DE69321909D1 - Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen Meningitiden - Google Patents
Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen MeningitidenInfo
- Publication number
- DE69321909D1 DE69321909D1 DE69321909T DE69321909T DE69321909D1 DE 69321909 D1 DE69321909 D1 DE 69321909D1 DE 69321909 T DE69321909 T DE 69321909T DE 69321909 T DE69321909 T DE 69321909T DE 69321909 D1 DE69321909 D1 DE 69321909D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- monoclonal antibodies
- bacterial meningitis
- tnf monoclonal
- bacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93793992A | 1992-08-28 | 1992-08-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69321909D1 true DE69321909D1 (de) | 1998-12-10 |
DE69321909T2 DE69321909T2 (de) | 1999-04-01 |
Family
ID=25470604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69321909T Expired - Lifetime DE69321909T2 (de) | 1992-08-28 | 1993-08-16 | Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen Meningitiden |
Country Status (6)
Country | Link |
---|---|
US (1) | US5616321A (de) |
EP (1) | EP0585705B1 (de) |
AT (1) | ATE172880T1 (de) |
DE (1) | DE69321909T2 (de) |
DK (1) | DK0585705T3 (de) |
ES (1) | ES2121907T3 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
DE69427928T3 (de) † | 1993-03-05 | 2012-05-10 | Bayer Healthcare Llc | Humane monoklonale anti-TNF alpha Antikörper |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
EP3299393A1 (de) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Gegen den tumornekrosefaktor-alpha gerichtete antikörper mit einfacher domäne und verwendungen dafür |
ES2347239T3 (es) * | 2002-12-02 | 2010-10-27 | Amgen Fremont Inc. | Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos. |
US7101978B2 (en) * | 2003-01-08 | 2006-09-05 | Applied Molecular Evolution | TNF-α binding molecules |
JP4484664B2 (ja) * | 2003-11-27 | 2010-06-16 | キヤノン株式会社 | 記録ヘッドカートリッジ |
US7435799B2 (en) * | 2004-01-08 | 2008-10-14 | Applied Molecular Evolution | TNF-α binding molecules |
TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
NZ591701A (en) | 2005-05-16 | 2012-11-30 | Abbott Biotech Ltd | Use of tnf inhibitor for treatment of erosive polyarthritis |
PL1888641T3 (pl) | 2005-05-18 | 2012-05-31 | Ablynx Nv | Białka wiążące albuminę surowicy |
TWI392684B (zh) | 2006-04-05 | 2013-04-11 | Abbott Biotech Ltd | 抗體之純化 |
US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN103764824B (zh) | 2011-06-20 | 2018-04-24 | 西奈山医学院 | 粘多糖贮积症和其它溶酶体病症的抗TNF-α疗法 |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
JP6134392B2 (ja) | 2013-01-25 | 2017-05-24 | サイモン・エルエルシー | 循環している生物学的に活性な可溶性tnfの選択的低減用の組成物およびtnf媒介性疾患を処置する方法 |
WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
EP2803365A1 (de) | 2013-05-14 | 2014-11-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Verwendung von Clonazepam in Verbindung mit Antibiotika bei der Behandlung von bakteriell verursachter Meningitis |
EP3052640A2 (de) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
WO2016160976A2 (en) | 2015-03-30 | 2016-10-06 | Abbvie Inc. | Monovalent tnf binding proteins |
EP3078675A1 (de) | 2015-04-10 | 2016-10-12 | Ares Trading S.A. | Induktionsdosierschema zur behandlung von krankheiten die von tnf alpha verursacht sind |
US10465003B2 (en) | 2016-02-05 | 2019-11-05 | Janssen Biotech, Inc. | Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes |
JOP20190162A1 (ar) | 2016-12-30 | 2019-06-27 | Biocad Joint Stock Co | تركيبة صيدلانية مائية من جسم مضاد لـ tnf? أحادي النسيلة معاود الارتباط الجيني |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL73883A (en) * | 1984-12-20 | 1990-12-23 | Yeda Res & Dev | Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha |
DE3631229A1 (de) * | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
EP0288088B1 (de) * | 1987-04-24 | 1994-03-09 | Teijin Limited | Bestimmung vom Tumornekrosefaktor; monoklonaler Antikörper und Zusammensetzung |
GB8806339D0 (en) * | 1988-03-17 | 1988-04-13 | Hoffmann La Roche | Monoclonal antibodies |
AU626572B2 (en) * | 1988-07-18 | 1992-08-06 | Chiron Corporation | Monoclonal antibodies reactive with cachectin |
EP0355067A1 (de) * | 1988-08-19 | 1990-02-21 | Celltech Limited | Arzneimittel gegen bösartige Gewebeneubildung |
US5360716A (en) * | 1988-10-24 | 1994-11-01 | Otsuka Pharmaceutical Co., Ltd. | Human tumor necrosis factor αspecific monoclonal antibody and method for detecting human tumor necrosis factor α |
GB8905400D0 (en) * | 1989-03-09 | 1989-04-19 | Jonker Margreet | Medicaments |
GB8921123D0 (en) * | 1989-09-19 | 1989-11-08 | Millar Ann B | Treatment of ards |
CA2090401A1 (en) * | 1990-08-27 | 1992-02-28 | Deborah A. Rathjen | Method of treating viral infection |
GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
DE07012626T1 (de) * | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE69312077T2 (de) * | 1992-10-08 | 1997-10-30 | Kennedy Inst Of Rheumatology | Behandlung von autoimmun- und entzundungskrankheiten |
GB9225448D0 (en) * | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
EP0732938A4 (de) * | 1993-12-01 | 1997-03-19 | Unisearch Ltd | Verfahren zur behandlung von intestinalen störungen |
-
1993
- 1993-08-16 DE DE69321909T patent/DE69321909T2/de not_active Expired - Lifetime
- 1993-08-16 EP EP93113072A patent/EP0585705B1/de not_active Expired - Lifetime
- 1993-08-16 ES ES93113072T patent/ES2121907T3/es not_active Expired - Lifetime
- 1993-08-16 DK DK93113072T patent/DK0585705T3/da active
- 1993-08-16 AT AT93113072T patent/ATE172880T1/de active
-
1995
- 1995-03-23 US US08/410,006 patent/US5616321A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0585705T3 (da) | 1999-07-26 |
DE69321909T2 (de) | 1999-04-01 |
ATE172880T1 (de) | 1998-11-15 |
US5616321A (en) | 1997-04-01 |
ES2121907T3 (es) | 1998-12-16 |
EP0585705A1 (de) | 1994-03-09 |
EP0585705B1 (de) | 1998-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE172880T1 (de) | Verwendung von monoklonalen anti-tnf-antikörpern für die behandlung von bakteriellen meningitiden | |
DE68927671D1 (de) | Produkte zur Behandlung des Endotoxin -Schocks bei einem Säugetier | |
ATE249518T1 (de) | Humanisierter antikörper gegen cd18 | |
ATE117434T1 (de) | Gefriergetrocknete zusammensetzung, die ein mit meerrettichperoxydase markiertes fab'-fragment eines gegen menschliches beta-interferon gerichteten antikörpers und trehalose enthält; eia kit, der diese zusammensetzung enthält. | |
GR3026750T3 (en) | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein. | |
DE69221501T2 (de) | Verfahren zum vermindern von durch medizinische vorrichtungen bedingten infektionen | |
DE69733960D1 (de) | Verwendung von antikörpen gegen cd45ro leukozytenantigen zur immunmodulation | |
ATE155043T1 (de) | Behandlung von autoimmun- und entzundungskrankheiten | |
GB9125768D0 (en) | Therapeutic method | |
DE69424915D1 (de) | Verwendung von 1-2-4-Benzotriazinoxiden zur Herstellung eines Arzneimittels zur Behandlung von Tumoren | |
DE68921979T2 (de) | Antikörper für die antilymphozyten-antikörpertherapie. | |
DE69426767D1 (de) | Anti idiotypische Antikörper gegen Gonococcen und diese verwendende Verfahren und Zusammensetzungen. | |
EA200400930A1 (ru) | Блокирующее моноклональное антитело к vla-1 или его применение для лечения воспалительных заболеваний | |
AU2456888A (en) | Monoclonal antibodies specific for HIV and hybridomas for their production | |
RU93004678A (ru) | Противомикробные производные карбапенема, способы их получения и применение | |
DK0792162T3 (da) | Anvendelse af antistoffer til blokering af virkningerne af grampositive bakterier og mycobakterier | |
ATE28214T1 (de) | Malolaktisches gaerungsverfahren. | |
NO934655L (no) | Legemiddel for gram-positive sykdommer i akvatiske arter | |
ATE222927T1 (de) | Monoklonaler antikörper gegen den tumorzytotoxischen faktor ii (tcf-ii) | |
DE59008759D1 (de) | Verwendung von interleukin-2 zur behandlung der endotoxinämie. | |
ATE33842T1 (de) | Immuninterferon und verfahren zu seiner reinigung. | |
EP0321094A3 (de) | Behandlung von Faktor-VIII-Inhibitoren | |
DE68924963D1 (de) | Zusammensetzungen und Methoden zur Behandlung und Vorbeugung von Gram-Negativen-Infektionen. | |
EA200101271A1 (ru) | Блокирующее моноклональное антитело к vla-1 и его применение для лечения воспалительных заболеваний | |
TR199700791T1 (xx) | Kendiliğinden bağışıklığı olan hastalıkların ve allograft rejeksiyonun tedavisi için LCK SH2 spesifik bileşimlerinin kullanılması. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |