DE69431471D1 - Amide derivate als 5-ht1a liganden - Google Patents
Amide derivate als 5-ht1a ligandenInfo
- Publication number
- DE69431471D1 DE69431471D1 DE69431471T DE69431471T DE69431471D1 DE 69431471 D1 DE69431471 D1 DE 69431471D1 DE 69431471 T DE69431471 T DE 69431471T DE 69431471 T DE69431471 T DE 69431471T DE 69431471 D1 DE69431471 D1 DE 69431471D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date
- amide derivatives
- sec
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 title abstract 2
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939305672A GB9305672D0 (en) | 1993-03-19 | 1993-03-19 | Amide derivatives |
| PCT/GB1994/000455 WO1994021611A1 (en) | 1993-03-19 | 1994-03-09 | Amide derivatives as 5-ht1a ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69431471D1 true DE69431471D1 (de) | 2002-11-07 |
| DE69431471T2 DE69431471T2 (de) | 2003-07-10 |
Family
ID=10732342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69431471T Expired - Fee Related DE69431471T2 (de) | 1993-03-19 | 1994-03-09 | Amidderivate als 5-HT1A-Liganden |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5629323A (de) |
| EP (1) | EP0689534B1 (de) |
| JP (1) | JPH08507779A (de) |
| AT (1) | ATE225335T1 (de) |
| AU (1) | AU6149094A (de) |
| DE (1) | DE69431471T2 (de) |
| DK (1) | DK0689534T3 (de) |
| ES (1) | ES2181711T3 (de) |
| GB (1) | GB9305672D0 (de) |
| PH (1) | PH31589A (de) |
| PT (1) | PT689534E (de) |
| WO (1) | WO1994021611A1 (de) |
| ZA (1) | ZA941739B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
| US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
| US6906069B1 (en) | 1999-01-08 | 2005-06-14 | Amgen Inc. | LXR modulators |
| EP1394150B1 (de) | 1999-02-24 | 2011-01-19 | F. Hoffmann-La Roche AG | 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten |
| WO2001060818A1 (en) * | 2000-02-14 | 2001-08-23 | Tularik Inc. | Lxr modulators |
| US6673543B2 (en) | 2000-04-05 | 2004-01-06 | Tularik, Inc. | Solid phase synthesis of LXR ligands |
| EP1476425A4 (de) | 2002-01-30 | 2010-05-05 | Amgen Inc | Heterocyclische arylsulfonamidobenzyl verbindungen |
| TWI280239B (en) | 2003-07-15 | 2007-05-01 | Hoffmann La Roche | Process for preparation of pyridine derivatives |
| KR20080043852A (ko) | 2005-09-23 | 2008-05-19 | 에프. 호프만-라 로슈 아게 | 신규 투여 제형 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR241161A1 (es) * | 1984-07-30 | 1991-12-30 | Merrelll Dow Pharmaceuticals I | "procedimiento para la preparacion de derivados n-aminoalquilen sustituidos de la glutarimida" |
| JPH02138181A (ja) * | 1988-11-08 | 1990-05-28 | Ist Luso Farmaco Italia Spa | 血圧降下活生を有する２，２‐ジ置換２，３‐ジヒドロ‐１，４ベンゾジオキシン誘導体 |
| GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
| MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
-
1993
- 1993-03-19 GB GB939305672A patent/GB9305672D0/en active Pending
-
1994
- 1994-03-09 US US08/446,651 patent/US5629323A/en not_active Expired - Lifetime
- 1994-03-09 JP JP6520749A patent/JPH08507779A/ja not_active Withdrawn
- 1994-03-09 AU AU61490/94A patent/AU6149094A/en not_active Abandoned
- 1994-03-09 ES ES94908456T patent/ES2181711T3/es not_active Expired - Lifetime
- 1994-03-09 EP EP94908456A patent/EP0689534B1/de not_active Expired - Lifetime
- 1994-03-09 AT AT94908456T patent/ATE225335T1/de not_active IP Right Cessation
- 1994-03-09 PT PT94908456T patent/PT689534E/pt unknown
- 1994-03-09 WO PCT/GB1994/000455 patent/WO1994021611A1/en active IP Right Grant
- 1994-03-09 DK DK94908456T patent/DK0689534T3/da active
- 1994-03-09 DE DE69431471T patent/DE69431471T2/de not_active Expired - Fee Related
- 1994-03-11 ZA ZA941739A patent/ZA941739B/xx unknown
- 1994-03-17 PH PH47940A patent/PH31589A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA941739B (en) | 1995-09-11 |
| ATE225335T1 (de) | 2002-10-15 |
| EP0689534B1 (de) | 2002-10-02 |
| PH31589A (en) | 1998-11-03 |
| DK0689534T3 (da) | 2003-02-03 |
| JPH08507779A (ja) | 1996-08-20 |
| EP0689534A1 (de) | 1996-01-03 |
| ES2181711T3 (es) | 2003-03-01 |
| US5629323A (en) | 1997-05-13 |
| AU6149094A (en) | 1994-10-11 |
| DE69431471T2 (de) | 2003-07-10 |
| PT689534E (pt) | 2003-01-31 |
| WO1994021611A1 (en) | 1994-09-29 |
| GB9305672D0 (en) | 1993-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB9300194D0 (en) | Piperazine derivatives | |
| DE69431471D1 (de) | Amide derivate als 5-ht1a liganden | |
| DE69414855D1 (en) | N-(piperidinyl-1-alkyl)-substituierte cyclohexancarbonsäureamide als 5ht1a rezeptor antagonisten | |
| TW281673B (de) | ||
| DE59304311D1 (de) | N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika | |
| DE69526097D1 (de) | Bicyclische carboxamide als 5-ht1a rezeptoren liganden | |
| TW282458B (de) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |