ATE160352T1 - Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren - Google Patents

Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren

Info

Publication number
ATE160352T1
ATE160352T1 AT94927234T AT94927234T ATE160352T1 AT E160352 T1 ATE160352 T1 AT E160352T1 AT 94927234 T AT94927234 T AT 94927234T AT 94927234 T AT94927234 T AT 94927234T AT E160352 T1 ATE160352 T1 AT E160352T1
Authority
AT
Austria
Prior art keywords
alkylidene
hydroxy
bisphosphonic acids
producing amino
producing
Prior art date
Application number
AT94927234T
Other languages
English (en)
Inventor
Richard R Dauer
Lisa Dimichele
Mauricio Futran
Gerard R Kieczykowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381051&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE160352(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE160352T1 publication Critical patent/ATE160352T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT94927234T 1993-08-25 1994-08-24 Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren ATE160352T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11175193A 1993-08-25 1993-08-25
US23964094A 1994-05-09 1994-05-09
US08/286,151 US5510517A (en) 1993-08-25 1994-08-04 Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Publications (1)

Publication Number Publication Date
ATE160352T1 true ATE160352T1 (de) 1997-12-15

Family

ID=27381051

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94927234T ATE160352T1 (de) 1993-08-25 1994-08-24 Verfahren zur herstellung von amino-1-hydroxy- alkyliden-1,1-bisphosphonsäuren

Country Status (25)

Country Link
US (1) US5510517A (de)
EP (1) EP0715631B1 (de)
JP (1) JP3675818B2 (de)
KR (1) KR100261202B1 (de)
CN (2) CN1067079C (de)
AT (1) ATE160352T1 (de)
AU (2) AU692468B2 (de)
BR (1) BR9407563A (de)
CA (1) CA2169561C (de)
CY (1) CY2086B1 (de)
CZ (1) CZ290185B6 (de)
DE (1) DE69406936T2 (de)
DK (1) DK0715631T3 (de)
ES (1) ES2109731T3 (de)
FI (1) FI115526B (de)
GR (1) GR3025450T3 (de)
HK (1) HK1008883A1 (de)
HR (1) HRP940479B1 (de)
HU (1) HU217362B (de)
LV (1) LV12189B (de)
NZ (1) NZ273458A (de)
RO (1) RO115524B1 (de)
RU (1) RU2154647C2 (de)
SI (1) SI0715631T1 (de)
WO (1) WO1995006052A1 (de)

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US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
EA001213B1 (ru) * 1996-10-04 2000-12-25 Мерк Энд Ко., Инк. Композиции жидкого алендроната
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
GB9800452D0 (en) 1998-01-10 1998-03-04 Albright & Wilson Preparation of phosphonic acid derivatives
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
CA2336201A1 (en) 1998-06-24 1999-12-29 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
SI1880744T1 (sl) * 2002-05-10 2015-04-30 F. Hoffmann-La Roche Ag Bifosfonske kisline za zdravljenje in prepreäśevanje osteoporoze
KR100681282B1 (ko) * 2002-05-17 2007-02-12 테바 파마슈티컬 인더스트리즈 리미티드 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
EP1513523A1 (de) * 2002-06-06 2005-03-16 Merck Frosst Canada & Co. 1,5-disubstituierte imidazolidin-2-on derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augen- und knochen-krankheiten
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
EP1653913B1 (de) * 2003-08-12 2012-05-23 3M Innovative Properties Company Selbstätzende dentalzusammensetzungen und verfahren
CA2535359A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
NZ545804A (en) * 2003-09-19 2009-09-25 Wisconsin Alumni Res Found Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1784154A1 (de) * 2004-07-08 2007-05-16 3M Innovative Properties Company Dentalverfahren, zusammensetzungen und kits mit säureempfindlichen farbstoffen
KR101260525B1 (ko) * 2004-08-11 2013-05-06 쓰리엠 도이칠란드 게엠베하 다수의 산성 화합물을 포함하는 자체-접착성 조성물
DK1855674T3 (da) 2005-03-02 2014-10-20 Merck Sharp & Dohme Sammensætning til hæmning af cathepsin k
CA2606879A1 (en) * 2005-05-06 2007-03-01 Medichem, S.A. Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007096896A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
WO2008076739A2 (en) 2006-12-13 2008-06-26 3M Innovative Properties Company Methods of using a dental composition having an acidic component and a photobleachable dye
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
BRPI0821090B8 (pt) * 2007-12-21 2021-05-25 Ligand Pharm Inc moduladores seletivos de receptores de androgênio (sarms) e uso do mesmo
WO2010003704A2 (en) 2008-07-11 2010-01-14 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2192126B1 (de) 2008-11-26 2013-03-27 Synthon B.V. Verfahren zur Herstellung von Zoledronsäure
EP2470549B1 (de) 2009-08-28 2014-07-16 Synthon B.V. Verfahren zur herstellung von hydroxyalkyliden-1,1-biphosphonsäuren
WO2011056589A1 (en) * 2009-10-26 2011-05-12 Warner Chilcott Company, Llc Bisphosphonate compounds for treating bone metabolism disorders
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
WO2012078528A2 (en) 2010-12-06 2012-06-14 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
FI20115315A0 (fi) * 2011-04-01 2011-04-01 Itae Suomen Yliopisto Menetelmä metallien keräämiseksi
CA2923272A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
CN106572997A (zh) 2014-05-30 2017-04-19 辉瑞公司 作为选择性雄激素受体调节剂的腈衍生物
EP3307747A4 (de) 2015-06-12 2019-02-27 Simon Fraser University Amid-verlinkte ep4-agonist-bisphosphonatverbindungen und verwendungen davon
CN112867724B (zh) 2018-07-23 2024-06-04 熙源安健医药(北京)有限公司 二膦酸盐药物缀合物
CN109456363A (zh) * 2018-11-01 2019-03-12 南京海纳医药科技股份有限公司 一种米诺膦酸工艺杂质的制备方法
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

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DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DD216465A1 (de) * 1983-07-01 1984-12-12 Agrochemie Piesteritz 4602 Wit Verfahren zur herstellung substituierter alkanphosphonsaeuren
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Also Published As

Publication number Publication date
AU7993798A (en) 1998-10-15
NZ273458A (en) 1998-04-27
AU7674394A (en) 1995-03-21
AU714996B2 (en) 2000-01-13
DK0715631T3 (da) 1997-12-22
AU692468B2 (en) 1998-06-11
HU217362B (hu) 2000-01-28
SI0715631T1 (en) 1998-02-28
FI960851A (fi) 1996-02-23
DE69406936D1 (de) 1998-01-02
CZ54296A3 (en) 1996-10-16
HRP940479B1 (en) 2000-10-31
CN1308082A (zh) 2001-08-15
KR100261202B1 (ko) 2000-07-01
CN1067079C (zh) 2001-06-13
EP0715631B1 (de) 1997-11-19
RU2154647C2 (ru) 2000-08-20
FI960851A0 (fi) 1996-02-23
DE69406936T2 (de) 1998-06-04
US5510517A (en) 1996-04-23
CN1211392C (zh) 2005-07-20
CA2169561C (en) 2007-02-20
EP0715631A1 (de) 1996-06-12
FI115526B (fi) 2005-05-31
CZ290185B6 (cs) 2002-06-12
CN1134703A (zh) 1996-10-30
HU9600429D0 (en) 1996-04-29
RO115524B1 (ro) 2000-03-30
BR9407563A (pt) 1996-12-31
CY2086B1 (en) 2002-04-05
WO1995006052A1 (en) 1995-03-02
CA2169561A1 (en) 1995-03-02
LV12189B (en) 1999-02-20
LV12189A (lv) 1998-12-20
ES2109731T3 (es) 1998-01-16
JPH09501935A (ja) 1997-02-25
HUT75261A (en) 1997-05-28
HK1008883A1 (en) 1999-05-21
HRP940479A2 (en) 1997-02-28
JP3675818B2 (ja) 2005-07-27
GR3025450T3 (en) 1998-02-27

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