DE69014490D1 - Piperaziniocephalosporine. - Google Patents

Piperaziniocephalosporine.

Info

Publication number
DE69014490D1
DE69014490D1 DE69014490T DE69014490T DE69014490D1 DE 69014490 D1 DE69014490 D1 DE 69014490D1 DE 69014490 T DE69014490 T DE 69014490T DE 69014490 T DE69014490 T DE 69014490T DE 69014490 D1 DE69014490 D1 DE 69014490D1
Authority
DE
Germany
Prior art keywords
alkyl
same
antibacterial
hydroxyarylpiperaziniocephalosporins
cephalosporins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69014490T
Other languages
English (en)
Other versions
DE69014490T2 (de
Inventor
Hiroshi Onoue
Toshiro Konoike
Hiroyuki Ishitobi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69014490D1 publication Critical patent/DE69014490D1/de
Publication of DE69014490T2 publication Critical patent/DE69014490T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69014490T 1989-09-07 1990-08-26 Piperaziniocephalosporine. Expired - Fee Related DE69014490T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23263189 1989-09-07

Publications (2)

Publication Number Publication Date
DE69014490D1 true DE69014490D1 (de) 1995-01-12
DE69014490T2 DE69014490T2 (de) 1995-04-20

Family

ID=16942341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69014490T Expired - Fee Related DE69014490T2 (de) 1989-09-07 1990-08-26 Piperaziniocephalosporine.

Country Status (7)

Country Link
US (1) US5143910A (de)
EP (1) EP0416410B1 (de)
JP (1) JP2969283B2 (de)
KR (1) KR0158452B1 (de)
AT (1) ATE114658T1 (de)
DE (1) DE69014490T2 (de)
DK (1) DK0416410T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0492277A3 (en) * 1990-12-20 1992-10-14 F. Hoffmann-La Roche Ag Cephalosporin derivatives
EP0550775A1 (de) * 1992-01-07 1993-07-14 F. Hoffmann-La Roche Ag Cephalosporinderivate
JP3081773B2 (ja) * 1995-03-31 2000-08-28 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
JP4189043B2 (ja) * 1996-09-30 2008-12-03 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
US6479495B1 (en) 1997-09-29 2002-11-12 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
PT1032559E (pt) * 1997-09-29 2007-02-28 Aventis Pharma Inc Derivados de aminoalquilfenol para tratamento de depressão e disfunção da memória
WO2005016276A2 (en) * 2003-08-05 2005-02-24 Samaritan Pharmaceuticals Inc. Sigma-1 receptor ligand with acetylcholinesterase inhibition properties
US20060247248A1 (en) * 2003-08-05 2006-11-02 Vassilios Papadopoulos Sigma-1 receptor ligand with acetylcholinesterase
CA2645666A1 (en) * 2006-03-15 2007-09-20 Mallinckrodt Inc. Chelating conjugates having a substituted aromatic moiety and derivatives thereof
US8883772B2 (en) 2007-10-09 2014-11-11 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
PE20120010A1 (es) 2008-10-31 2012-02-07 Shionogi & Co Cefalosporinas que tienen un grupo catecol
IN2012CN09242A (de) * 2010-04-05 2015-08-21 Shionogi & Co
US8883773B2 (en) 2010-04-05 2014-11-11 Shionogi & Co., Ltd. Cephem compound having pseudo-catechol group
WO2011136268A1 (ja) * 2010-04-28 2011-11-03 塩野義製薬株式会社 新規なセフェム誘導体
CN103635478A (zh) 2011-04-28 2014-03-12 盐野义制药株式会社 具有儿茶酚或假儿茶酚结构的新颖头孢烯类化合物
JP2014513116A (ja) 2011-05-02 2014-05-29 ゾエティス・エルエルシー 抗菌剤として有用な新規セファロスポリン
US9242999B2 (en) 2011-06-27 2016-01-26 Shionogi & Co., Ltd. Cephem compound having pyridinium group
WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
AU2013339040A1 (en) 2012-10-29 2015-04-30 Shionogi & Co., Ltd. Processes for production of intermediates for 2-alkyl cephem compounds
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
WO2021043973A1 (en) 2019-09-06 2021-03-11 Nabriva Therapeutics GmbH Siderophore cephalosporin conjugates and uses thereof
KR20220130725A (ko) 2020-01-22 2022-09-27 상하이 센후이 메디슨 컴퍼니 리미티드 세팔로스포린 항균 화합물 및 이의 약제학적 적용
TW202241913A (zh) 2021-01-12 2022-11-01 大陸商上海森輝醫藥有限公司 一種頭孢類抗菌化合物及其製備方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5285187A (en) * 1976-01-08 1977-07-15 Shionogi & Co Ltd Antibacterials against pseudomonas aeruginosa
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
US4785090A (en) * 1984-02-23 1988-11-15 Meiji Seika Kaisha, Ltd. Cephalosporin derivatives
JPS6117589A (ja) * 1984-07-03 1986-01-25 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体及びその製造法
US4880795A (en) * 1984-05-22 1989-11-14 Bayer Aktiengesellschaft Cephalosporins
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
ZA86405B (en) * 1985-01-31 1986-09-24 Yamanouchi Pharma Co Ltd Cephalosporin compounds and slats thereof,and their production
DE3506159A1 (de) * 1985-02-22 1986-08-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS6230786A (ja) * 1985-04-11 1987-02-09 Eisai Co Ltd ３−（キヌクリジニオ）メチル−３−セフエム誘導体
JPS625961A (ja) * 1985-07-01 1987-01-12 Meiji Seika Kaisha Ltd 酸性基を有するピリドチオン類化合物および該化合物より誘導される新規なセフアロスポリン誘導体
DE3541095A1 (de) * 1985-11-21 1987-05-27 Bayer Ag Neue cephalosporine, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
JPS62209082A (ja) * 1986-03-11 1987-09-14 Banyu Pharmaceut Co Ltd セフアロスポリン誘導体
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
US4782155A (en) * 1986-03-19 1988-11-01 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
EP0238060B1 (de) * 1986-03-19 1992-01-08 Banyu Pharmaceutical Co., Ltd. Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und antibakterielle Mittel
EP0272827A3 (de) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-Heterocyclethiomethyl-cephalosporine
DE3711343A1 (de) * 1987-04-03 1988-10-20 Bayer Ag Cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
PH25965A (en) * 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities

Also Published As

Publication number Publication date
JPH03173893A (ja) 1991-07-29
EP0416410A1 (de) 1991-03-13
KR0158452B1 (ko) 1998-12-01
ATE114658T1 (de) 1994-12-15
DK0416410T3 (da) 1995-05-15
DE69014490T2 (de) 1995-04-20
US5143910A (en) 1992-09-01
JP2969283B2 (ja) 1999-11-02
KR910006303A (ko) 1991-04-29
EP0416410B1 (de) 1994-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee