DE69024322T2 - Dreizyklische Chinoline als antineoplastische Wirkstoffe - Google Patents

Dreizyklische Chinoline als antineoplastische Wirkstoffe

Info

Publication number
DE69024322T2
DE69024322T2 DE69024322T DE69024322T DE69024322T2 DE 69024322 T2 DE69024322 T2 DE 69024322T2 DE 69024322 T DE69024322 T DE 69024322T DE 69024322 T DE69024322 T DE 69024322T DE 69024322 T2 DE69024322 T2 DE 69024322T2
Authority
DE
Germany
Prior art keywords
lower alkyl
group
quinolines
cycle
phenyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024322T
Other languages
English (en)
Other versions
DE69024322D1 (de
Inventor
Daniel T Chu
Jacob J Plattner
Larry L Klein
Linus L Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69024322D1 publication Critical patent/DE69024322D1/de
Application granted granted Critical
Publication of DE69024322T2 publication Critical patent/DE69024322T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/06—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
DE69024322T 1989-10-23 1990-10-18 Dreizyklische Chinoline als antineoplastische Wirkstoffe Expired - Fee Related DE69024322T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/425,536 US5071848A (en) 1989-10-23 1989-10-23 Tricyclic quinoline antineoplastic agents

Publications (2)

Publication Number Publication Date
DE69024322D1 DE69024322D1 (de) 1996-02-01
DE69024322T2 true DE69024322T2 (de) 1996-10-31

Family

ID=23686982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024322T Expired - Fee Related DE69024322T2 (de) 1989-10-23 1990-10-18 Dreizyklische Chinoline als antineoplastische Wirkstoffe

Country Status (11)

Country Link
US (1) US5071848A (de)
EP (1) EP0424802B1 (de)
JP (1) JPH03167191A (de)
AT (1) ATE131809T1 (de)
CA (1) CA2028246A1 (de)
DE (1) DE69024322T2 (de)
DK (1) DK0424802T3 (de)
ES (1) ES2083990T3 (de)
GR (1) GR3018961T3 (de)
IE (1) IE71688B1 (de)
PT (1) PT95646A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1554572B1 (de) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
AU2006214234B2 (en) * 2003-08-12 2012-04-12 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
EP1809639B1 (de) * 2004-11-11 2009-10-14 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] chinolin-3, 4-dione und verwandte verbindungen als infektionsschutzmittel
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
WO2006084053A1 (en) * 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
EP2671508B1 (de) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-Informatiksystem
PL1913004T3 (pl) 2005-07-27 2011-03-31 Achillion Pharmaceuticals Inc 8-metoksy-9H-izotiazolo[5,4-B] chinolino-3,4-diony i pokrewne związki jako środki przeciwzakaźne
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
KR101477817B1 (ko) 2008-01-25 2014-12-30 미쓰비시 마테리알 가부시키가이샤 반응로 세정 장치
CA2969926C (en) 2009-02-20 2018-05-15 2-Bbb Medicines B.V. Glutathione-based drug delivery system
SG174498A1 (en) * 2009-04-03 2011-10-28 Achillion Pharmaceuticals Inc Hydroxythienoquinolones and related compounds as anti-infective agents
EP4218718A3 (de) 2009-05-06 2024-04-24 Laboratory Skin Care, Inc. Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN115650913B (zh) * 2022-10-12 2024-03-01 北京中医药大学 醌式喹啉类化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
US4880814A (en) * 1987-11-13 1989-11-14 Abbott Laboratories 7-cycloalkyl naphthyridines
JPH01160985A (ja) * 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) * 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤

Also Published As

Publication number Publication date
IE903633A1 (en) 1991-04-24
US5071848A (en) 1991-12-10
ATE131809T1 (de) 1996-01-15
JPH03167191A (ja) 1991-07-19
DE69024322D1 (de) 1996-02-01
EP0424802A2 (de) 1991-05-02
EP0424802A3 (en) 1992-05-06
GR3018961T3 (en) 1996-05-31
PT95646A (pt) 1991-09-13
EP0424802B1 (de) 1995-12-20
IE71688B1 (en) 1997-02-26
CA2028246A1 (en) 1991-04-24
DK0424802T3 (da) 1996-04-22
ES2083990T3 (es) 1996-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee