DE69728869D1 - Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien - Google Patents

Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien

Info

Publication number: DE69728869D1
Authority: DE; Germany
Prior art keywords: acids; hydroxysic; agulants; antico; derivatives substituted
Prior art date: 1996-02-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69728869T

Other languages

English (en)

Other versions

DE69728869T2 (de

Inventor

Monica Kochanny

Raju Mohan

M Morrissey

P Ng

Weija Yun

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Berlex Laboratories Inc

Original Assignee

Berlex Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-12

Filing date

1997-02-07

Publication date

2004-06-03

1997-02-07 Application filed by Berlex Laboratories Inc filed Critical Berlex Laboratories Inc

2004-06-03 Publication of DE69728869D1 publication Critical patent/DE69728869D1/de

2005-01-05 Application granted granted Critical

2005-01-05 Publication of DE69728869T2 publication Critical patent/DE69728869T2/de

2017-02-08 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

DE69728869T 1996-02-12 1997-02-07 Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien Expired - Fee Related DE69728869T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US599834		1996-02-12
US08/599,834 US5994375A (en)	1996-02-12	1996-02-12	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
PCT/IB1997/000098 WO1997029067A1 (en)	1996-02-12	1997-02-07	Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants

Publications (2)

Publication Number	Publication Date
DE69728869D1 true DE69728869D1 (de)	2004-06-03
DE69728869T2 DE69728869T2 (de)	2005-01-05

Family

ID=24401285

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69728869T Expired - Fee Related DE69728869T2 (de)	1996-02-12	1997-02-07	Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien

Country Status (23)

Country	Link
US (4)	US5994375A (de)
EP (1)	EP0888271B1 (de)
JP (1)	JP3762790B2 (de)
KR (1)	KR19990082480A (de)
CN (1)	CN1211232A (de)
AT (1)	ATE265409T1 (de)
AU (1)	AU715992B2 (de)
CA (1)	CA2245925A1 (de)
CZ (1)	CZ255098A3 (de)
DE (1)	DE69728869T2 (de)
DK (1)	DK0888271T3 (de)
ES (1)	ES2221032T3 (de)
HU (1)	HU223604B1 (de)
IL (1)	IL125285A (de)
NO (1)	NO312834B1 (de)
NZ (1)	NZ326452A (de)
PL (1)	PL186474B1 (de)
PT (1)	PT888271E (de)
RU (1)	RU98117078A (de)
SK (1)	SK283306B6 (de)
UA (1)	UA51694C2 (de)
WO (1)	WO1997029067A1 (de)
ZA (1)	ZA971183B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0813525B9 (de) *	1995-03-10	2004-02-04	Berlex Laboratories, Inc.	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
JP3565864B2 (ja)	1996-09-12	2004-09-15	シエーリングアクチエンゲゼルシヤフト	環式アミノ酸または環式ヒドロキシ酸誘導体により置換されたベンズアミジン誘導体および抗擬固薬としてのこれらの使用
US6004985A (en) *	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en)	1997-12-08	2004-02-03	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) *	1997-12-19	2000-10-31	Berlex Laboratories, Inc.	Ortho-anthranilamide derivatives as anti-coagulants
JP3811006B2 (ja)	1997-12-19	2006-08-16	シエーリングアクチエンゲゼルシャフト	抗凝血物質類としてのオルト−アントラニルアミド誘導体類
US6262088B1 (en)	1998-11-19	2001-07-17	Berlex Laboratories, Inc.	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) *	1998-12-04	2000-10-03	Berlex Laboratories, Inc.	Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
EP1058549A4 (de)	1998-12-23	2003-11-12	Bristol Myers Squibb Pharma Co	THROMBIN- ODER FAKTOR-Xa HEMMER
US6350761B1 (en)	1999-07-30	2002-02-26	Berlex Laboratories, Inc.	Benzenamine derivatives as anti-coagulants
US6844367B1 (en)	1999-09-17	2005-01-18	Millennium Pharmaceuticals, Inc.	Benzamides and related inhibitors of factor Xa
US6376515B2 (en)	2000-02-29	2002-04-23	Cor Therapeutics, Inc.	Benzamides and related inhibitors of factor Xa
KR100841597B1 (ko) *	2000-09-13	2008-06-26	롬 앤드 하스 일렉트로닉 머트어리얼즈, 엘.엘.씨	전자 디바이스 제조
JP4087577B2 (ja)	2001-03-30	2008-05-21	富士フイルム株式会社	ヘテロ環連結体を含有する写真処理組成物及び画像形成方法
JP5082033B2 (ja)	2001-12-21	2012-11-28	エグゼリクシスパテントカンパニーエルエルシー	Ｌｘｒのモジュレーター
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
TW200409629A (en) *	2002-06-27	2004-06-16	Bristol Myers Squibb Co	2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors
PT1569912E (pt)	2002-12-03	2015-09-15	Pharmacyclics Llc	Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
EP2077995B1 (de)	2006-11-02	2012-02-08	Millennium Pharmaceuticals, Inc.	Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer
CA2702674C (en)	2007-10-19	2016-05-03	Avila Therapeutics, Inc.	Heteroaryl compounds and uses thereof
US7989465B2 (en)	2007-10-19	2011-08-02	Avila Therapeutics, Inc.	4,6-disubstituted pyrimidines useful as kinase inhibitors

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GB824908A (en) *	1958-06-03	1959-12-09	May & Baker Ltd	Improvements in or relating to triazine derivatives
JPS5922697B2 (ja) *	1976-01-13	1984-05-28	エーザイ株式会社	ビス−（メタ−アミジノフエノキシ）−化合物
JPH0813834B2 (ja) *	1990-08-01	1996-02-14	日東紡績株式会社	トリペプチド誘導体及びそれを有効成分とする蛋白分解酵素阻害剤
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
EP0518818A3 (en) *	1991-06-11	1993-04-28	Ciba-Geigy Ag	Arylethers, their manufacture and use as medicament
ZA928276B (en) *	1991-10-31	1993-05-06	Daiichi Seiyaku Co	Aromatic amidine derivates and salts thereof.
DE69321344D1 (de) *	1992-02-14	1998-11-05	Corvas Int Inc	Inhibitoren der thrombose
DE4213919A1 (de)	1992-04-28	1993-11-04	Thomae Gmbh Dr K	Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
IL106324A (en)	1992-07-17	1998-09-24	Shell Int Research	Transformed pyrimidine compounds, their preparation and use as pesticides
AU675981B2 (en)	1992-12-02	1997-02-27	Bristol-Myers Squibb Company	Guanidinyl-substituted heterocyclic thrombin inhibitors
DE69324041D1 (de)	1992-12-15	1999-04-22	Corvas Int Inc	NEUE INHIBITOREN VON FAKTOR Xa
US5332822A (en) *	1992-12-24	1994-07-26	Bristol-Myers Squibb Company	Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
WO1994017817A1 (en)	1993-02-12	1994-08-18	Corvas International, Inc.	Inhibitors of thrombosis
US5633381A (en) *	1994-07-05	1997-05-27	Berlex Laboratories, Inc.	(Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
EP0813525B9 (de)	1995-03-10	2004-02-04	Berlex Laboratories, Inc.	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5691364A (en) *	1995-03-10	1997-11-25	Berlex Laboratories, Inc.	Benzamidine derivatives and their use as anti-coagulants
US5612363A (en) *	1995-06-02	1997-03-18	Berlex Laboratories, Inc.	N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en) *	1995-12-08	1998-12-15	Berlex Laboratories, Inc.	Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5753635A (en) *	1996-08-16	1998-05-19	Berlex Laboratories, Inc.	Purine derivatives and their use as anti-coagulants
US5693641A (en) *	1996-08-16	1997-12-02	Berlex Laboratories Inc.	Bicyclic pyrimidine derivatives and their use as anti-coagulants
JP3565864B2 (ja) *	1996-09-12	2004-09-15	シエーリングアクチエンゲゼルシヤフト	環式アミノ酸または環式ヒドロキシ酸誘導体により置換されたベンズアミジン誘導体および抗擬固薬としてのこれらの使用
US6004985A (en)	1996-10-09	1999-12-21	Berlex Laboratories, Inc.	Thio acid derived monocylic N-heterocyclics as anticoagulants

1996
- 1996-02-12 US US08/599,834 patent/US5994375A/en not_active Expired - Fee Related
1997
- 1997-02-07 JP JP52833697A patent/JP3762790B2/ja not_active Expired - Fee Related
- 1997-02-07 DK DK97901221T patent/DK0888271T3/da active
- 1997-02-07 KR KR1019980706213A patent/KR19990082480A/ko active IP Right Grant
- 1997-02-07 IL IL12528597A patent/IL125285A/en not_active IP Right Cessation
- 1997-02-07 EP EP97901221A patent/EP0888271B1/de not_active Expired - Lifetime
- 1997-02-07 AU AU14548/97A patent/AU715992B2/en not_active Ceased
- 1997-02-07 WO PCT/IB1997/000098 patent/WO1997029067A1/en not_active Application Discontinuation
- 1997-02-07 NZ NZ326452A patent/NZ326452A/en unknown
- 1997-02-07 ES ES97901221T patent/ES2221032T3/es not_active Expired - Lifetime
- 1997-02-07 AT AT97901221T patent/ATE265409T1/de not_active IP Right Cessation
- 1997-02-07 DE DE69728869T patent/DE69728869T2/de not_active Expired - Fee Related
- 1997-02-07 CN CN97192215A patent/CN1211232A/zh active Pending
- 1997-02-07 HU HU9902017A patent/HU223604B1/hu not_active IP Right Cessation
- 1997-02-07 CZ CZ982550A patent/CZ255098A3/cs unknown
- 1997-02-07 PT PT97901221T patent/PT888271E/pt unknown
- 1997-02-07 CA CA002245925A patent/CA2245925A1/en not_active Abandoned
- 1997-02-07 PL PL97328412A patent/PL186474B1/pl not_active IP Right Cessation
- 1997-02-07 SK SK1092-98A patent/SK283306B6/sk unknown
- 1997-02-07 RU RU98117078/04A patent/RU98117078A/ru not_active Application Discontinuation
- 1997-02-12 ZA ZA9701183A patent/ZA971183B/xx unknown
- 1997-07-02 UA UA98094782A patent/UA51694C2/uk unknown
1998
- 1998-08-11 NO NO19983671A patent/NO312834B1/no not_active IP Right Cessation
1999
- 1999-09-09 US US09/394,458 patent/US6071912A/en not_active Expired - Fee Related
- 1999-09-09 US US09/393,198 patent/US6242454B1/en not_active Expired - Fee Related
- 1999-09-09 US US09/393,180 patent/US6166088A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO983671D0 (no)	1998-08-11
CZ255098A3 (cs)	1999-01-13
SK283306B6 (sk)	2003-05-02
IL125285A (en)	2002-11-10
UA51694C2 (uk)	2002-12-16
ZA971183B (en)	1997-09-18
SK109298A3 (en)	1999-02-11
CN1211232A (zh)	1999-03-17
PT888271E (pt)	2004-09-30
ATE265409T1 (de)	2004-05-15
JP2000505431A (ja)	2000-05-09
ES2221032T3 (es)	2004-12-16
HUP9902017A3 (en)	2000-06-28
PL328412A1 (en)	1999-01-18
DK0888271T3 (da)	2004-08-16
HUP9902017A2 (hu)	1999-09-28
RU98117078A (ru)	2000-06-10
US6242454B1 (en)	2001-06-05
AU715992B2 (en)	2000-02-17
AU1454897A (en)	1997-08-28
PL186474B1 (pl)	2004-01-30
US5994375A (en)	1999-11-30
CA2245925A1 (en)	1997-08-14
US6071912A (en)	2000-06-06
IL125285A0 (en)	1999-03-12
EP0888271B1 (de)	2004-04-28
HU223604B1 (hu)	2004-10-28
NZ326452A (en)	2000-02-28
US6166088A (en)	2000-12-26
EP0888271A1 (de)	1999-01-07
KR19990082480A (ko)	1999-11-25
NO312834B1 (no)	2002-07-08
NO983671L (no)	1998-09-11
DE69728869T2 (de)	2005-01-05
WO1997029067A1 (en)	1997-08-14
JP3762790B2 (ja)	2006-04-05
EP0888271A4 (de)	2000-03-15

Legal Events

Date	Code	Title	Description
2005-05-25	8364	No opposition during term of opposition
2008-03-13	8328	Change in the person/name/address of the agent	Representative=s name: DF-MP, 80333 MUENCHEN
2009-12-17	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69728869D1 (de)	2004-06-03	Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien
ATE228513T1 (de)	2002-12-15	Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
ATE251141T1 (de)	2003-10-15	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
IL129056A0 (en)	2000-02-17	Monocyclic N-heterocyclics substituted by thio acid derivatives and pharmaceutical compositions containing same
HK1020058A1 (en)	2000-03-10	Bicyclic pyrimidine derivatives and their use as anti-coagulants
DE69432035D1 (de)	2003-02-27	Saccharinderivate als proteolytische Enzyminhibitoren
DE69232929D1 (de)	2003-04-03	Saccharinderivate als proteolytische Enzyminhibitoren
MY106202A (en)	1995-03-31	Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
ATE169905T1 (de)	1998-09-15	Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten
EA200000081A1 (ru)	2000-08-28	Малеат 5-(2-этил-2h-тетразол-5-ил)-1-метил-1,2,3,6-тетрагидропиридина