DE69230046D1 - 2-Bromomelatonin zur Behandlung von Schlafstörungen - Google Patents
2-Bromomelatonin zur Behandlung von SchlafstörungenInfo
- Publication number
- DE69230046D1 DE69230046D1 DE69230046T DE69230046T DE69230046D1 DE 69230046 D1 DE69230046 D1 DE 69230046D1 DE 69230046 T DE69230046 T DE 69230046T DE 69230046 T DE69230046 T DE 69230046T DE 69230046 D1 DE69230046 D1 DE 69230046D1
- Authority
- DE
- Germany
- Prior art keywords
- bromomelatonin
- sleep disorders
- treatment
- therapy
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI911299A IT1251544B (it) | 1991-05-13 | 1991-05-13 | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230046D1 true DE69230046D1 (de) | 1999-10-28 |
DE69230046T2 DE69230046T2 (de) | 2000-05-31 |
Family
ID=11359886
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69213814T Expired - Fee Related DE69213814T2 (de) | 1991-05-13 | 1992-05-11 | Melatoninderivate zur Behandlung von Schlafstörungen und zur Pre-Anästhesie |
DE69230046T Expired - Fee Related DE69230046T2 (de) | 1991-05-13 | 1992-05-11 | 2-Bromomelatonin zur Behandlung von Schlafstörungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69213814T Expired - Fee Related DE69213814T2 (de) | 1991-05-13 | 1992-05-11 | Melatoninderivate zur Behandlung von Schlafstörungen und zur Pre-Anästhesie |
Country Status (9)
Country | Link |
---|---|
US (1) | US5430029A (de) |
EP (2) | EP0713701B1 (de) |
JP (1) | JPH05155769A (de) |
AT (2) | ATE184792T1 (de) |
DE (2) | DE69213814T2 (de) |
DK (2) | DK0713701T3 (de) |
ES (2) | ES2093735T3 (de) |
GR (2) | GR3022060T3 (de) |
IT (1) | IT1251544B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0483077B1 (de) * | 1990-09-28 | 1995-12-06 | I.F.L.O. S.a.s. di Giorgio e Aldo Laguzzi | Methode zur Synthese eines Präparats zur Regulation der Empfängnis und des Menstruationszyklus mit onkostatischen antikinetosischen, preventiven und therapeutischen Eigenschaften zur Behandlung von Brustkrebs und Melanomen. |
IT1254995B (it) * | 1992-06-24 | 1995-10-11 | Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani | |
IT1255199B (it) * | 1992-07-01 | 1995-10-20 | Franco Fraschini | Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani |
US5449683A (en) * | 1992-10-01 | 1995-09-12 | Massachussetts Institute Of Technology | Methods of inducing sleep using melatonin |
IT1262912B (it) * | 1992-12-30 | 1996-07-22 | Impiego della melatonina nella terapia della sclerosi sistemica, della sarcoidosi ed altro | |
US6180657B1 (en) * | 1993-11-18 | 2001-01-30 | Eli Lilly And Company | Melatonin derivatives for use in treating desynchronization disorders |
US5654325A (en) * | 1993-11-18 | 1997-08-05 | Eli Lilly And Company | Melatonin derivatives for use in treating sleep disorders |
AU726758B2 (en) * | 1993-11-18 | 2000-11-23 | Eli Lilly And Company | Melatonin derivatives for use in treating desynchronization disorders |
US5763471A (en) * | 1994-04-07 | 1998-06-09 | Cemaf | Melatoninergic agonist spiro indolepyrrolidine! derivatives, process for their preparation and their use as medicinal products |
US6469044B1 (en) | 1995-02-01 | 2002-10-22 | Neurim Pharmaceuticals (1991) Ltd. | Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies |
CZ291349B6 (cs) * | 1995-02-01 | 2003-02-12 | Neurim Pharmaceuticals Ltd. | Léčivo pro prevenci nebo léčbu závislosti na benzodiazepinech |
DE69910795T2 (de) * | 1998-06-09 | 2004-06-17 | Takeda Chemical Industries, Ltd. | Pharmazeutische kombination mit einer trizyclischen verbindung und mindestens einer von zolpidem, zopiclone und brotizolam, zur behandlung oder verhinderung von schlafstörungen |
FR2787447B1 (fr) | 1998-12-18 | 2001-03-23 | Centre Nat Rech Scient | Nouveaux derives de melatonine et medicament comprenant de tels derives |
US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
AU2445900A (en) * | 1999-02-05 | 2000-08-25 | Victoria University Of Manchester, The | Regulation of anaesthesia |
US6552064B2 (en) * | 2000-09-19 | 2003-04-22 | University Of Iowa Research Foundation | Use of melatonin for induction of general anesthesia |
US6638966B2 (en) | 2000-09-19 | 2003-10-28 | University Of Iowa Research Foundation | Use of melatonin analogues for induction of general anesthesia |
IL144900A (en) * | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
IL149377A (en) * | 2002-04-28 | 2012-10-31 | Neurim Pharma 1991 | Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds |
PL1691811T3 (pl) * | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
WO2005063248A1 (en) * | 2003-12-22 | 2005-07-14 | Sepracor Inc. | Modafinil combination therapy for improving sleep quality |
AU2004308962A1 (en) * | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
EP1742624B1 (de) * | 2004-02-18 | 2010-01-06 | Sepracor, Inc. | Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität |
US8053462B2 (en) | 2004-03-08 | 2011-11-08 | Masanori Somei | Indole derivative and application thereof |
JP3964417B2 (ja) | 2004-09-27 | 2007-08-22 | 国立大学法人金沢大学 | インドール誘導体を有効成分とするα2受容体遮断剤及び血管拡張剤 |
AR056076A1 (es) * | 2005-09-20 | 2007-09-19 | Takeda Pharmaceutical | Agente profilactico o terapeutico para el desorden de sueno |
MX2008014841A (es) * | 2006-05-22 | 2008-12-05 | Vanda Pharmaceuticals Inc | Tratamiento de agonista de melatonina. |
KR20180100450A (ko) | 2012-01-26 | 2018-09-10 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
KR102148990B1 (ko) | 2012-12-18 | 2020-08-27 | 반다 파마슈티칼즈, 인코퍼레이티드. | 일주기 리듬 장애의 치료 |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
JP7088153B2 (ja) * | 2019-09-19 | 2022-06-21 | カシオ計算機株式会社 | Cap(周期性脳波活動)検出装置、cap(周期性脳波活動)検出方法及びプログラム |
WO2023158424A1 (en) * | 2022-02-16 | 2023-08-24 | La Pharma Tech Inc. | Novel pharmaceutical compositions and methods for treatment of insomnia |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3466215D1 (en) * | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
KR910006124B1 (ko) * | 1987-08-17 | 1991-08-13 | 넬슨 리써취 앤드 디벨럽먼트 캄파니 | 멜라토닌 동족체 |
-
1991
- 1991-05-13 IT ITMI911299A patent/IT1251544B/it active IP Right Grant
-
1992
- 1992-05-11 EP EP95118386A patent/EP0713701B1/de not_active Expired - Lifetime
- 1992-05-11 EP EP92107865A patent/EP0513702B1/de not_active Expired - Lifetime
- 1992-05-11 AT AT95118386T patent/ATE184792T1/de active
- 1992-05-11 DE DE69213814T patent/DE69213814T2/de not_active Expired - Fee Related
- 1992-05-11 ES ES92107865T patent/ES2093735T3/es not_active Expired - Lifetime
- 1992-05-11 DK DK95118386T patent/DK0713701T3/da active
- 1992-05-11 AT AT92107865T patent/ATE142877T1/de active
- 1992-05-11 DE DE69230046T patent/DE69230046T2/de not_active Expired - Fee Related
- 1992-05-11 DK DK92107865.5T patent/DK0513702T3/da active
- 1992-05-11 ES ES95118386T patent/ES2139132T3/es not_active Expired - Lifetime
- 1992-05-13 JP JP4146983A patent/JPH05155769A/ja active Pending
-
1993
- 1993-12-02 US US08/161,744 patent/US5430029A/en not_active Expired - Fee Related
-
1996
- 1996-12-17 GR GR960403498T patent/GR3022060T3/el unknown
-
1999
- 1999-12-21 GR GR990403294T patent/GR3032207T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE142877T1 (de) | 1996-10-15 |
GR3022060T3 (en) | 1997-03-31 |
DE69213814T2 (de) | 1997-04-03 |
US5430029A (en) | 1995-07-04 |
EP0713701A1 (de) | 1996-05-29 |
IT1251544B (it) | 1995-05-17 |
ATE184792T1 (de) | 1999-10-15 |
ES2139132T3 (es) | 2000-02-01 |
EP0713701B1 (de) | 1999-09-22 |
EP0513702B1 (de) | 1996-09-18 |
GR3032207T3 (en) | 2000-04-27 |
ES2093735T3 (es) | 1997-01-01 |
ITMI911299A0 (it) | 1991-05-13 |
DE69213814D1 (de) | 1996-10-24 |
DK0713701T3 (da) | 2000-04-03 |
EP0513702A3 (de) | 1992-11-25 |
ITMI911299A1 (it) | 1992-11-13 |
JPH05155769A (ja) | 1993-06-22 |
DK0513702T3 (da) | 1996-12-30 |
DE69230046T2 (de) | 2000-05-31 |
EP0513702A2 (de) | 1992-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE184792T1 (de) | 2-bromomelatonin zur behandlung von schlafstörungen | |
DE69333321D1 (de) | Verwendung eines Consensus-Interferons zur Reduzierung der Nebeneffekte in der Interferon Behandlung von viralen Hepatiten. | |
DE69034018D1 (de) | Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts | |
ATE399553T1 (de) | Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen | |
DE3684190D1 (de) | Verwendung von tetrahydrobiopterinen zur herstellung eines medikaments zur behandlung von kinderautismus. | |
ATE204178T1 (de) | Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin | |
UA26213C2 (uk) | Засіб для профілактики та лікуваhhя остеопорозу та фармацевтичhа композиція hа їх осhові | |
SE9401406D0 (sv) | Pharmaceutical products for curing tumourous diseases and process for preparing same | |
HUP0100815A2 (hu) | Neurológiai és neuropszichiátriai rendellenességek kezelésére szolgáló gyógyszerkészítmények | |
DE58902094D1 (de) | Kombinationspraeparat zur behandlung von nervenzell-und nervenfasererkrankungen und verletzungen. | |
DE69738948D1 (de) | Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten | |
GEP20002300B (en) | Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof | |
ATE213411T1 (de) | Verwendung von phenserin zur herstellung von medikamenten zur behandlung von kognitiven störungen | |
ATE99932T1 (de) | Verwendung von pyrrolicloncarbonsaeurealkylestern zur herstellung eines arzneimittels zur behandlung von ichtyosis. | |
ATE137965T1 (de) | Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege | |
ES2160643T3 (es) | Composiciones que contienen g-csf y proteina de union al tnf. | |
DE69426471D1 (de) | Verwendung von Sulodexid und von Arzneimitteln, die dieses enthalten, zur Behandlung der diabetischen Nephropathie | |
ATE217191T1 (de) | Verwendung von phanquinon zur behandlung von alzheimer's krankheit | |
DE3582594D1 (de) | Proglumid und dessen pharmazeutische zusammensetzungen zur anwendung bei der behandlung von neoplastischen affektionen. | |
DE69431199D1 (de) | Melatonin-Derivate zur Verwendung in der Behandlung von Schlafstörungen | |
ATE200617T1 (de) | Pharmazeutische zusammensetzungen zur transdermalen verabreichung von melatonin und/oder seine analoge | |
DE69120933D1 (de) | Topische Anwendung von Glycosaminoglykane zur Prävention und Behandlung der Zervikal- oder Vaginalerkrankungen | |
DE69623316D1 (de) | Ctla-8 in kombination mit g-csf oder mit g-csf und il-6, und verwendung vom ctla-8 zur behandlung von infektionen | |
ATE69949T1 (de) | Liposomen mit inhalativen allergenen zur behandlung von allergien, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. | |
DE69307702D1 (de) | Verwendung von (e) - 2 - (p -fluorophenethyl)- 3 - fluoroallylamine zur behandlung der alzheimerschen krankheit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |