AR005869A1 - Procedimiento para purificar y derivar polisacáridos y procedimiento para preparar una vacuna. - Google Patents

Procedimiento para purificar y derivar polisacáridos y procedimiento para preparar una vacuna.

Info

Publication number
AR005869A1
AR005869A1 ARP970100560A ARP970100560A AR005869A1 AR 005869 A1 AR005869 A1 AR 005869A1 AR P970100560 A ARP970100560 A AR P970100560A AR P970100560 A ARP970100560 A AR P970100560A AR 005869 A1 AR005869 A1 AR 005869A1
Authority
AR
Argentina
Prior art keywords
procedure
polysaccharides
vaccine
deriving
purifying
Prior art date
Application number
ARP970100560A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9608546A external-priority patent/GB9608546D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR005869A1 publication Critical patent/AR005869A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se aislan polisacáridos bacterianos que se usan para producir vacunas y, después se les precipita con un detergente de cadena larga. Los polisacáridosprecipitados son solubles en solventes orgánicos y pueden derivatizarse adicionalmente yprocesarse para formar la vacuna.
ARP970100560A 1996-02-14 1997-02-12 Procedimiento para purificar y derivar polisacáridos y procedimiento para preparar una vacuna. AR005869A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1163196P 1996-02-14 1996-02-14
GB9608546A GB9608546D0 (en) 1996-04-25 1996-04-25 Polysaccharide precipitation process

Publications (1)

Publication Number Publication Date
AR005869A1 true AR005869A1 (es) 1999-07-21

Family

ID=26309205

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100560A AR005869A1 (es) 1996-02-14 1997-02-12 Procedimiento para purificar y derivar polisacáridos y procedimiento para preparar una vacuna.

Country Status (13)

Country Link
EP (1) EP0897427B1 (es)
JP (1) JP3990455B2 (es)
AR (1) AR005869A1 (es)
AT (1) ATE280834T1 (es)
AU (1) AU724862B2 (es)
CA (1) CA2245588C (es)
DE (1) DE69731380T2 (es)
DK (1) DK0897427T3 (es)
ES (1) ES2229336T3 (es)
HR (1) HRP970083A2 (es)
PT (1) PT897427E (es)
TW (1) TW411344B (es)
WO (1) WO1997030171A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20070184072A1 (en) * 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2388563A1 (fr) * 1977-04-29 1978-11-24 Fabre Sa Pierre Vaccins acellulaires perfectionnes contenant des polysaccharides capsulaires
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4686102A (en) * 1984-04-12 1987-08-11 American Cyanamid Company Multivalent pneumococcal vaccine and preparation thereof
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4877613A (en) * 1987-08-05 1989-10-31 Biotech Connections, Inc. Process for preparing veterinary acellular vaccines against gram-negative nonenteric pathogenic bacilli
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
HU9400426D0 (en) * 1991-08-16 1994-05-30 Merck & Co Inc Process for converting lipid-containing bacterial capsular polysaccharide into lipid-free polysaccharide
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
US5445817A (en) * 1992-08-21 1995-08-29 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines

Also Published As

Publication number Publication date
JP3990455B2 (ja) 2007-10-10
CA2245588C (en) 2006-05-09
WO1997030171A1 (en) 1997-08-21
AU724862B2 (en) 2000-10-05
AU2267797A (en) 1997-09-02
CA2245588A1 (en) 1997-08-21
HRP970083A2 (en) 1998-04-30
DE69731380D1 (de) 2004-12-02
ES2229336T3 (es) 2005-04-16
DE69731380T2 (de) 2006-02-23
DK0897427T3 (da) 2005-02-14
TW411344B (en) 2000-11-11
PT897427E (pt) 2005-01-31
JP2000506383A (ja) 2000-05-30
EP0897427A1 (en) 1999-02-24
ATE280834T1 (de) 2004-11-15
EP0897427B1 (en) 2004-10-27

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