DE69601993T2 - Verfahren zur herstellung von doxorubicin - Google Patents

Verfahren zur herstellung von doxorubicin

Info

Publication number
DE69601993T2
DE69601993T2 DE69601993T DE69601993T DE69601993T2 DE 69601993 T2 DE69601993 T2 DE 69601993T2 DE 69601993 T DE69601993 T DE 69601993T DE 69601993 T DE69601993 T DE 69601993T DE 69601993 T2 DE69601993 T2 DE 69601993T2
Authority
DE
Germany
Prior art keywords
producing doxorubicin
doxorubicin
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69601993T
Other languages
English (en)
Other versions
DE69601993D1 (de
Inventor
Inventi Augusto Solari
Umberto Breme
Anna Colombo
Charles Hutchinson
Sharee Otten
Claudio Scotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of DE69601993D1 publication Critical patent/DE69601993D1/de
Publication of DE69601993T2 publication Critical patent/DE69601993T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69601993T 1995-02-27 1996-02-20 Verfahren zur herstellung von doxorubicin Expired - Fee Related DE69601993T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/396,218 US5695966A (en) 1995-02-27 1995-02-27 DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
PCT/EP1996/000692 WO1996027014A1 (en) 1995-02-27 1996-02-20 Process for preparing doxorubicin

Publications (2)

Publication Number Publication Date
DE69601993D1 DE69601993D1 (de) 1999-05-12
DE69601993T2 true DE69601993T2 (de) 1999-11-04

Family

ID=23566340

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69601993T Expired - Fee Related DE69601993T2 (de) 1995-02-27 1996-02-20 Verfahren zur herstellung von doxorubicin

Country Status (19)

Country Link
US (2) US5695966A (de)
EP (1) EP0763112B1 (de)
JP (1) JPH10505506A (de)
KR (1) KR100414999B1 (de)
CN (1) CN1118574C (de)
AR (1) AR001014A1 (de)
AT (1) ATE178653T1 (de)
AU (1) AU711706B2 (de)
CA (1) CA2188571A1 (de)
DE (1) DE69601993T2 (de)
ES (1) ES2132891T3 (de)
FI (1) FI112251B (de)
HU (1) HU220530B1 (de)
IL (1) IL117246A0 (de)
NO (1) NO964482L (de)
RU (1) RU2205222C2 (de)
TW (1) TW419521B (de)
WO (1) WO1996027014A1 (de)
ZA (1) ZA961555B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin
EP0915983B1 (de) * 1997-03-06 2005-06-15 Pharmacia Italia S.p.A. Verfahren zur herstellung von doxorubicin
CN1198930C (zh) * 1998-04-24 2005-04-27 法玛西雅厄普约翰公司 制备阿霉素的方法
WO2004096992A2 (en) * 2003-04-25 2004-11-11 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
KR100629896B1 (ko) * 2005-04-28 2006-09-29 인하대학교 산학협력단 방선균 독소루비신 고생산 균주 및 독소루비신 생합성유전자군의 발현양상 분석을 위한 마이크로어레이칩
CN101016533B (zh) * 2005-11-09 2010-05-19 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
CN104059892A (zh) * 2013-03-18 2014-09-24 江苏禾昌生物科技有限公司 柔红霉素c-14羟化酶突变体及其基因工程菌的生产方法
CN105861455B (zh) * 2016-05-16 2018-10-26 浙江海正药业股份有限公司 DoxA蛋白突变体及其编码基因与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin

Also Published As

Publication number Publication date
FI964229A0 (fi) 1996-10-21
US5786190A (en) 1998-07-28
US5695966A (en) 1997-12-09
CA2188571A1 (en) 1996-09-06
WO1996027014A1 (en) 1996-09-06
IL117246A0 (en) 1996-06-18
MX9605018A (es) 1998-05-31
CN1147835A (zh) 1997-04-16
FI112251B (fi) 2003-11-14
AU711706B2 (en) 1999-10-21
HU220530B1 (hu) 2002-03-28
NO964482L (no) 1996-12-23
JPH10505506A (ja) 1998-06-02
NO964482D0 (no) 1996-10-22
HUP9603259A3 (en) 2000-04-28
ATE178653T1 (de) 1999-04-15
FI964229A (fi) 1996-10-21
AR001014A1 (es) 1997-08-27
EP0763112A1 (de) 1997-03-19
CN1118574C (zh) 2003-08-20
KR970702922A (ko) 1997-06-10
KR100414999B1 (ko) 2004-04-28
AU4878496A (en) 1996-09-18
EP0763112B1 (de) 1999-04-07
RU2205222C2 (ru) 2003-05-27
DE69601993D1 (de) 1999-05-12
TW419521B (en) 2001-01-21
ES2132891T3 (es) 1999-08-16
ZA961555B (en) 1996-08-19
HUP9603259A2 (en) 1997-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee