DE69637518D1 - Homogene vervielfältigung und nachweis von nukleinsäuren - Google Patents
Homogene vervielfältigung und nachweis von nukleinsäurenInfo
- Publication number
- DE69637518D1 DE69637518D1 DE69637518T DE69637518T DE69637518D1 DE 69637518 D1 DE69637518 D1 DE 69637518D1 DE 69637518 T DE69637518 T DE 69637518T DE 69637518 T DE69637518 T DE 69637518T DE 69637518 D1 DE69637518 D1 DE 69637518D1
- Authority
- DE
- Germany
- Prior art keywords
- duplication
- homogenous
- detection
- nucleic acids
- nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001514 detection method Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US909095P | 1995-12-22 | 1995-12-22 | |
PCT/US1996/019751 WO1997023647A1 (en) | 1995-12-22 | 1996-12-20 | Homogeneous amplification and detection of nucleic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69637518D1 true DE69637518D1 (de) | 2008-06-19 |
Family
ID=21735499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637518T Expired - Fee Related DE69637518D1 (de) | 1995-12-22 | 1996-12-20 | Homogene vervielfältigung und nachweis von nukleinsäuren |
Country Status (6)
Country | Link |
---|---|
US (1) | US5914230A (de) |
EP (1) | EP0876510B1 (de) |
JP (1) | JP2001517925A (de) |
CA (1) | CA2239683A1 (de) |
DE (1) | DE69637518D1 (de) |
WO (1) | WO1997023647A1 (de) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
US7195871B2 (en) * | 1996-01-24 | 2007-03-27 | Third Wave Technologies, Inc | Methods and compositions for detecting target sequences |
US7256020B2 (en) * | 1996-11-29 | 2007-08-14 | Third Wave Technologies, Inc. | Methods and compositions for detecting target sequences |
US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
WO2000055372A1 (en) * | 1999-03-16 | 2000-09-21 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
WO1999023258A1 (en) * | 1997-10-31 | 1999-05-14 | Gen-Probe Incorporated | Methods of nucleic acid detection |
DE10012007T1 (de) * | 1998-05-01 | 2012-01-26 | Gen-Probe Inc. | Automatisches Diagnoseanalysegerät und Verfahren |
EP1092047B1 (de) * | 1998-07-02 | 2009-08-26 | Gen-Probe Incorporated | Molekulare fackeln |
US6346384B1 (en) * | 2000-03-27 | 2002-02-12 | Dade Behring Inc. | Real-time monitoring of PCR using LOCI |
WO2001084157A2 (en) * | 2000-05-04 | 2001-11-08 | Dade Behring Marburg Gmbh | Compositions for detection of multiple analytes |
DE10123183A1 (de) * | 2000-05-18 | 2001-11-22 | Becton Dickinson Co | Modifizierte Amplifikationsprimer und ihre Verwendung |
US20030082549A1 (en) * | 2000-08-30 | 2003-05-01 | Xiangjun Liu | Method for determining alleles |
US8512953B2 (en) * | 2001-09-24 | 2013-08-20 | One Lambda | Diagnostic probe detection system |
WO2004013606A2 (en) | 2002-08-02 | 2004-02-12 | Stratatech Corporation | Species specific dna detection |
US7851150B2 (en) | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
ATE525469T1 (de) | 2002-12-18 | 2011-10-15 | Third Wave Tech Inc | Nachweis kleiner nukleinsäuren |
US8206904B2 (en) * | 2002-12-18 | 2012-06-26 | Third Wave Technologies, Inc. | Detection of nucleic acids |
US7297780B2 (en) | 2003-01-06 | 2007-11-20 | Third Wave Technologies, Inc. | Reactive functional groups for preparation of modified nucleic acid |
CA2520538C (en) | 2003-03-31 | 2014-04-29 | F. Hoffmann-La Roche Ag | Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup |
AU2004261999B2 (en) * | 2003-08-01 | 2010-05-20 | Dynal Biotech Inc. | Self-hybridizing multiple target nucleic acid probes and methods of use |
JP2007512543A (ja) * | 2003-12-01 | 2007-05-17 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | ホモジニアスな検出方法 |
US20050118727A1 (en) * | 2003-12-01 | 2005-06-02 | Carsten Schelp | Conjugates and their use in detection methods |
WO2005060618A2 (en) * | 2003-12-19 | 2005-07-07 | California Institute Of Technology | Enzyme-free isothermal exponential amplification of nucleic acids and nucleic acid analog signals |
US7462451B2 (en) * | 2004-04-26 | 2008-12-09 | Third Wave Technologies, Inc. | Compositions for modifying nucleic acids |
EP1778867B1 (de) | 2004-07-01 | 2010-04-28 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zum nachweis von nukleinsäuren in einer biologischen probe |
US20070026423A1 (en) * | 2005-03-16 | 2007-02-01 | Thomas Koehler | Method and test kit for the detection of target nucleic acids |
DE102005000021A1 (de) * | 2005-03-16 | 2006-09-21 | Köhler, Thomas, Dr. | Verfahren und Testkit zur Detektion von Ziel-Nukleinsäuren |
WO2007059348A2 (en) * | 2005-11-17 | 2007-05-24 | Third Wave Technologies, Inc. | Compositions and methods for detecting an hcv-1 subtype |
EP2029774B1 (de) | 2006-06-01 | 2015-04-01 | Third Wave Technologies, Inc. | Nachweis von nukleinsäuren |
EP2078756A4 (de) * | 2006-10-03 | 2010-09-08 | Univ Gifu | Bakteriennachweis mittels dnaj-gen und verwendung davon |
US8043810B2 (en) * | 2007-05-02 | 2011-10-25 | Eagle Eye Research, Inc. | Analyte detection using autocatalytic chain reactions |
GB0713183D0 (en) * | 2007-07-06 | 2007-08-15 | King S College London | Method |
EP2183394B1 (de) * | 2007-09-07 | 2012-12-12 | Third Wave Technologies, Inc. | Verfahren und anwendungen für zielquantifizierung |
MX2010010161A (es) * | 2008-03-15 | 2011-03-21 | Hologic Inc Star | Composiciones y metodos para el analisis de moleculas de acido nucleico durante reacciones de amplificacion. |
US10316352B2 (en) * | 2008-05-13 | 2019-06-11 | Gen-Probe Incorporated | Methods of capturing a target nucleic acid for amplification and detection using an inactivatable target capture oligomer |
CN102292457B (zh) * | 2008-11-25 | 2014-04-09 | 简·探针公司 | 检测小rna的组合物和方法及其用途 |
US20110091931A1 (en) * | 2009-04-24 | 2011-04-21 | Colby Pharmaceutical Company | Methods and Kits for Determining Oxygen Free Radical (OFR) Levels in Animal and Human Tissues as a Prognostic Marker for Cancer and Other Pathophysiologies |
US9910040B2 (en) * | 2012-07-09 | 2018-03-06 | Sevident, Inc. | Molecular nets comprising capture agents and linking agents |
US9733242B2 (en) | 2012-10-07 | 2017-08-15 | Sevident, Inc. | Devices for capturing analyte |
US20130052653A1 (en) * | 2009-11-24 | 2013-02-28 | Argos, Inc. | Devices for detection of analytes |
WO2011084772A2 (en) | 2009-12-21 | 2011-07-14 | Northwestern University | Allelic disorders caused by mutations in trpv4 |
DE102010003781B4 (de) * | 2010-04-08 | 2012-08-16 | Aj Innuscreen Gmbh | Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen |
WO2012012779A2 (en) | 2010-07-23 | 2012-01-26 | Beckman Coulter Inc. | System and method including analytical units |
US20150225792A1 (en) | 2014-01-17 | 2015-08-13 | Northwestern University | Compositions and methods for identifying depressive disorders |
US20150218639A1 (en) | 2014-01-17 | 2015-08-06 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
US10233501B2 (en) | 2010-10-19 | 2019-03-19 | Northwestern University | Biomarkers predictive of predisposition to depression and response to treatment |
US10093981B2 (en) | 2010-10-19 | 2018-10-09 | Northwestern University | Compositions and methods for identifying depressive disorders |
AU2012212127B2 (en) | 2011-02-02 | 2016-06-02 | Exact Sciences Corporation | Digital sequence analysis of DNA methylation |
US8993341B2 (en) | 2011-05-12 | 2015-03-31 | Exact Sciences Corporation | Removal of PCR inhibitors |
CA2835345C (en) | 2011-05-12 | 2021-03-09 | Exact Sciences Corporation | Isolation of nucleic acids |
US8808990B2 (en) | 2011-05-12 | 2014-08-19 | Exact Sciences Corporation | Serial isolation of multiple DNA targets from stool |
US8973736B2 (en) | 2011-11-07 | 2015-03-10 | Beckman Coulter, Inc. | Magnetic damping for specimen transport system |
CN104040357B (zh) | 2011-11-07 | 2016-11-23 | 贝克曼考尔特公司 | 等分器***以及工作流 |
ES2729283T3 (es) | 2011-11-07 | 2019-10-31 | Beckman Coulter Inc | Sistema de centrífuga y flujo de trabajo |
WO2013070756A2 (en) | 2011-11-07 | 2013-05-16 | Beckman Coulter, Inc. | System and method for processing samples |
EP2776844B1 (de) | 2011-11-07 | 2020-09-30 | Beckman Coulter, Inc. | Probenbehälterdetektion |
JP6165755B2 (ja) | 2011-11-07 | 2017-07-19 | ベックマン コールター, インコーポレイテッド | ロボットアーム |
WO2013096798A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Amplification of a sequence from a ribonucleic acid |
CN102559661B (zh) * | 2012-01-18 | 2014-06-04 | 厦门基科生物科技有限公司 | 一种新型连接酶反应介导的扩增方法及用途 |
CN104603287B (zh) | 2012-05-10 | 2018-01-19 | 通用医疗公司 | 用于测定核苷酸序列的方法 |
AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
CN105143465A (zh) | 2013-03-14 | 2015-12-09 | 梅奥医学教育和研究基金会 | 检测赘生物 |
CA2924669C (en) | 2013-09-20 | 2023-03-21 | The Regents Of The University Of Michigan | Compositions and methods for the analysis of radiosensitivity |
WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
CN111100911B (zh) * | 2013-11-26 | 2023-06-02 | 杭州联川基因诊断技术有限公司 | 一种扩增靶核酸的方法 |
US9909181B2 (en) | 2013-12-13 | 2018-03-06 | Northwestern University | Biomarkers for post-traumatic stress states |
EP3084004A4 (de) | 2013-12-19 | 2017-08-16 | Exact Sciences Corporation | Synthetische nukleinsäuresteuerungsmoleküle |
EP3099820A4 (de) | 2014-01-27 | 2018-01-03 | The General Hospital Corporation | Verfahren zur herstellung von nukleinsäuren zur sequenzierung |
US9897597B2 (en) * | 2014-04-23 | 2018-02-20 | Children's Medical Center Corporation | High-throughput structure determination using nucleic acid calipers |
US9856521B2 (en) * | 2015-01-27 | 2018-01-02 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
US10683534B2 (en) | 2015-01-27 | 2020-06-16 | BioSpyder Technologies, Inc. | Ligation assays in liquid phase |
WO2016094839A2 (en) | 2014-12-12 | 2016-06-16 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
ES2879964T3 (es) | 2014-12-12 | 2021-11-23 | Exact Sciences Dev Co Llc | Composiciones y métodos para realizar ensayos de detección de metilación |
EP3274440A4 (de) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Nachweis von erkrankungen der speiseröhre |
KR101817155B1 (ko) * | 2015-07-13 | 2018-01-11 | 국립암센터 | 나노입자를 이용한 핵산 검출용 키트 및 핵산 검출 방법 |
WO2017010854A1 (ko) * | 2015-07-13 | 2017-01-19 | 국립암센터 | 나노입자를 이용한 핵산 검출용 키트 및 핵산 검출 방법 |
US10040069B2 (en) | 2015-07-23 | 2018-08-07 | General Electric Company | Amplification and detection of nucleic acids |
EP3368686A1 (de) | 2015-10-30 | 2018-09-05 | Exact Sciences Development Company, LLC | Test für den nachweis von multiplexamplifikation und -isolierung und nachweis von dann aus plasma |
EP3414327B1 (de) * | 2016-02-10 | 2020-09-30 | The Regents of The University of Michigan | Nachweis von nukleinsäuren |
US20170321286A1 (en) | 2016-05-05 | 2017-11-09 | Exact Sciences Corporation | Detection of lung neoplasia by amplification of rna sequences |
AU2017260630B2 (en) | 2016-05-05 | 2023-07-13 | Exact Sciences Corporation | Detection of lung neoplasia by analysis of methylated DNA |
CN109642228B (zh) | 2016-07-19 | 2022-09-13 | 精密科学发展有限责任公司 | 甲基化对照dna |
CA3029838A1 (en) | 2016-07-19 | 2018-01-25 | Exact Sciences Development Company, Llc | Nucleic acid control molecules from non-human organisms |
AU2017318700B2 (en) | 2016-09-02 | 2022-09-22 | Exact Sciences Corporation | Detecting hepatocellular carcinoma |
AU2017328950B2 (en) | 2016-09-15 | 2023-09-14 | Archerdx, Llc | Methods of nucleic acid sample preparation |
AU2017328953B2 (en) | 2016-09-15 | 2023-09-14 | Archerdx, Llc | Methods of nucleic acid sample preparation for analysis of cell-free DNA |
US10427162B2 (en) | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
EP3574110A4 (de) | 2017-01-27 | 2021-01-13 | Exact Sciences Development Company, LLC | Nachweis von dickdarmneoplasien durch analyse von methylierter dna |
US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
CA3095292A1 (en) | 2018-04-02 | 2019-10-10 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
US11408030B2 (en) | 2018-09-10 | 2022-08-09 | Andy Madrid | Test for detecting Alzheimer's disease |
EP3947718A4 (de) | 2019-04-02 | 2022-12-21 | Enumera Molecular, Inc. | Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen |
WO2021087275A1 (en) | 2019-10-31 | 2021-05-06 | Mayo Foundation For Medical Education And Research | Detecting ovarian cancer |
CA3188230A1 (en) | 2020-08-19 | 2022-02-24 | John B. Kisiel | Detecting non-hodgkin lymphoma |
CN116438454A (zh) | 2020-09-21 | 2023-07-14 | 普罗根尼蒂公司 | 用于分离细胞游离dna的组合物和方法 |
WO2023011660A1 (en) | 2021-08-06 | 2023-02-09 | Sansure Biotech Inc. | Compositions for liquefying a viscous biological sample, combination products, liquefying agents, and kits thereof, and methods and application thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2609238B2 (ja) * | 1985-05-02 | 1997-05-14 | ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド | 標的ヌクレオチド配列の検定に有用な試薬複合体を作製するための方法および核酸構築物 |
US4868104A (en) * | 1985-09-06 | 1989-09-19 | Syntex (U.S.A.) Inc. | Homogeneous assay for specific polynucleotides |
DE3785591T2 (de) * | 1986-01-10 | 1993-09-02 | Amoco Corp | Kompetitiver homogener test. |
JPS63502875A (ja) * | 1986-03-04 | 1988-10-27 | ケンブリッジ バイオサイエンス コーポレーション | 粒子凝集を用いる核酸検出 |
WO1990002205A1 (en) * | 1988-08-25 | 1990-03-08 | Angenics, Inc. | Detection of nucleic acid sequences using particle agglutination |
WO1992008808A1 (en) * | 1990-11-14 | 1992-05-29 | Siska Diagnostics, Inc. | Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor |
WO1992014845A1 (en) * | 1991-02-26 | 1992-09-03 | Worcester Foundation For Experimental Biology | Diagnosing cystic fibrosis and other genetic diseases using fluorescence resonance energy transfer (fret) |
DE69231124T2 (de) * | 1991-11-15 | 2001-02-15 | Igen International, Inc. | Schnelle bestimmungsverfahren für amplifikationsprodukte |
DE69327326T2 (de) * | 1992-07-24 | 2001-08-16 | Diatech Pty. Ltd., Brisbane | Vervielfältigungs- und detektionsprozess |
EP0682716A4 (de) * | 1993-01-15 | 1999-10-27 | New York Health Res Inst | Rna-assays mittels binären rna proben und ribozym-ligase. |
DE4344742A1 (de) * | 1993-06-09 | 1994-12-15 | Boehringer Mannheim Gmbh | Verfahren zur Immobilisierung von Nukleinsäuren |
US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
DE4436534A1 (de) * | 1994-10-13 | 1996-04-18 | Bayer Ag | Verfahren und Vorrichtung zur Beschichtung von Rotationskörpern mit nicht geradlinig verlaufender Achse |
US5753439A (en) * | 1995-05-19 | 1998-05-19 | Trustees Of Boston University | Nucleic acid detection methods |
EP0845047A2 (de) * | 1995-08-14 | 1998-06-03 | Abbott Laboratories | Eintopf-amplifikationstestverfahren für nukleinsäuren |
US20030083758A1 (en) * | 2001-11-01 | 2003-05-01 | Williamson Charles G. | Remote updating of intelligent household appliances |
-
1996
- 1996-12-20 EP EP96945934A patent/EP0876510B1/de not_active Expired - Lifetime
- 1996-12-20 US US08/771,624 patent/US5914230A/en not_active Expired - Fee Related
- 1996-12-20 WO PCT/US1996/019751 patent/WO1997023647A1/en active Application Filing
- 1996-12-20 JP JP52370097A patent/JP2001517925A/ja not_active Ceased
- 1996-12-20 CA CA002239683A patent/CA2239683A1/en not_active Abandoned
- 1996-12-20 DE DE69637518T patent/DE69637518D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1997023647A1 (en) | 1997-07-03 |
CA2239683A1 (en) | 1997-07-03 |
US5914230A (en) | 1999-06-22 |
JP2001517925A (ja) | 2001-10-09 |
EP0876510B1 (de) | 2008-05-07 |
EP0876510A1 (de) | 1998-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69637518D1 (de) | Homogene vervielfältigung und nachweis von nukleinsäuren | |
DE69633941D1 (de) | Nachweis von unterschieden in nukleinsäuren | |
DE69331257D1 (de) | Elektrobiochemisches Nachweisverfahren und Elektroden dafür | |
DE69638248D1 (de) | Nachweis von DNS-Sequenz Variationen | |
FI941787A0 (fi) | Sähkökirurginen prosessori ja menetelmä sen käyttämiseksi | |
DE69431719D1 (de) | Hybridisierung und sequenzierung von nukleinsäuren | |
DE69516152D1 (de) | Zusammensetzungen und verfahren zur anewndung in nachweis von analyten | |
DE69633983D1 (de) | Inhibitoren von mikrosomalem triglycerid-transfer-protein und verfahren | |
DE69803199D1 (de) | Erkennung und entfernung von makroviren | |
DE69737258D1 (de) | Verfahren und Vorrichtung zur Detektion von akutem myokardischem Infarkt | |
DE69434476D1 (de) | Sensor und methode zur detektion von stickoxiden | |
DE69433201D1 (de) | Oligonukleotide und Verfahren zum Nachweis von Bakterien | |
DE69605590D1 (de) | Verfahren zum Nachweis von Protein und Kit dafür | |
DE69421200D1 (de) | System zur Überwachung und Detektierung von Wärmequellen in offenen Gebieten | |
DE69425450D1 (de) | Detektion und Identifikation von Mycobakterien | |
DE59603173D1 (de) | Erfassung und auswertung von sicherheitskritischen messgrössen | |
DE69317502D1 (de) | Amplifikation und Nachweis von Nukleinsäurematerial | |
DE69614958D1 (de) | Gerät und Verfahren zur Detektion von Fingerabdruckmerkmalen | |
DE59310308D1 (de) | Verfahren und Mittel zum Nachweis von Listerien | |
DE69514948D1 (de) | System zur Früherkennung von Bränden | |
DE69626646D1 (de) | Detektion und biologischer abbau von explosiven substanzen | |
DE69702554D1 (de) | Aminopeptidase GX und damit Hydrolysierungsverfahren von Proteine | |
DE69627742D1 (de) | Detektion und Zerstörung von Teilchen in fluiden Systemen | |
DE69404143D1 (de) | Erkennungssystem und erkennungsmethode | |
DE69624575D1 (de) | Detektion und ortung von leckstromfehlern |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH, , DE |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |