DE69828625D1 - Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche - Google Patents

Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche

Info

Publication number
DE69828625D1
DE69828625D1 DE69828625T DE69828625T DE69828625D1 DE 69828625 D1 DE69828625 D1 DE 69828625D1 DE 69828625 T DE69828625 T DE 69828625T DE 69828625 T DE69828625 T DE 69828625T DE 69828625 D1 DE69828625 D1 DE 69828625D1
Authority
DE
Germany
Prior art keywords
reagents
methods
target molecules
bonding target
bonding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828625T
Other languages
English (en)
Other versions
DE69828625T2 (de
Inventor
W Duran
J Swanson
A Amos
Sheau-Ping Hu
E Guire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Publication of DE69828625D1 publication Critical patent/DE69828625D1/de
Application granted granted Critical
Publication of DE69828625T2 publication Critical patent/DE69828625T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00716—Heat activated synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/905—Photochemical activation of reactions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y10T436/174614—Tertiary amine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69828625T 1997-09-30 1998-09-25 Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche Expired - Lifetime DE69828625T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US940213 1997-09-30
US08/940,213 US5858653A (en) 1997-09-30 1997-09-30 Reagent and method for attaching target molecules to a surface
PCT/US1998/020140 WO1999016907A2 (en) 1997-09-30 1998-09-25 Reagent and method for attaching target molecules to a surface

Publications (2)

Publication Number Publication Date
DE69828625D1 true DE69828625D1 (de) 2005-02-17
DE69828625T2 DE69828625T2 (de) 2005-12-29

Family

ID=25474428

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828625T Expired - Lifetime DE69828625T2 (de) 1997-09-30 1998-09-25 Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche

Country Status (7)

Country Link
US (1) US5858653A (de)
EP (1) EP1019424B1 (de)
JP (1) JP4426092B2 (de)
AU (1) AU737391B2 (de)
CA (1) CA2304362C (de)
DE (1) DE69828625T2 (de)
WO (1) WO1999016907A2 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150164A (en) * 1996-09-30 2000-11-21 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US6762019B2 (en) 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6096726A (en) 1998-03-11 2000-08-01 Surface Solutions Laboratories Incorporated Multicomponent complex for use with substrate
US6465525B1 (en) 1998-03-18 2002-10-15 Surmodics, Inc. Latent reactive blood compatible agents
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
DE69901927T2 (de) * 1998-04-27 2002-10-10 Surmodics, Inc. Bioaktive wirkstoffe freisetzende beschichtungen
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
JP2003524754A (ja) 1998-05-16 2003-08-19 ピーイー コーポレイション （エヌワイ） Ｄｎａのポリメラーゼ連鎖反応をモニタする装置
US6500481B1 (en) 1998-06-11 2002-12-31 Johnson & Johnson Vision Care, Inc. Biomedical devices with amid-containing coatings
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
ATE323113T1 (de) 1999-07-02 2006-04-15 Symyx Technologies Inc Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
WO2001016372A1 (en) 1999-08-27 2001-03-08 Matrix Technologies Corporation Methods of immobilizing ligands on solid supports and apparatus and methods of use therefor
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
ATE270590T1 (de) * 1999-09-22 2004-07-15 Surmodics Inc Initiationsgruppentragendes wasserlösliches beschichtungsmittel und beschichtungsverfahren
AU1075701A (en) 1999-10-08 2001-04-23 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6478423B1 (en) 1999-10-12 2002-11-12 Johnson & Johnson Vison Care, Inc. Contact lens coating selection and manufacturing process
US6077674A (en) * 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity
US6482638B1 (en) * 1999-12-09 2002-11-19 3M Innovative Properties Company Heat-relaxable substrates and arrays
US6278018B1 (en) * 1999-12-14 2001-08-21 Surmodics, Inc. Surface coating agents
EP1305444A2 (de) * 2000-02-28 2003-05-02 Variom Biotechnology AG Verfahren zur immobilisierung von nukleinsäuren
DE10053393A1 (de) * 2000-02-28 2001-12-20 Origen Biotechnology Ag Verfahren zur Immobilisierung von Nukleinsäuren
US6410643B1 (en) 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
AU2001249437A1 (en) * 2000-03-24 2001-10-08 Lyles, Mark B Diagnostic devices containing porous material
EP1204488B1 (de) * 2000-06-02 2008-09-17 Eppendorf Ag Verfahren zur herstellung von als ausgangsprodukte für mikroarrays dienenden oberflächenfunktionalisierten trägern zur immobilisierung von biomolekülen
DE10028323A1 (de) * 2000-06-07 2001-12-20 Evotec Biosystems Ag Titerplatte
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
WO2002030542A2 (en) * 2000-10-12 2002-04-18 Robert Corcoran Purification of substance by reaction affinity chromatography
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
KR100509217B1 (ko) * 2000-11-13 2005-08-18 도요 고한 가부시키가이샤 하이브리드 형성용 담체 및 하이브리드의 고정화 방법
US6591970B2 (en) 2000-12-13 2003-07-15 Ecolab Inc. Water-activatable conveyor lubricant and method for transporting articles on a conveyor system
WO2002056021A2 (en) * 2001-01-10 2002-07-18 Symyx Technologies Inc Polymer brushes for immobilizing molecules to a surface
US20020187249A1 (en) * 2001-05-08 2002-12-12 Wilhelm Pluster Process for the production of surface-functionalized supports that serve as starting materials for microarrays used for immobilizing biomolecules
US6825032B2 (en) * 2001-05-14 2004-11-30 Sigma-Aldrich Co. High capacity assay platforms
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
US6844028B2 (en) * 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US7501157B2 (en) * 2001-06-26 2009-03-10 Accelr8 Technology Corporation Hydroxyl functional surface coating
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US7687437B2 (en) * 2001-07-13 2010-03-30 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US6444318B1 (en) 2001-07-17 2002-09-03 Surmodics, Inc. Self assembling monolayer compositions
WO2003083040A2 (en) * 2001-07-30 2003-10-09 Sts Biopolymers, Inc. Graft polymer matrices
US7097882B2 (en) * 2001-08-21 2006-08-29 Samsung Sdi Co., Ltd. Substrate for immobilizing physiological material, and method of fabricating same
US7332330B2 (en) 2001-09-11 2008-02-19 Renamed Biologics, Inc. Device for maintaining vascularization near an implant
US20030099949A1 (en) * 2001-10-05 2003-05-29 Surmodics, Inc. Arrays having clustered arrangements and methods of making and using
US7348055B2 (en) * 2001-12-21 2008-03-25 Surmodics, Inc. Reagent and method for providing coatings on surfaces
KR100450202B1 (ko) * 2002-01-07 2004-09-24 삼성에스디아이 주식회사 생체물질 고정용 관능기의 패턴 형성 방법
KR100484640B1 (ko) * 2002-01-14 2005-04-20 삼성에스디아이 주식회사 생물분자 고정용 올리고머, 및 이를 포함하는 생물분자고정화 조성물
US20040029143A1 (en) * 2002-02-28 2004-02-12 Jeffrey Van Ness Cationic polyelectrolytes in biomolecule purification and analysis
US7442546B2 (en) * 2002-03-15 2008-10-28 The Regents Of The University Of Michigan Method of modulating inflammatory response
US7217512B2 (en) * 2002-05-09 2007-05-15 Corning Incorporated Reagent and method for attaching target molecules to a surface
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
JP2004101516A (ja) * 2002-07-19 2004-04-02 Canon Inc プローブ担体およびその製造方法
FR2843756B1 (fr) 2002-08-26 2005-04-22 Commissariat Energie Atomique Procede de soudage d'une surface polymere avec une surface conductrice ou semi-conductrice et ses applications
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US7919600B2 (en) * 2002-09-23 2011-04-05 Alcatel-Lucent Usa Inc. Compositions that reversibly gel and de-gel
US8389700B2 (en) * 2002-09-23 2013-03-05 Alcatel Lucent Agent delivery system capable of selectively releasing an agent
US20040076961A1 (en) * 2002-10-21 2004-04-22 Lewis Mark A. Biomolecule retaining material and methods for attaching biomolecules to a surface
US7195908B2 (en) 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
WO2004050729A1 (en) 2002-11-29 2004-06-17 Marcella Chiari Method for immobilizing biologic molecules on solid surfaces
US20040111144A1 (en) * 2002-12-06 2004-06-10 Lawin Laurie R. Barriers for polymeric coatings
WO2004076511A2 (en) * 2003-02-21 2004-09-10 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel surface coatings
US20040192842A1 (en) * 2003-03-25 2004-09-30 Council Of Scientific And Industrial Research Method for preparing photoreactive polymers and immobilization of biomolecules onto these polymers
EP1615034A4 (de) * 2003-03-31 2010-11-24 Rikagaku Kenkyusho Fixierungsmittel, verfahren zur fixierung einer substanz damit sowie substrat mit einer daran damit fixierten substanz
DE60317571T2 (de) * 2003-03-31 2008-09-25 Council Of Scientific And Industrial Research Verfahren zur herstellung von photoreaktiven polymeren zur immobilisierung von biomolekülen
US7585499B2 (en) * 2003-04-10 2009-09-08 Surmodics, Inc. Method for encapsulation of cellular material using a charged initiator polymer
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
US20050064431A1 (en) * 2003-09-09 2005-03-24 Eastman Kodak Company Biological microarray comprising polymer particles and method of use
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US20050112634A1 (en) * 2003-09-19 2005-05-26 Woudenberg Timothy M. High density sequence detection methods and apparatus
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
WO2005037338A1 (en) * 2003-10-14 2005-04-28 Cook Incorporated Hydrophilic coated medical device
US7361767B2 (en) 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7423155B2 (en) * 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US8202833B2 (en) * 2003-11-26 2012-06-19 Surmodics, Inc. Composition containing biocompatible polymerization accelerator and polymerizable material
JP2007525571A (ja) 2004-01-07 2007-09-06 ソレクサ リミテッド 修飾分子アレイ
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
WO2005097228A2 (en) * 2004-04-06 2005-10-20 Surmodics, Inc. Coating compositions for bioactive agents
US20050281857A1 (en) * 2004-05-25 2005-12-22 Heyer Toni M Methods and reagents for preparing biomolecule-containing coatings
US7217428B2 (en) * 2004-05-28 2007-05-15 Technology Innovations Llc Drug delivery apparatus utilizing cantilever
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
US20060147943A1 (en) * 2004-12-30 2006-07-06 Lewis Mark A Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
WO2006078470A2 (en) 2005-01-18 2006-07-27 Biocept, Inc. Cell separation using microchannel having patterned posts
KR100682919B1 (ko) * 2005-01-20 2007-02-15 삼성전자주식회사 미세 금속 박막 패턴 형성 방법, 이를 채용한 생체물질고정용 기판 및 바이오칩
JP2008531125A (ja) * 2005-02-23 2008-08-14 サーモディクス，インコーポレイティド ラミニンコーティングを有する移植可能な医療装置、及び使用方法
CA2600711C (en) * 2005-03-15 2014-07-08 Surmodics, Inc. Compliant polymeric coatings for insertable medical articles
US20080020941A1 (en) 2005-03-24 2008-01-24 Jimpei Tabata Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate
US8002730B2 (en) * 2005-04-29 2011-08-23 Medtronic, Inc. Anti-thrombogenic venous shunt system and method
WO2007012050A2 (en) * 2005-07-20 2007-01-25 Surmodics, Inc. Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
CA2615868C (en) * 2005-07-20 2014-04-15 Surmodics, Inc. Polymeric coatings and methods for cell attachment
US7544756B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US8277928B2 (en) * 2005-11-08 2012-10-02 Surmodics, Inc. Ultra-thin photo-polymer coatings and uses thereof
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
US20080082036A1 (en) * 2006-04-25 2008-04-03 Medtronic, Inc. Cerebrospinal fluid shunt having long term anti-occlusion agent delivery
US20080063627A1 (en) * 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
US8852620B2 (en) 2007-07-20 2014-10-07 Medtronic Vascular, Inc. Medical devices comprising polymeric drug delivery systems with drug solubility gradients
US8993068B2 (en) 2008-11-04 2015-03-31 The Trustees Of Columbia University In The City Of New York Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films
SG175373A1 (en) 2009-04-28 2011-11-28 Surmodics Inc Devices and methods for delivery of bioactive agents
US8932694B2 (en) 2010-06-29 2015-01-13 Surmodics, Inc. Fluorinated polymers and lubricious coatings
PL2461767T3 (pl) 2010-07-30 2013-09-30 Novartis Ag Soczewki silikonowo-hydrożelowe z powierzchniami bogatymi w wodę
US8722076B2 (en) 2010-09-30 2014-05-13 Surmodics, Inc. Photochrome- or near IR dye-coupled polymeric matrices for medical articles
WO2012092566A1 (en) 2010-12-30 2012-07-05 Surmodics, Inc. Cell attachment coatings and methods
US9006345B2 (en) 2011-03-25 2015-04-14 The Trustees Of Columbia University In The City Of New York Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
US9757497B2 (en) 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
EP2766750B1 (de) 2011-10-12 2016-02-03 Novartis AG Verfahren zur herstellung uv-licht-absorbierender brillengläser mit einer beschichtung
EP3012301B1 (de) 2012-01-18 2023-08-16 SurModics, Inc. Gleitfähige beschichtung einer medizinische vorrichtung mit niedrigem partikelgehalt
EP2838577B1 (de) 2012-04-02 2019-02-27 SurModics, Inc. Hydrophile polymerbeschichtungen für medizinische artikel mit einem visualisierungsteil
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
WO2014004997A1 (en) 2012-06-29 2014-01-03 Surmodics, Inc. Cell attachment coatings and methods using phosphorous-containing photoreagent
CA2890205C (en) 2012-11-05 2020-12-22 Surmodics, Inc. Composition and method for delivery of hydrophobic active agents
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
US9629945B2 (en) 2012-12-12 2017-04-25 Surmodics, Inc. Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence
WO2014095690A1 (en) 2012-12-17 2014-06-26 Novartis Ag Method for making improved uv-absorbing ophthalmic lenses
JP6383732B2 (ja) 2013-01-04 2018-08-29 サーモディクス，インコーポレイティド ビニルピロリドンポリマーおよび酸性ポリマーを含んでいる層を備えた、粒子が少ない潤滑性コーティング
CN103360807A (zh) * 2013-07-01 2013-10-23 恒昌涂料（惠阳）有限公司 一种含氟光固化水性涂料及其制备方法
CN105829081B (zh) 2013-12-17 2017-12-19 诺华股份有限公司 具有交联的亲水性涂层的硅水凝胶镜片
CN106794283B (zh) 2014-08-08 2021-03-02 舒尔默迪克斯公司 包含低聚多酚层的制品涂层及其生物使用方法
US11002884B2 (en) 2014-08-26 2021-05-11 Alcon Inc. Method for applying stable coating on silicone hydrogel contact lenses
US10124088B2 (en) 2014-09-29 2018-11-13 Surmodics, Inc. Lubricious medical device elements
RU2733375C2 (ru) 2015-01-29 2020-10-01 Сермодикс, Инк. Доставка частиц гидрофобного активного средства
US10478546B2 (en) 2015-09-15 2019-11-19 Surmodics, Inc. Hemodialysis catheter sleeve
CN108369291B (zh) 2015-12-15 2021-07-20 爱尔康公司 用于将稳定的涂层施加在硅酮水凝胶接触镜片上的方法
US10342898B2 (en) 2015-12-29 2019-07-09 Surmodics, Inc. Lubricious coatings with surface salt groups
US11174447B2 (en) 2015-12-29 2021-11-16 Surmodics, Inc. Lubricious coatings with surface salt groups
US10918835B2 (en) 2016-03-31 2021-02-16 Surmodics, Inc. Delivery system for active agent coated balloon
US20170281914A1 (en) 2016-03-31 2017-10-05 Surmodics, Inc. Localized treatment of tissues through transcatheter delivery of active agents
US10806904B2 (en) 2016-03-31 2020-10-20 Surmodics, Inc. Two-part insertion tool and methods
CN109195643A (zh) 2016-03-31 2019-01-11 舒尔默迪克斯公司 用于医疗装置的润滑涂层
US10391292B2 (en) 2016-06-15 2019-08-27 Surmodics, Inc. Hemostasis sealing device with constriction ring
EP3263623A1 (de) 2016-06-30 2018-01-03 Freie Universität Berlin Überzugsmittel und beschichtungsanordnung
EP3512591A1 (de) 2016-09-16 2019-07-24 Surmodics, Inc. Schmierende einsetzwerkzeuge für medizinische vorrichtungen und verfahren zur verwendung
US10758719B2 (en) 2016-12-15 2020-09-01 Surmodics, Inc. Low-friction sealing devices
WO2018112196A1 (en) 2016-12-16 2018-06-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
KR20200098540A (ko) 2017-12-13 2020-08-20 알콘 인코포레이티드 한 주 및 한 달 착용용 워터 그래디언트 콘택트 렌즈
CN113321763A (zh) * 2021-08-02 2021-08-31 微创视神医疗科技(上海)有限公司 一种聚合物及其应用、以及眼科医疗器材
WO2023059871A1 (en) 2021-10-08 2023-04-13 Surmodics Md, Llc Catheter with multiple braid layers
US20230338623A1 (en) 2022-04-25 2023-10-26 Surmodics, Inc. Medical device coatings with microcrystalline active agents

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073484A (en) * 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
DK0484472T3 (da) * 1990-04-12 1997-08-11 Max Dolder Fremgangsmåde til lysinduceret immobilisering af biomolekyler på kemisk "inerte" overflader
FR2679255B1 (fr) * 1991-07-17 1993-10-22 Bio Merieux Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation.
WO1993016176A1 (en) * 1992-02-13 1993-08-19 Bio-Metric Systems, Inc. Immobilization of chemical species in crosslinked matrices
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
WO1994017447A1 (en) * 1993-01-21 1994-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Chemical functionalization of surfaces
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5643580A (en) * 1994-10-17 1997-07-01 Surface Genesis, Inc. Biocompatible coating, medical device using the same and methods
US5707818A (en) * 1994-12-13 1998-01-13 Bsi Corporation Device and method for simultaneously performing multiple competitive immunoassays
DE19533682A1 (de) * 1995-09-12 1997-03-13 Biotronik Mess & Therapieg Verfahren zum Anlagern und Immobilisieren von Heparin auf anorganischen Substratoberflächen von kardiovaskulären Implantanten
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group

Also Published As

Publication number Publication date
US5858653A (en) 1999-01-12
AU9582898A (en) 1999-04-23
CA2304362A1 (en) 1999-04-08
EP1019424A2 (de) 2000-07-19
JP4426092B2 (ja) 2010-03-03
WO1999016907A3 (en) 1999-08-19
AU737391B2 (en) 2001-08-16
CA2304362C (en) 2009-12-01
DE69828625T2 (de) 2005-12-29
WO1999016907A2 (en) 1999-04-08
JP2001518604A (ja) 2001-10-16
EP1019424B1 (de) 2005-01-12

Similar Documents

Publication Publication Date Title
DE69828625D1 (de) Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche
DE69929099D1 (de) Gerät zur Extraktion von Nukleinsäuren
DE69819332D1 (de) VERBESSERTE ANTIKÖRPER GEGEN IgE UND VERFAHREN ZUR VERBESSERUNG VON ANTIKÖRPERN
DE69806802D1 (de) Verfahren zur unterscheidung von erythroblasten
DE69824845D1 (de) Verfahren zur aufkonzentration von kohlenwasserstoffen
ATA179998A (de) Vorrichtung zur visualisierung von molekülen
DE69804274D1 (de) Verfahren zur Verstärkung von Konstruktionselementen
ATE311474T1 (de) Verfahren zur amplifikation und zur sequenzierung von nukleinsäuren
DE69834129D1 (de) Verfahren und system zum vorausladen von information
ATE318146T1 (de) Verfahren zur aufkonzentrierung von antikörperlösungen
DE69811015D1 (de) Etikett zur Verhinderung von Diebstahl
DE59812731D1 (de) Vorrichtung zum gegenseitigen Ausrichten von Körpern
DE69925333D1 (de) Zur richtigen Ausführung von Heft- und Lochungsoperationen geeignetes Bildformgerät
DE69735664D1 (de) Vorrichtung zum Verarbeiten von Karten
DE69808868D1 (de) Vorrichtung zur Erkennung von Datenübereinstimmung und Vorrichtung zur Datenauswahl
DE69838513D1 (de) Verkürztes hepatitis-c-virus protein nsb5 und methoden, um antivirale substanzen zu identifizieren
DE69921311D1 (de) Vervielfältigung von nukleinsäuren
DE69833850D1 (de) Einrichtung zur relativbewegung von zwei elementen
DE69709631D1 (de) Vorrichtung zum Ausrichten von Teilen
DE69820319D1 (de) Vorrichtung zum Ausrichten von Gegenständen
DE69726190D1 (de) Verfahren zur anordnung von signal- und zielkontaktflächen zur realisierung mehrerer signal/ziel-verbindungskombinationen
ATA138096A (de) Vorrichtung zur gewinnung von biogas
DE69817914D1 (de) Vorrichtung zur Identifizierung von Banknoten
DE59711071D1 (de) Vorrichtung zur Handhabung von Bohrelementen
IS4629A (is) Samskeyttar veirukjarnsýrur

Legal Events

Date Code Title Description
8364 No opposition during term of opposition