DE69625176D1 - Camptothecin-derivate und verfahren zu ihrer herstellung - Google Patents

Camptothecin-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69625176D1
DE69625176D1 DE69625176T DE69625176T DE69625176D1 DE 69625176 D1 DE69625176 D1 DE 69625176D1 DE 69625176 T DE69625176 T DE 69625176T DE 69625176 T DE69625176 T DE 69625176T DE 69625176 D1 DE69625176 D1 DE 69625176D1
Authority
DE
Germany
Prior art keywords
production
camptothecin derivatives
camptothecin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69625176T
Other languages
English (en)
Other versions
DE69625176T2 (de
Inventor
Sup Jew
Soon Lee
Kyum Kim
Dae Ok
Hoi Cha
Goo Kim
Kyun Lee
Min Kim
Jin Kim
Mi Hah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chong Kun Dang Corp
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of DE69625176D1 publication Critical patent/DE69625176D1/de
Application granted granted Critical
Publication of DE69625176T2 publication Critical patent/DE69625176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69625176T 1995-01-09 1996-01-09 Camptothecin-derivate und verfahren zu ihrer herstellung Expired - Lifetime DE69625176T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019950000269A KR960029336A (ko) 1995-01-09 1995-01-09 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
PCT/KR1996/000004 WO1996021666A1 (en) 1995-01-09 1996-01-09 Camptothecin derivatives and its manufacturing method

Publications (2)

Publication Number Publication Date
DE69625176D1 true DE69625176D1 (de) 2003-01-16
DE69625176T2 DE69625176T2 (de) 2003-07-10

Family

ID=19406538

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69625176T Expired - Lifetime DE69625176T2 (de) 1995-01-09 1996-01-09 Camptothecin-derivate und verfahren zu ihrer herstellung

Country Status (9)

Country Link
US (2) US6265413B1 (de)
EP (1) EP0802915B1 (de)
JP (1) JP3023990B2 (de)
KR (2) KR960029336A (de)
CN (1) CN1077575C (de)
AU (1) AU4400696A (de)
CA (1) CA2208639C (de)
DE (1) DE69625176T2 (de)
WO (1) WO1996021666A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0837850B1 (de) * 1995-06-27 2004-09-01 Takeda Chemical Industries, Ltd. 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
SG116433A1 (en) * 1996-10-30 2005-11-28 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof.
IN189180B (de) * 1997-07-09 2003-01-04 Chong Kun Dang Corp
US6352996B1 (en) * 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AR035684A1 (es) * 2001-02-21 2004-06-23 Yakult Honsha Kk Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina
EP1433789A1 (de) * 2002-12-24 2004-06-30 Aponetics AG Pyrrolopyrazine und ihre Verwendung als selektive Apoptoseinduktoren
CN100425611C (zh) * 2003-12-17 2008-10-15 比奥纽默里克药物公司 制备喜树碱衍生物的方法
ITMI20061475A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale
CN101824038B (zh) * 2009-03-06 2013-08-21 复旦大学 喜树碱及其类似物的制备方法
WO2016027757A1 (ja) * 2014-08-18 2016-02-25 国立大学法人大阪大学 新規２－アミノベンゾイル誘導体
US9447126B2 (en) 2014-10-22 2016-09-20 Arno Therapeutics, Inc. Methods and systems for camptothecin analog synthesis
WO2020156189A1 (zh) * 2019-01-30 2020-08-06 四川科伦博泰生物医药股份有限公司 喜树碱衍生物及其水溶性前药、包含其的药物组合物及其制备方法和用途
TW202304524A (zh) 2021-04-10 2023-02-01 美商普方生物製藥美國公司 Folr1結合劑、其結合物及使用方法
JP2024516631A (ja) 2021-04-23 2024-04-16 プロファウンドバイオ ユーエス カンパニー 抗ｃｄ７０抗体、そのコンジュゲートおよびこれを使用する方法
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CN116253741B (zh) * 2022-12-30 2024-02-02 上海禧耀医药科技有限公司 一种贝洛替康衍生物的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
JPS5839685A (ja) 1981-09-04 1983-03-08 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体及びその製造法
JPS58154582A (ja) * 1982-03-10 1983-09-14 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体およびその製造法
US4894456A (en) 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
JP2848958B2 (ja) 1990-09-28 1999-01-20 スミスクライン・ビーチャム・コーポレイション 水溶性カンプトテシン類似体、方法および手段
DE69209969T2 (de) 1991-10-29 1996-09-12 Glaxo Wellcome Inc Wasserlösliche Camptothecinderivate
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs

Also Published As

Publication number Publication date
CA2208639C (en) 2001-07-31
US6265413B1 (en) 2001-07-24
WO1996021666A1 (en) 1996-07-18
AU4400696A (en) 1996-07-31
JPH10503525A (ja) 1998-03-31
CN1077575C (zh) 2002-01-09
KR960029336A (ko) 1996-08-17
US6177568B1 (en) 2001-01-23
EP0802915B1 (de) 2002-12-04
CN1168139A (zh) 1997-12-17
CA2208639A1 (en) 1996-07-18
JP3023990B2 (ja) 2000-03-21
KR960029337A (ko) 1996-08-17
KR0163267B1 (ko) 1998-12-01
EP0802915A1 (de) 1997-10-29
DE69625176T2 (de) 2003-07-10

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