DE69619868D1 - Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung - Google Patents
Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellungInfo
- Publication number
- DE69619868D1 DE69619868D1 DE69619868T DE69619868T DE69619868D1 DE 69619868 D1 DE69619868 D1 DE 69619868D1 DE 69619868 T DE69619868 T DE 69619868T DE 69619868 T DE69619868 T DE 69619868T DE 69619868 D1 DE69619868 D1 DE 69619868D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- pharmaceutical compositions
- compositions containing
- production
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009543 pathological alteration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503099A HUT76266A (en) | 1995-10-31 | 1995-10-31 | New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components |
| PCT/HU1996/000061 WO1997016429A1 (en) | 1995-10-31 | 1996-10-25 | Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69619868D1 true DE69619868D1 (de) | 2002-04-18 |
| DE69619868T2 DE69619868T2 (de) | 2002-10-10 |
Family
ID=10987317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69619868T Expired - Fee Related DE69619868T2 (de) | 1995-10-31 | 1996-10-25 | Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6130215A (de) |
| EP (1) | EP0901473B1 (de) |
| JP (1) | JPH11514641A (de) |
| KR (1) | KR19990067137A (de) |
| CN (1) | CN1207733A (de) |
| AT (1) | ATE214375T1 (de) |
| AU (1) | AU707166B2 (de) |
| CZ (1) | CZ112198A3 (de) |
| DE (1) | DE69619868T2 (de) |
| HU (1) | HUT76266A (de) |
| NZ (1) | NZ320522A (de) |
| PL (1) | PL327461A1 (de) |
| SK (1) | SK283489B6 (de) |
| WO (1) | WO1997016429A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4425143A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| KR20020016872A (ko) | 1999-06-29 | 2002-03-06 | 사바 키스 ; 아틸라 만디 야노스 템페 ; 기울라 시미그 | 신규한 피페라지닐알킬티오피리미딘 유도체, 그것을함유하는 약제 조성물, 및 활성성분의 제조방법 |
| US20040014966A1 (en) * | 2000-06-20 | 2004-01-22 | Jacobsen Eric Jon | Bis-arylsulfones |
| PE20020063A1 (es) | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
| US6586592B2 (en) | 2000-06-20 | 2003-07-01 | Pharmacia & Upjohn Company | Bis-arylsulfones |
| DE112009001776B4 (de) | 2008-07-30 | 2021-01-21 | Asahi Kasei Chemicals Corporation | Verfahren zur Herstellung von Cycloolefin und Vorrichtung zur Herstellung desselben |
| US10315655B2 (en) | 2017-03-07 | 2019-06-11 | Deere & Company | Vehicle control based on soil compaction |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792206A (de) * | 1971-12-02 | 1973-06-01 | Byk Gulden Lomberg Chem Fab | |
| EP0202654A3 (de) * | 1985-05-20 | 1987-12-16 | E.R. Squibb & Sons, Inc. | 5-Carboxy-1,4-dihydropyrimidinderivate |
-
1995
- 1995-10-31 HU HU9503099A patent/HUT76266A/hu unknown
-
1996
- 1996-10-25 NZ NZ320522A patent/NZ320522A/xx unknown
- 1996-10-25 EP EP96935194A patent/EP0901473B1/de not_active Expired - Lifetime
- 1996-10-25 CN CN96198654A patent/CN1207733A/zh active Pending
- 1996-10-25 PL PL96327461A patent/PL327461A1/xx unknown
- 1996-10-25 AU AU73262/96A patent/AU707166B2/en not_active Ceased
- 1996-10-25 WO PCT/HU1996/000061 patent/WO1997016429A1/en not_active Application Discontinuation
- 1996-10-25 US US09/066,465 patent/US6130215A/en not_active Expired - Fee Related
- 1996-10-25 KR KR1019980703083A patent/KR19990067137A/ko not_active Application Discontinuation
- 1996-10-25 AT AT96935194T patent/ATE214375T1/de not_active IP Right Cessation
- 1996-10-25 CZ CZ981121A patent/CZ112198A3/cs unknown
- 1996-10-25 JP JP9517175A patent/JPH11514641A/ja active Pending
- 1996-10-25 DE DE69619868T patent/DE69619868T2/de not_active Expired - Fee Related
- 1996-10-25 SK SK475-98A patent/SK283489B6/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ112198A3 (cs) | 1998-09-16 |
| EP0901473B1 (de) | 2002-03-13 |
| JPH11514641A (ja) | 1999-12-14 |
| AU7326296A (en) | 1997-05-22 |
| HU9503099D0 (en) | 1995-12-28 |
| SK47598A3 (en) | 1998-12-02 |
| HUT76266A (en) | 1997-07-28 |
| SK283489B6 (sk) | 2003-08-05 |
| CN1207733A (zh) | 1999-02-10 |
| US6130215A (en) | 2000-10-10 |
| PL327461A1 (en) | 1998-12-07 |
| DE69619868T2 (de) | 2002-10-10 |
| AU707166B2 (en) | 1999-07-01 |
| NZ320522A (en) | 1999-03-29 |
| KR19990067137A (ko) | 1999-08-16 |
| WO1997016429A1 (en) | 1997-05-09 |
| EP0901473A1 (de) | 1999-03-17 |
| ATE214375T1 (de) | 2002-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |