DE69015541D1 - Chinolinderivate, deren Herstellung und Verwendung. - Google Patents

Chinolinderivate, deren Herstellung und Verwendung.

Info

Publication number
DE69015541D1
DE69015541D1 DE69015541T DE69015541T DE69015541D1 DE 69015541 D1 DE69015541 D1 DE 69015541D1 DE 69015541 T DE69015541 T DE 69015541T DE 69015541 T DE69015541 T DE 69015541T DE 69015541 D1 DE69015541 D1 DE 69015541D1
Authority
DE
Germany
Prior art keywords
chem
production
quinoline derivatives
alkyl group
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69015541T
Other languages
English (en)
Other versions
DE69015541T2 (de
Inventor
Kanji Meguro
Hitoshi Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69015541D1 publication Critical patent/DE69015541D1/de
Publication of DE69015541T2 publication Critical patent/DE69015541T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measurement Of Radiation (AREA)
  • Quinoline Compounds (AREA)
  • Holo Graphy (AREA)
  • Detergent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69015541T 1989-10-06 1990-10-05 Chinolinderivate, deren Herstellung und Verwendung. Expired - Fee Related DE69015541T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26278289 1989-10-06
JP32229089 1989-12-11

Publications (2)

Publication Number Publication Date
DE69015541D1 true DE69015541D1 (de) 1995-02-09
DE69015541T2 DE69015541T2 (de) 1995-06-01

Family

ID=26545706

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69015541T Expired - Fee Related DE69015541T2 (de) 1989-10-06 1990-10-05 Chinolinderivate, deren Herstellung und Verwendung.

Country Status (17)

Country Link
US (1) US5223513A (de)
EP (1) EP0421456B1 (de)
KR (1) KR910007883A (de)
CN (1) CN1050715A (de)
AT (1) ATE116301T1 (de)
AU (1) AU629048B2 (de)
CA (1) CA2026890C (de)
DE (1) DE69015541T2 (de)
FI (1) FI904915A0 (de)
HU (1) HUT55364A (de)
IE (1) IE903454A1 (de)
IL (1) IL95839A (de)
NO (1) NO904300L (de)
NZ (1) NZ235582A (de)
PT (1) PT95515A (de)
RU (1) RU2001910C1 (de)
TW (1) TW205037B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
JPH0776215B2 (ja) * 1991-04-26 1995-08-16 フアイザー・インコーポレイテツド ４−アリール−３−（ヘテロアリールウレイド）キノリン誘導体
ES2125325T3 (es) * 1992-01-23 1999-03-01 Pfizer Derivados de 4-fenil-3-(heteroarilureido)-1,2-dihidro-2-oxoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.
TW241258B (de) * 1992-04-15 1995-02-21 Takeda Pharm Industry Co Ltd
CA2134359C (en) * 1992-05-28 1997-07-01 Ernest S. Hamanaka New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
NO179904C (no) * 1992-09-04 1997-01-08 Takeda Chemical Industries Ltd Kondenserte heterocykliske forbindelser og deres anvendelse
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
TW263498B (de) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
US5972961A (en) * 1997-08-28 1999-10-26 Bristol-Myers Squibb Company 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
WO1999043659A1 (fr) 1998-02-25 1999-09-02 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyridone et leur procede de fabrication
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
KR20020073574A (ko) * 2000-02-02 2002-09-27 워너-램버트 캄파니 피지선 장애 치료용 콜레스테롤 에스테르 및 왁스에스테르 합성 이중 억제제
CN1234691C (zh) * 2001-03-02 2006-01-04 住友化学工业株式会社 喹啉－3－羧酸化合物的制备方法
CA2539760C (en) * 2003-09-23 2011-01-25 Merck & Co., Inc. Quinoline potassium channel inhibitors
EP2773619B1 (de) * 2011-11-04 2016-11-16 F.Hoffmann-La Roche Ag Neue arylchinolinderivate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216878B (de) * 1963-04-02 1966-05-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
NO133758C (de) * 1970-04-04 1976-06-23 Takeda Chemical Industries Ltd
JPS555502B1 (de) * 1971-07-31 1980-02-07
US4530931A (en) * 1983-01-03 1985-07-23 Usv Pharmaceutical Corp. 8-Quinoline carbanilates for the inhibition of lipolysis
EP0166354B1 (de) * 1984-06-26 1992-08-05 Merck & Co. Inc. Kondensierte Benzo-Laktam-Verbindungen und deren pharmazeutische Zusammensetzungen
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use

Also Published As

Publication number Publication date
EP0421456B1 (de) 1994-12-28
HUT55364A (en) 1991-05-28
AU629048B2 (en) 1992-09-24
EP0421456A2 (de) 1991-04-10
RU2001910C1 (ru) 1993-10-30
EP0421456A3 (en) 1991-05-29
TW205037B (de) 1993-05-01
DE69015541T2 (de) 1995-06-01
CN1050715A (zh) 1991-04-17
JPH03223254A (ja) 1991-10-02
KR910007883A (ko) 1991-05-30
AU6370790A (en) 1991-04-11
NO904300L (no) 1991-04-08
NZ235582A (en) 1992-03-26
CA2026890A1 (en) 1991-04-07
HU906360D0 (en) 1991-04-29
PT95515A (pt) 1991-08-14
CA2026890C (en) 2001-09-18
US5223513A (en) 1993-06-29
IL95839A0 (en) 1991-06-30
IE903454A1 (en) 1991-04-10
ATE116301T1 (de) 1995-01-15
IL95839A (en) 1995-03-15
FI904915A0 (fi) 1990-10-05
NO904300D0 (no) 1990-10-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee