DE69534466D1 - Chondroitin lyase enzymen - Google Patents

Chondroitin lyase enzymen

Info

Publication number
DE69534466D1
DE69534466D1 DE69534466T DE69534466T DE69534466D1 DE 69534466 D1 DE69534466 D1 DE 69534466D1 DE 69534466 T DE69534466 T DE 69534466T DE 69534466 T DE69534466 T DE 69534466T DE 69534466 D1 DE69534466 D1 DE 69534466D1
Authority
DE
Germany
Prior art keywords
degrading
chondroitinase
chromatography
enzymes
exchange chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534466T
Other languages
English (en)
Other versions
DE69534466T2 (de
Inventor
Joseph Zimmermann
D Clark Bennett
Maryse Laliberte
Kangfu Gu
Anna Lydia Tkalec
Dominique Fink
Robert Linhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Biomarin Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharmaceutical Inc filed Critical Biomarin Pharmaceutical Inc
Publication of DE69534466D1 publication Critical patent/DE69534466D1/de
Application granted granted Critical
Publication of DE69534466T2 publication Critical patent/DE69534466T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69534466T 1994-07-08 1995-07-07 Chondroitinlyaseenzyme Expired - Fee Related DE69534466T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US272247 1994-07-08
US08/272,247 US6093563A (en) 1994-07-08 1994-07-08 Chondroitin lyase enzymes
PCT/US1995/008560 WO1996001894A1 (en) 1994-07-08 1995-07-07 Chondroitin lyase enzymes

Publications (2)

Publication Number Publication Date
DE69534466D1 true DE69534466D1 (de) 2006-02-02
DE69534466T2 DE69534466T2 (de) 2006-06-22

Family

ID=23039019

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69534466T Expired - Fee Related DE69534466T2 (de) 1994-07-08 1995-07-07 Chondroitinlyaseenzyme
DE69535939T Expired - Fee Related DE69535939D1 (de) 1994-07-08 1995-07-07 Chondroitinlyase-Enzyme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69535939T Expired - Fee Related DE69535939D1 (de) 1994-07-08 1995-07-07 Chondroitinlyase-Enzyme

Country Status (10)

Country Link
US (2) US6093563A (de)
EP (2) EP0764205B1 (de)
JP (2) JPH10506263A (de)
AT (2) ATE428774T1 (de)
AU (1) AU693916B2 (de)
CA (1) CA2194375C (de)
DE (2) DE69534466T2 (de)
DK (1) DK0764205T3 (de)
ES (1) ES2255062T3 (de)
WO (1) WO1996001894A1 (de)

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JP3271008B2 (ja) * 1999-11-18 2002-04-02 独立行政法人産業技術総合研究所 コンドロイチン硫酸類の製造方法
WO2001039795A2 (en) 1999-12-02 2001-06-07 Ibex Technologies, Inc. Attenuation of fibroblast proliferation
ATE357506T1 (de) * 2000-01-21 2007-04-15 Biomarin Pharm Inc Flavobakterium heparinum expressions-system
KR20040021697A (ko) * 2001-08-13 2004-03-10 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 신경 조직 복구를 증진시키는 물질 및 방법
CA2486388A1 (en) * 2002-02-19 2003-08-28 The Procter & Gamble Company Novel fungal lipase
GB0205022D0 (en) 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
US8183350B2 (en) * 2002-05-04 2012-05-22 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
US6962699B2 (en) * 2002-06-03 2005-11-08 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase B
AU2003265561A1 (en) * 2002-08-15 2004-03-03 Acorda Therapeutics, Inc. Chimeric protein
CA2504129A1 (en) * 2002-11-01 2004-05-21 Promega Corporation Cell lysis compositions, methods of use, apparatus, and kit
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
ATE524067T1 (de) 2003-05-16 2011-09-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur behandlung von zns-schäden
AU2013201097B2 (en) * 2003-05-16 2016-03-31 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for treatment of cns
JP2007532094A (ja) 2003-05-16 2007-11-15 アコーダ セラピューティクス、インク． Ｃｎｓ治療用のプロテオグリカン分解変異体
EP1676923A4 (de) * 2003-08-26 2007-02-28 Seikagaku Kogyo Co Ltd Zuckerketten schneidendes agens
US7507570B2 (en) * 2004-03-10 2009-03-24 Massachusetts Institute Of Technology Recombinant chondroitinase ABC I and uses thereof
JP4926962B2 (ja) * 2004-05-18 2012-05-09 アコーダ セラピューティクス、インク． コンドロイチン分解酵素とその安定な製剤の精製法
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
WO2007038548A2 (en) 2005-09-26 2007-04-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
CA3086902C (en) 2006-10-10 2021-11-09 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
US20080299622A1 (en) * 2007-02-07 2008-12-04 Paulson Bradley A Starch Hydrolysis Using Phytase with an Alpha Amylase
BRPI0907709A2 (pt) * 2008-02-06 2017-08-22 Danisco Us Inc Sistema isento de ajuste de ph para a produção de açúcares fermentáveis e álcool
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
US20100003238A1 (en) 2008-04-14 2010-01-07 Frost Gregory I Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US8529598B2 (en) 2009-02-20 2013-09-10 Boston Scientific Scimed, Inc. Tissue puncture closure device
US8292918B2 (en) 2009-02-20 2012-10-23 Boston Scientific Scimed, Inc. Composite plug for arteriotomy closure and method of use
US9913634B2 (en) * 2009-02-20 2018-03-13 Boston Scientific Scimed, Inc. Locking element for vascular closure device
US8375553B2 (en) * 2009-02-20 2013-02-19 Boston Scientific Scimed, Inc. Locking element for vascular closure device
US20100217309A1 (en) * 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Plug for arteriotomy closure and method of use
US8317824B2 (en) * 2009-02-20 2012-11-27 Boston Scientific Scimed, Inc. Tissue puncture closure device
US8052914B2 (en) * 2009-02-20 2011-11-08 Boston Scientific Scimed, Inc. Modified plug for arteriotomy closure
US8444673B2 (en) 2010-02-11 2013-05-21 Boston Scientific Scimed, Inc. Automatic vascular closure deployment devices and methods
KR20130125753A (ko) 2010-07-20 2013-11-19 할로자임, 아이엔씨 항-히알루로난제 투여와 관련된 유해 부작용의 치료
US8758402B2 (en) 2010-12-17 2014-06-24 Boston Scientific Scimed, Inc. Tissue puncture closure device
WO2012109387A1 (en) 2011-02-08 2012-08-16 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
NZ717728A (en) 2011-06-17 2016-04-29 Halozyme Inc Stable formulations of a hyaluronan-degrading enzyme
AU2012271361B2 (en) 2011-06-17 2017-03-02 Halozyme, Inc. Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
US20130071394A1 (en) 2011-09-16 2013-03-21 John K. Troyer Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
SG11201401797TA (en) 2011-10-24 2014-09-26 Halozyme Inc Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
PT2833905T (pt) 2012-04-04 2018-08-06 Halozyme Inc Terapia de combinação com hialuronidase e um taxano dirigido a tumor
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
EP2931872B1 (de) 2012-12-11 2018-01-17 Danisco US Inc. Trichoderma-reesei-wirtszellen zur expression einer glukoamylase aus aspergillus fumigatus und verfahren zur verwendung davon
PT3186281T (pt) 2014-08-28 2019-07-10 Halozyme Inc Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
US9796970B1 (en) 2017-04-24 2017-10-24 Advantek Serum Laboratories Ltd. Production of high purity chondroitinase ABC
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN114480182B (zh) * 2022-01-10 2023-10-31 中国农业大学 一种假节杆菌pl-410及其在产软骨素裂解酶中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6031478B2 (ja) * 1978-02-10 1985-07-22 生化学工業株式会社 純コンドロイチナ−ゼｂの製造法
JPS54107865A (en) * 1978-02-13 1979-08-24 Soujirou Fujino Periphery formation of cylindrical metal container
JPS55127988A (en) * 1979-03-23 1980-10-03 Seikagaku Kogyo Co Ltd Preparation of peptidase
US4390628A (en) * 1979-05-17 1983-06-28 De Forenede Bryggerier A/S Process for isolating Cu, Zn-superoxide dismutase from aqueous solutions containing said enzyme together with accompanying proteins
US4696816A (en) * 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
US5169772A (en) * 1988-06-06 1992-12-08 Massachusetts Institute Of Technology Large scale method for purification of high purity heparinase from flavobacterium heparinum
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
JPH0698769A (ja) * 1992-09-22 1994-04-12 Maruha Corp コンドロイチナーゼ及びその遺伝子

Also Published As

Publication number Publication date
CA2194375A1 (en) 1996-01-25
US6093563A (en) 2000-07-25
AU3004495A (en) 1996-02-09
EP0764205A1 (de) 1997-03-26
ES2255062T3 (es) 2006-06-16
DK0764205T3 (da) 2005-11-28
ATE305032T1 (de) 2005-10-15
JPH10506263A (ja) 1998-06-23
AU693916B2 (en) 1998-07-09
EP1607478B1 (de) 2009-04-15
DE69534466T2 (de) 2006-06-22
JP2008086325A (ja) 2008-04-17
EP1607478A3 (de) 2006-02-22
EP0764205B1 (de) 2005-09-21
ATE428774T1 (de) 2009-05-15
EP1607478A2 (de) 2005-12-21
US6054569A (en) 2000-04-25
CA2194375C (en) 2002-06-11
DE69535939D1 (de) 2009-05-28
WO1996001894A1 (en) 1996-01-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee