DE69533159D1 - Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten - Google Patents

Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten

Info

Publication number
DE69533159D1
DE69533159D1 DE69533159T DE69533159T DE69533159D1 DE 69533159 D1 DE69533159 D1 DE 69533159D1 DE 69533159 T DE69533159 T DE 69533159T DE 69533159 T DE69533159 T DE 69533159T DE 69533159 D1 DE69533159 D1 DE 69533159D1
Authority
DE
Germany
Prior art keywords
sample preparation
analyzes
treating
detecting
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533159T
Other languages
English (en)
Other versions
DE69533159T2 (de
Inventor
Peter Wilding
J Kricka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/338,369 external-priority patent/US5726026A/en
Priority claimed from US08/338,728 external-priority patent/US5587128A/en
Priority claimed from US08/338,380 external-priority patent/US5744366A/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Application granted granted Critical
Publication of DE69533159D1 publication Critical patent/DE69533159D1/de
Publication of DE69533159T2 publication Critical patent/DE69533159T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0213—Silicon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0215—Silicon carbide; Silicon nitride; Silicon oxycarbide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00826—Quartz
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
DE69533159T 1994-11-14 1995-11-13 Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten Expired - Lifetime DE69533159T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/338,369 US5726026A (en) 1992-05-01 1994-11-14 Mesoscale sample preparation device and systems for determination and processing of analytes
US338728 1994-11-14
US08/338,728 US5587128A (en) 1992-05-01 1994-11-14 Mesoscale polynucleotide amplification devices
US338380 1994-11-14
US338369 1994-11-14
US08/338,380 US5744366A (en) 1992-05-01 1994-11-14 Mesoscale devices and methods for analysis of motile cells
PCT/US1995/014825 WO1996014934A1 (en) 1994-11-14 1995-11-13 Mesoscale sample preparation device and systems for determination and processing of analytes

Publications (2)

Publication Number Publication Date
DE69533159D1 true DE69533159D1 (de) 2004-07-22
DE69533159T2 DE69533159T2 (de) 2005-07-21

Family

ID=27407263

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533159T Expired - Lifetime DE69533159T2 (de) 1994-11-14 1995-11-13 Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten

Country Status (8)

Country Link
EP (1) EP0739240B1 (de)
JP (1) JP3220158B2 (de)
CN (1) CN1110369C (de)
AT (1) ATE269160T1 (de)
AU (1) AU704277B2 (de)
CA (1) CA2181190C (de)
DE (1) DE69533159T2 (de)
WO (1) WO1996014934A1 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69619400T2 (de) 1995-06-16 2002-09-26 Univ Washington Seattle Flacher mikrogefertigter querstromfilter für flüssigkeiten
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) * 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析***
DE19648695C2 (de) 1996-11-25 1999-07-22 Abb Patent Gmbh Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben
ATE264717T1 (de) 1997-05-16 2004-05-15 Alberta Res Council Mikrofluidisches system und verfahren zu dessen betrieb
US6632619B1 (en) 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
AU3771599A (en) 1998-05-18 1999-12-06 University Of Washington Liquid analysis cartridge
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
EP1876444A3 (de) 1998-09-17 2008-03-12 Advion BioSciences, Inc. Integriertes monolithisches, auf Mikrobasis hergestelltes Elektrospray sowie System und Verfahren zur Flüssigkeitschromatographie
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
DE19846466A1 (de) * 1998-10-08 2000-04-27 Ghs Gesundheits Service Ag Analyseverfahren zur simultanen Bestimmung von Parametern aus unterschiedlichen Medien
EP1125105A2 (de) 1998-11-05 2001-08-22 ChemoMetec A/S Verfahren, gerät und system zur partikel-analyse
US6240790B1 (en) 1998-11-09 2001-06-05 Agilent Technologies, Inc. Device for high throughout sample processing, analysis and collection, and methods of use thereof
JP3984748B2 (ja) * 1999-03-17 2007-10-03 株式会社日立製作所 化学分析装置と化学分析システム
JP2001004628A (ja) * 1999-06-18 2001-01-12 Kanagawa Acad Of Sci & Technol 免疫分析装置と免疫分析方法
DE19928410C2 (de) * 1999-06-22 2002-11-28 Agilent Technologies Inc Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips
DE19928412C2 (de) 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
DE19933458B4 (de) 1999-07-15 2015-08-20 Eppendorf Ag Einrichtungen und Systeme zum Handhaben von Flüssigkeitsproben
EP1208240A4 (de) * 1999-08-26 2006-10-04 Univ Princeton Mikrofluidische und makrofluidische elektronische geräte zur detektion von änderungen der kapazität von flüssigkeiten und verfahren zu deren verwendung.
DE10010587A1 (de) * 2000-03-03 2001-09-06 Roche Diagnostics Gmbh System zur Bestimmung von Analytkonzentrationen in Körperflüssigkeiten
KR100408871B1 (ko) * 2001-12-20 2003-12-11 삼성전자주식회사 바이오칩 상에서 탄소나노튜브를 이용한 시료의 분리 또는여과 방법
DE10203211A1 (de) * 2002-01-28 2003-08-14 Siemens Ag Mikrofluidikprobenmodul mit Mitteln zur Temperaturbeeinflussung
DE10258840A1 (de) * 2002-01-28 2003-08-07 Eppendorf Ag Stapelanordnung von Reaktionsgefäßen
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
JP2004354364A (ja) 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
EP1608587B1 (de) * 2003-03-23 2016-11-23 Gyros Patent Ab Vorbefüllte vorrichtungen im mikromassstab
EP1607748B1 (de) 2003-03-24 2013-05-15 Sony Corporation Nukleinsäurenextraktions-Kit und Nukleinsäurenextraktionsverfahren
DE10321472B4 (de) * 2003-05-13 2005-05-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Fluidik-Modul, Verfahren zu seiner Herstellung und Verfahren zum Betreiben eines Fluidik-Moduls
JP4509632B2 (ja) * 2004-04-05 2010-07-21 株式会社アドバンス 血球分離構造物
JP4756835B2 (ja) * 2004-07-14 2011-08-24 キヤノン株式会社 生化学反応カートリッジ
JP4735119B2 (ja) * 2004-08-09 2011-07-27 日本精工株式会社 反応器及びその製造方法
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
CN100462710C (zh) * 2004-11-09 2009-02-18 横河电机株式会社 在盒中处理废液的方法及应用此方法的化学反应盒
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
ZA200704952B (en) 2004-12-03 2008-11-26 Cytonome Inc Unitary cartridge for particle processing
JP5165383B2 (ja) * 2004-12-23 2013-03-21 アイ−スタツト・コーポレイシヨン 分子診断システム及び方法
ZA200707354B (en) 2005-03-08 2009-04-29 Authentix Inc Microfluidic device for identification, quantification, and authentication of latent markers
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB0508983D0 (en) 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
DE102005054923B3 (de) * 2005-11-17 2007-04-12 Siemens Ag Vorrichtung und Verfahren zur Aufbereitung einer Probe
CA2641271A1 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20110039303A1 (en) 2007-02-05 2011-02-17 Stevan Bogdan Jovanovich Microfluidic and nanofluidic devices, systems, and applications
WO2008137008A2 (en) * 2007-05-04 2008-11-13 Claros Diagnostics, Inc. Fluidic connectors and microfluidic systems
DE102007054043B4 (de) * 2007-11-13 2010-02-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modulare mikrofluidische Funktionsplattform und deren Verwendung
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
EP3751005A3 (de) 2008-09-20 2021-02-24 The Board of Trustees of the Leland Stanford Junior University Nicht invasive diagnose von fötaler aneuploidie durch sequenzierung
WO2010040103A1 (en) 2008-10-03 2010-04-08 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
WO2010077322A1 (en) 2008-12-31 2010-07-08 Microchip Biotechnologies, Inc. Instrument with microfluidic chip
TR201815133T4 (tr) 2009-02-02 2018-11-21 Opko Diagnostics Llc Mikrofilidik cihazlar ile ışık etkileşiminin kontrol edilmesi için yapılar.
WO2010101950A1 (en) * 2009-03-02 2010-09-10 Catholic Healthcare West Diagnostic devices and methods of use
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
EP2412020B1 (de) 2009-03-24 2020-09-30 University Of Chicago Schiebe- und schneidevorrichtung und entsprechende verfahren
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
WO2010141326A1 (en) 2009-06-02 2010-12-09 Integenx Inc. Fluidic devices with diaphragm valves
US8584535B2 (en) * 2009-09-17 2013-11-19 Innova Prep LLC Liquid to liquid biological particle concentrator with disposable fluid path
CN102740975B (zh) 2009-11-24 2015-11-25 欧普科诊断有限责任公司 微流体***中的流体混合和递送
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
WO2011088247A1 (en) * 2010-01-13 2011-07-21 Nomadics, Inc. In situ-dilution method and system for measuring molecular and chemical interactions
CN107102156B (zh) 2010-04-16 2020-06-16 欧普科诊断有限责任公司 用于样本分析的***和装置
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
WO2012126478A1 (en) 2011-03-21 2012-09-27 Motilitycount Aps Device for analysis of cellular motility
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
PE20150333A1 (es) 2012-03-05 2015-03-25 Arctic Partners Ab Oy Metodos y aparatos para predecir riesgo de cancer de prostata y volumen de glandula prostatica
DE102012207796B4 (de) * 2012-05-10 2024-06-13 Robert Bosch Gmbh Probensammeleinheit, System und Verfahren zur mikrobiologischen Luftanalyse
US9990464B1 (en) 2012-10-09 2018-06-05 Pall Corporation Label-free biomolecular interaction analysis using a rapid analyte dispersion injection method
EP2962082B1 (de) * 2013-02-26 2023-06-07 Innovaprep LLC Biologischer flüssig-flüssig-partikelkonzentrator mit einwegflüssigkeitspfad
JP2014173934A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
EP2994750B1 (de) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben
GB2516666B (en) * 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
CN105960463A (zh) * 2013-11-20 2016-09-21 布里格姆女子医院有限公司 用于***分选的***和方法
CA2972587A1 (en) * 2014-12-31 2016-07-07 Click Diagnostics, Inc. Devices and methods for molecular diagnostic testing
CA2994669C (en) * 2015-08-05 2020-11-17 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
KR101726064B1 (ko) * 2015-08-06 2017-04-13 한양대학교 산학협력단 진동자를 구비하는 미세입자 분리소자
US20190382699A1 (en) * 2016-11-24 2019-12-19 Sensirion Ag Microorganism test system
CA3056256A1 (en) * 2017-03-29 2018-10-04 Cornell University Devices, processes, and systems for determination of nucleic acid sequence, expression, copy number, or methylation changes using combined nuclease, ligase, polymerase, and sequencing reactions
US10502707B1 (en) * 2018-05-31 2019-12-10 Taiwan Semiconductor Manufacturing Co., Ltd. Differential sensing with bioFET sensors
TW202223378A (zh) * 2020-12-14 2022-06-16 國立中央大學 複合式細胞成像與生化檢測晶片及其使用方法
DE102021106654B3 (de) * 2021-03-18 2022-07-14 Universität zu Köln, Körperschaft des öffentlichen Rechts Kartusche und Verfahren zur Durchführung einer Reaktion
DE102022213554A1 (de) 2022-12-13 2024-06-13 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zum Splitten dreidimensionaler Agglomerate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5100627A (en) * 1989-11-30 1992-03-31 The Regents Of The University Of California Chamber for the optical manipulation of microscopic particles
EP0637997B1 (de) * 1992-05-01 1998-07-01 Trustees Of The University Of Pennsylvania Analyse bei messung des durchflusswiderstandes

Also Published As

Publication number Publication date
EP0739240B1 (de) 2004-06-16
MX9602774A (es) 1997-07-31
DE69533159T2 (de) 2005-07-21
CN1110369C (zh) 2003-06-04
AU4236996A (en) 1996-06-06
CN1143917A (zh) 1997-02-26
WO1996014934A1 (en) 1996-05-23
JPH09509498A (ja) 1997-09-22
AU704277B2 (en) 1999-04-15
EP0739240A1 (de) 1996-10-30
CA2181190C (en) 2001-02-06
ATE269160T1 (de) 2004-07-15
CA2181190A1 (en) 1996-05-23
JP3220158B2 (ja) 2001-10-22

Similar Documents

Publication Publication Date Title
DE69533159D1 (de) Miniaturisierte probenvorbereitungsvorrichtungen sowie systeme zur feststellung und behandlung von analyten
CA2115276A1 (en) Reagent compositions for analytical testing
ATE212674T1 (de) Verfahren und analytisches system zur genauen schnellen und einfachen ausführung von fibrinogen-assays
CA2383262A1 (en) Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same
MY129171A (en) Chromatographic assay device and method for detecting the presence of an analyte in a blood sample
ES2157220T3 (es) Aparato de ensayo analitico con control negativo y positivo incorporado.
ES1030750U (es) Dispositivos analiticos y procedimientos de uso de los mismos.
FI963410A0 (fi) Laite nestemäisten näytteiden, kuten verinäytteideLaite nestemäisten näytteiden, kuten verinäytteiden ottamiseksi ja analysoimiseksi n ottamiseksi ja analysoimiseksi
DE60136335D1 (de) Parallele genotypisierung mehrerer patientenproben
ZA978630B (en) Method for collecting samples of liquid specimens for analytical testing.
EP1379693A4 (de) Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
DE69906986D1 (de) Analytisches testgerät und verfahren
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
GB9709821D0 (en) Allergy assay
DE69731504D1 (de) Reagenz und Verfahren zur Freisetzung und Bestimmung von Blei in biologischen Matrices
CA2500407A1 (en) Diagnostic devices
ATE397215T1 (de) Entstörung von immunoassays durch substanzen, die aus den framework-regionen von antikörpern abgeleitet sind
ES2121016T3 (es) Reactivos y procedimientos que permiten realizar analisis de fijacion con captura de iones en dos etapas.
ATE161332T1 (de) Vorrichtungen zur ausführung von ioneneinfangassays
EP0990901A3 (de) Computergestützte Identifizierung von Paraproteinen
WO2001007650A3 (en) Improvements in and relating to forensic investigations
DE69423815D1 (de) Reagens-Zusammensetzung zur quantitativen Analyse von anorganischem Phosphor und trockenes, analytisches Element dazu
IT1231773B (it) Metodo e dispositivo fotometrico per analisi di campioni trattati con reattivi fluorescenti.
WO2002057743A3 (en) Methods of analyzing and sorting one or more analytes
WO2004030721A3 (en) Fluid collecting device, methods of production and uses thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition