DE69126526T2 - Verfahren zur zellwachstumshinderung und dazu nützliche verbindungen - Google Patents

Verfahren zur zellwachstumshinderung und dazu nützliche verbindungen

Info

Publication number
DE69126526T2
DE69126526T2 DE69126526T DE69126526T DE69126526T2 DE 69126526 T2 DE69126526 T2 DE 69126526T2 DE 69126526 T DE69126526 T DE 69126526T DE 69126526 T DE69126526 T DE 69126526T DE 69126526 T2 DE69126526 T2 DE 69126526T2
Authority
DE
Germany
Prior art keywords
cell growth
combinations
combination
individually
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126526T
Other languages
English (en)
Other versions
DE69126526D1 (de
Inventor
Ian Trowbridge
Raymond Taetle
Suhaila White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Salk Institute for Biological Studies
Original Assignee
University of California
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Salk Institute for Biological Studies filed Critical University of California
Publication of DE69126526D1 publication Critical patent/DE69126526D1/de
Application granted granted Critical
Publication of DE69126526T2 publication Critical patent/DE69126526T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
DE69126526T 1990-03-27 1991-03-26 Verfahren zur zellwachstumshinderung und dazu nützliche verbindungen Expired - Fee Related DE69126526T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50003590A 1990-03-27 1990-03-27
PCT/US1991/002031 WO1991014452A1 (en) 1990-03-27 1991-03-26 Method for inhibiting cell growth and compositions useful therefor

Publications (2)

Publication Number Publication Date
DE69126526D1 DE69126526D1 (de) 1997-07-17
DE69126526T2 true DE69126526T2 (de) 1998-02-05

Family

ID=23987769

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126526T Expired - Fee Related DE69126526T2 (de) 1990-03-27 1991-03-26 Verfahren zur zellwachstumshinderung und dazu nützliche verbindungen

Country Status (8)

Country Link
US (1) US5667781A (de)
EP (1) EP0525005B1 (de)
JP (1) JPH05505823A (de)
AT (1) ATE154245T1 (de)
AU (1) AU642014B2 (de)
CA (1) CA2081368A1 (de)
DE (1) DE69126526T2 (de)
WO (1) WO1991014452A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69428041T2 (de) * 1993-05-03 2002-03-28 Genentech Inc Inhibierung von Leukozytenadhäsion
US5922346A (en) * 1997-12-01 1999-07-13 Thione International, Inc. Antioxidant preparation
US20020199218A1 (en) * 1999-08-19 2002-12-26 Daphne Goring Proline-rich extensin-like receptor kinases
CA2364983A1 (en) * 2000-12-13 2002-06-13 John R. Coleman Nucleic acid molecules and polypeptides for catabolism of abscisic acid
US7597895B2 (en) * 2001-02-20 2009-10-06 The Governing Council Of The University Of Toronto Signal peptides, nucleic acid molecules and methods for treatment of caries
US7556807B2 (en) 2001-02-20 2009-07-07 Kane Biotech, Inc. Signal peptides, nucleic acid molecules and methods for treatment of caries
CA2522700A1 (en) * 2003-04-18 2004-11-04 Cytovia, Inc. Methods of treating diseases responsive to induction of apoptosis and screening assays
US6977720B2 (en) * 2003-08-05 2005-12-20 Agilent Technologies, Inc. Characterization of active and passive optical properties of an optical device
WO2005094364A2 (en) * 2004-03-31 2005-10-13 Chimeric Technologies, Inc. Iga antibody protein as a cytotoxic drug
PT1740616E (pt) * 2004-04-30 2012-03-23 Inst Nat Sante Rech Med Anticorpo anti-rtf
EP1765868B1 (de) * 2004-06-07 2016-04-20 MacroGenics, Inc. Antikörper gegen den transferrinrezeptor
US7736647B2 (en) 2005-06-15 2010-06-15 Monoclonal Antibodies Therapeutics Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
EP2364366B1 (de) 2008-11-05 2014-01-08 MorphoSys AG Dekonvolutionsverfahren
ES2611032T3 (es) * 2009-02-05 2017-05-04 Oncoxx Biotech S.R.L. Anticuerpos monoclonales anti-Trop-2 y sus usos en el tratamiento y diagnóstico de tumores
MX2012000086A (es) 2009-06-26 2012-06-12 Soricimed Biopharma Inc Peptidos derivados de soricidi y metodos para la la deteccion de canceres trpv-6 y suministro de farmaco.
US8734799B2 (en) * 2010-04-13 2014-05-27 The Regents Of The University Of California Unconjugated anti-TfR antibodies and compositions thereof for the treatment of cancer
KR102099462B1 (ko) 2010-11-30 2020-04-10 제넨테크, 인크. 저친화도 혈액-뇌 장벽 수용체 항체 및 그의 용도
US9598496B2 (en) 2011-05-09 2017-03-21 Perseus Proteomics Inc. Antibody capable of specifically recognizing transferrin receptor
CN102827813B (zh) * 2012-09-30 2014-12-31 苏州大学 抗人cd133单克隆抗体及其制备和应用
CN104797600A (zh) 2012-11-08 2015-07-22 国立大学法人宫崎大学 能够特异性识别转铁蛋白受体的抗体
US9499628B2 (en) * 2013-06-14 2016-11-22 Children's Hospital Medical Center Method of boosting the immune response in neonates
JP2018024615A (ja) * 2016-08-10 2018-02-15 学校法人 聖マリアンナ医科大学 Ｈｔｌｖ−１関連炎症性疾患を治療する医薬組成物
WO2023015234A1 (en) * 2021-08-05 2023-02-09 Bristol-Myers Squibb Company Cell culture methods for producing therapeutic proteins
IL311175A (en) 2021-09-01 2024-04-01 Biogen Ma Inc Anti-transferrin receptor antibodies and their uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434156A (en) 1981-10-26 1984-02-28 The Salk Institute For Biological Studies Monoclonal antibodies specific for the human transferrin receptor glycoprotein
US4925922A (en) * 1983-02-22 1990-05-15 Xoma Corporation Potentiation of cytotoxic conjugates
US5182107A (en) * 1989-09-07 1993-01-26 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates

Also Published As

Publication number Publication date
WO1991014452A1 (en) 1991-10-03
EP0525005B1 (de) 1997-06-11
EP0525005A4 (en) 1993-06-16
DE69126526D1 (de) 1997-07-17
JPH05505823A (ja) 1993-08-26
CA2081368A1 (en) 1991-09-28
AU642014B2 (en) 1993-10-07
US5667781A (en) 1997-09-16
AU7667091A (en) 1991-10-21
ATE154245T1 (de) 1997-06-15
EP0525005A1 (de) 1993-02-03

Similar Documents

Publication Publication Date Title
DE69126526D1 (de) Verfahren zur zellwachstumshinderung und dazu nützliche verbindungen
DK0584082T3 (da) Domæner i den ekstracellulære region af humane blodpladeafledte vækstfaktorreceptorpolypeptider
MY108526A (en) Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
BG99605A (en) Antagonists of the growth factor or endothelial cells of the circulatory system
ATE124421T1 (de) Verfahren zur wachstumshemmung von stammzellen.
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
DE69713499D1 (de) Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung
ATE238800T1 (de) Verwendung von squalamin zur herstellung eines arzneimittels zur inhibierung von nhe
DK1113810T3 (da) Fremgangsmåder til behandling af multipelt myelom og myelom-induceret knogleresorption under anvendelse af antagonister af integrin/receptor-binding
DK388384A (da) Monoklone antistoffer med specifitet for membran-associerede antigener, deres fremstilling og anvendelse
DE3684211D1 (de)
ATE238066T1 (de) Induktion von immunologischer toleranz unter verwendung von nicht-zellmengeverringernden anti- cd4-antikoepern
PT939809E (pt) Ligandos do receptor de tie-2 (ligando 3 de tie e ligando 4 de tie) e suas utilizacoes
DE68918944T2 (de) Künstliche rezeptor-analoge.
FR2560212B1 (fr) Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
TR199701013T1 (xx) Nitrik oksit synthas'�n�n inhibit�rleri olarak mercapto ve seleno t�revleri.
DE69535263D1 (de) Angiotensin ii zur verbesserung der befruchtung
NO954781L (no) Fremgangsmåter for screening av substanser med en modulerende virkning på en interleukin-5-reseptoravhengig cellulær signaloverföringsvei
DE69428272D1 (de) Lo-cd2a antikörper und dessen verwendung zur inhibition von t-zell-aktivierung und -wachstum
DK0504307T3 (da) Fremgangsmåde til behandling af septisk shock
AU3088984A (en) Antibodies and compositions thereof for inhibiting dental induced by s. abitans
ATE298244T1 (de) Monoklonaler antikörper mit selektiver bindung an vgf und verwendung zur behandlung von vgf- erkrankungen
ATE70311T1 (de) Monoklonale antikoerper gegen menschliche igerezeptoren auf lymphocyten, diese antikoerper produzierende hybridomas und reaktionsansaetze zum gebrauch dieser antikoerper.
ECSP055740A (es) Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método.
NZ237533A (en) Monoclonal antibodies which bind to oncostatin m, cell lines producing them

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee