DE69636086D1 - Sauerstoff enthaltende heterocyclische verbindungen - Google Patents
Sauerstoff enthaltende heterocyclische verbindungenInfo
- Publication number
- DE69636086D1 DE69636086D1 DE69636086T DE69636086T DE69636086D1 DE 69636086 D1 DE69636086 D1 DE 69636086D1 DE 69636086 T DE69636086 T DE 69636086T DE 69636086 T DE69636086 T DE 69636086T DE 69636086 D1 DE69636086 D1 DE 69636086D1
- Authority
- DE
- Germany
- Prior art keywords
- bond
- containing heterocyclic
- cyano
- combined
- heterocyclic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12153795 | 1995-05-19 | ||
JP12153795 | 1995-05-19 | ||
JP25865195 | 1995-10-05 | ||
JP25865195 | 1995-10-05 | ||
PCT/JP1996/001327 WO1996036624A1 (fr) | 1995-05-19 | 1996-05-20 | Composes heterocycliques contenant de l'oxygene |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69636086D1 true DE69636086D1 (de) | 2006-06-08 |
DE69636086T2 DE69636086T2 (de) | 2006-11-30 |
Family
ID=26458881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69636086T Expired - Fee Related DE69636086T2 (de) | 1995-05-19 | 1996-05-20 | Sauerstoff enthaltende heterocyclische verbindungen |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0771794B1 (de) |
JP (1) | JP4172817B2 (de) |
KR (1) | KR100445356B1 (de) |
CN (1) | CN1163493C (de) |
AT (1) | ATE325110T1 (de) |
AU (1) | AU705690B2 (de) |
CA (1) | CA2195755A1 (de) |
DE (1) | DE69636086T2 (de) |
DK (1) | DK0771794T3 (de) |
ES (1) | ES2258775T3 (de) |
HK (1) | HK1000785A1 (de) |
NO (1) | NO317631B1 (de) |
PT (1) | PT771794E (de) |
WO (1) | WO1996036624A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0828728B1 (de) * | 1995-05-18 | 2003-01-22 | ALTANA Pharma AG | Phenyldihydrobenzofurane |
JPH11505539A (ja) * | 1995-05-18 | 1999-05-21 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルジヒドロベンゾフラン |
EP0873331B1 (de) * | 1995-12-05 | 2002-04-03 | Darwin Discovery Limited | Benzofuran-carboxamide und -sulfonamide |
SK282676B6 (sk) * | 1996-05-20 | 2002-11-06 | Darwin Discovery Limited | Benzofuránové karboxamidy a tioamidy, farmaceutický prípravok s ich obsahom a ich použitie |
DE69717827T2 (de) * | 1996-08-19 | 2003-09-04 | Altana Pharma Ag | Benzofuran-4-carboxamide |
CA2272327A1 (en) * | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
WO1999016768A1 (en) * | 1997-10-01 | 1999-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Benzofuran derivatives |
EP1054884A1 (de) * | 1998-02-09 | 2000-11-29 | Darwin Discovery Limited | Benzofuran-4-carboxamide und ihre therapeutische anwendung |
ZA200100088B (en) * | 1998-07-06 | 2002-05-06 | Byk Gulden Lomberg Chem Fab | New benzoxazoles with PDE-inhibiting activity. |
CA2341890C (en) | 1998-09-03 | 2006-07-18 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
ATE387498T1 (de) * | 1998-12-30 | 2008-03-15 | Oligos Etc Inc | Therapeutische pde4d phosphodiesterase inhibitoren |
AU6315300A (en) * | 1999-07-26 | 2001-02-13 | Shionogi & Co., Ltd. | Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same |
WO2003000697A1 (fr) * | 2001-06-22 | 2003-01-03 | Takeda Chemical Industries, Ltd. | Derive de furo-isoquinoline, procede de production de ce compose et utilisation de ce compose |
DE10205274A1 (de) * | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
WO2004005276A1 (ja) * | 2002-07-03 | 2004-01-15 | Kyowa Hakko Kogyo Co., Ltd. | 1,3−ベンゾジオキソール−2−スピロシクロアルカン誘導体の製造法 |
WO2004082683A1 (ja) * | 2003-03-17 | 2004-09-30 | Kyowa Hakko Kogyo Co., Ltd. | 慢性皮膚疾患の治療および/または予防剤 |
JPWO2004087151A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 医薬組成物 |
JPWO2004087146A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 微粒子混合物の製造方法 |
WO2004087150A1 (ja) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co. Ltd. | 医薬組成物 |
WO2004087147A1 (ja) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | 肺疾患の治療および/または予防剤 |
CA2520577A1 (en) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical composition |
WO2004096274A1 (ja) * | 2003-03-31 | 2004-11-11 | Kyowa Hakko Kogyo Co., Ltd. | 気道内投与剤 |
JPWO2004087148A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 肺疾患の治療および/または予防剤 |
WO2004112791A1 (ja) * | 2003-06-23 | 2004-12-29 | Kyowa Hakko Kogyo Co., Ltd. | 肺疾患の治療および/または予防剤 |
EP1504756A1 (de) * | 2003-08-06 | 2005-02-09 | Kyowa Hakko Kogyo Co., Ltd | Arzneimittelkompositionen enthaltend eine heterocyclischen Verbindung und ein Anticholinergikum |
US20070287689A1 (en) * | 2004-10-13 | 2007-12-13 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic And/Or Preventive Agents For Chronic Skin Diseases |
CA2584261A1 (en) * | 2004-10-13 | 2006-04-20 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical composition |
WO2006123726A1 (ja) * | 2005-05-18 | 2006-11-23 | Kyowa Hakko Kogyo Co., Ltd. | 医薬組成物 |
US20100056791A1 (en) * | 2006-09-01 | 2010-03-04 | Yasushi Kohno | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
WO2008029829A1 (fr) | 2006-09-06 | 2008-03-13 | Kyorin Pharmaceutical Co., Ltd. | Dérivé de pyrazolopyridine et inhibiteur de la phosphodiestérase (pde) qui le contient en tant que matière active |
KR101507717B1 (ko) * | 2006-12-22 | 2015-04-08 | 레오 파마 에이/에스 | Pde4 억제제로서 유용한 치환된 아세토페논 |
PT2114951E (pt) | 2007-02-28 | 2014-07-17 | Leo Pharma As | Inibidores inovadores da fosfodiesterase |
ATE540037T1 (de) | 2007-04-16 | 2012-01-15 | Leo Pharma As | Triazolopyridine als phosphodiesterasehemmer zur behandlung von hautkrankheiten |
BRPI0922452A2 (pt) | 2008-12-19 | 2015-12-15 | Leo Pharma As | composto, composição farmacêutica, uso em um composto, e método para prevenir, tratar ou melhorar doenças ou condições dérmicas, ou distúrbios de ferimento cutâneo agudos ou crônicos. |
TR201909709T4 (tr) | 2010-06-24 | 2019-07-22 | Leo Pharma As | Fosfordiesteraz inhibitörleri olarak benzodioksol türevleri. |
SG11201402424PA (en) | 2011-12-21 | 2014-09-26 | Leo Pharma As | [1,2,4]triazolopyridines and their use as phospodiesterase inhibitors |
WO2015197534A2 (en) * | 2014-06-23 | 2015-12-30 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
CN106588841B (zh) * | 2015-10-19 | 2019-01-25 | 富乐马鸿凯(大连)医药有限公司 | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 |
CN106588900A (zh) * | 2015-10-20 | 2017-04-26 | 北京康辰医药科技有限公司 | 一种苯并双环化合物或其药学上可接受的盐、药物组合物及其应用 |
CN106905336B (zh) * | 2017-01-22 | 2019-04-09 | 浙江工业大学 | 一种手性吡唑螺呋喃类化合物的不对称合成方法 |
CN107325067B (zh) * | 2017-05-03 | 2020-05-12 | 广州中医药大学 | 磷酸二酯酶4抑制剂桑辛素m衍生物及其用途 |
CN109721580B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 3-苯基-7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
CN109721579B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
CN114478413B (zh) * | 2022-01-14 | 2023-06-23 | 北京富盛嘉华医药科技有限公司 | 2-(2′-羟基-3′-甲代烯丙基-5′-甲基苯基)苯并三氮唑的制备方法及应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2507604A2 (fr) * | 1977-04-19 | 1982-12-17 | Delalande Sa | Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique |
CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
JPS62234083A (ja) * | 1986-02-28 | 1987-10-14 | アーバモント インク ディビーエイ アドリヤ ラボラトリーズ | 鎮吐薬または精神病治療薬として有用なカルボキサミド類 |
JPH01207267A (ja) * | 1987-03-05 | 1989-08-21 | Yamanouchi Pharmaceut Co Ltd | ピリジン誘導体及び該化合物を含有する肝疾患治療剤 |
IL87674A (en) * | 1987-09-08 | 1993-08-18 | Lilly Co Eli | Azabicycloalkyl esters and amides of heterocyclic acids, their preparation and pharmaceutical compositions containing them |
US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
CA2114114C (en) * | 1992-06-15 | 2005-05-03 | Nigel Robert Arnold Beeley | Trisubstituted phenyl derivatives as selective phosphodiesterase iv inhibitors |
RU2138498C1 (ru) * | 1994-07-22 | 1999-09-27 | Бык Гульден Ломберг Хемише Фабрик Гмбх | Дигидробензофураны, способ их получения и фармацевтическая композиция на их основе |
EP0828728B1 (de) * | 1995-05-18 | 2003-01-22 | ALTANA Pharma AG | Phenyldihydrobenzofurane |
-
1996
- 1996-05-20 WO PCT/JP1996/001327 patent/WO1996036624A1/ja active IP Right Grant
- 1996-05-20 CA CA002195755A patent/CA2195755A1/en not_active Abandoned
- 1996-05-20 PT PT96915194T patent/PT771794E/pt unknown
- 1996-05-20 EP EP96915194A patent/EP0771794B1/de not_active Expired - Lifetime
- 1996-05-20 AT AT96915194T patent/ATE325110T1/de not_active IP Right Cessation
- 1996-05-20 DE DE69636086T patent/DE69636086T2/de not_active Expired - Fee Related
- 1996-05-20 CN CNB961905298A patent/CN1163493C/zh not_active Expired - Fee Related
- 1996-05-20 JP JP53470896A patent/JP4172817B2/ja not_active Expired - Fee Related
- 1996-05-20 ES ES96915194T patent/ES2258775T3/es not_active Expired - Lifetime
- 1996-05-20 AU AU57029/96A patent/AU705690B2/en not_active Ceased
- 1996-05-20 KR KR1019970700326A patent/KR100445356B1/ko not_active IP Right Cessation
- 1996-05-20 DK DK96915194T patent/DK0771794T3/da active
-
1997
- 1997-01-14 NO NO19970151A patent/NO317631B1/no unknown
- 1997-11-28 HK HK97102285A patent/HK1000785A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO317631B1 (no) | 2004-11-29 |
EP0771794A1 (de) | 1997-05-07 |
ATE325110T1 (de) | 2006-06-15 |
CN1163493C (zh) | 2004-08-25 |
WO1996036624A1 (fr) | 1996-11-21 |
NO970151D0 (no) | 1997-01-14 |
DK0771794T3 (da) | 2006-09-11 |
HK1000785A1 (en) | 2006-06-30 |
CA2195755A1 (en) | 1996-11-21 |
KR970704724A (ko) | 1997-09-06 |
AU5702996A (en) | 1996-11-29 |
PT771794E (pt) | 2006-09-29 |
AU705690B2 (en) | 1999-05-27 |
ES2258775T3 (es) | 2006-09-01 |
NO970151L (no) | 1997-03-06 |
JP4172817B2 (ja) | 2008-10-29 |
EP0771794B1 (de) | 2006-05-03 |
KR100445356B1 (ko) | 2004-11-12 |
DE69636086T2 (de) | 2006-11-30 |
EP0771794A4 (de) | 1998-09-02 |
CN1154697A (zh) | 1997-07-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |