DE69828080D1 - Pyrimidinderivate als markierte bindungspartner - Google Patents

Pyrimidinderivate als markierte bindungspartner

Info

Publication number
DE69828080D1
DE69828080D1 DE1998628080 DE69828080T DE69828080D1 DE 69828080 D1 DE69828080 D1 DE 69828080D1 DE 1998628080 DE1998628080 DE 1998628080 DE 69828080 T DE69828080 T DE 69828080T DE 69828080 D1 DE69828080 D1 DE 69828080D1
Authority
DE
Germany
Prior art keywords
binding partners
pyrimidine derivatives
marked binding
compounds
marked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1998628080
Other languages
English (en)
Other versions
DE69828080T2 (de
Inventor
Kuei-Ying Lin
D Matteucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/966,392 external-priority patent/US6028183A/en
Priority claimed from US08/966,875 external-priority patent/US6007992A/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DE69828080D1 publication Critical patent/DE69828080D1/de
Application granted granted Critical
Publication of DE69828080T2 publication Critical patent/DE69828080T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/101Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69828080T 1997-11-07 1998-10-30 Pyrimidinderivate als markierte bindungspartner Expired - Lifetime DE69828080T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/966,392 US6028183A (en) 1997-11-07 1997-11-07 Pyrimidine derivatives and oligonucleotides containing same
US966392 1997-11-07
US08/966,875 US6007992A (en) 1997-11-10 1997-11-10 Pyrimidine derivatives for labeled binding partners
US966875 1997-11-10
PCT/US1998/023119 WO1999024452A2 (en) 1997-11-07 1998-10-30 Pyrimidine derivatives for labeled binding partners

Publications (2)

Publication Number Publication Date
DE69828080D1 true DE69828080D1 (de) 2005-01-13
DE69828080T2 DE69828080T2 (de) 2005-11-24

Family

ID=27130485

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828080T Expired - Lifetime DE69828080T2 (de) 1997-11-07 1998-10-30 Pyrimidinderivate als markierte bindungspartner

Country Status (7)

Country Link
EP (1) EP1027364B1 (de)
JP (1) JP2001522860A (de)
AT (1) ATE284407T1 (de)
AU (1) AU1292899A (de)
CA (1) CA2309340C (de)
DE (1) DE69828080T2 (de)
WO (1) WO1999024452A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376669B1 (en) * 1999-11-05 2002-04-23 3M Innovative Properties Company Dye labeled imidazoquinoline compounds
CA2452458A1 (en) * 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
US7070933B2 (en) 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
JP2003199568A (ja) * 2002-01-10 2003-07-15 Nichirei Corp Dna増幅反応の効率向上方法
JP4322554B2 (ja) * 2003-05-19 2009-09-02 株式会社ニチレイフーズ Dna増幅反応の効率向上方法
AU2010221419B2 (en) 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
KR20180051676A (ko) 2009-10-16 2018-05-16 멜린타 테라퓨틱스, 인크. 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
CN108456211A (zh) * 2009-10-16 2018-08-28 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
MX339000B (es) 2009-10-16 2016-05-09 Melinta Therapeutics Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
US9102938B2 (en) 2010-04-01 2015-08-11 Alnylam Pharmaceuticals, Inc. 2′ and 5′ modified monomers and oligonucleotides
AU2012308320C1 (en) 2011-09-14 2018-08-23 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
EP2781523A1 (de) 2013-03-18 2014-09-24 Miltenyi Biotec GmbH Lipophile Oligonukleotid-Analoga
CA2923214A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
CA2923179A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
EP3154996B1 (de) * 2014-06-10 2020-03-11 Agilent Technologies, Inc. Schutzgruppen für z-nukleotid und verfahren dafür
EP3268370A4 (de) 2015-03-11 2018-08-22 Melinta Therapeutics, Inc. Antimikrobielle verbindungen und verfahren zur herstellung und verwendung davon
JP6894747B2 (ja) 2017-04-19 2021-06-30 キヤノン株式会社 重合体
RU2731381C1 (ru) * 2019-04-26 2020-09-02 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Нуклеозидные производные 1,3-диаза-2-оксофеноксазина в качестве ингибиторов репликации герпесвирусов.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners

Also Published As

Publication number Publication date
WO1999024452A2 (en) 1999-05-20
WO1999024452A3 (en) 1999-09-16
WO1999024452A8 (en) 1999-10-21
JP2001522860A (ja) 2001-11-20
DE69828080T2 (de) 2005-11-24
WO1999024452A9 (en) 1999-08-12
EP1027364B1 (de) 2004-12-08
AU1292899A (en) 1999-05-31
CA2309340A1 (en) 1999-05-20
ATE284407T1 (de) 2004-12-15
CA2309340C (en) 2006-02-21
EP1027364A2 (de) 2000-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition