DE69214925D1 - Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen - Google Patents
Verfahren zur Herstellung von Pyrrolo (2,3-d)PyrimidinenInfo
- Publication number
- DE69214925D1 DE69214925D1 DE69214925T DE69214925T DE69214925D1 DE 69214925 D1 DE69214925 D1 DE 69214925D1 DE 69214925 T DE69214925 T DE 69214925T DE 69214925 T DE69214925 T DE 69214925T DE 69214925 D1 DE69214925 D1 DE 69214925D1
- Authority
- DE
- Germany
- Prior art keywords
- ethyl
- preparation
- pyrimidines
- pyrrolo
- diaminopyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/802,192 US5254687A (en) | 1991-12-04 | 1991-12-04 | Process for the preparation of pyrrolo[2,3-d]pyrimidines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69214925D1 true DE69214925D1 (de) | 1996-12-05 |
DE69214925T2 DE69214925T2 (de) | 1997-03-06 |
Family
ID=25183085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69214925T Expired - Fee Related DE69214925T2 (de) | 1991-12-04 | 1992-11-25 | Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5254687A (de) |
EP (1) | EP0549886B1 (de) |
JP (1) | JPH05247045A (de) |
AT (1) | ATE144774T1 (de) |
CA (1) | CA2084490C (de) |
DE (1) | DE69214925T2 (de) |
DK (1) | DK0549886T3 (de) |
ES (1) | ES2093756T3 (de) |
GR (1) | GR3021938T3 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958930A (en) * | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
WO1992017478A1 (en) * | 1991-04-08 | 1992-10-15 | Duquesne University Of The Holy Ghost | 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES |
US5508281A (en) * | 1991-04-08 | 1996-04-16 | Duquesne University Of The Holy Ghost | Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives |
US5939420A (en) * | 1991-04-08 | 1999-08-17 | Duquesne University Of The Holy Ghost | Pyrrolo 2,3d!derivatives |
US5877178A (en) | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
US6962920B2 (en) * | 1992-09-23 | 2005-11-08 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
WO1995033752A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
US6537999B2 (en) | 1996-06-06 | 2003-03-25 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
US6066732A (en) * | 1998-08-21 | 2000-05-23 | The Trustees Of Princeton University | Process for the preparation of pyrrolo[2,3-d]pyrimidines |
US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
US7071199B1 (en) | 1999-09-17 | 2006-07-04 | Abbott Gmbh & Cco. Kg | Kinase inhibitors as therapeutic agents |
EP1212327B8 (de) | 1999-09-17 | 2004-02-25 | Abbott GmbH & Co. KG | Pyrazolopyrimidine als arzneimittel |
CN100379729C (zh) * | 2006-04-06 | 2008-04-09 | 海南天源康泽医药科技有限公司 | 硝基化合物及其在培美曲塞制备中的应用 |
CN101417998B (zh) | 2007-10-24 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种培美曲塞盐的纯化方法 |
CN102372719B (zh) * | 2010-08-26 | 2013-10-30 | 齐鲁制药有限公司 | 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法 |
WO2014145576A2 (en) | 2013-03-15 | 2014-09-18 | Northwestern University | Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer |
NZ630292A (en) | 2013-11-25 | 2015-02-27 | Shilpa Medicare Ltd | Process for crystalline pemetrexed dipotassium salt |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1935009C3 (de) * | 1969-07-10 | 1973-10-31 | Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Furanen |
US4199584A (en) * | 1977-05-27 | 1980-04-22 | Imperial Chemical Industries Limited | Pesticidal active furo[2,3-d] pyrimidine derivatives, compositions containing the same and use thereof |
US4439225A (en) * | 1982-06-14 | 1984-03-27 | Shell Oil Company | Herbicidal cyano-tetrahydrofuranylmethyl ether and cyano-tetrahydropyranylmethyl ether derivatives |
US5047519A (en) | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
US4895946A (en) | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
-
1991
- 1991-12-04 US US07/802,192 patent/US5254687A/en not_active Expired - Fee Related
-
1992
- 1992-11-25 DK DK92120057.2T patent/DK0549886T3/da active
- 1992-11-25 AT AT92120057T patent/ATE144774T1/de active
- 1992-11-25 EP EP92120057A patent/EP0549886B1/de not_active Expired - Lifetime
- 1992-11-25 DE DE69214925T patent/DE69214925T2/de not_active Expired - Fee Related
- 1992-11-25 ES ES92120057T patent/ES2093756T3/es not_active Expired - Lifetime
- 1992-12-02 JP JP4323303A patent/JPH05247045A/ja active Pending
- 1992-12-03 CA CA002084490A patent/CA2084490C/en not_active Expired - Fee Related
-
1996
- 1996-12-06 GR GR960403355T patent/GR3021938T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0549886B1 (de) | 1996-10-30 |
DK0549886T3 (da) | 1996-11-25 |
GR3021938T3 (en) | 1997-03-31 |
ATE144774T1 (de) | 1996-11-15 |
CA2084490C (en) | 1998-08-25 |
US5254687A (en) | 1993-10-19 |
JPH05247045A (ja) | 1993-09-24 |
CA2084490A1 (en) | 1993-06-05 |
DE69214925T2 (de) | 1997-03-06 |
EP0549886A1 (de) | 1993-07-07 |
ES2093756T3 (es) | 1997-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |