DE69232287D1 - Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards - Google Patents

Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards

Info

Publication number
DE69232287D1
DE69232287D1 DE69232287T DE69232287T DE69232287D1 DE 69232287 D1 DE69232287 D1 DE 69232287D1 DE 69232287 T DE69232287 T DE 69232287T DE 69232287 T DE69232287 T DE 69232287T DE 69232287 D1 DE69232287 D1 DE 69232287D1
Authority
DE
Germany
Prior art keywords
myocard
composition
reperfusion damage
adenosine
reducing reperfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232287T
Other languages
English (en)
Other versions
DE69232287T2 (de
Inventor
Mervyn B Forman
Edwin K Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of DE69232287D1 publication Critical patent/DE69232287D1/de
Application granted granted Critical
Publication of DE69232287T2 publication Critical patent/DE69232287T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Dental Preparations (AREA)
DE69232287T 1991-05-22 1992-03-26 Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards Expired - Fee Related DE69232287T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/704,058 US5206222A (en) 1991-05-22 1991-05-22 Methods for the reduction of myocardial reperfusion injury
PCT/US1992/002528 WO1992020346A1 (en) 1991-05-22 1992-03-26 Method and composition to reduce myocardial reperfusion injury

Publications (2)

Publication Number Publication Date
DE69232287D1 true DE69232287D1 (de) 2002-01-24
DE69232287T2 DE69232287T2 (de) 2002-07-25

Family

ID=24827883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232287T Expired - Fee Related DE69232287T2 (de) 1991-05-22 1992-03-26 Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards

Country Status (7)

Country Link
US (1) US5206222A (de)
EP (1) EP0589964B1 (de)
JP (1) JPH06510751A (de)
AT (1) ATE210449T1 (de)
CA (1) CA2103458C (de)
DE (1) DE69232287T2 (de)
WO (1) WO1992020346A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
US5629298A (en) * 1995-03-13 1997-05-13 University Of Massachusetts Medical Center Adenosine as a positive inotrop in the compromised heart
CA2299320A1 (en) * 1997-09-22 1999-04-01 Item Development Ab New method of treatment
CA2305726A1 (en) * 1997-10-07 1999-04-15 Regents Of The University Of California Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine
US6015384A (en) * 1998-08-31 2000-01-18 Acuson Corporation Ultrasonic system and method for tissue viability imaging
ATE361667T1 (de) * 1999-03-23 2007-06-15 Hibernation Therapeutics Ltd Stoppen, schützen und konservieren von organen
US6368573B1 (en) * 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6599283B1 (en) * 2001-05-04 2003-07-29 Cv Therapeutics, Inc. Method of preventing reperfusion injury
DE10258770B4 (de) * 2001-12-18 2005-02-10 F. Hoffmann-La Roche Ag Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
GB2412067B (en) * 2002-12-23 2007-11-14 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery (2)
AU2003291847B2 (en) * 2002-12-23 2010-12-02 Hibernation Therapeutics, A Kf Llc Organ preconditioning, arrest, protection, preservation and recovery
WO2005117910A2 (en) * 2004-05-26 2005-12-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
US20110076255A1 (en) * 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
NZ568392A (en) * 2005-11-30 2011-07-29 Inotek Pharmaceuticals Corp Purine derivatives and methods of use thereof
CA2688028A1 (en) 2006-05-29 2007-12-06 Hibernation Therapeutics Limited Improved tissue maintenance
KR101490836B1 (ko) * 2006-07-25 2015-02-09 하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨 외상 치료법
AU2008222595B2 (en) 2007-03-02 2014-03-27 Hibernation Therapeutics, A Kf Llc Transplants
US20080269109A1 (en) * 2007-04-30 2008-10-30 Becker Lance B System and method of resuscitation of a mammal
US20090136460A1 (en) * 2007-07-10 2009-05-28 Vanderbilt University Use of adenosine receptor ligands to promote cell adhesion in cell-based therapies
EP2219442A4 (de) * 2007-07-25 2012-05-02 Hibernation Therapeutics Ltd Verbesserter organschutz, verbesserte organkonservierung und verbesserte organerholung
US20090218349A1 (en) * 2008-02-29 2009-09-03 Silgan Containers Corporation Vacuum container with protective features
LT2523669T (lt) 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
WO2011119969A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
RS56150B1 (sr) 2012-01-26 2017-11-30 Inotek Pharmaceuticals Corp Anhidrovani polimorfi (2r,3s,4r,5r)-5-(6-(ciklopentilamino)-9h-purin-9-yl)-3,4-dihidroksitetrahidrofuran-2-yl)} metil-nitrata i postupak njegove pripreme
KR20150139501A (ko) 2013-03-15 2015-12-11 이노텍 파마슈티컬스 코포레이션 안과용 제형
WO2015006827A1 (en) 2013-07-17 2015-01-22 Hts Therapeutics Pty Ltd A method for inducing whole body arrest

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0696534B2 (ja) * 1986-04-25 1994-11-30 ヘキストジヤパン株式会社 抗痴呆剤
EP0263071B1 (de) * 1986-09-30 1992-08-12 Ciba-Geigy Ag 2-Substituierte-e-kondensierte[1,2,4]Triazolo-[1,5-c]pyrimidine, pharmazeutische Zubereitungen und ihre Verwendung
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
AU3820989A (en) * 1988-08-02 1990-02-08 Ciba-Geigy Ag 7-amino-3-beta-d-ribofuranosyl-3h-imidazo(4,5-b) pyridin-5-amine derivatives
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物

Also Published As

Publication number Publication date
CA2103458A1 (en) 1992-11-23
CA2103458C (en) 2000-11-14
ATE210449T1 (de) 2001-12-15
US5206222A (en) 1993-04-27
JPH06510751A (ja) 1994-12-01
DE69232287T2 (de) 2002-07-25
EP0589964B1 (de) 2001-12-12
EP0589964A1 (de) 1994-04-06
EP0589964A4 (en) 1994-05-25
WO1992020346A1 (en) 1992-11-26

Similar Documents

Publication Publication Date Title
DE69232287D1 (de) Verfahren und zusammensetzung zur verminderung von reperfusionsschäden des myokards
ATE188341T1 (de) Konservierungsmittel und verfahren zur behandlung von holz
BR9304988A (pt) Composições auto-dispersáveis em água contendo organopolissiloxano e processo para o tratamento de madeira
RU93048466A (ru) Применение бензотиофенов для профилактики и лечения остеопороза и фармацевтическая композиция на их основе
ATE133564T1 (de) Flupirtin in kombination mit antiparkinsonika zur bekämpfung von muskelverspannungen
ATE110958T1 (de) Verwendung von sertralin zur behandlung verfrühter ejakulation.
DK0920309T3 (da) Konjugeret linolensyre til bevaring eller forøgelse af mineralindhold i knogler
ATE331515T1 (de) Verwendung von n-substituirten-1,5-dideoxy-1,5- imino-d-glucitolen zur behandlung von hepatitis infektionen
ATE190840T1 (de) Zusammensetzung zur behandlung der parkinson- krankheit
FI831230L (fi) N-glykosylerade karboxylsyraamidderivat, foerfarande foer deras framstaellning samt deras anvaendnifoer att paoverka kroppens eget foersvar
CA2070685A1 (en) Method for treating painful, inflammatory or allergic disorders
DE3576834D1 (de) Oberflaechlich behandeltes magnesium oder dessen legierungen und verfahren zum oberflaechenbehandeln.
ATE271873T1 (de) Verwendung von glukosamin und glukosaminderivaten zur schnellen linderung von juckreiz oder lokalisiertem schmerz
DE3650620D1 (de) Behandlungsverfahren kataboler dysfunktion
DE69113221D1 (en) Antiatherosclerotische und antithrombotische 2-amino-6-phenyl-4h-pyran-4-one.
WO1998032428A3 (en) Compositions comprising choline and use of choline to treat endotoxic shock
TR28228A (tr) Deri gönlerinin islak muamelesi.
DE69429856D1 (de) Substituierte caprolactame und deren derivate verwendbar zur behandlung der hiv-krankheit
RO92632B (ro) Compozitie farmaceutica sinergica pentru tratamentul inflamatiilor pancreasului
DE69818809D1 (de) Verfahren zur behandlung von narbengewebe
BR8403770A (pt) Concentrado,composicao de tratamento de materiais do solo e processo para o tratamento de materiais do solo
DE69314022D1 (de) Derivate von 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranen
DE3864615D1 (de) Verfahren und anordnung zur behandlung von bei verbrennung schadstoffe freisetzendem holz, bzw. holzkohle.
ATE253438T1 (de) Mittel und verfahren zur schutzbehandlung von holz
EP0381142A3 (de) Methode zur Verwendung von Aryl- oder Heteroaryl-1-alkyl-pyrrol-2-carbonsäure-Derivaten in der Behandlung von Krankheiten in Verbindung mit Interleukin-1

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee