ATE198888T1 - Antifungizide trisubstituierte tetrahydrofurane - Google Patents
Antifungizide trisubstituierte tetrahydrofuraneInfo
- Publication number
- ATE198888T1 ATE198888T1 AT92923060T AT92923060T ATE198888T1 AT E198888 T1 ATE198888 T1 AT E198888T1 AT 92923060 T AT92923060 T AT 92923060T AT 92923060 T AT92923060 T AT 92923060T AT E198888 T1 ATE198888 T1 AT E198888T1
- Authority
- AT
- Austria
- Prior art keywords
- antifungicide
- tetrahydrofuranes
- trisubstituted
- chem
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78535791A | 1991-10-30 | 1991-10-30 | |
| US90726292A | 1992-07-01 | 1992-07-01 | |
| PCT/US1992/008981 WO1993009114A1 (en) | 1991-10-30 | 1992-10-28 | Tri-substituted tetrahydrofuran antifungals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE198888T1 true ATE198888T1 (de) | 2001-02-15 |
Family
ID=27120397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92923060T ATE198888T1 (de) | 1991-10-30 | 1992-10-28 | Antifungizide trisubstituierte tetrahydrofurane |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0539938A1 (de) |
| JP (1) | JP3210017B2 (de) |
| CN (1) | CN1037267C (de) |
| AT (1) | ATE198888T1 (de) |
| AU (1) | AU665218B2 (de) |
| CA (1) | CA2122270C (de) |
| CZ (1) | CZ102794A3 (de) |
| DE (1) | DE69231661T2 (de) |
| ES (1) | ES2153364T3 (de) |
| FI (1) | FI941986A0 (de) |
| HR (1) | HRP921145A2 (de) |
| HU (1) | HUT70742A (de) |
| IL (1) | IL103558A0 (de) |
| MX (1) | MX9206222A (de) |
| MY (1) | MY109529A (de) |
| NO (1) | NO941589L (de) |
| NZ (1) | NZ244910A (de) |
| SG (1) | SG42920A1 (de) |
| SI (1) | SI9200285A (de) |
| SK (1) | SK48894A3 (de) |
| WO (1) | WO1993009114A1 (de) |
| YU (1) | YU94792A (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5661151A (en) * | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| US5693626A (en) * | 1993-12-21 | 1997-12-02 | Schering Corporation | Tetrahydrofuran antifungals |
| ATE204875T1 (de) * | 1993-12-21 | 2001-09-15 | Schering Corp | Fungizide tetrahydrofurane |
| US5710154A (en) * | 1993-12-21 | 1998-01-20 | Schering Corporation | Tetrahydrofuran antifungals |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703079A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703236A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| ES2141329T3 (es) * | 1994-01-24 | 2000-03-16 | Janssen Pharmaceutica Nv | Antifungicos azolicos solubles en agua. |
| DE69521857T2 (de) * | 1994-04-19 | 2002-01-17 | Kanegafuchi Chemical Ind | Verfahren zur herstellung von optisch aktiven 2-aryl-3-acyloxy-1,2-propandiolen |
| US5442093A (en) * | 1994-05-09 | 1995-08-15 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| WO1996002664A1 (fr) * | 1994-07-18 | 1996-02-01 | Daicel Chemical Industries, Ltd. | Procede pour produire et racemiser un compose triazole optiquement actif |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| US5616777A (en) * | 1995-04-19 | 1997-04-01 | Schering Corporation | Chiral hydrazine derivatives |
| SK27097A3 (en) * | 1995-06-02 | 1997-09-10 | Schering Corp | Tetrahydrofuran antifungals |
| MX9710270A (es) * | 1995-06-19 | 1998-08-30 | Schering Corp | Fungicidas de tetrahidrofurano. |
| US5698557A (en) * | 1995-06-19 | 1997-12-16 | Schering Corporation | Hydroxy-substituted antifungals |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| TW593312B (en) | 1997-07-11 | 2004-06-21 | Janssen Pharmaceutica Nv | 2,4,4-trisubstituted-1,3-dioxolane antifungals |
| EP1021439B1 (de) * | 1997-10-07 | 2004-03-31 | Schering Corporation | Krytallinischer fungizider polymorph |
| EA200401336A1 (ru) * | 2002-04-12 | 2006-02-24 | Ранбакси Лабораторис Лимитед | Производные 2,2,4-тризамещенного тетрагидрофурана в качестве противогрибковых средств |
| AU2011254656B2 (en) | 2010-05-19 | 2015-04-16 | Sandoz Ag | Process for the preparation of chiral hydrazides |
| AU2011254658B2 (en) | 2010-05-19 | 2016-02-18 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| CN102906087B (zh) | 2010-05-19 | 2016-03-23 | 桑多斯股份公司 | 制备手性***酮的方法 |
| WO2011144656A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Preparation of posaconazole intermediates |
| CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
| KR102240329B1 (ko) * | 2013-06-07 | 2021-04-14 | 더 스크립스 리서치 인스티튜트 | 섬유증의 소분자 억제제 |
| CN106397417A (zh) * | 2016-08-30 | 2017-02-15 | 甘肃皓天化学科技有限公司 | 用于制备泊沙康唑的中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4218458A (en) * | 1978-06-23 | 1980-08-19 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| DK354185A (da) * | 1984-08-31 | 1986-03-01 | Hoffmann La Roche | 1,3-dioxolanderivater |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| US5006513A (en) | 1987-11-09 | 1991-04-09 | Miles Inc. | Antimycotic compositions of nikkomycin compounds and azole antimycotica |
| JPH0717634B2 (ja) * | 1987-11-20 | 1995-03-01 | シェリング・コーポレーション | トリ‐およびテトラ‐置換‐オキセタンおよびテトラヒドロフランおよびその中間体 |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| NZ233502A (en) * | 1989-06-09 | 1991-11-26 | Janssen Pharmaceutica Nv | 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
-
1992
- 1992-10-27 IL IL103558A patent/IL103558A0/xx unknown
- 1992-10-28 CA CA002122270A patent/CA2122270C/en not_active Expired - Lifetime
- 1992-10-28 ES ES92923060T patent/ES2153364T3/es not_active Expired - Lifetime
- 1992-10-28 SG SG1996000735A patent/SG42920A1/en unknown
- 1992-10-28 EP EP92118413A patent/EP0539938A1/de active Pending
- 1992-10-28 AT AT92923060T patent/ATE198888T1/de active
- 1992-10-28 NZ NZ244910A patent/NZ244910A/en unknown
- 1992-10-28 SK SK488-94A patent/SK48894A3/sk unknown
- 1992-10-28 EP EP92923060A patent/EP0610377B1/de not_active Expired - Lifetime
- 1992-10-28 DE DE69231661T patent/DE69231661T2/de not_active Expired - Lifetime
- 1992-10-28 MX MX9206222A patent/MX9206222A/es unknown
- 1992-10-28 AU AU29169/92A patent/AU665218B2/en not_active Ceased
- 1992-10-28 JP JP50846493A patent/JP3210017B2/ja not_active Expired - Fee Related
- 1992-10-28 WO PCT/US1992/008981 patent/WO1993009114A1/en active IP Right Grant
- 1992-10-28 MY MYPI92001943A patent/MY109529A/en unknown
- 1992-10-28 CZ CZ941027A patent/CZ102794A3/cs unknown
- 1992-10-28 HU HU9401256A patent/HUT70742A/hu unknown
- 1992-10-29 YU YU94792A patent/YU94792A/sh unknown
- 1992-10-29 SI SI19929200285A patent/SI9200285A/sl unknown
- 1992-10-29 CN CN92113399A patent/CN1037267C/zh not_active Expired - Fee Related
- 1992-10-29 HR HR921145A patent/HRP921145A2/hr not_active Application Discontinuation
-
1994
- 1994-04-29 NO NO941589A patent/NO941589L/no unknown
- 1994-04-29 FI FI941986A patent/FI941986A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO941589L (de) | 1994-06-23 |
| JPH07500605A (ja) | 1995-01-19 |
| SG42920A1 (en) | 1997-10-17 |
| AU665218B2 (en) | 1995-12-21 |
| HUT70742A (en) | 1995-10-30 |
| CN1073944A (zh) | 1993-07-07 |
| FI941986A (fi) | 1994-04-29 |
| NZ244910A (en) | 1996-01-26 |
| YU94792A (sh) | 1995-12-04 |
| FI941986A0 (fi) | 1994-04-29 |
| MX9206222A (es) | 1993-04-01 |
| DE69231661T2 (de) | 2001-08-02 |
| JP3210017B2 (ja) | 2001-09-17 |
| AU2916992A (en) | 1993-06-07 |
| EP0539938A1 (de) | 1993-05-05 |
| EP0610377A1 (de) | 1994-08-17 |
| WO1993009114A1 (en) | 1993-05-13 |
| SI9200285A (en) | 1993-06-30 |
| IL103558A0 (en) | 1993-03-15 |
| CA2122270C (en) | 2006-05-23 |
| CZ102794A3 (en) | 1995-03-15 |
| NO941589D0 (de) | 1994-04-29 |
| HU9401256D0 (en) | 1994-08-29 |
| MY109529A (en) | 1997-02-28 |
| CA2122270A1 (en) | 1993-05-13 |
| CN1037267C (zh) | 1998-02-04 |
| SK48894A3 (en) | 1995-02-08 |
| EP0610377B1 (de) | 2001-01-24 |
| ES2153364T3 (es) | 2001-03-01 |
| DE69231661D1 (de) | 2001-03-01 |
| HRP921145A2 (en) | 1994-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE198888T1 (de) | Antifungizide trisubstituierte tetrahydrofurane | |
| LU91519I2 (fr) | "Doripenem et ses dérivés pharmaceutiquement acceptables - DORIBAXr" | |
| AU3822193A (en) | Azole compounds, their production and use | |
| HUT54357A (en) | Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients | |
| TW268005B (de) | ||
| TW290546B (de) | ||
| AU7299694A (en) | Azole compounds, their production and use | |
| IE883860L (en) | Novel antiarrhythmic agents ii | |
| FI95247C (fi) | Menetelmä lääkeaineina käytettävien 1,3-tiatsolidinien -karbonyylikarboksiamidien valmistamiseksi | |
| GR3007219T3 (de) | ||
| DE3477781D1 (en) | Spiro(indolo(1,7-ab)(1,5)benzodiazepine-2,4'-piperidines) and intermediates, a process for the preparation thereof and their use as medicaments | |
| ATE105565T1 (de) | Pradimicinderivate. | |
| TW275629B (de) |