DE69731380D1 - Verfahren zur präzipitation von polysacchariden - Google Patents

Verfahren zur präzipitation von polysacchariden

Info

Publication number
DE69731380D1
DE69731380D1 DE69731380T DE69731380T DE69731380D1 DE 69731380 D1 DE69731380 D1 DE 69731380D1 DE 69731380 T DE69731380 T DE 69731380T DE 69731380 T DE69731380 T DE 69731380T DE 69731380 D1 DE69731380 D1 DE 69731380D1
Authority
DE
Germany
Prior art keywords
precipitating
polysaccharides
precipitating polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731380T
Other languages
English (en)
Other versions
DE69731380T2 (de
Inventor
J Lander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9608546A external-priority patent/GB9608546D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69731380D1 publication Critical patent/DE69731380D1/de
Application granted granted Critical
Publication of DE69731380T2 publication Critical patent/DE69731380T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/102Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69731380T 1996-02-14 1997-02-10 Verfahren zur präzipitation von polysacchariden Expired - Lifetime DE69731380T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1163196P 1996-02-14 1996-02-14
US11631P 1996-02-14
GB9608546 1996-04-25
GB9608546A GB9608546D0 (en) 1996-04-25 1996-04-25 Polysaccharide precipitation process
PCT/US1997/002124 WO1997030171A1 (en) 1996-02-14 1997-02-10 Polysaccharide precipitation process

Publications (2)

Publication Number Publication Date
DE69731380D1 true DE69731380D1 (de) 2004-12-02
DE69731380T2 DE69731380T2 (de) 2006-02-23

Family

ID=26309205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731380T Expired - Lifetime DE69731380T2 (de) 1996-02-14 1997-02-10 Verfahren zur präzipitation von polysacchariden

Country Status (13)

Country Link
EP (1) EP0897427B1 (de)
JP (1) JP3990455B2 (de)
AR (1) AR005869A1 (de)
AT (1) ATE280834T1 (de)
AU (1) AU724862B2 (de)
CA (1) CA2245588C (de)
DE (1) DE69731380T2 (de)
DK (1) DK0897427T3 (de)
ES (1) ES2229336T3 (de)
HR (1) HRP970083A2 (de)
PT (1) PT897427E (de)
TW (1) TW411344B (de)
WO (1) WO1997030171A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2388563A1 (fr) * 1977-04-29 1978-11-24 Fabre Sa Pierre Vaccins acellulaires perfectionnes contenant des polysaccharides capsulaires
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4686102A (en) * 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4877613A (en) * 1987-08-05 1989-10-31 Biotech Connections, Inc. Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
HU9400426D0 (en) * 1991-08-16 1994-05-30 Merck & Co Inc Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5445817A (en) * 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines

Also Published As

Publication number Publication date
JP3990455B2 (ja) 2007-10-10
CA2245588C (en) 2006-05-09
WO1997030171A1 (en) 1997-08-21
AU724862B2 (en) 2000-10-05
AU2267797A (en) 1997-09-02
CA2245588A1 (en) 1997-08-21
HRP970083A2 (en) 1998-04-30
ES2229336T3 (es) 2005-04-16
DE69731380T2 (de) 2006-02-23
AR005869A1 (es) 1999-07-21
DK0897427T3 (da) 2005-02-14
TW411344B (en) 2000-11-11
PT897427E (pt) 2005-01-31
JP2000506383A (ja) 2000-05-30
EP0897427A1 (de) 1999-02-24
ATE280834T1 (de) 2004-11-15
EP0897427B1 (de) 2004-10-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US

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