DE69231661T2 - Antifungizide trisubstituierte tetrahydrofurane - Google Patents

Antifungizide trisubstituierte tetrahydrofurane

Info

Publication number
DE69231661T2
DE69231661T2 DE69231661T DE69231661T DE69231661T2 DE 69231661 T2 DE69231661 T2 DE 69231661T2 DE 69231661 T DE69231661 T DE 69231661T DE 69231661 T DE69231661 T DE 69231661T DE 69231661 T2 DE69231661 T2 DE 69231661T2
Authority
DE
Germany
Prior art keywords
antifungicide
tetrahydrofurane
trisubstituted
chem
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231661T
Other languages
English (en)
Other versions
DE69231661D1 (de
Inventor
K Saksena
M Girijavallabhan
K Ganguly
G Lovey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69231661D1 publication Critical patent/DE69231661D1/de
Application granted granted Critical
Publication of DE69231661T2 publication Critical patent/DE69231661T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
DE69231661T 1991-10-30 1992-10-28 Antifungizide trisubstituierte tetrahydrofurane Expired - Lifetime DE69231661T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78535791A 1991-10-30 1991-10-30
US90726292A 1992-07-01 1992-07-01
PCT/US1992/008981 WO1993009114A1 (en) 1991-10-30 1992-10-28 Tri-substituted tetrahydrofuran antifungals

Publications (2)

Publication Number Publication Date
DE69231661D1 DE69231661D1 (de) 2001-03-01
DE69231661T2 true DE69231661T2 (de) 2001-08-02

Family

ID=27120397

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231661T Expired - Lifetime DE69231661T2 (de) 1991-10-30 1992-10-28 Antifungizide trisubstituierte tetrahydrofurane

Country Status (22)

Country Link
EP (2) EP0610377B1 (de)
JP (1) JP3210017B2 (de)
CN (1) CN1037267C (de)
AT (1) ATE198888T1 (de)
AU (1) AU665218B2 (de)
CA (1) CA2122270C (de)
CZ (1) CZ102794A3 (de)
DE (1) DE69231661T2 (de)
ES (1) ES2153364T3 (de)
FI (1) FI941986A0 (de)
HR (1) HRP921145A2 (de)
HU (1) HUT70742A (de)
IL (1) IL103558A0 (de)
MX (1) MX9206222A (de)
MY (1) MY109529A (de)
NO (1) NO941589L (de)
NZ (1) NZ244910A (de)
SG (1) SG42920A1 (de)
SI (1) SI9200285A (de)
SK (1) SK48894A3 (de)
WO (1) WO1993009114A1 (de)
YU (1) YU94792A (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5349099A (en) * 1993-12-13 1994-09-20 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5693626A (en) * 1993-12-21 1997-12-02 Schering Corporation Tetrahydrofuran antifungals
US5703079A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
US5710154A (en) * 1993-12-21 1998-01-20 Schering Corporation Tetrahydrofuran antifungals
SK283035B6 (sk) * 1993-12-21 2003-02-04 Schering Corporation Tetrahydrofuránová zlúčenina, spôsob jej prípravy, jej farmaceuticky prijateľný ester, soľ a farmaceutický prostriedok
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
US5714490A (en) * 1993-12-21 1998-02-03 Schering Corporation Tetrahydrofuran antifungals
US5703236A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
JP3764750B2 (ja) * 1994-01-24 2006-04-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 水溶性アゾール抗真菌剤
WO1995028374A1 (fr) * 1994-04-19 1995-10-26 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Procede de production de derive de triazole
US5442093A (en) * 1994-05-09 1995-08-15 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5486625A (en) * 1994-07-08 1996-01-23 Schering Corporation Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents
US5702928A (en) * 1994-07-18 1997-12-30 Daicel Chemical Industries, Ltd. Process for producing optically active triazole compounds and method of racemizing optically active triazole compounds
US5616777A (en) * 1995-04-19 1997-04-01 Schering Corporation Chiral hydrazine derivatives
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
CN1073109C (zh) * 1995-06-02 2001-10-17 先灵公司 四氢呋喃杀真菌剂
MX9710270A (es) * 1995-06-19 1998-08-30 Schering Corp Fungicidas de tetrahidrofurano.
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
TW593312B (en) 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
CN1125067C (zh) * 1997-10-07 2003-10-22 先灵公司 结晶抗真菌多晶型物
MXPA04010066A (es) * 2002-04-12 2004-12-13 Ranbaxy Lab Ltd Derivados de tetrahidrofurano 2,2,4-trisubstituido como agentes antifungicos.
CN102892763B (zh) 2010-05-19 2016-03-09 桑多斯股份公司 泊沙康唑及泊沙康唑中间体的纯化
BR112012029225B1 (pt) 2010-05-19 2020-10-27 Sandoz Ag processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral
MX338514B (es) 2010-05-19 2016-04-20 Sandoz Ag Preparacion de intermediarios de posaconazol.
CA2798002C (en) 2010-05-19 2019-12-03 Sandoz Ag Process for the preparation of chiral triazolones
CN108329303A (zh) 2011-06-16 2018-07-27 桑多斯股份公司 制备手性化合物的方法
KR102240329B1 (ko) * 2013-06-07 2021-04-14 더 스크립스 리서치 인스티튜트 섬유증의 소분자 억제제
CN106397417A (zh) * 2016-08-30 2017-02-15 甘肃皓天化学科技有限公司 用于制备泊沙康唑的中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
DK354185A (da) 1984-08-31 1986-03-01 Hoffmann La Roche 1,3-dioxolanderivater
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5006513A (en) 1987-11-09 1991-04-09 Miles Inc. Antimycotic compositions of nikkomycin compounds and azole antimycotica
DE3852477T2 (de) 1987-11-20 1995-05-04 Schering Corp Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte.
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
US5039676A (en) 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US20040220100A1 (en) 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems

Also Published As

Publication number Publication date
AU2916992A (en) 1993-06-07
DE69231661D1 (de) 2001-03-01
HRP921145A2 (en) 1994-08-31
MX9206222A (es) 1993-04-01
NO941589D0 (de) 1994-04-29
HUT70742A (en) 1995-10-30
SK48894A3 (en) 1995-02-08
CA2122270A1 (en) 1993-05-13
NO941589L (de) 1994-06-23
EP0539938A1 (de) 1993-05-05
CA2122270C (en) 2006-05-23
CN1073944A (zh) 1993-07-07
MY109529A (en) 1997-02-28
WO1993009114A1 (en) 1993-05-13
HU9401256D0 (en) 1994-08-29
SI9200285A (en) 1993-06-30
IL103558A0 (en) 1993-03-15
SG42920A1 (en) 1997-10-17
JP3210017B2 (ja) 2001-09-17
NZ244910A (en) 1996-01-26
FI941986A (fi) 1994-04-29
EP0610377A1 (de) 1994-08-17
CZ102794A3 (en) 1995-03-15
ATE198888T1 (de) 2001-02-15
AU665218B2 (en) 1995-12-21
ES2153364T3 (es) 2001-03-01
YU94792A (sh) 1995-12-04
CN1037267C (zh) 1998-02-04
EP0610377B1 (de) 2001-01-24
JPH07500605A (ja) 1995-01-19
FI941986A0 (fi) 1994-04-29

Similar Documents

Publication Publication Date Title
DE69231661D1 (de) Antifungizide trisubstituierte tetrahydrofurane
AU3822193A (en) Azole compounds, their production and use
CA2076430A1 (en) Pyrrolidylthiocarbapenem derivative
TW268005B (de)
TW290546B (de)
AU7299694A (en) Azole compounds, their production and use
EP0601191A4 (en) Novel tetracyclic compound.
GR3007219T3 (de)
DE3477781D1 (en) Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments
ATE105565T1 (de) Pradimicinderivate.
TW275629B (de)
MY109672A (en) Azole compounds, their production and use

Legal Events

Date Code Title Description
8364 No opposition during term of opposition