DE69535229D1 - Hochgeschwindigkeitsfluoreszensabtaster - Google Patents

Hochgeschwindigkeitsfluoreszensabtaster

Info

Publication number
DE69535229D1
DE69535229D1 DE69535229T DE69535229T DE69535229D1 DE 69535229 D1 DE69535229 D1 DE 69535229D1 DE 69535229 T DE69535229 T DE 69535229T DE 69535229 T DE69535229 T DE 69535229T DE 69535229 D1 DE69535229 D1 DE 69535229D1
Authority
DE
Germany
Prior art keywords
hochgeschwindigkeitsfluoreszensabtaster
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535229T
Other languages
English (en)
Other versions
DE69535229T2 (de
Inventor
Iain Hueton
Gelder Ezra Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integenx Acquisition Corp
Original Assignee
GE Healthcare SV Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare SV Corp filed Critical GE Healthcare SV Corp
Application granted granted Critical
Publication of DE69535229D1 publication Critical patent/DE69535229D1/de
Publication of DE69535229T2 publication Critical patent/DE69535229T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/447Systems using electrophoresis
    • G01N27/44704Details; Accessories
    • G01N27/44717Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N2021/6417Spectrofluorimetric devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/10Scanning
    • G01N2201/101Scanning measuring head

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE69535229T 1994-07-19 1995-06-20 Hochgeschwindigkeitsfluoreszensabtaster Expired - Fee Related DE69535229T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/277,900 US5459325A (en) 1994-07-19 1994-07-19 High-speed fluorescence scanner
PCT/US1995/007834 WO1996002824A1 (en) 1994-07-19 1995-06-20 High-speed fluorescence scanner
US277900 2002-10-23

Publications (2)

Publication Number Publication Date
DE69535229D1 true DE69535229D1 (de) 2006-11-02
DE69535229T2 DE69535229T2 (de) 2007-09-06

Family

ID=23062860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535229T Expired - Fee Related DE69535229T2 (de) 1994-07-19 1995-06-20 Hochgeschwindigkeitsfluoreszensabtaster

Country Status (5)

Country Link
US (1) US5459325A (de)
EP (1) EP0724719B1 (de)
JP (2) JP4022255B2 (de)
DE (1) DE69535229T2 (de)
WO (1) WO1996002824A1 (de)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH697814B1 (de) * 2001-01-26 2009-02-27 Tecan Trading Ag Optisches System und Verfahren zum Anregen und Messen von Fluoreszenz an oder in mit Fluoreszenzfarbstoffen behandelten Proben.
US20030017081A1 (en) * 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6090555A (en) * 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US6068753A (en) * 1996-05-06 2000-05-30 Helena Laboratories Corporation Automatic electrophoresis apparatus with fluorescent and visible scanning
EP0902885A4 (de) * 1996-05-16 2006-09-27 Affymetrix Inc System und verfahren zur erkennung markierter materialien
JPH103134A (ja) * 1996-06-18 1998-01-06 Fuji Photo Film Co Ltd 画像読み取り装置
JP3595907B2 (ja) * 1996-06-21 2004-12-02 デイド、ベーリング、インコーポレイテッド イオン選択性電極製造のための組成物および方法
DE69732510T2 (de) * 1996-10-31 2005-08-25 Fuji Photo Film Co., Ltd., Minami-Ashigara Bilderzeugende Vorrichtung
US5837475A (en) * 1997-01-30 1998-11-17 Hewlett-Packard Co. Apparatus and method for scanning a chemical array
CN1251609A (zh) 1997-02-12 2000-04-26 尤金·Y·查恩 分析聚合物的方法和产品
US6403311B1 (en) 1997-02-12 2002-06-11 Us Genomics Methods of analyzing polymers using ordered label strategies
DE19707226A1 (de) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US5951838A (en) * 1997-03-10 1999-09-14 Bio-Rad Laboratories, Inc. Method and apparatus for correcting illumination non-uniformities
US5895915A (en) * 1997-07-24 1999-04-20 General Scanning, Inc. Bi-directional scanning system with a pixel clock system
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6051835A (en) * 1998-01-07 2000-04-18 Bio-Rad Laboratories, Inc. Spectral imaging apparatus and methodology
US6201639B1 (en) 1998-03-20 2001-03-13 James W. Overbeck Wide field of view and high speed scanning microscopy
EP2267506A3 (de) 1998-02-26 2011-03-02 The General Hospital Corporation Konfokale Mikroskopie mit multispektraler Kodierung
US6831781B2 (en) 1998-02-26 2004-12-14 The General Hospital Corporation Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy
US6185030B1 (en) 1998-03-20 2001-02-06 James W. Overbeck Wide field of view and high speed scanning microscopy
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6139562A (en) * 1998-03-30 2000-10-31 Agilent Technologies, Inc. Apparatus and method for incising
US6078390A (en) * 1998-05-04 2000-06-20 General Scanning, Inc. Scanning system and method of operation for automatically setting detection sensitivity
US6472671B1 (en) 2000-02-09 2002-10-29 Jean I. Montagu Quantified fluorescence microscopy
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
US6608671B2 (en) 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6236456B1 (en) * 1998-08-18 2001-05-22 Molecular Devices Corporation Optical system for a scanning fluorometer
ATE543093T1 (de) * 1998-09-10 2012-02-15 Wallac Oy Analysegerät für ein grossflächiges bild
JP2000121559A (ja) * 1998-10-14 2000-04-28 Hitachi Denshi Ltd 微小点光量読取装置
US6545264B1 (en) * 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
AU773664B2 (en) * 1998-10-30 2004-06-03 Affymetrix, Inc. Systems and methods for high performance scanning
WO2001015193A1 (en) * 1999-08-26 2001-03-01 Affymetrix, Inc. Systems and methods for high performance scanning
US6246046B1 (en) 1999-01-21 2001-06-12 University Of Pittsburgh Method and apparatus for electronically controlled scanning of micro-area devices
US6628385B1 (en) * 1999-02-05 2003-09-30 Axon Instruments, Inc. High efficiency, large field scanning microscope
JP3488124B2 (ja) 1999-03-17 2004-01-19 富士通株式会社 光情報記憶媒体
CN1209755C (zh) * 1999-04-20 2005-07-06 株式会社三协精机制作所 光学拾取***及其制做方法
WO2000068671A2 (en) * 1999-05-12 2000-11-16 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6838680B2 (en) * 1999-05-12 2005-01-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US6371370B2 (en) * 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
AU6834700A (en) * 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
JP2001074656A (ja) * 1999-09-03 2001-03-23 Fuji Photo Film Co Ltd 画像情報読取装置
JP2001091463A (ja) * 1999-09-22 2001-04-06 Tosoh Corp 小型励起光源を使用したスキャナー型蛍光検出装置
US6486457B1 (en) * 1999-10-07 2002-11-26 Agilent Technologies, Inc. Apparatus and method for autofocus
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
GB2360162B (en) 2000-01-07 2004-06-02 Axon Instr Inc Scanning microscope
US6407395B1 (en) 2000-02-29 2002-06-18 The University Of Chicago Portable biochip scanner device
US6329661B1 (en) 2000-02-29 2001-12-11 The University Of Chicago Biochip scanner device
US6537433B1 (en) 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US6577453B2 (en) 2000-04-26 2003-06-10 Fuji Photo Film Co., Ltd. Image reading apparatus
US20040224421A1 (en) * 2000-06-15 2004-11-11 Deweerd Herman Bi-directional scanning method
US6511277B1 (en) * 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
US6563581B1 (en) * 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
US6544477B1 (en) 2000-08-01 2003-04-08 Regents Of The University Of Minnesota Apparatus for generating a temperature gradient
US6586750B2 (en) 2000-08-03 2003-07-01 Perlegen Sciences High performance substrate scanning
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
EP1182044B1 (de) * 2000-08-24 2005-06-29 Hewlett-Packard Company, A Delaware Corporation Tragprofil für Transferwagen
EP1434522B1 (de) 2000-10-30 2010-01-13 The General Hospital Corporation Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
JP3663125B2 (ja) * 2000-11-28 2005-06-22 日立ソフトウエアエンジニアリング株式会社 蛍光読み取り方法及び蛍光読み取り装置
AU2002227156A1 (en) 2000-12-01 2002-06-11 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
WO2002048693A1 (fr) * 2000-12-14 2002-06-20 Olympus Optical Co., Ltd. Analyseur fluorometrique et analyse fluorometrique
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
AU785425B2 (en) * 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US9897538B2 (en) 2001-04-30 2018-02-20 The General Hospital Corporation Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating
US7865231B2 (en) * 2001-05-01 2011-01-04 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
AU2002315177A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
JP4149911B2 (ja) 2001-06-12 2008-09-17 ペリカン テクノロジーズ インコーポレイテッド 電気式ランセットアクチュエータ
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US20080026367A9 (en) * 2001-08-17 2008-01-31 Perlegen Sciences, Inc. Methods for genomic analysis
US6980299B1 (en) * 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
JP3678192B2 (ja) * 2001-11-21 2005-08-03 横河電機株式会社 計測装置
US20040023237A1 (en) * 2001-11-26 2004-02-05 Perelegen Sciences Inc. Methods for genomic analysis
EP2290319B1 (de) 2002-01-11 2015-08-26 The General Hospital Corporation OCT Einrichtung mit axialem Linienfokus für verbesserte Auflösung und Tiefenschärfe
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US20050054118A1 (en) * 2002-02-27 2005-03-10 Lebrun Stewart J. High throughput screening method
EP1520037A4 (de) * 2002-02-27 2006-06-07 Miragene Inc Verbesserte substratchemie für die immobilisierung von proteinen auf einem festen träger
DE60332406D1 (de) 2002-03-15 2010-06-17 Affymetrix Inc System und Verfahren zur Abtastung von biologischen Materialien
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
JP3913602B2 (ja) * 2002-04-23 2007-05-09 富士フイルム株式会社 読取画像処理方法および装置
US20040072274A1 (en) * 2002-05-09 2004-04-15 Lebrun Stewart J. System and method for visualization and digital analysis of protein and other macromolecule microarrays
US7126619B2 (en) * 2002-05-31 2006-10-24 Buzz Sales Company, Inc. System and method for direct laser engraving of images onto a printing substrate
US20040021911A1 (en) * 2002-07-31 2004-02-05 Corson John F. Array scanner noise reduction system
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
EP2319404B1 (de) 2003-01-24 2015-03-11 The General Hospital Corporation System und Verfahren zur Gewebeidentifizierung mittels Interferometrie mit niedriger Kohärenz
JP4805142B2 (ja) 2003-03-31 2011-11-02 ザ ジェネラル ホスピタル コーポレイション 光路長が変更された異なる角度の光の合成により光学的に干渉する断層撮影におけるスペックルの減少
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
EP1628567B1 (de) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Verfahren und vorrichtung zur injektion von flüssigkeit
EP2290337B1 (de) 2003-06-06 2018-12-12 The General Hospital Corporation Laser mit abstimmbarer Wellenlänge
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
WO2005040856A2 (en) * 2003-09-22 2005-05-06 Honeywell International Inc. Confocal scanner system and method
EP1671096A4 (de) 2003-09-29 2009-09-16 Pelikan Technologies Inc Verfahren und apparatur für eine verbesserte probeneinfangvorrichtung
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
CN103181753B (zh) 2003-10-27 2016-12-28 通用医疗公司 用于使用频域干涉测量法进行光学成像的方法和设备
US20060127963A1 (en) * 2003-11-21 2006-06-15 Lebrun Stewart J Microarray-based analysis of rheumatoid arthritis markers
US7551293B2 (en) 2003-11-28 2009-06-23 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US20050124017A1 (en) * 2003-12-05 2005-06-09 Stewart Lebrun Quantitative alkaline-phosphatase precipitation reagent and methods for visualization of protein microarrays
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7247494B2 (en) * 2004-02-27 2007-07-24 Agilent Technologies, Inc. Scanner with array anti-degradation features
DE102004022263A1 (de) 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
AU2004320269B2 (en) 2004-05-29 2011-07-21 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (OCT) imaging
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2006014392A1 (en) 2004-07-02 2006-02-09 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
US7532326B2 (en) * 2004-07-07 2009-05-12 Corcoran Timothy C Multiple-label fluorescence imaging using excitation-emission matrices
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
EP2275024A3 (de) 2004-08-24 2011-05-04 The General Hospital Corporation Verfahren und Vorrichtung zur Abbildung von Gefäßsegmenten
ES2379468T3 (es) 2004-08-24 2012-04-26 The General Hospital Corporation Procedimiento, sistema y configuración de software para determinar el módulo de elasticidad
EP1787105A2 (de) 2004-09-10 2007-05-23 The General Hospital Corporation System und verfahren zur optischen kohärenzabbildung
JP4997112B2 (ja) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション 少なくとも1つの電磁放射を伝送させるための装置およびその製造方法
JP5623692B2 (ja) 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション 試料の画像形成のための光ファイバ回転装置、光学システム及び方法
EP1825214A1 (de) 2004-11-24 2007-08-29 The General Hospital Corporation Interferometer mit gemeinsamem pfad für endoskopische optische kohärenztomographie
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
ATE451669T1 (de) 2005-04-28 2009-12-15 Gen Hospital Corp Bewertung von bildmerkmalen einer anatomischen struktur in optischen kohärenztomographiebildern
US7859679B2 (en) 2005-05-31 2010-12-28 The General Hospital Corporation System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging
EP1889037A2 (de) 2005-06-01 2008-02-20 The General Hospital Corporation Vorrichtung, verfahren und system zur abbildung phasenaufgelöster optischer frequenzdomänen
ATE484727T1 (de) 2005-08-09 2010-10-15 Gen Hospital Corp Gerät und verfahren zur durchführung von polarisationsbasierter quadraturdemodulation bei optischer kohärenztomographie
US7397042B2 (en) * 2005-08-24 2008-07-08 Dr. Chip Biotechnology Incorporation Optical detection apparatus and method thereof
US20070121196A1 (en) 2005-09-29 2007-05-31 The General Hospital Corporation Method and apparatus for method for viewing and analyzing of one or more biological samples with progressively increasing resolutions
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
US7279814B2 (en) * 2005-11-01 2007-10-09 Bio-Rad Laboratories, Inc. Moving coil actuator for reciprocating motion with controlled force distribution
FR2893132B1 (fr) * 2005-11-09 2008-07-25 Innopsys Sa Dispositif d'analyse a balayage d'echantillons biologiques par fluorescence
US7661593B2 (en) * 2005-11-30 2010-02-16 Bio-Rad Laboratories, Inc. Moving coil actuator with expandable range of motion
JP5680826B2 (ja) 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション 1以上のスペクトルを符号化する内視鏡技術によるデータ生成システム
JP5384944B2 (ja) 2006-01-19 2014-01-08 ザ ジェネラル ホスピタル コーポレイション ビームスキャニングによる上皮性管腔器官の光学的撮像システム
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US8055098B2 (en) 2006-01-27 2011-11-08 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
WO2007149601A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
WO2007149603A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
WO2007149602A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
JP5519152B2 (ja) 2006-02-08 2014-06-11 ザ ジェネラル ホスピタル コーポレイション 光学顕微鏡法を用いて解剖学的サンプルに関わる情報を取得するための装置
EP2306141A1 (de) 2006-02-24 2011-04-06 The General Hospital Corporation Verfahren und Systeme zur Durchführung von winkelaufgelöster optischer Kohärenztomografie im Fourier-Bereich
JP5135324B2 (ja) 2006-04-05 2013-02-06 ザ ジェネラル ホスピタル コーポレイション サンプルの偏光感応性光周波数領域画像形成のための方法、構成およびシステム
EP2015669A2 (de) 2006-05-10 2009-01-21 The General Hospital Corporation Verfahren, anordnungen und systeme für frequenzbereichsabbildung einer probe
US7782464B2 (en) 2006-05-12 2010-08-24 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
JP4431549B2 (ja) * 2006-05-31 2010-03-17 株式会社日立ハイテクノロジーズ 蛍光分析装置
CN101589301B (zh) 2006-08-25 2012-11-07 通用医疗公司 利用体积测定过滤技术来增强光学相干断层成像的装置和方法
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
JP5507258B2 (ja) 2007-01-19 2014-05-28 ザ ジェネラル ホスピタル コーポレイション 光周波数領域イメージングにおける測定深度を制御するための装置及び方法
US7949019B2 (en) 2007-01-19 2011-05-24 The General Hospital Wavelength tuning source based on a rotatable reflector
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
WO2008131082A1 (en) 2007-04-17 2008-10-30 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques
US8115919B2 (en) 2007-05-04 2012-02-14 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy
WO2009002225A2 (ru) * 2007-06-25 2008-12-31 Closed Company 'molecular-Medicine Technologies' Многофункциональное устройство для диагностики и способ тестирования биологических объектов
US9375158B2 (en) 2007-07-31 2016-06-28 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
EP2191254B1 (de) 2007-08-31 2017-07-19 The General Hospital Corporation System und verfahren für selbstinterferenz-fluoreszenzmikroskopie und damit assoziiertes rechnerzugriffsmedium
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
WO2009062197A1 (en) 2007-11-09 2009-05-14 Deltanu, Inc. Optical beam spectrometer
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
EP2274572A4 (de) 2008-05-07 2013-08-28 Gen Hospital Corp System, verfahren und computermedium zur verfolgung einer gefässbewegung in einer dreidimensionalen koronararterienmikroskopie
EP2163884A1 (de) 2008-05-26 2010-03-17 Koninklijke Philips Electronics N.V. Optisches Beleuchtungsgerät und Verfahren
US8861910B2 (en) 2008-06-20 2014-10-14 The General Hospital Corporation Fused fiber optic coupler arrangement and method for use thereof
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
EP3330696B1 (de) 2008-12-10 2023-07-12 The General Hospital Corporation Systeme, vorrichtung und verfahren zur erweiterung der bildgebungstiefenbereichs bei der optischen kohärenztomopgrafie mittels optischer unterabtastung
US8374818B2 (en) * 2008-12-19 2013-02-12 Affymetrix, Inc. System, method and apparatus for calibrating inspection tools
WO2010085775A2 (en) 2009-01-26 2010-07-29 The General Hospital Corporation System, method and computer-accessible medium for providing wide-field superresolution microscopy
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
EP2394336B1 (de) 2009-02-04 2023-05-24 The General Hospital Corporation Vorrichtung und verfahren zur verwendung einer optischen hochgeschwindigkeits-wellenlängenabstimmungsquelle
WO2010105197A2 (en) 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
DE102009029831A1 (de) * 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
DE102009029832A1 (de) * 2009-06-17 2010-12-23 W.O.M. World Of Medicine Ag System für die medizinische Bildgebung
BR112012001042A2 (pt) 2009-07-14 2016-11-22 Gen Hospital Corp equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica.
US8680429B2 (en) * 2009-11-10 2014-03-25 Instrument Associates LLC Laser beam scribing system
DK2542145T3 (da) 2010-03-05 2020-11-02 Massachusetts Gen Hospital Systemer der tilvejebringer mikroskopiske billeder af mindst en anatomisk struktur ved en bestemt opløsning
TW201135227A (en) * 2010-04-15 2011-10-16 Yayatech Co Ltd Image capture device of biological sample
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011150069A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP2575591A4 (de) 2010-06-03 2017-09-13 The General Hospital Corporation Vorrichtung und verfahren für geräte zur abbildung von strukturen in oder an einem oder mehreren lumenorganen
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
JP6240064B2 (ja) 2011-04-29 2017-11-29 ザ ジェネラル ホスピタル コーポレイション 散乱媒質の深さ分解した物理的及び/又は光学的特性を決定する方法
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
WO2013029047A1 (en) 2011-08-25 2013-02-28 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および/または提供するための装置および方法
CN102393358B (zh) * 2011-12-12 2015-10-21 珠海丽珠试剂股份有限公司 化学液体发光强度的测量方法
WO2013089817A1 (en) 2011-12-16 2013-06-20 Li-Cor, Inc. Luminescence imaging scanner
EP2833776A4 (de) 2012-03-30 2015-12-09 Gen Hospital Corp Abbildungssystem, verfahren und distaler anschluss zur multidirektionalen sichtfeldendoskopie
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
EP2856117A4 (de) * 2012-05-29 2016-02-17 Univ Macquarie Bidirektionale abtastung für die lumineszenzmikroskopie
JP5934585B2 (ja) * 2012-06-19 2016-06-15 シャープ株式会社 蛍光検出装置
EP2888616A4 (de) 2012-08-22 2016-04-27 Gen Hospital Corp System, verfahren, und über computer zugängliches medium zur herstellung eines miniaturendoskops mit weicher lithografie
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
CN105338931B (zh) 2013-03-13 2018-08-03 光学医疗公司 激光眼科手术***
CA2904893C (en) 2013-03-13 2021-11-16 Optimedica Corporation Free floating patient interface for laser surgery system
US10478072B2 (en) 2013-03-15 2019-11-19 The General Hospital Corporation Methods and system for characterizing an object
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
EP3021734B1 (de) 2013-07-19 2020-04-08 The General Hospital Corporation Abbildungsvorrichtung unter verwendung einer endoskopie mit multidirektionalem sichtfeld
EP3021735A4 (de) 2013-07-19 2017-04-19 The General Hospital Corporation Bestimmung der augenbewegung mittels netzhautabbildung mit rückkopplung
WO2015013651A2 (en) 2013-07-26 2015-01-29 The General Hospital Corporation System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
US9618733B2 (en) * 2013-07-29 2017-04-11 Bio-Rad Laboratories, Inc. Mechanical zoom imaging apparatus
FR3013118B1 (fr) * 2013-11-12 2015-11-06 Centre Nat Detudes Spatiales Cnes Spectrophotometre hyperspectral large bande pour analyser un objet dans le domaine fluorescent
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
WO2016015052A1 (en) 2014-07-25 2016-01-28 The General Hospital Corporation Apparatus, devices and methods for in vivo imaging and diagnosis
US9739661B2 (en) * 2015-06-30 2017-08-22 Agilent Technologies, Inc. Infrared imaging system with automatic referencing
CN106645045B (zh) * 2016-09-09 2020-01-21 华中科技大学 一种荧光光学显微成像中基于tdi-ccd的双向扫描成像方法
EP3299780A1 (de) * 2016-09-26 2018-03-28 Berthold Technologies GmbH & Co. KG Verfahren und system zum spektroskopischen messen optischer eigenschaften von proben
WO2018125925A1 (en) * 2016-12-27 2018-07-05 The Regents Of The University Of Michigan Laser emission based microscope
FR3068780B1 (fr) 2017-07-06 2021-05-14 Centre Nat Etd Spatiales Spectrophotometre hyperspectral large bande
US11680950B2 (en) 2019-02-20 2023-06-20 Pacific Biosciences Of California, Inc. Scanning apparatus and methods for detecting chemical and biological analytes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684797A (en) * 1984-02-29 1987-08-04 Kabushiki Kaisha Toshiba Optical system and method for reducing vibration of an objective lens in an optical head assembly of an optical read/write system
US4712887A (en) * 1985-12-20 1987-12-15 Dazar Corporation Optical system for fast access optical data storage device
US4877966A (en) * 1986-02-12 1989-10-31 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
US5001694A (en) * 1986-05-06 1991-03-19 Pencom International Corp. Tracking and focus actuator for a holographic optical head
JPH0799353B2 (ja) * 1987-03-31 1995-10-25 株式会社島津製作所 塩基配列決定装置
US5195074A (en) * 1988-07-07 1993-03-16 Oki Electric Industry Co., Ltd. Rotatable read/write optical head apparatus
JPH0262734A (ja) * 1988-08-30 1990-03-02 Hitachi Ltd 分離形光ヘッド
US5088079A (en) * 1989-09-08 1992-02-11 Stuff Technology Partners-Ii Carriage optics system for optical data storage system
US5218461A (en) * 1989-09-14 1993-06-08 Asahi Kogaku Kogyo Kabushiki Kaisha Scanning optical apparatus
US5293363A (en) * 1989-10-13 1994-03-08 Mitsubishi Denki Kabushiki Kaisha Optical head apparatus with light weight movable lens holder
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
JPH0743353B2 (ja) * 1990-05-31 1995-05-15 株式会社島津製作所 蛍光検出型ゲル電気泳動装置
US5196709A (en) * 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5543026A (en) * 1994-02-07 1996-08-06 The Perkin-Elmer Corporation Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments

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JP3715307B2 (ja) 2005-11-09
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JP2005201911A (ja) 2005-07-28
DE69535229T2 (de) 2007-09-06
US5459325A (en) 1995-10-17
EP0724719A4 (de) 1998-12-09
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WO1996002824A1 (en) 1996-02-01
JPH09503308A (ja) 1997-03-31

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