HUP0001937A2 - Új vegyületek, eljárás előállításukra és alkalmazásuk nukleinsavak sejtekbe való bevitelére - Google Patents

Új vegyületek, eljárás előállításukra és alkalmazásuk nukleinsavak sejtekbe való bevitelére

Info

Publication number
HUP0001937A2
HUP0001937A2 HU0001937A HUP0001937A HUP0001937A2 HU P0001937 A2 HUP0001937 A2 HU P0001937A2 HU 0001937 A HU0001937 A HU 0001937A HU P0001937 A HUP0001937 A HU P0001937A HU P0001937 A2 HUP0001937 A2 HU P0001937A2
Authority
HU
Hungary
Prior art keywords
nucleic acids
compounds
cells
preparation
transferring nucleic
Prior art date
Application number
HU0001937A
Other languages
English (en)
Inventor
Gérardo Byk
Catherine Dubertret
Daniel Scherman
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of HUP0001937A2 publication Critical patent/HUP0001937A2/hu
Publication of HUP0001937A3 publication Critical patent/HUP0001937A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány nukleinsavak sejtekbe való bevitelére alkalmas újvegyületekre vonatkozik. Ezek az új vegyületek elsősorban alipopoliaminok családjával rokon vegyületek, és amidinocsoportokattartalmaznak. Ezek a vegyületek az érdeklődésre számot tartónukleinsavak különböző sejttípusokba való in vitro, in vivo vagy exvivo transzfekciójára alkalmazhatók. Ó
HU0001937A 1997-05-28 1998-05-25 Compounds, preparation and use for transferring nucleic acids into cells HUP0001937A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706549A FR2763943B1 (fr) 1997-05-28 1997-05-28 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
PCT/FR1998/001041 WO1998054130A1 (fr) 1997-05-28 1998-05-25 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules

Publications (2)

Publication Number Publication Date
HUP0001937A2 true HUP0001937A2 (hu) 2000-10-28
HUP0001937A3 HUP0001937A3 (en) 2003-10-28

Family

ID=9507333

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001937A HUP0001937A3 (en) 1997-05-28 1998-05-25 Compounds, preparation and use for transferring nucleic acids into cells

Country Status (17)

Country Link
US (1) US6300321B1 (hu)
EP (1) EP0984925B1 (hu)
JP (1) JP4467084B2 (hu)
KR (1) KR20010013029A (hu)
CN (1) CN1131208C (hu)
AT (1) ATE284383T1 (hu)
AU (1) AU738320B2 (hu)
BR (1) BR9809506A (hu)
CA (1) CA2290664C (hu)
DE (1) DE69828045T2 (hu)
FR (1) FR2763943B1 (hu)
HU (1) HUP0001937A3 (hu)
IL (1) IL132951A0 (hu)
NO (1) NO314497B1 (hu)
PL (1) PL336983A1 (hu)
WO (1) WO1998054130A1 (hu)
ZA (1) ZA984440B (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
DK1181304T3 (da) 1999-04-08 2008-02-11 Antisoma Res Ltd Antiproliferativ virkning af G-rige oligonucleotider samt fremgangsmåde til anvendelse af dem til binding af nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
JP2004520288A (ja) * 2000-11-29 2004-07-08 ジヤンセル・エス・アー 中性及び陰イオン性の遺伝子送達用コロイド粒子
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
WO2003106636A2 (en) * 2002-06-14 2003-12-24 Mirus Corporation Novel methods for the delivery of polynucleotides to cells
US7906122B2 (en) * 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
JP4695075B2 (ja) * 2003-06-18 2011-06-08 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム トランスフェクションで使用するためのスフィンゴ脂質ポリアルキルアミン抱合体
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
KR100699279B1 (ko) 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
US7973084B2 (en) 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
WO2007021839A2 (en) * 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
CA2856742A1 (en) 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
HUE060907T2 (hu) 2014-06-25 2023-04-28 Acuitas Therapeutics Inc Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére
WO2017004143A1 (en) 2015-06-29 2017-01-05 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
CA3003055C (en) 2015-10-28 2023-08-01 Acuitas Therapeutics, Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
AU2018256877B2 (en) 2017-04-28 2022-06-02 Acuitas Therapeutics, Inc. Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
JP7355731B2 (ja) 2017-08-16 2023-10-03 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
US11524932B2 (en) 2017-08-17 2022-12-13 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
JP2022517783A (ja) 2019-01-11 2022-03-10 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
EP4182297A1 (en) 2020-07-16 2023-05-24 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2176715A1 (en) * 1993-11-24 1995-06-01 Timothy D. Heath Amphiphilic derivatives of guanidine
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
HU228072B1 (en) * 1996-03-01 2012-09-28 Centre Nat Rech Scient New cholesterol amidinium derivatives, pharmaceutical compositions containing same, and uses thereof

Also Published As

Publication number Publication date
NO995808D0 (no) 1999-11-26
CN1257480A (zh) 2000-06-21
IL132951A0 (en) 2001-03-19
HUP0001937A3 (en) 2003-10-28
EP0984925B1 (fr) 2004-12-08
NO995808L (no) 1999-11-26
FR2763943B1 (fr) 1999-07-09
CA2290664C (fr) 2010-04-13
WO1998054130A1 (fr) 1998-12-03
JP2002502388A (ja) 2002-01-22
PL336983A1 (en) 2000-07-31
CA2290664A1 (fr) 1998-12-03
ZA984440B (en) 1998-12-10
ATE284383T1 (de) 2004-12-15
US6300321B1 (en) 2001-10-09
BR9809506A (pt) 2000-06-20
CN1131208C (zh) 2003-12-17
DE69828045D1 (de) 2005-01-13
NO314497B1 (no) 2003-03-31
EP0984925A1 (fr) 2000-03-15
KR20010013029A (ko) 2001-02-26
JP4467084B2 (ja) 2010-05-26
DE69828045T2 (de) 2005-12-01
AU8022198A (en) 1998-12-30
FR2763943A1 (fr) 1998-12-04
AU738320B2 (en) 2001-09-13

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees