DE69529765D1 - Verfahren zur fermentativen herstellung von clavamderivaten, wobei der ammoniak und harnstoffgehalt im fermentationsmedium niedrig gehalten wird - Google Patents

Verfahren zur fermentativen herstellung von clavamderivaten, wobei der ammoniak und harnstoffgehalt im fermentationsmedium niedrig gehalten wird

Info

Publication number
DE69529765D1
DE69529765D1 DE69529765T DE69529765T DE69529765D1 DE 69529765 D1 DE69529765 D1 DE 69529765D1 DE 69529765 T DE69529765 T DE 69529765T DE 69529765 T DE69529765 T DE 69529765T DE 69529765 D1 DE69529765 D1 DE 69529765D1
Authority
DE
Germany
Prior art keywords
clavame
ammonia
derivatives
low
fermentation medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69529765T
Other languages
English (en)
Other versions
DE69529765T2 (de
Inventor
Peter Valentine
Alan Jeffkins
Henry Holms
Michael Mousdale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10765725&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69529765(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69529765D1 publication Critical patent/DE69529765D1/de
Application granted granted Critical
Publication of DE69529765T2 publication Critical patent/DE69529765T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69529765T 1994-12-10 1995-12-07 Verfahren zur fermentativen herstellung von clavamderivaten, wobei der ammoniak und harnstoffgehalt im fermentationsmedium niedrig gehalten wird Revoked DE69529765T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9424950.5A GB9424950D0 (en) 1994-12-10 1994-12-10 Novel process
PCT/EP1995/004888 WO1996018743A1 (en) 1994-12-10 1995-12-07 Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low

Publications (2)

Publication Number Publication Date
DE69529765D1 true DE69529765D1 (de) 2003-04-03
DE69529765T2 DE69529765T2 (de) 2003-10-16

Family

ID=10765725

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529765T Revoked DE69529765T2 (de) 1994-12-10 1995-12-07 Verfahren zur fermentativen herstellung von clavamderivaten, wobei der ammoniak und harnstoffgehalt im fermentationsmedium niedrig gehalten wird

Country Status (21)

Country Link
US (2) US5985624A (de)
EP (1) EP0796340B1 (de)
JP (1) JP3916251B2 (de)
KR (1) KR100411839B1 (de)
CN (1) CN1119423C (de)
AT (1) ATE233322T1 (de)
AU (1) AU702660B2 (de)
BR (1) BR9509878A (de)
CA (1) CA2207411A1 (de)
CZ (1) CZ292673B6 (de)
DE (1) DE69529765T2 (de)
DK (1) DK0796340T3 (de)
ES (1) ES2193207T3 (de)
FI (1) FI972446A0 (de)
GB (1) GB9424950D0 (de)
HU (1) HU221755B1 (de)
MX (1) MX9704279A (de)
NO (1) NO319278B1 (de)
NZ (1) NZ298035A (de)
PL (1) PL184403B1 (de)
WO (1) WO1996018743A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
US6440708B1 (en) * 1998-09-29 2002-08-27 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
CA2342181A1 (en) * 1998-09-29 2000-04-06 Dsm N.V. Fermentation of clavulanic acid at a controlled level of ammonia
JP2003304893A (ja) * 2002-04-16 2003-10-28 Sumitomo Heavy Ind Ltd 有機酸の製造方法及び製造装置並びに有機酸の保存方法
US7790231B2 (en) * 2003-07-10 2010-09-07 Brewer Science Inc. Automated process and apparatus for planarization of topographical surfaces

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US5100635A (en) * 1990-07-31 1992-03-31 The Boc Group, Inc. Carbon dioxide production from combustion exhaust gases with nitrogen and argon by-product recovery
EP0673432B1 (de) * 1992-12-02 1999-03-24 Smithkline Beecham Plc Verfahren zur herstellung von clavulansäure

Also Published As

Publication number Publication date
CA2207411A1 (en) 1996-06-20
BR9509878A (pt) 1997-11-25
NO972647D0 (no) 1997-06-09
CZ292673B6 (cs) 2003-11-12
JPH10510426A (ja) 1998-10-13
GB9424950D0 (en) 1995-02-08
EP0796340A1 (de) 1997-09-24
AU4343296A (en) 1996-07-03
CN1169162A (zh) 1997-12-31
KR100411839B1 (ko) 2004-02-18
ES2193207T3 (es) 2003-11-01
CN1119423C (zh) 2003-08-27
HUT77082A (hu) 1998-03-02
AU702660B2 (en) 1999-02-25
DK0796340T3 (da) 2003-05-05
CZ177197A3 (en) 1997-09-17
MX9704279A (es) 1997-09-30
HU221755B1 (hu) 2002-12-28
ATE233322T1 (de) 2003-03-15
NZ298035A (en) 1999-01-28
FI972446A (fi) 1997-06-09
FI972446A0 (fi) 1997-06-09
NO972647L (no) 1997-06-09
PL184403B1 (pl) 2002-10-31
US5985624A (en) 1999-11-16
WO1996018743A1 (en) 1996-06-20
US6235506B1 (en) 2001-05-22
DE69529765T2 (de) 2003-10-16
EP0796340B1 (de) 2003-02-26
PL320662A1 (en) 1997-10-13
NO319278B1 (no) 2005-07-11
JP3916251B2 (ja) 2007-05-16

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation