ATE173251T1 - Kondensierte pyrimidinderivate als antitumorverbindungen - Google Patents

Kondensierte pyrimidinderivate als antitumorverbindungen

Info

Publication number
ATE173251T1
ATE173251T1 AT92114005T AT92114005T ATE173251T1 AT E173251 T1 ATE173251 T1 AT E173251T1 AT 92114005 T AT92114005 T AT 92114005T AT 92114005 T AT92114005 T AT 92114005T AT E173251 T1 ATE173251 T1 AT E173251T1
Authority
AT
Austria
Prior art keywords
group
rdurule
same
chem
hydrogen
Prior art date
Application number
AT92114005T
Other languages
English (en)
Inventor
Hiroaki Nomura
Toru Haneda
Yoshihiko Kotake
Norohiro Ueda
Kyosuke Kitoh
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE173251T1 publication Critical patent/ATE173251T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT92114005T 1991-08-21 1992-08-17 Kondensierte pyrimidinderivate als antitumorverbindungen ATE173251T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20925291 1991-08-21
JP25154891 1991-09-30

Publications (1)

Publication Number Publication Date
ATE173251T1 true ATE173251T1 (de) 1998-11-15

Family

ID=26517317

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114005T ATE173251T1 (de) 1991-08-21 1992-08-17 Kondensierte pyrimidinderivate als antitumorverbindungen

Country Status (4)

Country Link
US (2) US5554615A (de)
EP (1) EP0530579B1 (de)
AT (1) ATE173251T1 (de)
DE (1) DE69227561T2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877178A (en) * 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5939420A (en) * 1991-04-08 1999-08-17 Duquesne University Of The Holy Ghost Pyrrolo 2,3d!derivatives
US6962920B2 (en) 1992-09-23 2005-11-08 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5468757A (en) * 1994-01-31 1995-11-21 Eli Lilly And Company 6-azaindole thromboxane synthase inhibitors
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
US6946554B2 (en) * 1996-12-10 2005-09-20 Biocryst Pharmaceuticals, Inc. Process for the preparation of 9-deazaguanine derivatives
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
CA2319810C (en) * 1998-02-10 2008-12-23 Gensia Sicor Inc. Propofol composition containing sulfite
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
US8946239B2 (en) * 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
US8252804B2 (en) * 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
EP3675864A4 (de) 2017-08-31 2022-02-16 Duquesne University of The Holy Spirit Erste vertreter von shmt2- und mthfd2-inhibitoren als antitumormittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
EP0530537B1 (de) * 1991-08-12 1997-01-08 Takeda Chemical Industries, Ltd. Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel

Also Published As

Publication number Publication date
EP0530579B1 (de) 1998-11-11
DE69227561T2 (de) 1999-06-02
US5688800A (en) 1997-11-18
US5554615A (en) 1996-09-10
DE69227561D1 (de) 1998-12-17
EP0530579A1 (de) 1993-03-10

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties