DE69132055D1 - Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen - Google Patents
Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffenInfo
- Publication number
- DE69132055D1 DE69132055D1 DE69132055T DE69132055T DE69132055D1 DE 69132055 D1 DE69132055 D1 DE 69132055D1 DE 69132055 T DE69132055 T DE 69132055T DE 69132055 T DE69132055 T DE 69132055T DE 69132055 D1 DE69132055 D1 DE 69132055D1
- Authority
- DE
- Germany
- Prior art keywords
- immunoglobulin
- immunoglobulines
- locally
- derivatized
- conjugate formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/624,169 US5191066A (en) | 1990-12-07 | 1990-12-07 | Site-specific conjugation of immunoglobulins and detectable labels |
PCT/US1991/008971 WO1992010507A1 (en) | 1990-12-07 | 1991-12-02 | Site-specific conjugation of immunoglobulins and detectable labels |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69132055D1 true DE69132055D1 (de) | 2000-04-20 |
DE69132055T2 DE69132055T2 (de) | 2000-10-26 |
Family
ID=24500943
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132055T Expired - Fee Related DE69132055T2 (de) | 1990-12-07 | 1991-12-02 | Ortsgenaue konjugatbildung zwischen immunglobulinen und nachweisbaren markierungsstoffen |
Country Status (12)
Country | Link |
---|---|
US (1) | US5191066A (de) |
EP (1) | EP0560912B1 (de) |
JP (1) | JP3390430B2 (de) |
KR (1) | KR930703347A (de) |
AT (1) | ATE190624T1 (de) |
AU (1) | AU659427B2 (de) |
CA (1) | CA2097920C (de) |
DE (1) | DE69132055T2 (de) |
DK (1) | DK0560912T3 (de) |
ES (1) | ES2146209T3 (de) |
GR (1) | GR3033553T3 (de) |
WO (1) | WO1992010507A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5561045A (en) * | 1994-01-04 | 1996-10-01 | Intracel Corporation | Detection reagent, article, and immunoassay method |
US5547833A (en) * | 1994-01-04 | 1996-08-20 | Intracel Corporation | Radial flow assay, delivering member, test kit, and methods |
US5596081A (en) * | 1994-03-11 | 1997-01-21 | University Of Kentucky Research Foundation | Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics |
AU3559695A (en) * | 1994-09-30 | 1996-04-26 | Inex Pharmaceuticals Corp. | Glycosylated protein-liposome conjugates and methods for their preparation |
US5736624A (en) * | 1994-12-02 | 1998-04-07 | Abbott Laboratories | Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents |
ES2153090T3 (es) * | 1995-01-23 | 2001-02-16 | Pasteur Sanofi Diagnostics | Conjugado inmunoenzimatico, su procedimiento de preparacion y sus aplicaciones. |
CA2257357C (en) * | 1996-06-07 | 2010-04-13 | Neorx Corporation | Humanized antibodies with modified glycosylation |
US20050033033A1 (en) * | 1998-05-04 | 2005-02-10 | Heinz Kohler | Trans-membrane-antibody induced inhibition of apoptosis |
US20040185039A1 (en) * | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
US7569674B2 (en) * | 1998-05-04 | 2009-08-04 | Innexus Biotechnology International Limited | Autophilic antibodies |
US6218160B1 (en) * | 1997-10-31 | 2001-04-17 | Roche Diagnostics Corporation | Site-specific conjugation of glycoproteins |
WO1999052561A1 (en) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition of xenoreactive antibodies |
US20090208418A1 (en) * | 2005-04-29 | 2009-08-20 | Innexus Biotechnology Internaltional Ltd. | Superantibody synthesis and use in detection, prevention and treatment of disease |
US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
DE69934903T2 (de) * | 1998-11-10 | 2007-10-18 | Emory University | Mitogene regulatoren |
NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
AU2004282984B2 (en) | 2003-11-13 | 2011-07-14 | Hanmi Science Co., Ltd. | Protein complex using immunoglobulin fragment andmethod for the preparation thereof |
EP1877101B1 (de) | 2005-04-28 | 2016-11-16 | Ventana Medical Systems, Inc. | Mit antikörpern über einen heterobifuntionellen peg-linker konjugierte enzyme |
CA2606018A1 (en) * | 2005-04-28 | 2006-11-02 | Ventana Medical Systems, Inc. | Nanoparticle conjugates |
EP1951316B1 (de) | 2005-11-23 | 2015-08-19 | Ventana Medical Systems, Inc. | Molekulares Konjugat |
US20080108147A1 (en) * | 2006-11-03 | 2008-05-08 | Tie Wei | Reduction of non-specific binding in immunoassays |
WO2013016449A2 (en) | 2011-07-26 | 2013-01-31 | Indicator Systems International, Inc. | Assays for the detection of microbes |
WO2014127211A1 (en) | 2013-02-15 | 2014-08-21 | Research Development Foundation | Deimmunized gelonin molecules and therapies |
SG11201601424PA (en) | 2013-08-28 | 2016-03-30 | Stemcentrx Inc | Site-specific antibody conjugation methods and compositions |
US10053511B2 (en) | 2013-11-06 | 2018-08-21 | Abbvie Stemcentrx Llc | Anti-claudin antibodies and methods of use |
AU2014361856A1 (en) | 2013-12-12 | 2016-06-30 | Abbvie Stemcentrx Llc | Novel anti-DPEP3 antibodies and methods of use |
JP2017514143A (ja) | 2014-02-21 | 2017-06-01 | アッヴィ・ステムセントルクス・エル・エル・シー | メラノーマに使用するための抗dll3抗体および薬物コンジュゲート |
TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
EP4155731A4 (de) * | 2020-05-22 | 2024-04-24 | School Corporation, Azabu Veterinary Medicine Educational Institution | Verfahren zur beurteilung eines allergeninaktivators und beurteilungskit für allergeninaktivator |
CN112067826B (zh) * | 2020-09-15 | 2024-02-06 | 济南国科医工科技发展有限公司 | 基于高比活力碱性磷酸酶构建的NT-proBNP检测试剂盒及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140679A (en) * | 1976-10-12 | 1979-02-20 | Research Corporation | Antigen-protein complex for blocking allergic reactions |
SE427505B (sv) * | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
FR2601679B1 (fr) * | 1986-07-15 | 1990-05-25 | Sanofi Sa | Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant |
US4994385A (en) * | 1987-10-30 | 1991-02-19 | Abbott Laboratories | Heterobifunctional coupling agents |
-
1990
- 1990-12-07 US US07/624,169 patent/US5191066A/en not_active Expired - Lifetime
-
1991
- 1991-12-02 DK DK92902190T patent/DK0560912T3/da active
- 1991-12-02 AU AU91452/91A patent/AU659427B2/en not_active Ceased
- 1991-12-02 DE DE69132055T patent/DE69132055T2/de not_active Expired - Fee Related
- 1991-12-02 ES ES92902190T patent/ES2146209T3/es not_active Expired - Lifetime
- 1991-12-02 KR KR1019930701742A patent/KR930703347A/ko not_active Application Discontinuation
- 1991-12-02 WO PCT/US1991/008971 patent/WO1992010507A1/en active IP Right Grant
- 1991-12-02 JP JP50267992A patent/JP3390430B2/ja not_active Expired - Fee Related
- 1991-12-02 AT AT92902190T patent/ATE190624T1/de not_active IP Right Cessation
- 1991-12-02 CA CA002097920A patent/CA2097920C/en not_active Expired - Fee Related
- 1991-12-02 EP EP92902190A patent/EP0560912B1/de not_active Expired - Lifetime
-
2000
- 2000-05-31 GR GR20000401245T patent/GR3033553T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0560912T3 (da) | 2000-07-24 |
AU9145291A (en) | 1992-07-08 |
DE69132055T2 (de) | 2000-10-26 |
EP0560912B1 (de) | 2000-03-15 |
AU659427B2 (en) | 1995-05-18 |
CA2097920A1 (en) | 1992-06-08 |
JPH06504776A (ja) | 1994-06-02 |
KR930703347A (ko) | 1993-11-29 |
EP0560912A4 (en) | 1996-08-28 |
WO1992010507A1 (en) | 1992-06-25 |
ES2146209T3 (es) | 2000-08-01 |
EP0560912A1 (de) | 1993-09-22 |
GR3033553T3 (en) | 2000-09-29 |
JP3390430B2 (ja) | 2003-03-24 |
ATE190624T1 (de) | 2000-04-15 |
US5191066A (en) | 1993-03-02 |
CA2097920C (en) | 2003-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |