DE69621953T2 - Vehikel zum einbringen von nukleinsäuren in zellen - Google Patents
Vehikel zum einbringen von nukleinsäuren in zellenInfo
- Publication number
- DE69621953T2 DE69621953T2 DE69621953T DE69621953T DE69621953T2 DE 69621953 T2 DE69621953 T2 DE 69621953T2 DE 69621953 T DE69621953 T DE 69621953T DE 69621953 T DE69621953 T DE 69621953T DE 69621953 T2 DE69621953 T2 DE 69621953T2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- nucleic acids
- vehicle
- introducing nucleic
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11519995A IL115199A (en) | 1995-09-07 | 1995-09-07 | Composition comprising a polynucleic acid molecule in a liposome and method using said composition |
PCT/IL1996/000101 WO1997010851A2 (en) | 1995-09-07 | 1996-09-05 | Nucleic acid delivery vehicle |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69621953D1 DE69621953D1 (de) | 2002-07-25 |
DE69621953T2 true DE69621953T2 (de) | 2003-01-30 |
Family
ID=11067956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69621953T Expired - Lifetime DE69621953T2 (de) | 1995-09-07 | 1996-09-05 | Vehikel zum einbringen von nukleinsäuren in zellen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6207456B1 (de) |
EP (1) | EP0879062B1 (de) |
JP (1) | JPH11514349A (de) |
AT (1) | ATE219380T1 (de) |
CA (1) | CA2231172A1 (de) |
DE (1) | DE69621953T2 (de) |
IL (1) | IL115199A (de) |
WO (1) | WO1997010851A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890555B1 (en) * | 1992-02-05 | 2005-05-10 | Qlt, Inc. | Liposome compositions of porphyrin photosensitizers |
DE19605548A1 (de) * | 1996-02-15 | 1997-09-04 | Boehringer Ingelheim Int | Zusammensetzung für die Transfektion höherer eukaryotischer Zellen |
FR2751222B1 (fr) * | 1996-07-16 | 1998-10-09 | Capsulis | Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique |
DE19740092A1 (de) * | 1997-09-12 | 1999-03-18 | Ulrich Dr Med Hengge | Liposomen und Verfahren zur Transfektion von Zellen |
WO1999042091A2 (en) | 1998-02-19 | 1999-08-26 | Massachusetts Institute Of Technology | Use of polycations as endosomolytic agents |
US7276359B1 (en) * | 1998-03-13 | 2007-10-02 | Wyeth | Polynucleotide composition, method of preparation, and use thereof |
IL126681A0 (en) * | 1998-10-21 | 1999-08-17 | Opperbas Holding Bv | Treatment of trauma-related conditions |
US20040086558A1 (en) * | 2001-02-22 | 2004-05-06 | Moshe Baru | Liposome mediated dna administration |
CN1210296C (zh) * | 2001-07-13 | 2005-07-13 | 一泰医药研究(深圳)有限公司 | 序列号30的生物活性肽 |
PL208666B1 (pl) | 2001-07-13 | 2011-05-31 | Cms Peptides Patent Holding Company Ltd | Środek farmaceutyczny zawierający peptyd, sposób wytwarzania środka farmaceutycznego i zastosowanie peptydu |
CA2498918A1 (en) * | 2002-10-09 | 2004-04-22 | Pfizer Products Inc. | Stabilized naked dna compositions |
EP1606313A2 (de) * | 2003-03-19 | 2005-12-21 | Isogenis, Inc. | Spezifische hemmung der abstossreaktion bei allotransplantaten |
TWI353252B (en) | 2004-04-28 | 2011-12-01 | Cms Peptides Patent Holding Company Ltd | Biologically active peptide vapeehptllteaplnpk der |
WO2006012416A2 (en) * | 2004-07-20 | 2006-02-02 | Isogenis, Inc. | Specific inhibition of autoimmunity and diseases associated with autoantigens |
EP1909815A4 (de) | 2005-07-26 | 2011-05-18 | Cms Peptides Patent Holding Company Ltd | Neuartige biologisch aktive peptide und neue verwendungen dafür |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
AU2006308765B2 (en) | 2005-11-02 | 2013-09-05 | Arbutus Biopharma Corporation | Modified siRNA molecules and uses thereof |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
WO2008026781A1 (fr) * | 2006-08-31 | 2008-03-06 | Astellas Pharma Inc. | Vésicule de lipide à ciblage inverse |
PL2081551T3 (pl) * | 2006-10-06 | 2013-06-28 | Scil Tech Gmbh | Wytworzenie wysuszonego rekonstytuowanego pęcherzyka do zastosowania farmaceutycznego |
DK2167069T3 (da) * | 2007-05-23 | 2011-11-21 | Amcol International Corp | Cholesterol-interagerende lagdelte phyllosilikater og fremgangsmåder til at reducere hypercholesterolæmi hos et pattedyr |
AU2008342535B2 (en) | 2007-12-27 | 2015-02-05 | Arbutus Biopharma Corporation | Silencing of polo-like kinase expression using interfering RNA |
CA2721380A1 (en) | 2008-04-15 | 2009-10-22 | Protiva Biotherapeutics, Inc. | Silencing of csn5 gene expression using interfering rna |
EP2342321B1 (de) | 2008-09-17 | 2018-04-11 | Isogenis, Inc. | Konstruktion von genzuführungsvektoren auf basis eines vollständig deletierten adenovirus und verwendungen davon |
CA2802994A1 (en) | 2010-06-17 | 2011-12-22 | The United States Of America As Represented By The Secretary, National I Nstitutes Of Health | Compositions and methods for treating inflammatory conditions |
WO2012106490A1 (en) | 2011-02-03 | 2012-08-09 | The Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services | Multivalent vaccines for rabies virus and filoviruses |
WO2013075132A1 (en) | 2011-11-17 | 2013-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Therapeutic rna switches compositions and methods of use |
US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
WO2014046983A1 (en) | 2012-09-21 | 2014-03-27 | Intensity Therapeutic | Method of treating cancer |
AU2015328012A1 (en) | 2014-10-02 | 2017-05-11 | Arbutus Biopharma Corporation | Compositions and methods for silencing Hepatitis B virus gene expression |
US10627340B2 (en) | 2015-04-09 | 2020-04-21 | Bikanta Corporation | Imaging systems and methods using fluorescent nanodiamonds |
US20180245074A1 (en) | 2015-06-04 | 2018-08-30 | Protiva Biotherapeutics, Inc. | Treating hepatitis b virus infection using crispr |
WO2017019891A2 (en) | 2015-07-29 | 2017-02-02 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing hepatitis b virus gene expression |
US20170360815A1 (en) | 2016-02-25 | 2017-12-21 | Applied Biological Laboratories, Inc. | Compositions and methods for protecting against airborne pathogens and irritants |
KR20180120204A (ko) | 2016-02-25 | 2018-11-05 | 어플라이드 바이올로지컬 래버러토리즈 인코포레이티드 | 공기 매개 병원체 및 자극물질에 대한 보호용 조성물 및 방법 |
US11041170B2 (en) | 2016-04-04 | 2021-06-22 | Thomas Jefferson University | Multivalent vaccines for rabies virus and coronaviruses |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4789633A (en) * | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
US5283122A (en) | 1984-04-19 | 1994-02-01 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
WO1991006309A1 (en) | 1989-11-03 | 1991-05-16 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
US5928944A (en) | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
-
1995
- 1995-09-07 IL IL11519995A patent/IL115199A/xx not_active IP Right Cessation
-
1996
- 1996-09-05 US US09/029,376 patent/US6207456B1/en not_active Expired - Fee Related
- 1996-09-05 CA CA002231172A patent/CA2231172A1/en not_active Abandoned
- 1996-09-05 WO PCT/IL1996/000101 patent/WO1997010851A2/en active IP Right Grant
- 1996-09-05 JP JP9512542A patent/JPH11514349A/ja active Pending
- 1996-09-05 EP EP96929504A patent/EP0879062B1/de not_active Expired - Lifetime
- 1996-09-05 AT AT96929504T patent/ATE219380T1/de active
- 1996-09-05 DE DE69621953T patent/DE69621953T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU6888496A (en) | 1997-04-09 |
IL115199A0 (en) | 1995-12-31 |
DE69621953D1 (de) | 2002-07-25 |
IL115199A (en) | 2005-05-17 |
JPH11514349A (ja) | 1999-12-07 |
WO1997010851A3 (en) | 1997-06-05 |
ATE219380T1 (de) | 2002-07-15 |
WO1997010851A2 (en) | 1997-03-27 |
US6207456B1 (en) | 2001-03-27 |
AU703271B2 (en) | 1999-03-25 |
EP0879062B1 (de) | 2002-06-19 |
CA2231172A1 (en) | 1997-03-27 |
EP0879062A2 (de) | 1998-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |