DE69822164D1 - Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität - Google Patents
Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivitätInfo
- Publication number
- DE69822164D1 DE69822164D1 DE69822164T DE69822164T DE69822164D1 DE 69822164 D1 DE69822164 D1 DE 69822164D1 DE 69822164 T DE69822164 T DE 69822164T DE 69822164 T DE69822164 T DE 69822164T DE 69822164 D1 DE69822164 D1 DE 69822164D1
- Authority
- DE
- Germany
- Prior art keywords
- reduced systemic
- human
- systemic activity
- identifying connections
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9713818 | 1997-06-30 | ||
GBGB9713819.2A GB9713819D0 (en) | 1997-06-30 | 1997-06-30 | Method of reducing the systemic effects of compounds |
GBGB9713818.4A GB9713818D0 (en) | 1997-06-30 | 1997-06-30 | Compounds |
GB9713819 | 1997-06-30 | ||
PCT/EP1998/003905 WO1999001467A2 (en) | 1997-06-30 | 1998-06-26 | Therapeutically active compounds with low systemic activity due to reduce half life |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69822164D1 true DE69822164D1 (de) | 2004-04-08 |
DE69822164T2 DE69822164T2 (de) | 2005-04-14 |
Family
ID=26311812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69822164T Expired - Fee Related DE69822164T2 (de) | 1997-06-30 | 1998-06-26 | Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0998484B1 (de) |
JP (2) | JP2000513380A (de) |
AT (1) | ATE260931T1 (de) |
AU (1) | AU8439998A (de) |
DE (1) | DE69822164T2 (de) |
ES (1) | ES2215310T3 (de) |
WO (1) | WO1999001467A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6403580B1 (en) | 2000-08-26 | 2002-06-11 | Boehringer Ingelheim Pharma Kg | Quinazolines, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
US6656946B2 (en) | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
US6617329B2 (en) | 2000-08-26 | 2003-09-09 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines and their use as medicaments |
UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
AR059216A1 (es) | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
EA200901041A1 (ru) | 2007-02-06 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
MX2010008621A (es) | 2008-02-07 | 2010-09-24 | Boehringer Ingelheim Int | Heterociclos espirociclicos, medicamentos que contienen a estos compuestos, su uso y procedimiento para su preparacion. |
CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
CN111201222A (zh) * | 2017-10-11 | 2020-05-26 | 大金工业株式会社 | 具有不饱和基团的环状碳酸酯的制造方法和新型环状碳酸酯 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093721A (en) * | 1974-08-30 | 1978-06-06 | Glaxo Laboratories Limited | Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof |
SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
DE3133631A1 (de) * | 1981-08-21 | 1983-03-03 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue kortikoide ihre herstellung und verwendung |
US4906661A (en) * | 1981-11-12 | 1990-03-06 | E. I. Du Pont De Nemours And Company | Esters of aryloxypropanolamine derivatives |
US4935421A (en) * | 1981-11-12 | 1990-06-19 | E. I. Du Pont De Nemours And Company | 2-hydroxypropylamine aryl ester derivatives and pharmaceutical use |
EP0174956B1 (de) * | 1984-03-14 | 1990-08-16 | BODOR, Nicholas S. | Sanfte beta-adrenergische blockierende agenzien |
IL78144A0 (en) * | 1985-04-04 | 1986-07-31 | Draco Ab | Novel androstane-17beta-carboxylic acid esters |
JP3176075B2 (ja) * | 1991-03-04 | 2001-06-11 | 帝國製薬株式会社 | 新規なステロイド誘導体 |
JPH08502278A (ja) * | 1992-10-16 | 1996-03-12 | ビイク ネダーラント ベスローテン フェンノートシャップ | 置換されたエタノールアミンエステル |
US5629193A (en) * | 1994-07-05 | 1997-05-13 | Human Genome Sciences, Inc. | Paraoxonase |
US5775329A (en) * | 1995-06-07 | 1998-07-07 | Gensia, Inc. | Method and compounds for diagnosing coronary artery disease |
US6013244A (en) * | 1995-12-29 | 2000-01-11 | Glaxo Wellcome Inc. | 21-(2-oxo-tetrahydrofuran)-thio pregnane derivatives, a process for their production and pharmaceutical compositions containing them |
DE69609870T2 (de) * | 1995-12-29 | 2001-01-25 | Glaxo Group Ltd., Greenford | 17beta-(2-oxo-tetrahydrofuran-4-yl)-thio-androstane derivate (17beta-(gamma-buttersäure-lacton)-thio derivate) zur behandlung von entzündungen, pharmazeutische präparate davon und ein verfahren zu ihrer herstellung |
KR19990076859A (ko) * | 1995-12-29 | 1999-10-25 | 그레이엄 브레레톤, 레슬리 에드워즈 | 17.베타.-카르복시, 카르보티오 및 아미드 안드로스탄 유도체의락톤 유도체 |
-
1998
- 1998-06-26 EP EP98934998A patent/EP0998484B1/de not_active Expired - Lifetime
- 1998-06-26 JP JP11506277A patent/JP2000513380A/ja not_active Ceased
- 1998-06-26 AT AT98934998T patent/ATE260931T1/de not_active IP Right Cessation
- 1998-06-26 AU AU84399/98A patent/AU8439998A/en not_active Abandoned
- 1998-06-26 ES ES98934998T patent/ES2215310T3/es not_active Expired - Lifetime
- 1998-06-26 DE DE69822164T patent/DE69822164T2/de not_active Expired - Fee Related
- 1998-06-26 WO PCT/EP1998/003905 patent/WO1999001467A2/en active IP Right Grant
-
2002
- 2002-02-28 JP JP2002054329A patent/JP2002322168A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2215310T3 (es) | 2004-10-01 |
EP0998484A1 (de) | 2000-05-10 |
JP2002322168A (ja) | 2002-11-08 |
WO1999001467A2 (en) | 1999-01-14 |
AU8439998A (en) | 1999-01-25 |
JP2000513380A (ja) | 2000-10-10 |
WO1999001467A3 (en) | 1999-05-14 |
EP0998484B1 (de) | 2004-03-03 |
ATE260931T1 (de) | 2004-03-15 |
DE69822164T2 (de) | 2005-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |