DE69812983D1 - Verfahren zur herstellung von phosphodiestern - Google Patents

Verfahren zur herstellung von phosphodiestern

Info

Publication number: DE69812983D1
Authority: DE; Germany
Prior art keywords: alcohol; reaction; phosphodia; star; producing
Prior art date: 1997-04-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69812983T

Other languages

English (en)

Other versions

DE69812983T2 (de

Inventor

C Amedio

J Bernard

Mark Fountain

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Epix Pharmaceuticals Inc

Original Assignee

Epix Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-11

Filing date

1998-01-27

Publication date

2003-05-08

1998-01-27 Application filed by Epix Pharmaceuticals Inc filed Critical Epix Pharmaceuticals Inc

2003-05-08 Application granted granted Critical

2003-05-08 Publication of DE69812983D1 publication Critical patent/DE69812983D1/de

2004-01-08 Publication of DE69812983T2 publication Critical patent/DE69812983T2/de

2018-01-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
238000006243 chemical reaction Methods 0.000 abstract 3
150000004713 phosphodiesters Chemical class 0.000 abstract 2
108010043958 Peptoids Proteins 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
ZLRAAUUPULJGTL-UHFFFAOYSA-N diaminophosphinous acid Chemical compound NP(N)O ZLRAAUUPULJGTL-UHFFFAOYSA-N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
-1 phosphoramidite diester Chemical class 0.000 abstract 1
150000008300 phosphoramidites Chemical class 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE69812983T 1997-04-11 1998-01-27 Verfahren zur herstellung von phosphodiestern Expired - Lifetime DE69812983T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/833,745 US5919967A (en)	1997-04-11	1997-04-11	Process for synthesizing phosphodiesters
US833745		1997-04-11
PCT/US1998/001473 WO1998046612A1 (en)	1997-04-11	1998-01-27	Process for synthesizing phosphodiesters

Publications (2)

Publication Number	Publication Date
DE69812983D1 true DE69812983D1 (de)	2003-05-08
DE69812983T2 DE69812983T2 (de)	2004-01-08

Family

ID=25265165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69812983T Expired - Lifetime DE69812983T2 (de)	1997-04-11	1998-01-27	Verfahren zur herstellung von phosphodiestern

Country Status (21)

Country	Link
US (1)	US5919967A (de)
EP (1)	EP1021452B1 (de)
JP (2)	JP4014231B2 (de)
KR (2)	KR20060066122A (de)
AT (1)	ATE236171T1 (de)
AU (1)	AU728902B2 (de)
BR (1)	BR9809084B1 (de)
CA (1)	CA2285417C (de)
CZ (1)	CZ294469B6 (de)
DE (1)	DE69812983T2 (de)
DK (1)	DK1021452T3 (de)
ES (1)	ES2195315T3 (de)
HU (1)	HU224257B1 (de)
IL (1)	IL131964A (de)
IS (1)	IS1994B (de)
NO (1)	NO325619B1 (de)
NZ (1)	NZ337921A (de)
PL (1)	PL188258B1 (de)
PT (1)	PT1021452E (de)
SK (1)	SK283832B6 (de)
WO (1)	WO1998046612A1 (de)

Families Citing this family (29)

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EP1019094B1 (de)	1997-10-02	2003-11-19	Epix Medical, Inc.	Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung
US20030203879A1 (en) *	1999-09-09	2003-10-30	Schering Ag	Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US6559330B1 (en) *	1999-09-09	2003-05-06	Schering Aktiengesellschaft	Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (de) *	1999-09-09	2005-09-01	Schering Ag	Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
WO2003029257A1 (de) *	2001-09-27	2003-04-10	Schering Aktiengesellschaft	(ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
US7261876B2 (en)	2002-03-01	2007-08-28	Bracco International Bv	Multivalent constructs for therapeutic and diagnostic applications
ES2506142T3 (es)	2002-03-01	2014-10-13	Dyax Corp.	Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
EP1587944A4 (de)	2002-03-01	2007-03-21	Dyax Corp	Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie
US7794693B2 (en)	2002-03-01	2010-09-14	Bracco International B.V.	Targeting vector-phospholipid conjugates
US8623822B2 (en)	2002-03-01	2014-01-07	Bracco Suisse Sa	KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
ES2396368T3 (es)	2003-03-03	2013-02-21	Dyax Corporation	Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
KR100585219B1 (ko) *	2004-05-07	2006-06-01	주식회사 태평양	포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) *	2006-03-15	2009-05-13	中国石油化工股份有限公司	一种亚磷酰胺酯类极压抗磨剂及其制备和应用
WO2010121133A2 (en)	2009-04-17	2010-10-21	The General Hospital Corporation	Multimodal imaging of fibrin
KR20110139274A (ko)	2009-03-19	2011-12-28	와이어쓰 엘엘씨	［2-(8,9-다이옥소-2,6-다이아자바이사이클로［5.2.0］논-1(7)-엔-2-일)에틸］포스폰산 및 이의 전구체의 제조 방법
TW201514188A (zh) *	2013-03-13	2015-04-16	Lantheus Medical Imaging Inc	製備釓磷維塞三鈉單水合物之方法
US20150344523A1 (en)	2014-05-05	2015-12-03	California Institute Of Technology	Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en)	2014-06-20	2015-12-23	The General Hospital Corporation	Collagen targeted imaging probes
WO2016149404A1 (en)	2015-03-16	2016-09-22	California Institute Of Technology	Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
CN115112898A (zh)	2015-07-15	2022-09-27	加州理工学院	Il-17f-特异性捕获剂、组合物以及使用和制造的方法
EP3519425B1 (de)	2016-09-29	2024-02-28	Indi Molecular, Inc.	Zusammensetzungen zum nachweis, zur hemmung und zur bildgebung von indolamin 2,3-dioxygenase 1 (ido1) und verfahren zur herstellung und verwendung davon
WO2018085375A1 (en)	2016-11-01	2018-05-11	Ohio State Innovation Foundation	Methods for the iodination of biomolecules
EP3638687A1 (de)	2017-06-15	2020-04-22	Indi Molecular, Inc.	Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US11919972B2 (en)	2018-11-02	2024-03-05	Regeneron Pharmaceuticals, Inc.	Peptide libraries with non-canonical amino acids
US11638764B2 (en)	2018-11-08	2023-05-02	Indi Molecular, Inc.	Theranostic capture agents, compositions, and methods of using and making
US11414460B2 (en)	2019-07-19	2022-08-16	Institute For Systems Biology	KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, delivery systems, and methods useful in tumor therapy
EP4303222A1 (de) *	2021-03-03	2024-01-10	Tokyo Institute of Technology	Verfahren zur herstellung von asymmetrischem phosphorsäuretriester, verfahren zur herstellung von symmetrischen phosphorsäuretriestern, verfahren zur herstellung von phosphorsäureester und verfahren zur herstellung einer organophosphorverbindung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
TW319763B (de) *	1995-02-01	1997-11-11	Epix Medical Inc
CA2214789A1 (en) *	1995-03-08	1996-09-12	The Scripps Research Institute	Carbopeptoids and carbonucleotoids

1997
- 1997-04-11 US US08/833,745 patent/US5919967A/en not_active Expired - Lifetime
1998
- 1998-01-27 CA CA002285417A patent/CA2285417C/en not_active Expired - Lifetime
- 1998-01-27 DK DK98903734T patent/DK1021452T3/da active
- 1998-01-27 DE DE69812983T patent/DE69812983T2/de not_active Expired - Lifetime
- 1998-01-27 AT AT98903734T patent/ATE236171T1/de active
- 1998-01-27 NZ NZ337921A patent/NZ337921A/xx not_active IP Right Cessation
- 1998-01-27 CZ CZ19993559A patent/CZ294469B6/cs not_active IP Right Cessation
- 1998-01-27 SK SK1382-99A patent/SK283832B6/sk not_active IP Right Cessation
- 1998-01-27 AU AU60425/98A patent/AU728902B2/en not_active Ceased
- 1998-01-27 ES ES98903734T patent/ES2195315T3/es not_active Expired - Lifetime
- 1998-01-27 PL PL98337423A patent/PL188258B1/pl not_active IP Right Cessation
- 1998-01-27 EP EP98903734A patent/EP1021452B1/de not_active Expired - Lifetime
- 1998-01-27 WO PCT/US1998/001473 patent/WO1998046612A1/en not_active Application Discontinuation
- 1998-01-27 HU HU0004239A patent/HU224257B1/hu not_active IP Right Cessation
- 1998-01-27 KR KR1020067007449A patent/KR20060066122A/ko not_active Application Discontinuation
- 1998-01-27 PT PT98903734T patent/PT1021452E/pt unknown
- 1998-01-27 BR BRPI9809084-4A patent/BR9809084B1/pt not_active IP Right Cessation
- 1998-01-27 KR KR1019997009256A patent/KR100593650B1/ko not_active IP Right Cessation
- 1998-01-27 IL IL13196498A patent/IL131964A/en not_active IP Right Cessation
- 1998-01-27 JP JP54386798A patent/JP4014231B2/ja not_active Expired - Fee Related
1999
- 1999-09-24 IS IS5193A patent/IS1994B/is unknown
- 1999-10-08 NO NO19994919A patent/NO325619B1/no not_active IP Right Cessation
2005
- 2005-02-21 JP JP2005044872A patent/JP2005206605A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
NO994919L (no)	1999-10-08
JP2005206605A (ja)	2005-08-04
JP4014231B2 (ja)	2007-11-28
PL188258B1 (pl)	2005-01-31
CZ294469B6 (cs)	2005-01-12
EP1021452B1 (de)	2003-04-02
BR9809084A (pt)	2000-08-01
PL337423A1 (en)	2000-08-14
AU6042598A (en)	1998-11-11
NO994919D0 (no)	1999-10-08
DE69812983T2 (de)	2004-01-08
CA2285417C (en)	2006-01-24
SK138299A3 (en)	2000-05-16
WO1998046612A1 (en)	1998-10-22
KR100593650B1 (ko)	2006-07-03
ES2195315T3 (es)	2003-12-01
IS1994B (is)	2005-03-15
KR20060066122A (ko)	2006-06-15
SK283832B6 (sk)	2004-02-03
IS5193A (is)	1999-09-24
CA2285417A1 (en)	1998-10-22
IL131964A (en)	2004-01-04
NO325619B1 (no)	2008-06-30
JP2002511060A (ja)	2002-04-09
KR20010006177A (ko)	2001-01-26
NZ337921A (en)	2000-09-29
CZ355999A3 (cs)	2000-01-12
DK1021452T3 (da)	2003-08-18
AU728902B2 (en)	2001-01-18
BR9809084B1 (pt)	2010-12-14
HUP0004239A2 (en)	2001-03-28
HUP0004239A3 (en)	2001-11-28
PT1021452E (pt)	2003-08-29
US5919967A (en)	1999-07-06
ATE236171T1 (de)	2003-04-15
HU224257B1 (hu)	2005-07-28
IL131964A0 (en)	2001-03-19
EP1021452A1 (de)	2000-07-26

Legal Events

Date	Code	Title	Description
2004-04-29	8364	No opposition during term of opposition
2006-06-29	8327	Change in the person/name/address of the patent owner	Owner name: EPIX PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DELAWA
2008-02-28	8327	Change in the person/name/address of the patent owner	Owner name: EPIX PHARMACEUTICALS, INC., LEXINGTON, MASS., US

Publication	Publication Date	Title
DE69812983D1 (de)	2003-05-08	Verfahren zur herstellung von phosphodiestern
ATE220404T1 (de)	2002-07-15	Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-biphosphonsäure
DE69113325D1 (de)	1995-11-02	Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure.
DE50100353D1 (de)	2003-08-14	Verfahren zur Herstellung von Alkanolaminen mit verbesserter Farbqualität
ATE90392T1 (de)	1993-06-15	Verfahren zur herstellung von optisch aktiven 2- arylalkansaeuren.
DE69931493D1 (de)	2006-06-29	Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE69505532D1 (de)	1998-11-26	Verfahren zur herstellung von n-phosphonomethylamino carboxylsäuren
EP0675076A3 (de)	1996-05-01	Phosphorylierungsreagens, Verfahren und Verwendung.
DE3864927D1 (de)	1991-10-24	Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten.
ATE155789T1 (de)	1997-08-15	Verfahren zur herstellung von aminomethanphosphonsäure
ATE360087T1 (de)	2007-05-15	Verfahren zur racematspaltung von arylalkylcarbonsäureestern
DE69703140D1 (de)	2000-10-26	Verfahren zur Herstellung von seltenem Erdphosphat mit niedrigem überstöchiometrischem Phosphorgehalt
DE69005309D1 (de)	1994-01-27	Verfahren zur herstellung von peroxykarbonsäuren unter verwendung eines enzymkatalysators.
DE50003163D1 (de)	2003-09-11	Verfahren zur Herstellung von Alkylphosphonigsäureestern
DE69033833D1 (de)	2001-11-22	Verfahren zur Herstellung von Butantetracarbonsäure
DE60110019D1 (de)	2005-05-19	Verfahren zur Herstellung von Cyclopropancarboxylaten
MX9307454A (es)	1994-08-31	Novedosos 2-sacarinilmetil fosfatos, fosfonatos y fosfinatos utiles como inhibidores de enzima proteolitica y composiciones y metodos de uso de los mismos.
DE60035494D1 (de)	2007-08-23	Verfahren zur herstellung von pseudomycin aus pseudomonas syringae
DE69415784D1 (de)	1999-02-18	Substituierte Phosphorsäuren
DE59009231D1 (de)	1995-07-20	Verfahren zur Herstellung von Tris(2,4-di-tert-butyl-phenyl)phosphit.
ATE217316T1 (de)	2002-05-15	Verfahren zur herstellung von diphosphonat- derivaten
ATE135692T1 (de)	1996-04-15	Verfahren zur herstellung von dichlormethylpyridinen