DE69828625D1 - Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche - Google Patents
Reagenzien und methoden zur bindung von zielmolekülen an eine oberflächeInfo
- Publication number
- DE69828625D1 DE69828625D1 DE69828625T DE69828625T DE69828625D1 DE 69828625 D1 DE69828625 D1 DE 69828625D1 DE 69828625 T DE69828625 T DE 69828625T DE 69828625 T DE69828625 T DE 69828625T DE 69828625 D1 DE69828625 D1 DE 69828625D1
- Authority
- DE
- Germany
- Prior art keywords
- reagents
- methods
- target molecules
- bonding target
- bonding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/42—Y being a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00709—Type of synthesis
- B01J2219/00711—Light-directed synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00709—Type of synthesis
- B01J2219/00716—Heat activated synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/905—Photochemical activation of reactions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/173845—Amine and quaternary ammonium
- Y10T436/174614—Tertiary amine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/18—Sulfur containing
- Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US940213 | 1997-09-30 | ||
US08/940,213 US5858653A (en) | 1997-09-30 | 1997-09-30 | Reagent and method for attaching target molecules to a surface |
PCT/US1998/020140 WO1999016907A2 (en) | 1997-09-30 | 1998-09-25 | Reagent and method for attaching target molecules to a surface |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69828625D1 true DE69828625D1 (de) | 2005-02-17 |
DE69828625T2 DE69828625T2 (de) | 2005-12-29 |
Family
ID=25474428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69828625T Expired - Lifetime DE69828625T2 (de) | 1997-09-30 | 1998-09-25 | Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche |
Country Status (7)
Country | Link |
---|---|
US (1) | US5858653A (de) |
EP (1) | EP1019424B1 (de) |
JP (1) | JP4426092B2 (de) |
AU (1) | AU737391B2 (de) |
CA (1) | CA2304362C (de) |
DE (1) | DE69828625T2 (de) |
WO (1) | WO1999016907A2 (de) |
Families Citing this family (149)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150164A (en) * | 1996-09-30 | 2000-11-21 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US6762019B2 (en) | 1997-09-30 | 2004-07-13 | Surmodics, Inc. | Epoxide polymer surfaces |
US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
US6096726A (en) | 1998-03-11 | 2000-08-01 | Surface Solutions Laboratories Incorporated | Multicomponent complex for use with substrate |
US6465525B1 (en) | 1998-03-18 | 2002-10-15 | Surmodics, Inc. | Latent reactive blood compatible agents |
US6376619B1 (en) | 1998-04-13 | 2002-04-23 | 3M Innovative Properties Company | High density, miniaturized arrays and methods of manufacturing same |
DE69901927T2 (de) * | 1998-04-27 | 2002-10-10 | Surmodics, Inc. | Bioaktive wirkstoffe freisetzende beschichtungen |
US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
JP2003524754A (ja) | 1998-05-16 | 2003-08-19 | ピーイー コーポレイション (エヌワイ) | Dnaのポリメラーゼ連鎖反応をモニタする装置 |
US6500481B1 (en) | 1998-06-11 | 2002-12-31 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with amid-containing coatings |
US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
US6372813B1 (en) | 1999-06-25 | 2002-04-16 | Motorola | Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays |
ATE323113T1 (de) | 1999-07-02 | 2006-04-15 | Symyx Technologies Inc | Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen |
WO2001016372A1 (en) | 1999-08-27 | 2001-03-08 | Matrix Technologies Corporation | Methods of immobilizing ligands on solid supports and apparatus and methods of use therefor |
US6358557B1 (en) * | 1999-09-10 | 2002-03-19 | Sts Biopolymers, Inc. | Graft polymerization of substrate surfaces |
ATE270590T1 (de) * | 1999-09-22 | 2004-07-15 | Surmodics Inc | Initiationsgruppentragendes wasserlösliches beschichtungsmittel und beschichtungsverfahren |
AU1075701A (en) | 1999-10-08 | 2001-04-23 | Protogene Laboratories, Inc. | Method and apparatus for performing large numbers of reactions using array assembly |
US6478423B1 (en) | 1999-10-12 | 2002-11-12 | Johnson & Johnson Vison Care, Inc. | Contact lens coating selection and manufacturing process |
US6077674A (en) * | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
US6482638B1 (en) * | 1999-12-09 | 2002-11-19 | 3M Innovative Properties Company | Heat-relaxable substrates and arrays |
US6278018B1 (en) * | 1999-12-14 | 2001-08-21 | Surmodics, Inc. | Surface coating agents |
EP1305444A2 (de) * | 2000-02-28 | 2003-05-02 | Variom Biotechnology AG | Verfahren zur immobilisierung von nukleinsäuren |
DE10053393A1 (de) * | 2000-02-28 | 2001-12-20 | Origen Biotechnology Ag | Verfahren zur Immobilisierung von Nukleinsäuren |
US6410643B1 (en) | 2000-03-09 | 2002-06-25 | Surmodics, Inc. | Solid phase synthesis method and reagent |
US7875442B2 (en) * | 2000-03-24 | 2011-01-25 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
AU2001249437A1 (en) * | 2000-03-24 | 2001-10-08 | Lyles, Mark B | Diagnostic devices containing porous material |
EP1204488B1 (de) * | 2000-06-02 | 2008-09-17 | Eppendorf Ag | Verfahren zur herstellung von als ausgangsprodukte für mikroarrays dienenden oberflächenfunktionalisierten trägern zur immobilisierung von biomolekülen |
DE10028323A1 (de) * | 2000-06-07 | 2001-12-20 | Evotec Biosystems Ag | Titerplatte |
US6706479B2 (en) * | 2000-10-05 | 2004-03-16 | Virginia Tech Intellectual Properties, Inc. | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
WO2002030542A2 (en) * | 2000-10-12 | 2002-04-18 | Robert Corcoran | Purification of substance by reaction affinity chromatography |
US6538010B1 (en) * | 2000-11-08 | 2003-03-25 | Research Triangle Institute | Compounds and methods for promoting smoking cessation |
KR100509217B1 (ko) * | 2000-11-13 | 2005-08-18 | 도요 고한 가부시키가이샤 | 하이브리드 형성용 담체 및 하이브리드의 고정화 방법 |
US6591970B2 (en) | 2000-12-13 | 2003-07-15 | Ecolab Inc. | Water-activatable conveyor lubricant and method for transporting articles on a conveyor system |
WO2002056021A2 (en) * | 2001-01-10 | 2002-07-18 | Symyx Technologies Inc | Polymer brushes for immobilizing molecules to a surface |
US20020187249A1 (en) * | 2001-05-08 | 2002-12-12 | Wilhelm Pluster | Process for the production of surface-functionalized supports that serve as starting materials for microarrays used for immobilizing biomolecules |
US6825032B2 (en) * | 2001-05-14 | 2004-11-30 | Sigma-Aldrich Co. | High capacity assay platforms |
NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
US6844028B2 (en) * | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
US7501157B2 (en) * | 2001-06-26 | 2009-03-10 | Accelr8 Technology Corporation | Hydroxyl functional surface coating |
US7297553B2 (en) * | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
US7687437B2 (en) * | 2001-07-13 | 2010-03-30 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
US6444318B1 (en) | 2001-07-17 | 2002-09-03 | Surmodics, Inc. | Self assembling monolayer compositions |
WO2003083040A2 (en) * | 2001-07-30 | 2003-10-09 | Sts Biopolymers, Inc. | Graft polymer matrices |
US7097882B2 (en) * | 2001-08-21 | 2006-08-29 | Samsung Sdi Co., Ltd. | Substrate for immobilizing physiological material, and method of fabricating same |
US7332330B2 (en) | 2001-09-11 | 2008-02-19 | Renamed Biologics, Inc. | Device for maintaining vascularization near an implant |
US20030099949A1 (en) * | 2001-10-05 | 2003-05-29 | Surmodics, Inc. | Arrays having clustered arrangements and methods of making and using |
US7348055B2 (en) * | 2001-12-21 | 2008-03-25 | Surmodics, Inc. | Reagent and method for providing coatings on surfaces |
KR100450202B1 (ko) * | 2002-01-07 | 2004-09-24 | 삼성에스디아이 주식회사 | 생체물질 고정용 관능기의 패턴 형성 방법 |
KR100484640B1 (ko) * | 2002-01-14 | 2005-04-20 | 삼성에스디아이 주식회사 | 생물분자 고정용 올리고머, 및 이를 포함하는 생물분자고정화 조성물 |
US20040029143A1 (en) * | 2002-02-28 | 2004-02-12 | Jeffrey Van Ness | Cationic polyelectrolytes in biomolecule purification and analysis |
US7442546B2 (en) * | 2002-03-15 | 2008-10-28 | The Regents Of The University Of Michigan | Method of modulating inflammatory response |
US7217512B2 (en) * | 2002-05-09 | 2007-05-15 | Corning Incorporated | Reagent and method for attaching target molecules to a surface |
US7097850B2 (en) * | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US20030232087A1 (en) * | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
JP2004101516A (ja) * | 2002-07-19 | 2004-04-02 | Canon Inc | プローブ担体およびその製造方法 |
FR2843756B1 (fr) | 2002-08-26 | 2005-04-22 | Commissariat Energie Atomique | Procede de soudage d'une surface polymere avec une surface conductrice ou semi-conductrice et ses applications |
US20040043508A1 (en) * | 2002-09-03 | 2004-03-04 | Frutos Anthony G. | Polymer-coated substrates for binding biological molecules |
US7919600B2 (en) * | 2002-09-23 | 2011-04-05 | Alcatel-Lucent Usa Inc. | Compositions that reversibly gel and de-gel |
US8389700B2 (en) * | 2002-09-23 | 2013-03-05 | Alcatel Lucent | Agent delivery system capable of selectively releasing an agent |
US20040076961A1 (en) * | 2002-10-21 | 2004-04-22 | Lewis Mark A. | Biomolecule retaining material and methods for attaching biomolecules to a surface |
US7195908B2 (en) | 2002-10-31 | 2007-03-27 | Corning Incorporated | Supports treated with triamine for immobilizing biomolecules |
WO2004050729A1 (en) | 2002-11-29 | 2004-06-17 | Marcella Chiari | Method for immobilizing biologic molecules on solid surfaces |
US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
WO2004076511A2 (en) * | 2003-02-21 | 2004-09-10 | Ciphergen Biosystems, Inc. | Photocrosslinked hydrogel surface coatings |
US20040192842A1 (en) * | 2003-03-25 | 2004-09-30 | Council Of Scientific And Industrial Research | Method for preparing photoreactive polymers and immobilization of biomolecules onto these polymers |
EP1615034A4 (de) * | 2003-03-31 | 2010-11-24 | Rikagaku Kenkyusho | Fixierungsmittel, verfahren zur fixierung einer substanz damit sowie substrat mit einer daran damit fixierten substanz |
DE60317571T2 (de) * | 2003-03-31 | 2008-09-25 | Council Of Scientific And Industrial Research | Verfahren zur herstellung von photoreaktiven polymeren zur immobilisierung von biomolekülen |
US7585499B2 (en) * | 2003-04-10 | 2009-09-08 | Surmodics, Inc. | Method for encapsulation of cellular material using a charged initiator polymer |
US7820158B2 (en) * | 2003-04-10 | 2010-10-26 | Surmodics, Inc. | Ligand-coupled initiator polymers and methods of use |
US20050064431A1 (en) * | 2003-09-09 | 2005-03-24 | Eastman Kodak Company | Biological microarray comprising polymer particles and method of use |
US20050233472A1 (en) * | 2003-09-19 | 2005-10-20 | Kao H P | Spotting high density plate using a banded format |
US20050226771A1 (en) * | 2003-09-19 | 2005-10-13 | Lehto Dennis A | High speed microplate transfer |
US20050112634A1 (en) * | 2003-09-19 | 2005-05-26 | Woudenberg Timothy M. | High density sequence detection methods and apparatus |
US7309593B2 (en) * | 2003-10-01 | 2007-12-18 | Surmodics, Inc. | Attachment of molecules to surfaces |
WO2005037338A1 (en) * | 2003-10-14 | 2005-04-28 | Cook Incorporated | Hydrophilic coated medical device |
US7361767B2 (en) | 2003-11-14 | 2008-04-22 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
US7423155B2 (en) * | 2003-11-14 | 2008-09-09 | 3M Innovative Properties Company | N-sulfonyldicarboximide containing tethering compounds |
US8202833B2 (en) * | 2003-11-26 | 2012-06-19 | Surmodics, Inc. | Composition containing biocompatible polymerization accelerator and polymerizable material |
JP2007525571A (ja) | 2004-01-07 | 2007-09-06 | ソレクサ リミテッド | 修飾分子アレイ |
US20060083772A1 (en) * | 2004-04-06 | 2006-04-20 | Dewitt David M | Coating compositions for bioactive agents |
WO2005097228A2 (en) * | 2004-04-06 | 2005-10-20 | Surmodics, Inc. | Coating compositions for bioactive agents |
US20050281857A1 (en) * | 2004-05-25 | 2005-12-22 | Heyer Toni M | Methods and reagents for preparing biomolecule-containing coatings |
US7217428B2 (en) * | 2004-05-28 | 2007-05-15 | Technology Innovations Llc | Drug delivery apparatus utilizing cantilever |
US20060110594A1 (en) * | 2004-11-24 | 2006-05-25 | Frutos Anthony G | Polymer-coated substrates for binding biomolecules and methods of making and using thereof |
US20060147943A1 (en) * | 2004-12-30 | 2006-07-06 | Lewis Mark A | Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof |
US20060252087A1 (en) * | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US20090136982A1 (en) * | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
WO2006078470A2 (en) | 2005-01-18 | 2006-07-27 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
KR100682919B1 (ko) * | 2005-01-20 | 2007-02-15 | 삼성전자주식회사 | 미세 금속 박막 패턴 형성 방법, 이를 채용한 생체물질고정용 기판 및 바이오칩 |
JP2008531125A (ja) * | 2005-02-23 | 2008-08-14 | サーモディクス,インコーポレイティド | ラミニンコーティングを有する移植可能な医療装置、及び使用方法 |
CA2600711C (en) * | 2005-03-15 | 2014-07-08 | Surmodics, Inc. | Compliant polymeric coatings for insertable medical articles |
US20080020941A1 (en) | 2005-03-24 | 2008-01-24 | Jimpei Tabata | Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate |
US8002730B2 (en) * | 2005-04-29 | 2011-08-23 | Medtronic, Inc. | Anti-thrombogenic venous shunt system and method |
WO2007012050A2 (en) * | 2005-07-20 | 2007-01-25 | Surmodics, Inc. | Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation |
CA2615868C (en) * | 2005-07-20 | 2014-04-15 | Surmodics, Inc. | Polymeric coatings and methods for cell attachment |
US7544756B2 (en) * | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
US7544755B2 (en) * | 2005-09-30 | 2009-06-09 | 3M Innovative Properties Company | Crosslinked polymers with amine binding groups |
US8277928B2 (en) * | 2005-11-08 | 2012-10-02 | Surmodics, Inc. | Ultra-thin photo-polymer coatings and uses thereof |
US7781203B2 (en) * | 2005-12-29 | 2010-08-24 | Corning Incorporated | Supports for assaying analytes and methods of making and using thereof |
US7695956B2 (en) * | 2006-01-12 | 2010-04-13 | Biocept, Inc. | Device for cell separation and analysis and method of using |
US20080082036A1 (en) * | 2006-04-25 | 2008-04-03 | Medtronic, Inc. | Cerebrospinal fluid shunt having long term anti-occlusion agent delivery |
US20080063627A1 (en) * | 2006-09-12 | 2008-03-13 | Surmodics, Inc. | Tissue graft materials containing biocompatible agent and methods of making and using same |
US8852620B2 (en) | 2007-07-20 | 2014-10-07 | Medtronic Vascular, Inc. | Medical devices comprising polymeric drug delivery systems with drug solubility gradients |
US8993068B2 (en) | 2008-11-04 | 2015-03-31 | The Trustees Of Columbia University In The City Of New York | Heterobifunctional polymers and methods for layer-by-layer construction of multilayer films |
SG175373A1 (en) | 2009-04-28 | 2011-11-28 | Surmodics Inc | Devices and methods for delivery of bioactive agents |
US8932694B2 (en) | 2010-06-29 | 2015-01-13 | Surmodics, Inc. | Fluorinated polymers and lubricious coatings |
PL2461767T3 (pl) | 2010-07-30 | 2013-09-30 | Novartis Ag | Soczewki silikonowo-hydrożelowe z powierzchniami bogatymi w wodę |
US8722076B2 (en) | 2010-09-30 | 2014-05-13 | Surmodics, Inc. | Photochrome- or near IR dye-coupled polymeric matrices for medical articles |
WO2012092566A1 (en) | 2010-12-30 | 2012-07-05 | Surmodics, Inc. | Cell attachment coatings and methods |
US9006345B2 (en) | 2011-03-25 | 2015-04-14 | The Trustees Of Columbia University In The City Of New York | Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials |
US9861727B2 (en) | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
US9757497B2 (en) | 2011-05-20 | 2017-09-12 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
EP2766750B1 (de) | 2011-10-12 | 2016-02-03 | Novartis AG | Verfahren zur herstellung uv-licht-absorbierender brillengläser mit einer beschichtung |
EP3012301B1 (de) | 2012-01-18 | 2023-08-16 | SurModics, Inc. | Gleitfähige beschichtung einer medizinische vorrichtung mit niedrigem partikelgehalt |
EP2838577B1 (de) | 2012-04-02 | 2019-02-27 | SurModics, Inc. | Hydrophile polymerbeschichtungen für medizinische artikel mit einem visualisierungsteil |
US9012022B2 (en) | 2012-06-08 | 2015-04-21 | Illumina, Inc. | Polymer coatings |
WO2014004997A1 (en) | 2012-06-29 | 2014-01-03 | Surmodics, Inc. | Cell attachment coatings and methods using phosphorous-containing photoreagent |
CA2890205C (en) | 2012-11-05 | 2020-12-22 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
US9629945B2 (en) | 2012-12-12 | 2017-04-25 | Surmodics, Inc. | Stilbene-based reactive compounds, polymeric matrices formed therefrom, and articles visualizable by fluorescence |
WO2014095690A1 (en) | 2012-12-17 | 2014-06-26 | Novartis Ag | Method for making improved uv-absorbing ophthalmic lenses |
JP6383732B2 (ja) | 2013-01-04 | 2018-08-29 | サーモディクス,インコーポレイティド | ビニルピロリドンポリマーおよび酸性ポリマーを含んでいる層を備えた、粒子が少ない潤滑性コーティング |
CN103360807A (zh) * | 2013-07-01 | 2013-10-23 | 恒昌涂料(惠阳)有限公司 | 一种含氟光固化水性涂料及其制备方法 |
CN105829081B (zh) | 2013-12-17 | 2017-12-19 | 诺华股份有限公司 | 具有交联的亲水性涂层的硅水凝胶镜片 |
CN106794283B (zh) | 2014-08-08 | 2021-03-02 | 舒尔默迪克斯公司 | 包含低聚多酚层的制品涂层及其生物使用方法 |
US11002884B2 (en) | 2014-08-26 | 2021-05-11 | Alcon Inc. | Method for applying stable coating on silicone hydrogel contact lenses |
US10124088B2 (en) | 2014-09-29 | 2018-11-13 | Surmodics, Inc. | Lubricious medical device elements |
RU2733375C2 (ru) | 2015-01-29 | 2020-10-01 | Сермодикс, Инк. | Доставка частиц гидрофобного активного средства |
US10478546B2 (en) | 2015-09-15 | 2019-11-19 | Surmodics, Inc. | Hemodialysis catheter sleeve |
CN108369291B (zh) | 2015-12-15 | 2021-07-20 | 爱尔康公司 | 用于将稳定的涂层施加在硅酮水凝胶接触镜片上的方法 |
US10342898B2 (en) | 2015-12-29 | 2019-07-09 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
US11174447B2 (en) | 2015-12-29 | 2021-11-16 | Surmodics, Inc. | Lubricious coatings with surface salt groups |
US10918835B2 (en) | 2016-03-31 | 2021-02-16 | Surmodics, Inc. | Delivery system for active agent coated balloon |
US20170281914A1 (en) | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Localized treatment of tissues through transcatheter delivery of active agents |
US10806904B2 (en) | 2016-03-31 | 2020-10-20 | Surmodics, Inc. | Two-part insertion tool and methods |
CN109195643A (zh) | 2016-03-31 | 2019-01-11 | 舒尔默迪克斯公司 | 用于医疗装置的润滑涂层 |
US10391292B2 (en) | 2016-06-15 | 2019-08-27 | Surmodics, Inc. | Hemostasis sealing device with constriction ring |
EP3263623A1 (de) | 2016-06-30 | 2018-01-03 | Freie Universität Berlin | Überzugsmittel und beschichtungsanordnung |
EP3512591A1 (de) | 2016-09-16 | 2019-07-24 | Surmodics, Inc. | Schmierende einsetzwerkzeuge für medizinische vorrichtungen und verfahren zur verwendung |
US10758719B2 (en) | 2016-12-15 | 2020-09-01 | Surmodics, Inc. | Low-friction sealing devices |
WO2018112196A1 (en) | 2016-12-16 | 2018-06-21 | Surmodics, Inc. | Hydrophobic active agent particle coatings and methods for treatment |
US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
KR20200098540A (ko) | 2017-12-13 | 2020-08-20 | 알콘 인코포레이티드 | 한 주 및 한 달 착용용 워터 그래디언트 콘택트 렌즈 |
CN113321763A (zh) * | 2021-08-02 | 2021-08-31 | 微创视神医疗科技(上海)有限公司 | 一种聚合物及其应用、以及眼科医疗器材 |
WO2023059871A1 (en) | 2021-10-08 | 2023-04-13 | Surmodics Md, Llc | Catheter with multiple braid layers |
US20230338623A1 (en) | 2022-04-25 | 2023-10-26 | Surmodics, Inc. | Medical device coatings with microcrystalline active agents |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5073484A (en) * | 1982-03-09 | 1991-12-17 | Bio-Metric Systems, Inc. | Quantitative analysis apparatus and method |
US5512329A (en) * | 1982-09-29 | 1996-04-30 | Bsi Corporation | Substrate surface preparation |
US4722906A (en) * | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
US5217492A (en) * | 1982-09-29 | 1993-06-08 | Bio-Metric Systems, Inc. | Biomolecule attachment to hydrophobic surfaces |
US5002582A (en) * | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US4973493A (en) * | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
US4979959A (en) * | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
DK0484472T3 (da) * | 1990-04-12 | 1997-08-11 | Max Dolder | Fremgangsmåde til lysinduceret immobilisering af biomolekyler på kemisk "inerte" overflader |
FR2679255B1 (fr) * | 1991-07-17 | 1993-10-22 | Bio Merieux | Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation. |
WO1993016176A1 (en) * | 1992-02-13 | 1993-08-19 | Bio-Metric Systems, Inc. | Immobilization of chemical species in crosslinked matrices |
US5414075A (en) * | 1992-11-06 | 1995-05-09 | Bsi Corporation | Restrained multifunctional reagent for surface modification |
WO1994017447A1 (en) * | 1993-01-21 | 1994-08-04 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Chemical functionalization of surfaces |
US5610287A (en) * | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5643580A (en) * | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
US5707818A (en) * | 1994-12-13 | 1998-01-13 | Bsi Corporation | Device and method for simultaneously performing multiple competitive immunoassays |
DE19533682A1 (de) * | 1995-09-12 | 1997-03-13 | Biotronik Mess & Therapieg | Verfahren zum Anlagern und Immobilisieren von Heparin auf anorganischen Substratoberflächen von kardiovaskulären Implantanten |
US5714360A (en) * | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
-
1997
- 1997-09-30 US US08/940,213 patent/US5858653A/en not_active Expired - Lifetime
-
1998
- 1998-09-25 CA CA002304362A patent/CA2304362C/en not_active Expired - Fee Related
- 1998-09-25 JP JP2000513975A patent/JP4426092B2/ja not_active Expired - Fee Related
- 1998-09-25 WO PCT/US1998/020140 patent/WO1999016907A2/en active IP Right Grant
- 1998-09-25 AU AU95828/98A patent/AU737391B2/en not_active Ceased
- 1998-09-25 EP EP98949524A patent/EP1019424B1/de not_active Expired - Lifetime
- 1998-09-25 DE DE69828625T patent/DE69828625T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5858653A (en) | 1999-01-12 |
AU9582898A (en) | 1999-04-23 |
CA2304362A1 (en) | 1999-04-08 |
EP1019424A2 (de) | 2000-07-19 |
JP4426092B2 (ja) | 2010-03-03 |
WO1999016907A3 (en) | 1999-08-19 |
AU737391B2 (en) | 2001-08-16 |
CA2304362C (en) | 2009-12-01 |
DE69828625T2 (de) | 2005-12-29 |
WO1999016907A2 (en) | 1999-04-08 |
JP2001518604A (ja) | 2001-10-16 |
EP1019424B1 (de) | 2005-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69828625D1 (de) | Reagenzien und methoden zur bindung von zielmolekülen an eine oberfläche | |
DE69929099D1 (de) | Gerät zur Extraktion von Nukleinsäuren | |
DE69819332D1 (de) | VERBESSERTE ANTIKÖRPER GEGEN IgE UND VERFAHREN ZUR VERBESSERUNG VON ANTIKÖRPERN | |
DE69806802D1 (de) | Verfahren zur unterscheidung von erythroblasten | |
DE69824845D1 (de) | Verfahren zur aufkonzentration von kohlenwasserstoffen | |
ATA179998A (de) | Vorrichtung zur visualisierung von molekülen | |
DE69804274D1 (de) | Verfahren zur Verstärkung von Konstruktionselementen | |
ATE311474T1 (de) | Verfahren zur amplifikation und zur sequenzierung von nukleinsäuren | |
DE69834129D1 (de) | Verfahren und system zum vorausladen von information | |
ATE318146T1 (de) | Verfahren zur aufkonzentrierung von antikörperlösungen | |
DE69811015D1 (de) | Etikett zur Verhinderung von Diebstahl | |
DE59812731D1 (de) | Vorrichtung zum gegenseitigen Ausrichten von Körpern | |
DE69925333D1 (de) | Zur richtigen Ausführung von Heft- und Lochungsoperationen geeignetes Bildformgerät | |
DE69735664D1 (de) | Vorrichtung zum Verarbeiten von Karten | |
DE69808868D1 (de) | Vorrichtung zur Erkennung von Datenübereinstimmung und Vorrichtung zur Datenauswahl | |
DE69838513D1 (de) | Verkürztes hepatitis-c-virus protein nsb5 und methoden, um antivirale substanzen zu identifizieren | |
DE69921311D1 (de) | Vervielfältigung von nukleinsäuren | |
DE69833850D1 (de) | Einrichtung zur relativbewegung von zwei elementen | |
DE69709631D1 (de) | Vorrichtung zum Ausrichten von Teilen | |
DE69820319D1 (de) | Vorrichtung zum Ausrichten von Gegenständen | |
DE69726190D1 (de) | Verfahren zur anordnung von signal- und zielkontaktflächen zur realisierung mehrerer signal/ziel-verbindungskombinationen | |
ATA138096A (de) | Vorrichtung zur gewinnung von biogas | |
DE69817914D1 (de) | Vorrichtung zur Identifizierung von Banknoten | |
DE59711071D1 (de) | Vorrichtung zur Handhabung von Bohrelementen | |
IS4629A (is) | Samskeyttar veirukjarnsýrur |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |