DE69428142D1 - Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung - Google Patents

Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung

Info

Publication number
DE69428142D1
DE69428142D1 DE69428142T DE69428142T DE69428142D1 DE 69428142 D1 DE69428142 D1 DE 69428142D1 DE 69428142 T DE69428142 T DE 69428142T DE 69428142 T DE69428142 T DE 69428142T DE 69428142 D1 DE69428142 D1 DE 69428142D1
Authority
DE
Germany
Prior art keywords
quinoline
preparation
quinazoline derivatives
integer
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69428142T
Other languages
English (en)
Other versions
DE69428142T2 (de
Inventor
Takashi Sohda
Haruhiko Makino
Atsuo Baba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69428142D1 publication Critical patent/DE69428142D1/de
Application granted granted Critical
Publication of DE69428142T2 publication Critical patent/DE69428142T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE69428142T 1993-01-28 1994-01-27 Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung Expired - Fee Related DE69428142T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1262893 1993-01-28
JP20612893 1993-08-20

Publications (2)

Publication Number Publication Date
DE69428142D1 true DE69428142D1 (de) 2001-10-11
DE69428142T2 DE69428142T2 (de) 2002-07-04

Family

ID=26348258

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69428142T Expired - Fee Related DE69428142T2 (de) 1993-01-28 1994-01-27 Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung

Country Status (15)

Country Link
US (3) US5436247A (de)
EP (1) EP0608870B1 (de)
KR (1) KR100224135B1 (de)
CN (1) CN1041520C (de)
AT (1) ATE205199T1 (de)
AU (1) AU673213B2 (de)
CA (1) CA2114300C (de)
DE (1) DE69428142T2 (de)
FI (1) FI940414A (de)
HU (1) HU217907B (de)
NO (2) NO940245D0 (de)
NZ (1) NZ250761A (de)
RU (1) RU2132330C1 (de)
SG (1) SG50546A1 (de)
TW (1) TW256832B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW232013B (de) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
NO940245D0 (no) * 1993-01-28 1994-01-24 Takeda Chemical Industries Ltd Quinolin eller quinazolinderivater, deres fremstilling og anvendelse
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
AU1860995A (en) * 1994-03-08 1995-09-25 Takeda Chemical Industries Ltd. Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis
US5641788A (en) * 1994-06-07 1997-06-24 Takeda Chemical Industries, Ltd. Quinoline derivatives and pharmaceutical composition containing them
WO1996000223A1 (en) * 1994-06-24 1996-01-04 Takeda Chemical Industries, Ltd. Processes for production of quinoline or quinazoline derivatives and intermediates therefor
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
HUP9801628A2 (hu) * 1995-04-28 1999-01-28 Takeda Chemical Industries, Ltd. Artritisz elleni gyógyászati készítmények
DE19610882A1 (de) * 1996-03-20 1997-09-25 Dresden Arzneimittel Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
BR9809172A (pt) * 1997-05-28 2000-08-01 Rhone Poulenc Rorer Pharma Composto, composição farmacêutica, e, processos de inibir a atividade da tirosina cinase pdgf, a atividade da tirosina cinase lck, a proliferação celular, diferenciação ou liberação de mediador em um paciente, para tratar uma patologia ligada a um distúrbio hiperproliferativo, para tratar restenose e para tratar a inflamação em um paciente
EP1354603A1 (de) * 2000-12-26 2003-10-22 Takeda Chemical Industries, Ltd. Begleitmedikamente
DE03764677T1 (de) * 2002-07-15 2007-01-04 Scinopharm Taiwan, Ltd. Verfahren zur herstellung von imidazo(1,2-a)pyridin-3-acetamiden
WO2004041787A1 (ja) * 2002-11-06 2004-05-21 Nissan Chemical Industries, Ltd. キノリンカルバルデヒド類の製造方法
JP2006525357A (ja) * 2003-04-30 2006-11-09 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー プロテインチロシンホスファターゼ阻害物質としての置換ヘテロアリール類
US7937406B2 (en) * 2003-09-11 2011-05-03 Oracle America, Inc. Mechanism for automatically establishing a resource grid
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
AU2007227312A1 (en) * 2006-03-21 2007-09-27 Alza Corporation Hydratable polymeric ester matrix for drug electrotransport
UY32743A (es) 2009-06-25 2010-12-31 Amgen Inc Compuestos heterocíclicos y sus usos
MX2013005567A (es) 2010-11-17 2013-10-30 Amgen Inc Derivados de quinolina como inhibidores de pik3.
CA2873295A1 (en) * 2012-08-24 2014-02-27 F. Hoffmann-La Roche Ag New bicyclicpyridine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8827822D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
TW232013B (de) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
NO940245D0 (no) * 1993-01-28 1994-01-24 Takeda Chemical Industries Ltd Quinolin eller quinazolinderivater, deres fremstilling og anvendelse
WO1996000223A1 (en) * 1994-06-24 1996-01-04 Takeda Chemical Industries, Ltd. Processes for production of quinoline or quinazoline derivatives and intermediates therefor

Also Published As

Publication number Publication date
TW256832B (de) 1995-09-11
EP0608870B1 (de) 2001-09-05
NZ250761A (en) 1995-03-28
US5932592A (en) 1999-08-03
ATE205199T1 (de) 2001-09-15
KR100224135B1 (ko) 1999-10-15
SG50546A1 (en) 1998-07-20
AU5474294A (en) 1994-08-04
HU9400250D0 (en) 1994-05-30
US5770602A (en) 1998-06-23
HU217907B (hu) 2000-05-28
CA2114300A1 (en) 1994-07-29
US5436247A (en) 1995-07-25
HUT70194A (en) 1995-09-28
NO306992B1 (no) 2000-01-24
DE69428142T2 (de) 2002-07-04
FI940414A0 (fi) 1994-01-27
CN1105363A (zh) 1995-07-19
EP0608870A1 (de) 1994-08-03
CA2114300C (en) 2000-10-17
NO940245L (no) 1994-07-29
AU673213B2 (en) 1996-10-31
RU2132330C1 (ru) 1999-06-27
NO940245D0 (no) 1994-01-24
FI940414A (fi) 1994-07-29
CN1041520C (zh) 1999-01-06
KR940018381A (ko) 1994-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee