DE69109886D1 - Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen. - Google Patents

Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen.

Info

Publication number
DE69109886D1
DE69109886D1 DE69109886T DE69109886T DE69109886D1 DE 69109886 D1 DE69109886 D1 DE 69109886D1 DE 69109886 T DE69109886 T DE 69109886T DE 69109886 T DE69109886 T DE 69109886T DE 69109886 D1 DE69109886 D1 DE 69109886D1
Authority
DE
Germany
Prior art keywords
factor viii
analogue
analogs
preparation
human factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69109886T
Other languages
English (en)
Other versions
DE69109886T2 (de
Inventor
Gerard Mignot
Nicolas Bihoreau
Philippe Adamowicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TM Innovation
Original Assignee
TM Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TM Innovation filed Critical TM Innovation
Application granted granted Critical
Publication of DE69109886D1 publication Critical patent/DE69109886D1/de
Publication of DE69109886T2 publication Critical patent/DE69109886T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69109886T 1990-02-05 1991-02-05 Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen. Expired - Fee Related DE69109886T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909001302A FR2657884B1 (fr) 1990-02-05 1990-02-05 Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.

Publications (2)

Publication Number Publication Date
DE69109886D1 true DE69109886D1 (de) 1995-06-29
DE69109886T2 DE69109886T2 (de) 1996-02-29

Family

ID=9393391

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69109886T Expired - Fee Related DE69109886T2 (de) 1990-02-05 1991-02-05 Verfahren zur Herstellung von humanem Faktor VIII und dessen Analogen.

Country Status (10)

Country Link
US (2) US5422250A (de)
EP (1) EP0441695B1 (de)
JP (1) JPH06113879A (de)
AT (1) ATE123069T1 (de)
CA (1) CA2035691A1 (de)
DE (1) DE69109886T2 (de)
DK (1) DK0441695T3 (de)
ES (1) ES2075378T3 (de)
FR (1) FR2657884B1 (de)
GR (1) GR3017201T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
CA2149212A1 (en) * 1992-11-17 1994-05-26 Mirella Ezban Rasmussen Improved recombinant production of proteins having factor viii:c activity
JP3428687B2 (ja) * 1993-06-30 2003-07-22 財団法人化学及血清療法研究所 組織因子凝固系インヒビターの調製法
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
EP2243827B2 (de) * 1996-08-30 2017-11-22 Life Technologies Corporation Serumfreies kulturmedium für säugerzellen und seine verwendung
KR20010085830A (ko) 1998-09-21 2001-09-07 브루스 엠. 에이센, 토마스 제이 데스로저 치료 단백질에 대한 면역 반응을 하향조절하는 방법
EP2305313B1 (de) 2001-10-10 2014-03-26 ratiopharm GmbH Neumodulierung und Glykokonjugation von Interferon alpha (IFNa)
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
BRPI0610600A2 (pt) * 2005-04-20 2010-07-06 Wyeth Corp sistema de expressão; composição farmacêutica; método para o aumento da expressão de uma proteìna expressa de modo recombinante; e método para a produção de uma proteìna
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US9441030B2 (en) * 2007-02-23 2016-09-13 Sk Chemicals Co., Ltd. Process for producing and purifying factor VIII and its derivatives
BR112012011740A2 (pt) 2009-11-13 2018-03-27 Grifols Therapeutics Inc polipeptídeo, composição compreendendo o referido polipeptídeo, complexo de proteína, seqüência de nucleotídeo, vetor de expressão célula, e métodos para a preparação do complexo de proteína, para a preparação de um fviii, e para intensificar uma propriedade farmacocinética no plasma de um fviii
WO2013098676A1 (en) 2011-12-30 2013-07-04 Grifols, S.A. Method for purifying factor viii
JP2014138614A (ja) * 2014-04-09 2014-07-31 Sk Chemicals Co Ltd 第ｖｉｉｉ因子とその誘導体の製造及び精製方法
US10119117B2 (en) 2016-01-28 2018-11-06 Nanogen Pharmaceutical Biotechnology Co., Ltd Universal, glycosylation enhancer, completely chemically defined medium formulation
JP6351679B2 (ja) * 2016-09-30 2018-07-04 エスケー ケミカルズ カンパニー リミテッド 第ｖｉｉｉ因子とその誘導体の製造及び精製方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803115A (en) * 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
US4443546A (en) * 1980-07-07 1984-04-17 The Beth Israel Hospital Association Process and composition for propagating mammalian cells
US4359463A (en) * 1980-11-26 1982-11-16 Rock Gail A Stabilization of Factor VIII activity in whole blood or blood plasma
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
US5132223A (en) * 1983-11-10 1992-07-21 Thomas Jefferson University Process and medium for cloning and long-term serial cultivation of adult human endothelial cells
ZA852099B (en) 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4670394A (en) * 1984-11-16 1987-06-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation and culture of adrenal medullary endothelial cells producing blood clotting factor VIII:C
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
JP2525022B2 (ja) 1986-01-03 1996-08-14 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド ▲ＶＩＩＩ▼：ｃ因子型タンパク質の改良生産方法
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
FI98829C (fi) 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
DK155388C (da) 1986-07-08 1989-10-23 Palle Pedersen Laas
EP0254076B1 (de) * 1986-07-11 1991-05-08 Miles Inc. Herstellung von rekombinantem Protein
IL83192A (en) 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
US4980456A (en) * 1987-04-06 1990-12-25 Scripps Clinic And Research Foundation Recombinant factor VIIIC derived fragments
US5171844A (en) * 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0294910B1 (de) 1987-06-12 1996-09-11 Immuno Ag Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen
FR2619314B1 (fr) * 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.

Also Published As

Publication number Publication date
EP0441695B1 (de) 1995-05-24
EP0441695A1 (de) 1991-08-14
DE69109886T2 (de) 1996-02-29
FR2657884B1 (fr) 1994-09-02
ES2075378T3 (es) 1995-10-01
GR3017201T3 (en) 1995-11-30
ATE123069T1 (de) 1995-06-15
JPH06113879A (ja) 1994-04-26
US5422250A (en) 1995-06-06
US5707832A (en) 1998-01-13
DK0441695T3 (da) 1995-10-16
CA2035691A1 (fr) 1991-08-06
FR2657884A1 (fr) 1991-08-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee