DE69109886T2 - Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen. - Google Patents
Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen.Info
- Publication number
- DE69109886T2 DE69109886T2 DE69109886T DE69109886T DE69109886T2 DE 69109886 T2 DE69109886 T2 DE 69109886T2 DE 69109886 T DE69109886 T DE 69109886T DE 69109886 T DE69109886 T DE 69109886T DE 69109886 T2 DE69109886 T2 DE 69109886T2
- Authority
- DE
- Germany
- Prior art keywords
- factor viii
- analogue
- analogs
- preparation
- human factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR909001302A FR2657884B1 (fr) | 1990-02-05 | 1990-02-05 | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69109886D1 DE69109886D1 (de) | 1995-06-29 |
DE69109886T2 true DE69109886T2 (de) | 1996-02-29 |
Family
ID=9393391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69109886T Expired - Fee Related DE69109886T2 (de) | 1990-02-05 | 1991-02-05 | Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5422250A (de) |
EP (1) | EP0441695B1 (de) |
JP (1) | JPH06113879A (de) |
AT (1) | ATE123069T1 (de) |
CA (1) | CA2035691A1 (de) |
DE (1) | DE69109886T2 (de) |
DK (1) | DK0441695T3 (de) |
ES (1) | ES2075378T3 (de) |
FR (1) | FR2657884B1 (de) |
GR (1) | GR3017201T3 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2657884B1 (fr) * | 1990-02-05 | 1994-09-02 | Tm Innovation | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
US5318898A (en) * | 1991-04-02 | 1994-06-07 | Genetics Institute, Inc. | Production of recombinant bone-inducing proteins |
DK53792D0 (da) * | 1992-04-24 | 1992-04-24 | Novo Nordisk As | Fremgangsmaade til fremstilling af proteiner |
WO1994011525A1 (en) * | 1992-11-17 | 1994-05-26 | Novo Nordisk A/S | Improved recombinant production of proteins having factor viii:c activity |
JP3428687B2 (ja) * | 1993-06-30 | 2003-07-22 | 財団法人化学及血清療法研究所 | 組織因子凝固系インヒビターの調製法 |
SE9303601D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Improved cell cultivation method and medium |
EP1482031B1 (de) | 1996-08-30 | 2015-10-28 | Life Technologies Corporation | Serumfreies Kulturmedium für Säugerzellen und seine Verwendung |
PL346796A1 (en) | 1998-09-21 | 2002-02-25 | Genetics Inst | Methods of downmodulating the immune response to therapeutic proteins |
ZA200700168B (en) | 2001-10-10 | 2010-02-24 | Novo Nordisk As | Remodeling and glycoconjugation of peptides |
US20030181416A1 (en) * | 2002-01-10 | 2003-09-25 | Comper Wayne D. | Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof |
WO2006113861A2 (en) * | 2005-04-20 | 2006-10-26 | Wyeth | Mammalian expression systems |
US20070087061A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components |
US20070086958A1 (en) * | 2005-10-14 | 2007-04-19 | Medafor, Incorporated | Formation of medically useful gels comprising microporous particles and methods of use |
AU2007347505B2 (en) * | 2007-02-23 | 2012-11-22 | Sk Bioscience Co., Ltd. | Process for producing and purifying factor VIII and its derivatives |
PT2499165T (pt) | 2009-11-13 | 2016-10-28 | Grifols Therapeutics Inc | Preparações que contêm o fator de von willebrand (vwf), e métodos, kits e utilizações relacionadas com as mesmas |
AU2012324020A1 (en) | 2011-12-30 | 2013-07-18 | Grifols, S.A. | Method for purifying Factor VIII |
JP2014138614A (ja) * | 2014-04-09 | 2014-07-31 | Sk Chemicals Co Ltd | 第viii因子とその誘導体の製造及び精製方法 |
US10119117B2 (en) | 2016-01-28 | 2018-11-06 | Nanogen Pharmaceutical Biotechnology Co., Ltd | Universal, glycosylation enhancer, completely chemically defined medium formulation |
JP6351679B2 (ja) * | 2016-09-30 | 2018-07-04 | エスケー ケミカルズ カンパニー リミテッド | 第viii因子とその誘導体の製造及び精製方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3803115A (en) * | 1972-05-17 | 1974-04-09 | Baxter Laboratories Inc | Stabilization of ahf using heparin |
US4443546A (en) * | 1980-07-07 | 1984-04-17 | The Beth Israel Hospital Association | Process and composition for propagating mammalian cells |
US4359463A (en) * | 1980-11-26 | 1982-11-16 | Rock Gail A | Stabilization of Factor VIII activity in whole blood or blood plasma |
US4397841A (en) * | 1982-06-28 | 1983-08-09 | Monsanto Company | Production of blood coagulation factor VIII:C |
NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
US5132223A (en) * | 1983-11-10 | 1992-07-21 | Thomas Jefferson University | Process and medium for cloning and long-term serial cultivation of adult human endothelial cells |
ZA852099B (en) | 1984-03-26 | 1985-12-24 | Meloy Lab | Recombinant factor viii-c. |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4670394A (en) * | 1984-11-16 | 1987-06-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C |
GB8505882D0 (en) * | 1985-03-07 | 1985-04-11 | Central Blood Lab Authority | Purification of blood coagulation factor viii |
US5198349A (en) * | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
WO1987004187A1 (en) | 1986-01-03 | 1987-07-16 | Genetics Institute, Inc. | METHOD FOR PRODUCING FACTOR VIII:c-TYPE PROTEINS |
FI98829C (fi) | 1986-01-27 | 1997-08-25 | Chiron Corp | Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta |
DK155388C (da) | 1986-07-08 | 1989-10-23 | Palle Pedersen | Laas |
ATE63335T1 (de) * | 1986-07-11 | 1991-05-15 | Miles Inc | Herstellung von rekombinantem protein. |
IL83192A (en) | 1986-07-18 | 1992-11-15 | Gist Brocades Nv | Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
US5171844A (en) * | 1987-06-12 | 1992-12-15 | Gist-Brocades N.W. | Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
EP0294910B1 (de) | 1987-06-12 | 1996-09-11 | Immuno Ag | Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen |
FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
JPH0387173A (ja) * | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
FR2657884B1 (fr) * | 1990-02-05 | 1994-09-02 | Tm Innovation | Procede pour la preparation du facteur viii humain et d'analogues du facteur viii. |
-
1990
- 1990-02-05 FR FR909001302A patent/FR2657884B1/fr not_active Expired - Fee Related
-
1991
- 1991-02-05 CA CA002035691A patent/CA2035691A1/fr not_active Abandoned
- 1991-02-05 AT AT91400267T patent/ATE123069T1/de not_active IP Right Cessation
- 1991-02-05 ES ES91400267T patent/ES2075378T3/es not_active Expired - Lifetime
- 1991-02-05 DK DK91400267.0T patent/DK0441695T3/da active
- 1991-02-05 DE DE69109886T patent/DE69109886T2/de not_active Expired - Fee Related
- 1991-02-05 EP EP91400267A patent/EP0441695B1/de not_active Expired - Lifetime
- 1991-02-05 JP JP3102185A patent/JPH06113879A/ja active Pending
-
1992
- 1992-11-03 US US07/970,951 patent/US5422250A/en not_active Expired - Lifetime
-
1995
- 1995-02-07 US US08/384,774 patent/US5707832A/en not_active Expired - Fee Related
- 1995-08-23 GR GR950402314T patent/GR3017201T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3017201T3 (en) | 1995-11-30 |
ATE123069T1 (de) | 1995-06-15 |
ES2075378T3 (es) | 1995-10-01 |
EP0441695B1 (de) | 1995-05-24 |
US5707832A (en) | 1998-01-13 |
CA2035691A1 (fr) | 1991-08-06 |
DK0441695T3 (da) | 1995-10-16 |
EP0441695A1 (de) | 1991-08-14 |
FR2657884A1 (fr) | 1991-08-09 |
US5422250A (en) | 1995-06-06 |
DE69109886D1 (de) | 1995-06-29 |
JPH06113879A (ja) | 1994-04-26 |
FR2657884B1 (fr) | 1994-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |