DE69214925D1 - Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen - Google Patents

Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen

Info

Publication number
DE69214925D1
DE69214925D1 DE69214925T DE69214925T DE69214925D1 DE 69214925 D1 DE69214925 D1 DE 69214925D1 DE 69214925 T DE69214925 T DE 69214925T DE 69214925 T DE69214925 T DE 69214925T DE 69214925 D1 DE69214925 D1 DE 69214925D1
Authority
DE
Germany
Prior art keywords
ethyl
preparation
pyrimidines
pyrrolo
diaminopyrrolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69214925T
Other languages
English (en)
Other versions
DE69214925T2 (de
Inventor
Edward C Taylor
Hemantkumar H Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of DE69214925D1 publication Critical patent/DE69214925D1/de
Application granted granted Critical
Publication of DE69214925T2 publication Critical patent/DE69214925T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE69214925T 1991-12-04 1992-11-25 Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen Expired - Fee Related DE69214925T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/802,192 US5254687A (en) 1991-12-04 1991-12-04 Process for the preparation of pyrrolo[2,3-d]pyrimidines

Publications (2)

Publication Number Publication Date
DE69214925D1 true DE69214925D1 (de) 1996-12-05
DE69214925T2 DE69214925T2 (de) 1997-03-06

Family

ID=25183085

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69214925T Expired - Fee Related DE69214925T2 (de) 1991-12-04 1992-11-25 Verfahren zur Herstellung von Pyrrolo (2,3-d)Pyrimidinen

Country Status (9)

Country Link
US (1) US5254687A (de)
EP (1) EP0549886B1 (de)
JP (1) JPH05247045A (de)
AT (1) ATE144774T1 (de)
CA (1) CA2084490C (de)
DE (1) DE69214925T2 (de)
DK (1) DK0549886T3 (de)
ES (1) ES2093756T3 (de)
GR (1) GR3021938T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958930A (en) * 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
WO1992017478A1 (en) * 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5508281A (en) * 1991-04-08 1996-04-16 Duquesne University Of The Holy Ghost Derivatives of pyrido [2,3-d] and [3,2-d] pyrimidine and methods of using these derivatives
US5939420A (en) * 1991-04-08 1999-08-17 Duquesne University Of The Holy Ghost Pyrrolo 2,3d!derivatives
US5877178A (en) 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US6962920B2 (en) * 1992-09-23 2005-11-08 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
WO1995033752A1 (en) * 1994-06-09 1995-12-14 Smithkline Beecham Corporation Endothelin receptor antagonists
US6537999B2 (en) 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
US6066732A (en) * 1998-08-21 2000-05-23 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
EP1212327B8 (de) 1999-09-17 2004-02-25 Abbott GmbH & Co. KG Pyrazolopyrimidine als arzneimittel
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
CN102372719B (zh) * 2010-08-26 2013-10-30 齐鲁制药有限公司 培美曲塞二甲酯对甲苯磺酸盐晶型及其制备方法
WO2014145576A2 (en) 2013-03-15 2014-09-18 Northwestern University Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1935009C3 (de) * 1969-07-10 1973-10-31 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Furanen
US4199584A (en) * 1977-05-27 1980-04-22 Imperial Chemical Industries Limited Pesticidal active furo[2,3-d] pyrimidine derivatives, compositions containing the same and use thereof
US4439225A (en) * 1982-06-14 1984-03-27 Shell Oil Company Herbicidal cyano-tetrahydrofuranylmethyl ether and cyano-tetrahydropyranylmethyl ether derivatives
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4895946A (en) 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)

Also Published As

Publication number Publication date
EP0549886B1 (de) 1996-10-30
DK0549886T3 (da) 1996-11-25
GR3021938T3 (en) 1997-03-31
ATE144774T1 (de) 1996-11-15
CA2084490C (en) 1998-08-25
US5254687A (en) 1993-10-19
JPH05247045A (ja) 1993-09-24
CA2084490A1 (en) 1993-06-05
DE69214925T2 (de) 1997-03-06
EP0549886A1 (de) 1993-07-07
ES2093756T3 (es) 1997-01-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee