DE69023748D1 - Verwendung von Stickstoff enthaltenden Makrozyklen zur Behandlung retroviraler Infektionen. - Google Patents

Verwendung von Stickstoff enthaltenden Makrozyklen zur Behandlung retroviraler Infektionen.

Info

Publication number
DE69023748D1
DE69023748D1 DE69023748T DE69023748T DE69023748D1 DE 69023748 D1 DE69023748 D1 DE 69023748D1 DE 69023748 T DE69023748 T DE 69023748T DE 69023748 T DE69023748 T DE 69023748T DE 69023748 D1 DE69023748 D1 DE 69023748D1
Authority
DE
Germany
Prior art keywords
nitrogen
retroviral infections
containing macrocycles
treat retroviral
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69023748T
Other languages
English (en)
Other versions
DE69023748T2 (de
Inventor
Barry Anthony Murrer
David Aaron Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey PLC
Original Assignee
Johnson Matthey PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Application granted granted Critical
Publication of DE69023748D1 publication Critical patent/DE69023748D1/de
Publication of DE69023748T2 publication Critical patent/DE69023748T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69023748T 1989-12-21 1990-12-19 Verwendung von Stickstoff enthaltenden Makrozyklen zur Behandlung retroviraler Infektionen. Expired - Lifetime DE69023748T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/454,418 US5021409A (en) 1989-12-21 1989-12-21 Antiviral cyclic polyamines

Publications (2)

Publication Number Publication Date
DE69023748D1 true DE69023748D1 (de) 1996-01-04
DE69023748T2 DE69023748T2 (de) 1996-05-02

Family

ID=23804523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69023748T Expired - Lifetime DE69023748T2 (de) 1989-12-21 1990-12-19 Verwendung von Stickstoff enthaltenden Makrozyklen zur Behandlung retroviraler Infektionen.

Country Status (17)

Country Link
US (1) US5021409A (de)
EP (1) EP0434385B1 (de)
JP (1) JP3133345B2 (de)
KR (1) KR0180019B1 (de)
AT (1) ATE130514T1 (de)
AU (1) AU639514B2 (de)
CA (1) CA2032261C (de)
DE (1) DE69023748T2 (de)
DK (1) DK0434385T3 (de)
ES (1) ES2079453T3 (de)
GR (1) GR3018206T3 (de)
HU (2) HUT67031A (de)
IE (1) IE71640B1 (de)
IL (1) IL96666A (de)
NZ (1) NZ236463A (de)
PT (1) PT96289B (de)
ZA (1) ZA9010184B (de)

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US5606053A (en) * 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US6506770B1 (en) * 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
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ATE309794T1 (de) * 1995-06-26 2005-12-15 Chelator Llc Methode zur hemmung des wachstums von bakterien oder pilzen mit einem komplexbildner
US5608061A (en) * 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
US7118859B2 (en) 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
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US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
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US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
US6365583B1 (en) * 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
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CA2371625C (en) * 1999-04-30 2012-04-17 Slil Biomedical Corporation Polyamines and their use in therapy
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WO2003050072A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
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US7354932B2 (en) 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
WO2004091518A2 (en) 2003-04-11 2004-10-28 Anormed Inc. Cxcr4 chemokine receptor binding compounds
WO2004093817A2 (en) 2003-04-22 2004-11-04 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7501518B2 (en) * 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
US7491735B2 (en) * 2003-12-11 2009-02-17 Genzyme Corporation Chemokine receptor binding compounds
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BRPI0514343A (pt) * 2004-08-13 2008-06-10 Anormed Inc combinações de quimiocinas para mobilizar células progenitoras/tronco
JP2008543858A (ja) * 2005-06-15 2008-12-04 ジェンザイム・コーポレーション ケモカインレセプター結合化合物
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CN108883091A (zh) 2015-12-22 2018-11-23 X4 制药有限公司 用于治疗免疫缺陷病的方法
JP2019510785A (ja) 2016-04-08 2019-04-18 エックス４ ファーマシューティカルズ， インコーポレイテッド 癌を処置する方法
CN116554168A (zh) 2016-06-21 2023-08-08 X4 制药有限公司 Cxcr4抑制剂及其用途
CA3027495A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
US11332470B2 (en) 2016-06-21 2022-05-17 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
WO2019089833A1 (en) 2017-10-31 2019-05-09 Magenta Therapeutics Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
AU2018358241A1 (en) 2017-10-31 2020-05-07 Edigene Biotechnology, Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells
US11260079B2 (en) 2017-12-06 2022-03-01 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
JP2021505172A (ja) 2017-12-06 2021-02-18 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 造血幹細胞及び前駆細胞を動員させるための投薬レジメン
CN111902411A (zh) 2018-01-03 2020-11-06 美真达治疗公司 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法
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DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
NZ236463A (en) 1992-04-28
KR0180019B1 (ko) 1999-03-20
GR3018206T3 (en) 1996-02-29
IL96666A0 (en) 1991-09-16
HU210534A9 (en) 1995-04-28
IE71640B1 (en) 1997-02-26
AU639514B2 (en) 1993-07-29
EP0434385A3 (en) 1992-03-04
JP3133345B2 (ja) 2001-02-05
PT96289B (pt) 1998-06-30
KR910011267A (ko) 1991-08-07
CA2032261A1 (en) 1991-06-22
ZA9010184B (en) 1991-11-27
DK0434385T3 (da) 1995-12-18
DE69023748T2 (de) 1996-05-02
IL96666A (en) 1996-01-31
IE904619A1 (en) 1991-07-17
CA2032261C (en) 2002-04-23
ES2079453T3 (es) 1996-01-16
EP0434385B1 (de) 1995-11-22
HUT67031A (en) 1995-01-30
EP0434385A2 (de) 1991-06-26
US5021409A (en) 1991-06-04
AU6809090A (en) 1991-06-27
PT96289A (pt) 1991-10-15
HU908367D0 (en) 1991-07-29
ATE130514T1 (de) 1995-12-15
JPH06219945A (ja) 1994-08-09

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Legal Events

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336