DE69535623D1 - Androstane und Pregane zur allosterischen Modulation des GABA Rezeptors - Google Patents
Androstane und Pregane zur allosterischen Modulation des GABA RezeptorsInfo
- Publication number
- DE69535623D1 DE69535623D1 DE69535623T DE69535623T DE69535623D1 DE 69535623 D1 DE69535623 D1 DE 69535623D1 DE 69535623 T DE69535623 T DE 69535623T DE 69535623 T DE69535623 T DE 69535623T DE 69535623 D1 DE69535623 D1 DE 69535623D1
- Authority
- DE
- Germany
- Prior art keywords
- pregangans
- androstanes
- gaba receptor
- allosteric modulation
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19691994A | 1994-02-14 | 1994-02-14 | |
US196919 | 1994-02-14 | ||
US34692794A | 1994-11-23 | 1994-11-23 | |
US346927 | 1994-11-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69535623D1 true DE69535623D1 (de) | 2007-11-29 |
DE69535623T2 DE69535623T2 (de) | 2008-07-24 |
Family
ID=26892391
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535623T Expired - Lifetime DE69535623T2 (de) | 1994-02-14 | 1995-02-14 | Androstane und Pregane zur allosterischen Modulation des GABA Rezeptors |
DE69518509T Expired - Lifetime DE69518509T2 (de) | 1994-02-14 | 1995-02-14 | Androstane und pregnane zur allosterischen modulation des gaba-rezeptors |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69518509T Expired - Lifetime DE69518509T2 (de) | 1994-02-14 | 1995-02-14 | Androstane und pregnane zur allosterischen modulation des gaba-rezeptors |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0752860B1 (de) |
JP (1) | JP4066272B2 (de) |
KR (1) | KR100338287B1 (de) |
AT (2) | ATE375993T1 (de) |
AU (1) | AU691905B2 (de) |
BR (1) | BR9506779A (de) |
CA (1) | CA2183231A1 (de) |
DE (2) | DE69535623T2 (de) |
DK (2) | DK0752860T3 (de) |
ES (2) | ES2296594T3 (de) |
FI (2) | FI118008B (de) |
GR (1) | GR3034810T3 (de) |
HK (1) | HK1014665A1 (de) |
IL (1) | IL112638A (de) |
NO (1) | NO308307B1 (de) |
NZ (1) | NZ282939A (de) |
PT (2) | PT752860E (de) |
WO (1) | WO1995021617A1 (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6780853B1 (en) | 1995-06-06 | 2004-08-24 | Euro-Celtique S.A. | Neuroactive steroids of the androstane and pregnane series |
ATE284895T1 (de) * | 1995-06-06 | 2005-01-15 | Euro Celtique Sa | Neuroaktive steroide der androstan- und pregnanreihe |
US20010051599A1 (en) | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
EP1449846A1 (de) * | 1999-04-29 | 2004-08-25 | Euro-Celtique S.A. | 3alpha-hydroxy-3beta Methoxymethyl-21-heterozyklish substituierte Steroide mit anesthetische Aktivität |
WO2000066614A1 (en) * | 1999-04-29 | 2000-11-09 | Purdue Pharma Ltd. | 3α-HYDROXY-3β METHOXYMETHYL-21-HETEROCYCLE SUBSTITUTED STEROIDS WITH ANESTHETIC ACTIVITY |
JP2001039954A (ja) * | 1999-05-24 | 2001-02-13 | Tomono Agrica Co Ltd | ヘテロ環誘導体 |
DE60045751D1 (de) | 1999-09-30 | 2011-04-28 | Harbor Biosciences Inc | Therapeutische Behandlung androgenrezeptorbedingter Leiden |
US8771740B2 (en) | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
ES2240222T3 (es) | 1999-12-20 | 2005-10-16 | Nicholas J. Kerkhof | Procedimiento para producir particulas nanometricas mediante secado por pulverizacion en lecho fluidizado. |
US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
KR20100095661A (ko) * | 2005-06-09 | 2010-08-31 | 유로-셀띠끄 소시에떼 아노님 | 신경 자극성 스테로이드의 약학적 조성물 및 그 용도 |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
EP2068872A1 (de) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Kombinationen mit einem 4-acylaminopyridin-derivat |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
AU2007299010B2 (en) * | 2006-09-19 | 2013-01-31 | Solvay Pharmaceuticals Gmbh | Estratriene derivatives and their uses as 17beta-hydroxysteroid dehydrogenase inhibitors |
ES2662500T3 (es) | 2006-11-21 | 2018-04-06 | Asarina Pharma Ab | El uso de esteroides de pregnano y androstano para la preparación de una composición farmacéutica para el tratamiento de trastornos del sistema nervioso central |
WO2008157460A1 (en) | 2007-06-15 | 2008-12-24 | Cook, Kevin, M. | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
CZ302050B6 (cs) * | 2009-08-04 | 2010-09-15 | Ústav organické chemie a biochemie, Akademie ved CR, v.v.i. | 3alfa-Hydroxy-21ksí,22-oxido-21-homo-5alfa-pregnan-20-on, zpusob jeho výroby a jeho použití |
LT2753632T (lt) | 2011-09-08 | 2023-07-10 | Sage Therapeutics, Inc. | Neuroaktyvieji steroidai, jų kompozicijos ir naudojimas |
WO2013043985A1 (en) | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
EP2766380B1 (de) * | 2011-10-14 | 2019-04-24 | Sage Therapeutics, Inc. | 3,3-disubstituierte 19-nor-pregnan verbindungen, zusammensetzungen damit und verwendungen davon |
SI2806877T1 (sl) | 2012-01-23 | 2020-01-31 | Sage Therapeutics, Inc. | Nevroaktivne steroidne formulacije, ki obsegajo kompleks alopregnanolona in sulfobutil etra beta-ciklodekstrina |
CN102702126B (zh) * | 2012-04-26 | 2014-08-06 | 四川大学华西医院 | 一种可用于麻醉剂的化合物 |
JP2016501876A (ja) | 2012-11-30 | 2016-01-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ステロイドの抗痙攣活性 |
CN105246486B (zh) | 2013-03-13 | 2020-11-03 | 萨奇治疗股份有限公司 | 神经活性甾类化合物 |
WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
CN105246909B (zh) * | 2013-04-17 | 2020-10-13 | 萨奇治疗股份有限公司 | 刺激神经活性的19-去甲类固醇及其使用方法 |
US9512165B2 (en) * | 2013-04-17 | 2016-12-06 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof |
BR112016000975B1 (pt) * | 2013-07-19 | 2020-10-06 | Sage Therapeutics, Inc. | Compostos esteróides neuroativos e composições compreendendo os mesmos |
LT3488852T (lt) * | 2013-08-23 | 2021-02-25 | Sage Therapeutics, Inc. | Neuroaktyvūs steroidai, kompozicijos, ir jų naudojimas |
HRP20221294T1 (hr) * | 2014-05-29 | 2023-03-03 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, njihovi pripravci i uporabe |
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EP3188734A4 (de) | 2014-09-02 | 2018-01-10 | The Texas A&M University System | Verfahren zur behandlung einer organophosphatvergiftung |
HUE051488T2 (hu) | 2014-10-16 | 2021-03-01 | Sage Therapeutics Inc | Készítmények és eljárások központi idegrendszeri rendellenességek kezelésére |
MY190408A (en) * | 2014-10-16 | 2022-04-21 | Sage Therapeutics Inc | Compositions and methods for treating cns disorders |
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ES2857082T3 (es) | 2015-01-26 | 2021-09-28 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
DK3258939T3 (da) | 2015-02-20 | 2022-12-12 | Sage Therapeutics Inc | Neuroaktive steroider, sammensætninger og anvendelser heraf |
ES2884086T3 (es) | 2015-07-06 | 2021-12-10 | Sage Therapeutics Inc | Oxisteroles y sus procedimientos de uso |
MA42409A (fr) | 2015-07-06 | 2018-05-16 | Sage Therapeutics Inc | Oxystérols et leurs procédés d'utilisation |
RS61718B1 (sr) | 2015-07-06 | 2021-05-31 | Sage Therapeutics Inc | Oksisteroli i postupci za njihovu upotrebu |
US9637514B1 (en) | 2015-10-26 | 2017-05-02 | MAX BioPharma, Inc. | Oxysterols and hedgehog signaling |
JOP20170059B1 (ar) | 2016-03-08 | 2021-08-17 | Sage Therapeutics Inc | ستيرويدات وتركيبات نشطة عصبيًا واستخداماتها |
RS63280B1 (sr) | 2016-04-01 | 2022-06-30 | Sage Therapeutics Inc | Oksisteroli i postupci za njihovu upotrebu |
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PL3481846T3 (pl) | 2016-07-07 | 2021-12-20 | Sage Therapeutics, Inc. | 11-podstawione 24-hydroksysterole do stosowania w leczeniu stanów związanych z NMDA |
DK3481845T3 (da) | 2016-07-11 | 2023-11-27 | Sage Therapeutics Inc | C17, c20 og c21 substituerede neuroaktive steroider og deres anvendelsesmetoder |
MA46351A (fr) | 2016-09-30 | 2021-06-02 | Sage Therapeutics Inc | Oxystérols substitués en c7 et procédés en tant que modulateurs nmda |
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KR20220016098A (ko) | 2019-05-31 | 2022-02-08 | 세이지 테라퓨틱스, 인크. | 신경활성 스테로이드 및 이의 조성물 |
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CN112341511A (zh) * | 2019-08-09 | 2021-02-09 | 南京诺瑞特医药科技有限公司 | 3-羟基-5-孕烷-20-酮衍生物及其用途 |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274179A (en) * | 1964-03-19 | 1966-09-20 | Merck & Co Inc | 3-haloethynyl-3-hydroxy derivatives of the androstane-17-one and pregnane-20-one series |
US3953429A (en) * | 1970-12-17 | 1976-04-27 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstance and pregnane series |
GB1430942A (en) * | 1972-05-05 | 1976-04-07 | Glaxo Lab Ltd | 21-substituted 3alpha-hydroxy pregnanes |
US5120723A (en) * | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
EP0603312A4 (de) * | 1991-09-13 | 1995-06-07 | Cocensys Inc | Neuer gaba a-rezeptor mit steroidbindungsstellen. |
AU698834B2 (en) * | 1993-05-24 | 1998-11-12 | Purdue Pharma Ltd. | Methods and compositions for inducing sleep |
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1995
- 1995-02-14 EP EP95913478A patent/EP0752860B1/de not_active Expired - Lifetime
- 1995-02-14 CA CA002183231A patent/CA2183231A1/en not_active Abandoned
- 1995-02-14 NZ NZ282939A patent/NZ282939A/en not_active IP Right Cessation
- 1995-02-14 AT AT00200119T patent/ATE375993T1/de active
- 1995-02-14 DK DK95913478T patent/DK0752860T3/da active
- 1995-02-14 DK DK00200119T patent/DK1038880T3/da active
- 1995-02-14 DE DE69535623T patent/DE69535623T2/de not_active Expired - Lifetime
- 1995-02-14 JP JP52135695A patent/JP4066272B2/ja not_active Expired - Fee Related
- 1995-02-14 WO PCT/US1995/001712 patent/WO1995021617A1/en active IP Right Grant
- 1995-02-14 ES ES00200119T patent/ES2296594T3/es not_active Expired - Lifetime
- 1995-02-14 EP EP00200119A patent/EP1038880B1/de not_active Expired - Lifetime
- 1995-02-14 DE DE69518509T patent/DE69518509T2/de not_active Expired - Lifetime
- 1995-02-14 PT PT95913478T patent/PT752860E/pt unknown
- 1995-02-14 AT AT95913478T patent/ATE195654T1/de active
- 1995-02-14 IL IL11263895A patent/IL112638A/xx not_active IP Right Cessation
- 1995-02-14 ES ES95913478T patent/ES2151593T3/es not_active Expired - Lifetime
- 1995-02-14 AU AU20901/95A patent/AU691905B2/en not_active Ceased
- 1995-02-14 BR BR9506779A patent/BR9506779A/pt not_active IP Right Cessation
- 1995-02-14 PT PT00200119T patent/PT1038880E/pt unknown
- 1995-02-14 KR KR1019960704396A patent/KR100338287B1/ko not_active IP Right Cessation
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1996
- 1996-08-12 NO NO963355A patent/NO308307B1/no not_active IP Right Cessation
- 1996-08-13 FI FI963174A patent/FI118008B/fi not_active IP Right Cessation
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1998
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2000
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2005
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