ATE305032T1 - Chondroitin lyase enzymen - Google Patents

Chondroitin lyase enzymen

Info

Publication number
ATE305032T1
ATE305032T1 AT95926207T AT95926207T ATE305032T1 AT E305032 T1 ATE305032 T1 AT E305032T1 AT 95926207 T AT95926207 T AT 95926207T AT 95926207 T AT95926207 T AT 95926207T AT E305032 T1 ATE305032 T1 AT E305032T1
Authority
AT
Austria
Prior art keywords
enzymes
degrading
chondroitin
chondroitinase
chromatography
Prior art date
Application number
AT95926207T
Other languages
English (en)
Inventor
Joseph Zimmermann
D Clark Bennett
Maryse Laliberte
Kangfu Gu
Anna Lydia Tkalec
Dominique Fink
Robert Linhardt
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Application granted granted Critical
Publication of ATE305032T1 publication Critical patent/ATE305032T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT95926207T 1994-07-08 1995-07-07 Chondroitin lyase enzymen ATE305032T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/272,247 US6093563A (en) 1994-07-08 1994-07-08 Chondroitin lyase enzymes
PCT/US1995/008560 WO1996001894A1 (en) 1994-07-08 1995-07-07 Chondroitin lyase enzymes

Publications (1)

Publication Number Publication Date
ATE305032T1 true ATE305032T1 (de) 2005-10-15

Family

ID=23039019

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05075080T ATE428774T1 (de) 1994-07-08 1995-07-07 Chondroitinlyase-enzyme
AT95926207T ATE305032T1 (de) 1994-07-08 1995-07-07 Chondroitin lyase enzymen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05075080T ATE428774T1 (de) 1994-07-08 1995-07-07 Chondroitinlyase-enzyme

Country Status (10)

Country Link
US (2) US6093563A (de)
EP (2) EP0764205B1 (de)
JP (2) JPH10506263A (de)
AT (2) ATE428774T1 (de)
AU (1) AU693916B2 (de)
CA (1) CA2194375C (de)
DE (2) DE69534466T2 (de)
DK (1) DK0764205T3 (de)
ES (1) ES2255062T3 (de)
WO (1) WO1996001894A1 (de)

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CA2242693C (en) * 1997-09-04 2002-09-17 Becton, Dickinson And Company Additive formulation and method of use thereof
US6979563B1 (en) 1999-11-17 2005-12-27 Biomarin Enzymes, Inc. Attenuation of tumor growth, metastasis and angiogenesis
JP3271008B2 (ja) * 1999-11-18 2002-04-02 独立行政法人産業技術総合研究所 コンドロイチン硫酸類の製造方法
AU781600B2 (en) 1999-12-02 2005-06-02 Biomarin Pharmaceutical Inc. Attenuation of fibroblast proliferation
AU5790801A (en) * 2000-01-21 2001-07-31 Biomarin Pharmaceutical Inc. Flavobacterium heparinum expression system
CN1553952A (zh) * 2001-08-13 2004-12-08 ��ѧ�о��� 促进神经组织修复的材料和方法
AU2003216317A1 (en) * 2002-02-19 2003-09-09 The Procter & Gamble Company Novel fungal lipase
GB0205022D0 (en) 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
ATE500842T1 (de) 2002-05-04 2011-03-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
DE60334220D1 (de) * 2002-06-03 2010-10-28 Massachusetts Inst Technology Rationell konstruierte, von chondroitinase b abgeleitete lyasen
WO2004017044A2 (en) * 2002-08-15 2004-02-26 Acorda Therapeutics, Inc. Chimeric protein
JP2006507818A (ja) * 2002-11-01 2006-03-09 プロメガ　コーポレイション 細胞溶解のための組成物、使用方法、装置およびキット
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
PL1631234T3 (pl) 2003-05-16 2012-02-29 Acorda Therapeutics Inc Kompozycje i sposoby leczenia uszkodzeń OUN
AU2013201097B2 (en) * 2003-05-16 2016-03-31 Acorda Therapeutics, Inc. Proteoglycan degrading mutants for treatment of cns
EP2460881B1 (de) * 2003-05-16 2017-05-03 Acorda Therapeutics, Inc. Proteoglycan-abbauende Mutanten zur Behandlung des ZNS
WO2005019465A1 (ja) * 2003-08-26 2005-03-03 Seikagaku Corporation 糖鎖切断剤
CA2558984A1 (en) * 2004-03-10 2005-09-22 Massachusetts Institute Of Technology Recombinant chondroitinase abc i and uses thereof
ES2411504T3 (es) * 2004-05-18 2013-07-05 Acorda Therapeutics, Inc. Métodos de purificación de condroitinasa y formulaciones estables de la misma
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
AU2006294755B2 (en) * 2005-09-26 2012-04-19 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants
CA3009034C (en) * 2006-10-10 2020-08-18 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
US20080299622A1 (en) * 2007-02-07 2008-12-04 Paulson Bradley A Starch Hydrolysis Using Phytase with an Alpha Amylase
EP2250277A1 (de) * 2008-02-06 2010-11-17 Danisco US Inc. Ph-einstellungsfreies system zur herstellung von vergärbaren zuckern und alkohol
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
SG187427A1 (en) 2008-04-14 2013-02-28 Halozyme Inc Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US8529598B2 (en) 2009-02-20 2013-09-10 Boston Scientific Scimed, Inc. Tissue puncture closure device
US8052914B2 (en) * 2009-02-20 2011-11-08 Boston Scientific Scimed, Inc. Modified plug for arteriotomy closure
US8375553B2 (en) * 2009-02-20 2013-02-19 Boston Scientific Scimed, Inc. Locking element for vascular closure device
US20100217309A1 (en) * 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Plug for arteriotomy closure and method of use
US8292918B2 (en) 2009-02-20 2012-10-23 Boston Scientific Scimed, Inc. Composite plug for arteriotomy closure and method of use
US9913634B2 (en) * 2009-02-20 2018-03-13 Boston Scientific Scimed, Inc. Locking element for vascular closure device
US8317824B2 (en) * 2009-02-20 2012-11-27 Boston Scientific Scimed, Inc. Tissue puncture closure device
WO2011100547A2 (en) * 2010-02-11 2011-08-18 Boston Scientific Scimed, Inc. Automatic vascular closure deployment devices and methods
DK2595624T3 (en) 2010-07-20 2018-03-26 Halozyme Inc Methods of treating or preventing adverse side effects associated with administration of an anti-hyaluronan agent
US8758402B2 (en) 2010-12-17 2014-06-24 Boston Scientific Scimed, Inc. Tissue puncture closure device
WO2012109387A1 (en) 2011-02-08 2012-08-16 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
EA201400031A1 (ru) 2011-06-17 2014-07-30 Галозим, Инк. Стабильные составы на основе фермента, разрушающего хиалуронан
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
WO2012174480A2 (en) 2011-06-17 2012-12-20 Halozyme, Inc. Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme
WO2013040501A1 (en) 2011-09-16 2013-03-21 Pharmathene, Inc. Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
AU2012328880B2 (en) 2011-10-24 2017-02-23 Halozyme, Inc. Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
WO2013151774A1 (en) 2012-04-04 2013-10-10 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US20160115509A1 (en) 2012-12-11 2016-04-28 Danisco Us Inc. Trichoderma reesei host cells expressing a glucoamylase from aspergillus fumigatus and methods of use thereof
DK3186281T3 (da) 2014-08-28 2019-06-11 Halozyme Inc Kombinationsterapi med et hyaluronan-nedbrydende enzym og en immun-checkpoint-inhibitor
US9796970B1 (en) 2017-04-24 2017-10-24 Advantek Serum Laboratories Ltd. Production of high purity chondroitinase ABC
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
CN114480182B (zh) * 2022-01-10 2023-10-31 中国农业大学 一种假节杆菌pl-410及其在产软骨素裂解酶中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6031478B2 (ja) * 1978-02-10 1985-07-22 生化学工業株式会社 純コンドロイチナ−ゼｂの製造法
JPS54107865A (en) * 1978-02-13 1979-08-24 Soujirou Fujino Periphery formation of cylindrical metal container
JPS55127988A (en) * 1979-03-23 1980-10-03 Seikagaku Kogyo Co Ltd Preparation of peptidase
US4390628A (en) * 1979-05-17 1983-06-28 De Forenede Bryggerier A/S Process for isolating Cu, Zn-superoxide dismutase from aqueous solutions containing said enzyme together with accompanying proteins
US4696816A (en) * 1985-11-07 1987-09-29 Brown Mark D Method for treating intervertebral disc displacement with enzymes
US5169772A (en) * 1988-06-06 1992-12-08 Massachusetts Institute Of Technology Large scale method for purification of high purity heparinase from flavobacterium heparinum
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
JPH0698769A (ja) * 1992-09-22 1994-04-12 Maruha Corp コンドロイチナーゼ及びその遺伝子

Also Published As

Publication number Publication date
WO1996001894A1 (en) 1996-01-25
DE69534466T2 (de) 2006-06-22
JP2008086325A (ja) 2008-04-17
EP1607478A2 (de) 2005-12-21
EP0764205B1 (de) 2005-09-21
EP1607478B1 (de) 2009-04-15
EP0764205A1 (de) 1997-03-26
AU693916B2 (en) 1998-07-09
DE69534466D1 (de) 2006-02-02
US6093563A (en) 2000-07-25
JPH10506263A (ja) 1998-06-23
ATE428774T1 (de) 2009-05-15
DE69535939D1 (de) 2009-05-28
US6054569A (en) 2000-04-25
CA2194375A1 (en) 1996-01-25
DK0764205T3 (da) 2005-11-28
ES2255062T3 (es) 2006-06-16
AU3004495A (en) 1996-02-09
EP1607478A3 (de) 2006-02-22
CA2194375C (en) 2002-06-11

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