DE69719765T2 - 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden - Google Patents

4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden

Info

Publication number
DE69719765T2
DE69719765T2 DE69719765T DE69719765T DE69719765T2 DE 69719765 T2 DE69719765 T2 DE 69719765T2 DE 69719765 T DE69719765 T DE 69719765T DE 69719765 T DE69719765 T DE 69719765T DE 69719765 T2 DE69719765 T2 DE 69719765T2
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
addiction
dopamine
aminoethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69719765T
Other languages
English (en)
Other versions
DE69719765D1 (de
Inventor
Richard Eric Mewshaw
Michael Byron Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE69719765D1 publication Critical patent/DE69719765D1/de
Publication of DE69719765T2 publication Critical patent/DE69719765T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69719765T 1996-08-27 1997-08-26 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden Expired - Fee Related DE69719765T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70356296A 1996-08-27 1996-08-27
PCT/US1997/015026 WO1998008817A1 (en) 1996-08-27 1997-08-26 4-aminoethoxy indoles as dopamin d2 agonists and as 5ht1a ligands

Publications (2)

Publication Number Publication Date
DE69719765D1 DE69719765D1 (de) 2003-04-17
DE69719765T2 true DE69719765T2 (de) 2003-10-16

Family

ID=24825871

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719765T Expired - Fee Related DE69719765T2 (de) 1996-08-27 1997-08-26 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden

Country Status (12)

Country Link
EP (1) EP0923548B1 (de)
JP (1) JP2000516936A (de)
KR (1) KR20000035880A (de)
CN (1) CN1234023A (de)
AT (1) ATE234281T1 (de)
AU (1) AU4091697A (de)
CA (1) CA2264080A1 (de)
DE (1) DE69719765T2 (de)
DK (1) DK0923548T3 (de)
ES (1) ES2188970T3 (de)
PT (1) PT923548E (de)
WO (1) WO1998008817A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU746717B2 (en) * 1997-02-18 2002-05-02 Wyeth 4-aminoalkoxy-1H-benzimidazole derivatives, their preparation and their use as dopamine autoreceptor (D2) agonists
US6127380A (en) * 1997-02-18 2000-10-03 American Home Products Corporation 4-aminoalkoxy-1H-benzoimidazoles
US6110956A (en) * 1998-04-08 2000-08-29 American Home Products Corp. N-aryloxyethylamine derivatives for the treatment of depression
DK1068199T3 (da) * 1998-04-08 2003-03-03 Wyeth Corp N-Aryloxyethyl-indolyl-alkylaminer til behandling af depression
ES2182509T3 (es) * 1998-04-08 2003-03-01 Wyeth Corp Derivados de n-ariloxietilamina para el tratamiento de la depresion.
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
EP0982030A3 (de) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden
FR2786767B1 (fr) * 1998-12-02 2001-02-23 Pf Medicament Nouveaux derives de 3-alkoxybenzylamines et leur utilisation a titre de medicaments pour le traitement de la schizophrenie
DE10006139A1 (de) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl-Derivate
DE10029371A1 (de) * 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
KR100467693B1 (ko) * 2002-05-07 2005-01-24 삼성에스디아이 주식회사 플라즈마 디스플레이 패널의 어드레스 전력을 효율적으로회생시키는 회로
TWI284124B (en) * 2002-12-03 2007-07-21 Hoffmann La Roche Aminoalkoxyindoles
AU2004226838B8 (en) 2003-04-04 2009-06-11 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
TWI347183B (en) * 2003-12-23 2011-08-21 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzyl amine derivatives
BRPI0417858B1 (pt) 2003-12-23 2017-10-10 H. Lundbeck A/S Derivative compounds of aniline and pharmaceutical composition that understand it
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
CN101563320B (zh) * 2006-09-28 2012-05-30 H.隆德贝克有限公司 用于治疗情感障碍的[2-(6-氟-1h-吲哚-3-基硫烷基)苄基]甲胺
CN110041318B (zh) * 2018-01-17 2022-07-29 中国科学院上海药物研究所 一类多巴胺d5受体激动剂及其制备和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906000A (en) * 1972-02-23 1975-09-16 Pfizer Tricyclicazaindole derivatives
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives

Also Published As

Publication number Publication date
ES2188970T3 (es) 2003-07-01
KR20000035880A (ko) 2000-06-26
CA2264080A1 (en) 1998-03-05
ATE234281T1 (de) 2003-03-15
JP2000516936A (ja) 2000-12-19
CN1234023A (zh) 1999-11-03
EP0923548A1 (de) 1999-06-23
PT923548E (pt) 2003-06-30
DK0923548T3 (da) 2003-06-23
WO1998008817A1 (en) 1998-03-05
AU4091697A (en) 1998-03-19
DE69719765D1 (de) 2003-04-17
EP0923548B1 (de) 2003-03-12

Similar Documents

Publication Publication Date Title
DE69719765T2 (de) 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden
CA2045955A1 (en) Indole derivatives
AU2004287245A1 (en) Use of CRTH2 antagonist compounds in therapy
JP2006502183A5 (de)
SE0200411D0 (sv) Novel use
HUP0302337A2 (hu) Pirimidin-2,4,6-trion metalloproteáz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CN105683157A (zh) 用作钠通道调节剂的磺酰胺类
DE69329727D1 (de) Neue imidazol derivate, ihre herstellung und therapeutische verwendung
HUP0102300A2 (hu) Diazepinszármazékok alkalmazása szomatosztatin-receptor által befolyásolt betegségek kezelésére szánt gyógyszerek előállítására, valamint új vegyületek
DE69530094D1 (de) Thiazolidindione derivate, ihre herstellung und verwendung
JP2001518507A (ja) 新規シクロアルケニル置換化合物
BRPI0409110A (pt) derivados de 4-(4-heterociclilalcoxi)fenil-1-(heterociclil-carboni l)piridina e compostos relacionados como antagonistas de histamina h3 para o tratamento de doenças neurológicas tais como alzheimer
BR0009278A (pt) 1-arenossulfonil-2-aril-pirrolidina e derivados depiperidina
IE72953B1 (en) 3-arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions
AU2001293804A1 (en) New benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
CA2169804A1 (en) Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
CN106535894A (zh) 用于癌症治疗的mcl‑1调节化合物
HUP0101746A2 (hu) Fenilszulfonamid-feniletilamin-származékok és ezek alkalmazása dopamin receptorként
KR900009605A (ko) 치환된 이미다졸 유도체 및 그들의 제법 및 용도
DK0923551T3 (da) 4-Aminoethoxy-indolon-derivater
HUP0104701A2 (hu) 3-Tetrahidro-piridin-4-il-indolok pszichotikus betegségek kezelésére és a vegyületeket tartalmazó gyógyszerkészítmények
DE69716932D1 (de) 4-aminoethoxy-indolonderivate als dopamin d2 agonisten
KR930021629A (ko) 피페라진 유도체
ATE294780T1 (de) Arylpiperidin- und aryl-1,2,5,6- tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
CA2672920A1 (en) Aryl piperazine derivatives useful for the treatment of neuropsychiatric disorders

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee