DE69229348T2 - Fullerene zusammensetzungen für m.r.i. - Google Patents

Fullerene zusammensetzungen für m.r.i.

Info

Publication number
DE69229348T2
DE69229348T2 DE69229348T DE69229348T DE69229348T2 DE 69229348 T2 DE69229348 T2 DE 69229348T2 DE 69229348 T DE69229348 T DE 69229348T DE 69229348 T DE69229348 T DE 69229348T DE 69229348 T2 DE69229348 T2 DE 69229348T2
Authority
DE
Germany
Prior art keywords
imaging
fluorine
compositions
carbon
carbon clusters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69229348T
Other languages
English (en)
Other versions
DE69229348D1 (de
Inventor
William L Neumann
William P Cacheris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Application granted granted Critical
Publication of DE69229348D1 publication Critical patent/DE69229348D1/de
Publication of DE69229348T2 publication Critical patent/DE69229348T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
DE69229348T 1991-08-19 1992-07-30 Fullerene zusammensetzungen für m.r.i. Expired - Fee Related DE69229348T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/746,836 US5248498A (en) 1991-08-19 1991-08-19 Fullerene compositions for magnetic resonance spectroscopy and imaging
PCT/US1992/006336 WO1993003771A1 (en) 1991-08-19 1992-07-30 Fullerene compositions for magnetic resonance spectroscopy and imaging

Publications (2)

Publication Number Publication Date
DE69229348D1 DE69229348D1 (de) 1999-07-08
DE69229348T2 true DE69229348T2 (de) 1999-11-11

Family

ID=25002556

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229348T Expired - Fee Related DE69229348T2 (de) 1991-08-19 1992-07-30 Fullerene zusammensetzungen für m.r.i.

Country Status (8)

Country Link
US (1) US5248498A (de)
EP (1) EP0599946B1 (de)
JP (1) JPH06509802A (de)
AT (1) ATE180677T1 (de)
AU (1) AU657789B2 (de)
CA (1) CA2113996A1 (de)
DE (1) DE69229348T2 (de)
WO (1) WO1993003771A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9203037D0 (en) * 1992-02-11 1992-03-25 Salutar Inc Contrast agents
US5468467A (en) * 1993-04-23 1995-11-21 Bracco International B.V. Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds
JPH0797340A (ja) * 1993-06-03 1995-04-11 Terumo Corp Ｍｒｉ造影剤組成物
US5456986A (en) * 1993-06-30 1995-10-10 Carnegie Mellon University Magnetic metal or metal carbide nanoparticles and a process for forming same
EP0706709A1 (de) * 1993-06-30 1996-04-17 Carnegie Mellon University Metall, legierung, oder metallkarbid nanopartikeln und ihrer herstellungsverfahren
JPH09503765A (ja) * 1993-10-04 1997-04-15 マリンクロット・メディカル・インコーポレイテッド 磁気共鳴イメージング、ｘ線イメージング、および放射性医薬品用組成物および方法
WO1996024139A2 (en) 1995-01-23 1996-08-08 Schaefer Daniel R Trapping and storage of free thermal neutrons in fullerene molecules
US5660815A (en) * 1995-04-28 1997-08-26 Molecular Biosystems, Inc. Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents
DE19549656B4 (de) * 1995-05-19 2005-08-25 Marijan Bradic Oberflächenbeschichtung für Werkzeuge, Werkstoffe oder Polymere, deren Herstellung und Verwendung
US5958523A (en) * 1995-05-19 1999-09-28 Bradic; Marijan Coating and lubricant compositions containing polyfluorfullerenes and methods of use
CA2229781A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
DE19603033A1 (de) 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
ES2123449B1 (es) 1997-03-06 1999-09-16 Univ Madrid Nac Educacion Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
AU3532197A (en) * 1997-07-24 1999-02-16 Australian National University, The Method for detection of fibrin clots
US6355224B1 (en) * 1998-09-17 2002-03-12 Massachusetts Institute Of Technology Conductive polymer contrast agent compositions and uses therefor
US6355225B1 (en) * 1999-10-05 2002-03-12 Wm. Marsh Rice University Tda Research, Inc. Fullerene contrast agent for magnetic resonance imaging and spectroscopy
WO2002051301A2 (en) * 2000-11-10 2002-07-04 Wm. Marsh Rice University Fullerene (c60)-based x-ray contrast agent for diagnostic imaging
US20040038946A1 (en) * 2001-04-27 2004-02-26 Wilson Lon J. Fullerene-based drugs targeted to bone
WO2003105762A2 (en) * 2002-06-14 2003-12-24 Actinium Pharmaceuticals Ltd. Treating disease using radium-225
WO2004048301A1 (ja) * 2002-11-27 2004-06-10 Mitsubishi Chemical Corporation 耐酸化性水素化フラーレンの製造方法及びその方法により得られる水素化フラーレン
US20060039521A1 (en) * 2004-06-22 2006-02-23 Schaefer Daniel R Direct production of thermal antineutrons and antiprotons
BRPI0517790A (pt) * 2004-11-12 2008-10-21 Neurochem Int Ltd métodos e composições fluoradas para tratar doenças relacionadas à amilóide
DE102005005704B4 (de) * 2005-02-03 2010-08-12 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Verwendung von Partikeln für die Ermittlung der lokalen Temperatur in organischen und nichtorganischen Körpern
DE102005020379A1 (de) * 2005-05-02 2006-11-16 Johannes-Gutenberg-Universität Mainz Verfahren zur Abbildung der Mikrostruktur der Lunge und eine Vorrichtung hierfür
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5132105A (en) * 1990-02-02 1992-07-21 Quantametrics, Inc. Materials with diamond-like properties and method and means for manufacturing them
US5114477A (en) * 1991-09-03 1992-05-19 Xerox Corporation Liquid ink compositions
GB9203037D0 (en) * 1992-02-11 1992-03-25 Salutar Inc Contrast agents

Also Published As

Publication number Publication date
AU2406292A (en) 1993-03-16
US5248498A (en) 1993-09-28
ATE180677T1 (de) 1999-06-15
CA2113996A1 (en) 1993-03-04
DE69229348D1 (de) 1999-07-08
EP0599946A1 (de) 1994-06-08
WO1993003771A1 (en) 1993-03-04
AU657789B2 (en) 1995-03-23
EP0599946B1 (de) 1999-06-02
JPH06509802A (ja) 1994-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee