DE69127482T2 - Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien - Google Patents

Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien

Info

Publication number
DE69127482T2
DE69127482T2 DE69127482T DE69127482T DE69127482T2 DE 69127482 T2 DE69127482 T2 DE 69127482T2 DE 69127482 T DE69127482 T DE 69127482T DE 69127482 T DE69127482 T DE 69127482T DE 69127482 T2 DE69127482 T2 DE 69127482T2
Authority
DE
Germany
Prior art keywords
alkaline phosphatase
specific activity
image
improved specific
indicator reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69127482T
Other languages
English (en)
Other versions
DE69127482D1 (de
Inventor
Wlodzimierz Mandecki
Susan J Tomazic-Allen
Mary Ann Shallcross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69127482D1 publication Critical patent/DE69127482D1/de
Application granted granted Critical
Publication of DE69127482T2 publication Critical patent/DE69127482T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69127482T 1990-02-07 1991-02-01 Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien Expired - Fee Related DE69127482T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47619990A 1990-02-07 1990-02-07

Publications (2)

Publication Number Publication Date
DE69127482D1 DE69127482D1 (de) 1997-10-09
DE69127482T2 true DE69127482T2 (de) 1998-03-19

Family

ID=23890914

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127482T Expired - Fee Related DE69127482T2 (de) 1990-02-07 1991-02-01 Alkalische Phosphatase mit verbesserter spezifischer Aktivität zur Verwendung in Indikatorreagenzien

Country Status (8)

Country Link
EP (1) EP0441252B1 (de)
JP (1) JP2620416B2 (de)
KR (1) KR910015700A (de)
AT (1) ATE157702T1 (de)
AU (1) AU656313B2 (de)
CA (1) CA2035826A1 (de)
DE (1) DE69127482T2 (de)
ES (1) ES2106737T3 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0651783B1 (de) * 1992-07-07 2003-05-28 Abbott Laboratories Alkalische phosphatase-enzyme mit verbesserter spezifischer aktivität in der verwendung als indikator-reagenzien
US5304472A (en) * 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
EP0688364A4 (de) * 1993-03-09 1997-10-15 Abbott Lab Gentechnologisch hergestellte enzyme und ihre konjugate für diagnostische tests
WO1995005455A1 (en) * 1993-08-13 1995-02-23 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
ATE260987T1 (de) * 1995-12-07 2004-03-15 Diversa Corp Verfahren zum screening enzymatischer aktivität
US6720014B1 (en) 1997-08-13 2004-04-13 Diversa Corporation Phytase-containing foodstuffs and methods of making and using them
US7432097B2 (en) 1997-08-13 2008-10-07 Verenium Corporation Phytases, nucleic acids encoding them and methods of making and using them
US7078035B2 (en) 1997-08-13 2006-07-18 Diversa Corporation Phytases, nucleic acids encoding them and methods for making and using them
US6183740B1 (en) 1997-08-13 2001-02-06 Diversa Corporation Recombinant bacterial phytases and uses thereof
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
CN101220368B (zh) 2003-02-24 2013-06-05 新英格兰生物实验室公司 一种热敏磷酸酶的过量表达、纯化和表征
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US8622905B2 (en) 2003-08-01 2014-01-07 Dexcom, Inc. System and methods for processing analyte sensor data
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8332008B2 (en) 2003-08-01 2012-12-11 Dexcom, Inc. System and methods for processing analyte sensor data
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005051170A2 (en) 2003-11-19 2005-06-09 Dexcom, Inc. Integrated receiver for continuous analyte sensor
EP2256493B1 (de) 2003-12-05 2014-02-26 DexCom, Inc. Kalibrierverfahren für einen kontinuierlichen Analytsensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
EP3263032B1 (de) 2003-12-09 2024-01-24 Dexcom, Inc. Signalverarbeitung in einem durchgehenden analytsensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2007102842A2 (en) 2006-03-09 2007-09-13 Dexcom, Inc. Systems and methods for processing analyte sensor data
EP1985697A1 (de) 2007-04-27 2008-10-29 AM-Pharma B.V. Modifizierte Phosphatasen
EP2152350A4 (de) 2007-06-08 2013-03-27 Dexcom Inc Integrierte medikamentenfreisetzungsvorrichtung mit kontinuierlichem analytsensor
EP4159114B1 (de) 2007-10-09 2024-04-10 DexCom, Inc. Integriertes insulin-abgabesystem mit kontinuierlichem glucosesensor
EP2252196A4 (de) 2008-02-21 2013-05-15 Dexcom Inc Systeme und verfahren zur verarbeitung, übertragung und anzeige von sensordaten
US9801575B2 (en) 2011-04-15 2017-10-31 Dexcom, Inc. Advanced analyte sensor calibration and error detection
US20110004085A1 (en) 2009-04-30 2011-01-06 Dexcom, Inc. Performance reports associated with continuous sensor data from multiple analysis time periods
CN106011159A (zh) 2009-05-21 2016-10-12 巴斯夫酶有限责任公司 肌醇六磷酸酶、编码它们的核酸及制备和使用它们的方法
EP2620162A1 (de) 2012-01-27 2013-07-31 Life Science Inkubator Enzym-Polymer-Konjugat zur Endotoxin-Detoxifikation
WO2013122799A1 (en) * 2012-02-16 2013-08-22 Eli Lilly And Company Methods and compositions for reducing the environmental impact of animal waste
JP5866715B2 (ja) 2013-10-18 2016-02-17 国立大学法人九州大学 タンパク質検出用融合タンパク質およびタンパク質の検出方法
KR102166110B1 (ko) 2014-01-24 2020-10-16 에이엠-파마 비.브이. 키메라 알칼리성 포스파타제-유사 단백질
JP6713147B2 (ja) 2014-01-24 2020-06-24 アーエム−ファルマ ベー．フェー．ＡＭ−Ｐｈａｒｍａ Ｂ．Ｖ． アルカリホスファターゼの下流プロセシング
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
AU2018354120B2 (en) 2017-10-24 2024-05-30 Dexcom, Inc. Pre-connected analyte sensors

Also Published As

Publication number Publication date
EP0441252A3 (en) 1991-11-21
ES2106737T3 (es) 1997-11-16
AU656313B2 (en) 1995-02-02
JP2620416B2 (ja) 1997-06-11
ATE157702T1 (de) 1997-09-15
CA2035826A1 (en) 1991-08-08
JPH04349881A (ja) 1992-12-04
AU7083791A (en) 1991-08-08
EP0441252B1 (de) 1997-09-03
DE69127482D1 (de) 1997-10-09
KR910015700A (ko) 1991-09-30
EP0441252A2 (de) 1991-08-14

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee