DE69227805T2 - Verwendung von Tri-n-Butylphosphat bei niedrigem pH in Lösungen von biologisch aktiven Proteinen für eine verbesserte viruzide Wirkung - Google Patents

Verwendung von Tri-n-Butylphosphat bei niedrigem pH in Lösungen von biologisch aktiven Proteinen für eine verbesserte viruzide Wirkung

Info

Publication number
DE69227805T2
DE69227805T2 DE69227805T DE69227805T DE69227805T2 DE 69227805 T2 DE69227805 T2 DE 69227805T2 DE 69227805 T DE69227805 T DE 69227805T DE 69227805 T DE69227805 T DE 69227805T DE 69227805 T2 DE69227805 T2 DE 69227805T2
Authority
DE
Germany
Prior art keywords
tri
solutions
low
biologically active
active proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69227805T
Other languages
English (en)
Other versions
DE69227805D1 (de
Inventor
Milton B Dobkin
George B Dove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24917171&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69227805(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of DE69227805D1 publication Critical patent/DE69227805D1/de
Publication of DE69227805T2 publication Critical patent/DE69227805T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261—Methods of inactivation or attenuation
    • C12N2760/20263—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69227805T 1991-07-05 1992-06-23 Verwendung von Tri-n-Butylphosphat bei niedrigem pH in Lösungen von biologisch aktiven Proteinen für eine verbesserte viruzide Wirkung Revoked DE69227805T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72608691A 1991-07-05 1991-07-05

Publications (2)

Publication Number Publication Date
DE69227805D1 DE69227805D1 (de) 1999-01-21
DE69227805T2 true DE69227805T2 (de) 1999-04-29

Family

ID=24917171

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227805T Revoked DE69227805T2 (de) 1991-07-05 1992-06-23 Verwendung von Tri-n-Butylphosphat bei niedrigem pH in Lösungen von biologisch aktiven Proteinen für eine verbesserte viruzide Wirkung

Country Status (8)

Country Link
EP (1) EP0523406B1 (de)
JP (1) JPH05184361A (de)
AT (1) ATE174383T1 (de)
CA (1) CA2072797C (de)
DE (1) DE69227805T2 (de)
DK (1) DK0523406T3 (de)
ES (1) ES2124235T3 (de)
GR (1) GR3029319T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06166634A (ja) * 1992-12-01 1994-06-14 Green Cross Corp:The プラスミノーゲン含有組成物の製造方法
US6034073A (en) * 1995-04-24 2000-03-07 Novavax, Inc. Solvent detergent emulsions having antiviral activity
US6686191B1 (en) * 1995-09-22 2004-02-03 Bayer Healthcare Llc Preparation of virally inactivated intravenously injectable immune serum globulin
US6225289B1 (en) 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
CN1302009C (zh) * 2005-09-05 2007-02-28 武汉海特生物制药股份有限公司 用有机溶剂病毒灭活法制备鼠神经生长因子的工艺
KR100791502B1 (ko) * 2006-09-29 2008-01-03 한스바이오메드 주식회사 바이러스 불활화된 무세포 인체 이식재 생산방법
US8669045B2 (en) 2007-02-13 2014-03-11 Ajinomoto Co., Inc. Method for inactivating viruses with slightly acidic arginine
CN108342368A (zh) * 2018-01-25 2018-07-31 武汉珈创生物技术股份有限公司 一种低pH孵育病毒灭活的验证方法
CN108535491B (zh) * 2018-03-22 2019-11-08 北京九强生物技术股份有限公司 一种肌钙蛋白i的胶乳增强免疫比浊检测试剂盒

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962421A (en) * 1973-06-18 1976-06-08 American Home Products Corporation Method for the disruption of lipid-containing viruses
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
DE3730533A1 (de) * 1987-09-11 1989-03-30 Biotest Pharma Gmbh Verfahren zur sterilisation von plasma oder plasmafraktionen
DE69011136T3 (de) * 1989-01-13 2003-10-23 Mitsubishi Pharma Corp Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung.
US5071650A (en) * 1990-06-04 1991-12-10 Miles Inc. Use of intermediate length alcohols as virucidal agents in solutions of biologically active proteins
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation

Also Published As

Publication number Publication date
ES2124235T3 (es) 1999-02-01
EP0523406A1 (de) 1993-01-20
CA2072797A1 (en) 1993-01-06
EP0523406B1 (de) 1998-12-09
GR3029319T3 (en) 1999-05-28
JPH05184361A (ja) 1993-07-27
ATE174383T1 (de) 1998-12-15
DK0523406T3 (da) 1999-08-16
DE69227805D1 (de) 1999-01-21
CA2072797C (en) 1998-10-06

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation