DE69128273T2 - Für toxin b von clostridium difficile spezifische monoklonale antikörper - Google Patents
Für toxin b von clostridium difficile spezifische monoklonale antikörperInfo
- Publication number
- DE69128273T2 DE69128273T2 DE69128273T DE69128273T DE69128273T2 DE 69128273 T2 DE69128273 T2 DE 69128273T2 DE 69128273 T DE69128273 T DE 69128273T DE 69128273 T DE69128273 T DE 69128273T DE 69128273 T2 DE69128273 T2 DE 69128273T2
- Authority
- DE
- Germany
- Prior art keywords
- toxin
- monoclonal antibodies
- clostridium difficile
- specific monoclonal
- difficile specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000193163 Clostridioides difficile Species 0.000 title abstract 3
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 101710182223 Toxin B Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/522,881 US5231003A (en) | 1990-05-11 | 1990-05-11 | Monoclonal antibodies specific for toxin b of clostridium difficile |
PCT/US1991/003108 WO1991018293A1 (en) | 1990-05-11 | 1991-05-06 | Monoclonal antibodies specific for toxin b of clostridium difficile |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69128273D1 DE69128273D1 (de) | 1998-01-08 |
DE69128273T2 true DE69128273T2 (de) | 1998-06-25 |
Family
ID=24082747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69128273T Expired - Fee Related DE69128273T2 (de) | 1990-05-11 | 1991-05-06 | Für toxin b von clostridium difficile spezifische monoklonale antikörper |
Country Status (11)
Country | Link |
---|---|
US (1) | US5231003A (de) |
EP (1) | EP0482176B1 (de) |
JP (1) | JPH05500011A (de) |
AT (1) | ATE160575T1 (de) |
AU (1) | AU655586B2 (de) |
CA (1) | CA2063709A1 (de) |
DE (1) | DE69128273T2 (de) |
DK (1) | DK0482176T3 (de) |
ES (1) | ES2110993T3 (de) |
IE (1) | IE911617A1 (de) |
WO (1) | WO1991018293A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5610023A (en) * | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
US7179611B2 (en) * | 1997-02-10 | 2007-02-20 | Bd Lee Laboratories | Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A |
US5965375A (en) * | 1997-04-04 | 1999-10-12 | Biosite Diagnostics | Diagnostic tests and kits for Clostridium difficile |
DE19739685A1 (de) * | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
US6270755B1 (en) | 1999-05-13 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders |
US6290946B1 (en) | 1999-05-13 | 2001-09-18 | Geltex Pharmaceuticals, Inc. | Anionic polymers as toxin binders and antibacterial agents |
CA2314494A1 (en) | 2000-05-02 | 2001-11-02 | Geltex Pharmaceuticals, Inc. | Anionic polymers as species specific antibacterial agents |
MXPA05000687A (es) * | 2002-07-22 | 2005-04-08 | Genzyme Corp | Poli (estirenosulfonato potasico y sodico), su fabricacion y sus usos. |
AU2005320349C1 (en) * | 2004-02-06 | 2019-06-13 | E. R. Squibb & Sons, L.L.C. | Antibodies against clostridium difficile toxins and uses thereof |
WO2006044577A1 (en) * | 2004-10-13 | 2006-04-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising a toxin-binding oligosaccharide and a polymeric particle |
US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
US8598321B2 (en) | 2007-03-22 | 2013-12-03 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
WO2009108652A1 (en) | 2008-02-28 | 2009-09-03 | 3M Innovative Properties Company | Antibodies to clostridium difficile spores and uses thereof |
WO2010014854A2 (en) | 2008-07-31 | 2010-02-04 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
ES2589606T3 (es) * | 2009-07-27 | 2016-11-15 | Biodics Gmbh | Procedimiento para la detección y para la identificación de una cepa de C. difficile variante en una muestra |
ES2757675T3 (es) * | 2010-04-15 | 2020-04-29 | Progenics Pharm Inc | Anticuerpos para el tratamiento de la infección y enfermedad asociada a Clostridium difficile |
WO2012047427A2 (en) | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
EP4365196A2 (de) | 2011-04-22 | 2024-05-08 | Wyeth LLC | Zusammensetzungen im zusammenhang mit einem mutierten clostridium-difficile-toxin und verfahren dafür |
SG10201804809RA (en) | 2011-08-22 | 2018-07-30 | Cnj Holdings Inc | Clostridium difficile antibodies |
US8790880B2 (en) * | 2011-09-26 | 2014-07-29 | Techlab, Inc. | Cysteine protease Cwp84 (CD2787) as a diagnostic marker for Clostridium difficile |
CN108101983A (zh) | 2012-03-02 | 2018-06-01 | 瑞泽恩制药公司 | 艰难梭状芽孢杆菌毒素的人源抗体 |
BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
CN112812189B (zh) * | 2020-11-30 | 2022-05-17 | 四川大学华西医院 | 一种抗糖基转移酶a亚单位的纳米抗体及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4533630A (en) * | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
US4879218A (en) * | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
EP0154064A1 (de) * | 1984-03-02 | 1985-09-11 | Tracy Dale Wilkins | Toxine und Antikörper von C. Difficile |
-
1990
- 1990-05-11 US US07/522,881 patent/US5231003A/en not_active Expired - Fee Related
-
1991
- 1991-05-06 AT AT91909906T patent/ATE160575T1/de active
- 1991-05-06 ES ES91909906T patent/ES2110993T3/es not_active Expired - Lifetime
- 1991-05-06 AU AU78830/91A patent/AU655586B2/en not_active Ceased
- 1991-05-06 WO PCT/US1991/003108 patent/WO1991018293A1/en active IP Right Grant
- 1991-05-06 DE DE69128273T patent/DE69128273T2/de not_active Expired - Fee Related
- 1991-05-06 JP JP3509843A patent/JPH05500011A/ja active Pending
- 1991-05-06 DK DK91909906.9T patent/DK0482176T3/da active
- 1991-05-06 CA CA002063709A patent/CA2063709A1/en not_active Abandoned
- 1991-05-06 EP EP91909906A patent/EP0482176B1/de not_active Expired - Lifetime
- 1991-05-10 IE IE161791A patent/IE911617A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH05500011A (ja) | 1993-01-14 |
ES2110993T3 (es) | 1998-03-01 |
EP0482176A1 (de) | 1992-04-29 |
US5231003A (en) | 1993-07-27 |
DE69128273D1 (de) | 1998-01-08 |
CA2063709A1 (en) | 1991-11-12 |
IE911617A1 (en) | 1991-11-20 |
DK0482176T3 (da) | 1998-05-18 |
ATE160575T1 (de) | 1997-12-15 |
WO1991018293A1 (en) | 1991-11-28 |
EP0482176A4 (en) | 1992-08-05 |
AU7883091A (en) | 1991-12-10 |
EP0482176B1 (de) | 1997-11-26 |
AU655586B2 (en) | 1995-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |