | Stable pharmaceutical compositions | |
| DE3781986D1 (de) | Substituierte chinoxaline. | |
| ATE74604T1 (de) | Substituierte pyrimidochinoxaline. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |