DE69505484D1 - 2-substituierte Benzothiazol-Derivate als Mittel zur Behandlung von Komplikationen in Zusammenhang mit Diabetes - Google Patents

2-substituierte Benzothiazol-Derivate als Mittel zur Behandlung von Komplikationen in Zusammenhang mit Diabetes

Info

Publication number
DE69505484D1
DE69505484D1 DE69505484T DE69505484T DE69505484D1 DE 69505484 D1 DE69505484 D1 DE 69505484D1 DE 69505484 T DE69505484 T DE 69505484T DE 69505484 T DE69505484 T DE 69505484T DE 69505484 D1 DE69505484 D1 DE 69505484D1
Authority
DE
Germany
Prior art keywords
diabetes
complications related
benzothiazole derivatives
substituted benzothiazole
treating complications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69505484T
Other languages
English (en)
Other versions
DE69505484T2 (de
Inventor
Tomoji Aotsuka
Naoki Abe
Naoki Ashizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Publication of DE69505484D1 publication Critical patent/DE69505484D1/de
Application granted granted Critical
Publication of DE69505484T2 publication Critical patent/DE69505484T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69505484T 1994-11-29 1995-11-24 2-substituierte Benzothiazol-Derivate als Mittel zur Behandlung von Komplikationen in Zusammenhang mit Diabetes Expired - Fee Related DE69505484T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31780994 1994-11-29

Publications (2)

Publication Number Publication Date
DE69505484D1 true DE69505484D1 (de) 1998-11-26
DE69505484T2 DE69505484T2 (de) 1999-05-12

Family

ID=18092290

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69505484T Expired - Fee Related DE69505484T2 (de) 1994-11-29 1995-11-24 2-substituierte Benzothiazol-Derivate als Mittel zur Behandlung von Komplikationen in Zusammenhang mit Diabetes

Country Status (4)

Country Link
US (1) US5700819A (de)
EP (1) EP0714893B1 (de)
CA (1) CA2163950A1 (de)
DE (1) DE69505484T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4647726B2 (ja) * 1997-03-25 2011-03-09 興和株式会社 新規なアニリド化合物及びこれを含有する医薬
CN1205207C (zh) 1998-03-31 2005-06-08 药品发现学会公司 取代的吲哚链烷酸
US6121300A (en) 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
US6436489B1 (en) 1999-03-24 2002-08-20 Clariant International Ltd. Fluorine-containing benzothiazoles, and their use in liquid-crystalline mixtures
NZ535603A (en) 2002-03-20 2007-10-26 Metabolex Inc Substituted phenylacetic acids
US20060100255A1 (en) * 2002-07-26 2006-05-11 Van Zandt Michael C Substituted indolealkanoic acids derivative and formulations containing same for use in the treatment of diabetic complications
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
EP1749000A4 (de) * 2004-05-25 2009-12-30 Metabolex Inc Bicyclische substituierte triazole als ppar-modulatoren und verfahren zu deren herstellung
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
WO2013018095A1 (en) * 2011-08-01 2013-02-07 Yissum Research And Development Of The Hebrew University Of Jerusalem Ltd. Compounds and compositions for use in augmentation of glucose uptake and insulin secretion
CN108034476B (zh) * 2017-12-15 2021-02-26 东莞理工学院 一种苯并噻唑黄原酸酯衍生物多功能润滑油添加剂及其制备方法与应用
CN114163396B (zh) * 2021-12-14 2022-10-04 北京阳光诺和药物研究股份有限公司 一种依帕司他中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4325959A (en) * 1979-08-09 1982-04-20 The Dow Chemical Company Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
US5347008A (en) * 1983-05-14 1994-09-13 Ciba-Geigy Corporation Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents
GB8313322D0 (en) * 1983-05-14 1983-06-22 Ciba Geigy Ag Heterocyclic-(cyclo)aliphatic carboxylic acids
EP0222576B1 (de) * 1985-11-07 1992-03-18 Pfizer Inc. Heterocyclische Oxophthalazinylessigsäure
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (de) * 1987-12-21 1990-08-16 Pfizer Inc. Heterozyklyl Oxophtalazynyl-Essigsäuren
IE914455A1 (en) * 1990-12-27 1992-07-01 Green Cross Corp 1,4-benzothiazine-2-acetic acid derivatives, processes for production thereof
JPH06172353A (ja) * 1992-09-21 1994-06-21 Senju Pharmaceut Co Ltd １，４−ベンゾオキサジン−２−酢酸誘導体及びそれを含有する糖尿病合併症治療剤
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
JP3126541B2 (ja) * 1993-03-26 2001-01-22 千寿製薬株式会社 ベンゾチアゾール誘導体、その製法及びその用途
JPH06279453A (ja) * 1993-03-29 1994-10-04 Green Cross Corp:The ピリドチアジン酢酸誘導体，その製法及びその用途

Also Published As

Publication number Publication date
EP0714893A1 (de) 1996-06-05
CA2163950A1 (en) 1996-05-30
DE69505484T2 (de) 1999-05-12
EP0714893B1 (de) 1998-10-21
US5700819A (en) 1997-12-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee